Hypertriglyceridemia omega-3 fatty acids: Difference between revisions

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Latest revision as of 19:58, 23 November 2016

For full Omega-3 fatty acid drug info click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the diet, as well as with niacin, fibrates and statins (three classes of drugs). Increased fish oil intake may substantially lower an individual's triglycerides.^[1]^[2]^[3].

Trial Supportive Data

Study name	Source & year	Study question	Study Design	Study Population	Time period	Intervention	Results	Conclusions
Effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia ^[4]	Heart, 2001	To access the safety and efficacy of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia	Double blinded randomized controlled trial	59 patients with CHD, on simvastatin 10-40 mg/d, with serum triglycerides > 2.3 mmol/l	1 year	Omacor (84% omega-3 fatty acid) 2 g BD or placebo	Decrease in serum triglycerides by 20-30% (p<0.005) Decrease in very low-density lipoprotein (VLDL) cholesterol by 30-40% (p<0.005)	Omacor combination with simvastatin was found to be a safe and effective in decreasing serum triglycerides in coronary heart disease

Researchers say diets rich in Omega-3 fatty acids can help people with heart disease live longer, but why these oils are so beneficial remains unclear. A new study looks at how higher fish oil levels in the blood may protect the caps on chromosomes, which help measure biological aging

External Links

http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184

References

↑ "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".
↑ Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.
↑ "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".
↑ Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA; et al. (2001). "An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia". Heart. 85 (5): 544–8. PMC 1729738. PMID 11303007.

Template:WikiDoc Sources

[1] "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".

[pmid2035283-2] Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.

[3] "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".

[pmid11303007-4] Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA; et al. (2001). "An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia". Heart. 85 (5): 544–8. PMC 1729738. PMID 11303007.

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-{{Hypertriglyceridemia}}
+__NOTOC__
+{{Hyperlipoproteinemia}}
-{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh@perfuse.org]
+'''For full Omega-3 fatty acid drug info click [[Omega-3 fatty acid|here]]'''
+{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com]
 ==Overview==
 Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the [[diet (nutrition)|diet]], as well as with [[niacin]], [[fibrate]]s and [[statin]]s (three classes of drugs).  Increased [[fish oil]] intake may substantially lower an individual's triglycerides.<ref>{{cite web |url=http://www.lipidsonline.org/slides/slide01.cfm?q=hypertriglyceridemia&dpg=13 |title=Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin | format= |work=}}</ref><ref name="pmid2035283">{{cite journal |author=Terres W, Beil U, Reimann B, Tiede S, Bleifeld W |title=[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study] |language=German |journal=Zeitschrift für Kardiologie |volume=80 |issue=1 |pages=20-4 |year=1991 |pmid=2035283 |doi=}}</ref><ref>{{cite web |url=http://www.findarticles.com/p/articles/mi_m0887/is_n4_v9/ai_8960077 |title=Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles |format= |work=}}</ref>.
-==Omega-3 fatty acids==
+===Trial Supportive Data===
-===Mechanism of benefit===
-* Decreased hepatic [[lipogenesis]]
+{|border="1" align="center" style="background:light gray"
-* Increased plasma [[lipoprotein lipase]] activity.
+|-
-* Increased hepatic mitochondrial and peroxisomal beta-oxidation
+| bgcolor="Gray" |'''Study name'''
-* Inhibition of acyl CoA:1,2-diacylglycerol acyltransferase enzyme
+| bgcolor="Gray" |'''Source & year'''
-* Omega-3 fatty acids component EPA and DHA are poor enzyme substrates for triglyceride synthesis in the liver
+| bgcolor="Gray" |'''Study question'''
-* EPA and DHA inhibit esterification of other fatty acids.
+| bgcolor="Gray" |'''Study Design'''
+| bgcolor="Gray" |'''Study Population'''
+| bgcolor="Gray" |'''Time period'''
+| bgcolor="Gray" |'''Intervention'''
+| bgcolor="Gray" |'''Results'''
+| bgcolor="Gray" |'''Conclusions'''
+|-
+| Effect of combination of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia <ref name="pmid11303007">{{cite journal| author=Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA et al.| title=An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. | journal=Heart | year= 2001 | volume= 85 | issue= 5 | pages= 544-8 | pmid=11303007 | doi= | pmc=PMC1729738 | url= }} </ref>
+| Heart, 2001
+| To access the safety and efficacy of Omega-3 fatty acid and Simvastatin on hypertriglyceridemia
+| Double blinded randomized controlled trial
+| 59 patients with CHD, on simvastatin 10-40 mg/d, with serum triglycerides > 2.3 mmol/l
+| 1 year
+| Omacor (84% omega-3 fatty acid) 2 g BD or placebo
+|
+*Decrease in serum [[triglycerides]] by 20-30% (p<0.005)
+*Decrease in very low-density lipoprotein ([[VLDL]]) cholesterol by 30-40% (p<0.005)
+|
+* [[Omacor]] combination with [[simvastatin]] was found to be a safe and effective in decreasing serum [[triglycerides]] in [[coronary heart disease]]
+|-
+|}
+{{#ev:youtube|9l94Nm241GI}}
+===Researchers say diets rich in Omega-3 fatty acids can help people with heart disease live longer, but why these oils are so beneficial remains unclear. A new study looks at how higher fish oil levels in the blood may protect the caps on chromosomes, which help measure biological aging===
+==External Links==
+http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184
 ==References==
 {{Reflist|2}}
-[[fr:Hypertriglycéridémie]]
+{{Lipopedia}}
-[[pt:Hipertrigliceridemia]]
+[[Category:Lipopedia]]
 [[Category:Cardiology]]
 [[Category:Dermatology]]

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Abnormal Laboratory Lipid Profile	Low chylomicron • Low chylomicron remnant • Low HDL • Low IDL • Low LDL • Low lipoprotein(a) • Low VLDL High chylomicron • High chylomicron remnant • High HDL • High IDL • High LDL • High Lipoprotein(a) • High VLDL