Cryptococcus infection pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathophysiology== | |||
===Pathogenesis=== | |||
*Cryptococcus neoformans enters the body through the respiratory tract. | |||
*Immunocompetent individuals can contain C. neoformans in the lung.<ref name="pmid11204147">{{cite journal| author=Kwon-Chung KJ, Sorrell TC, Dromer F, Fung E, Levitz SM| title=Cryptococcosis: clinical and biological aspects. | journal=Med Mycol | year= 2000 | volume= 38 Suppl 1 | issue= | pages= 205-13 | pmid=11204147 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11204147 }} </ref> | |||
*In the case of an immunocompromised host, the yeast cells division is uncontrolled and the infection can disseminate into the brain via the hematogenous route, causing meningoencephalitis.<ref name="pmid11051295">{{cite journal| author=Gottfredsson M, Perfect JR| title=Fungal meningitis. | journal=Semin Neurol | year= 2000 | volume= 20 | issue= 3 | pages= 307-22 | pmid=11051295 | doi=10.1055/s-2000-9394 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11051295 }} </ref> | |||
*Cryptococcus neoformans enters the brain parenchyma passing through the blood brain barrier via a mechanism called transcytosis which is mediated by interactions between CD44 expressed on endothelium and cryptococcal hyaluronic acids.<ref name="pmid22418440">{{cite journal| author=Jong A, Wu CH, Gonzales-Gomez I, Kwon-Chung KJ, Chang YC, Tseng HK et al.| title=Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection. | journal=J Biol Chem | year= 2012 | volume= 287 | issue= 19 | pages= 15298-306 | pmid=22418440 | doi=10.1074/jbc.M112.353375 | pmc=3346080 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22418440 }} </ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} |
Latest revision as of 15:14, 5 June 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Pathophysiology
Pathogenesis
- Cryptococcus neoformans enters the body through the respiratory tract.
- Immunocompetent individuals can contain C. neoformans in the lung.[1]
- In the case of an immunocompromised host, the yeast cells division is uncontrolled and the infection can disseminate into the brain via the hematogenous route, causing meningoencephalitis.[2]
- Cryptococcus neoformans enters the brain parenchyma passing through the blood brain barrier via a mechanism called transcytosis which is mediated by interactions between CD44 expressed on endothelium and cryptococcal hyaluronic acids.[3]
References
- ↑ Kwon-Chung KJ, Sorrell TC, Dromer F, Fung E, Levitz SM (2000). "Cryptococcosis: clinical and biological aspects". Med Mycol. 38 Suppl 1: 205–13. PMID 11204147.
- ↑ Gottfredsson M, Perfect JR (2000). "Fungal meningitis". Semin Neurol. 20 (3): 307–22. doi:10.1055/s-2000-9394. PMID 11051295.
- ↑ Jong A, Wu CH, Gonzales-Gomez I, Kwon-Chung KJ, Chang YC, Tseng HK; et al. (2012). "Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection". J Biol Chem. 287 (19): 15298–306. doi:10.1074/jbc.M112.353375. PMC 3346080. PMID 22418440.