Sandbox:Filariasis pathogenesis: Difference between revisions
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{| class="wikitable" | {| class="wikitable" | ||
! | !Factor | ||
! | !Role in pathogenesis | ||
|- | |- | ||
| | |Immune response of the host | ||
| | | | ||
* In several studies, it has been noticed that there is a strong correlation between the host immune response and lymphoedema development. The immune response is higher in the lymphedema patients more than the patients with microfilariae just cirulating in the blood. | |||
* Hence, it is believed the role of the immune response in development of the lymphedema as it leads to inflammation and obstruction of the lymphatic vessels. | |||
* Infection by filariasis induces cell mediated immunity in response to the filarial antigens. This will lead to production of cytokines and interleukns. | |||
* High levels of immunoglobulins (IgG1,2,3) has been detected in patients with lymphedema which increases the evidence of the role of the immune response in pathogenesis of the disease. | |||
|- | |- | ||
| | |Secondary bacterial infections | ||
| | | | ||
* Adenolymphangitis is a result of the inflammation induced by the filarial infection and the immune response. It is believed that it worsens the disease and leads to morbidity. | |||
* It affects the lower limbs resulting in cord like lesion of the lymphatic vessels and worsening of the filariasis. | |||
|- | |- | ||
| | |Worm antigens accumulation | ||
| | | | ||
|- | |- | ||
| | |Wolbachia bacteria | ||
| | | | ||
|} | |} | ||
Latest revision as of 20:56, 27 June 2017
Factor | Role in pathogenesis |
---|---|
Immune response of the host |
|
Secondary bacterial infections |
|
Worm antigens accumulation | |
Wolbachia bacteria |