Elevated TSH: Difference between revisions
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{{CMG}} {{AE}} {{MIR}} | |||
{{SK}} Elevated thyroid stimulating hormone, High TSH, High thyroid stimulating hormone, TSH crisis, Thyroid stimulating hormone crisis. | |||
== Differentiating different causes of TSH elevation == | == Differentiating different causes of TSH elevation == | ||
Various kinds of diseases that cause elevated TSH (which all are categorized as hypothyroidism) can be differentiated from each other on the basis of history and symptoms and laboratory findings:<ref name="pmid19949140" /><ref name="pmid18177256" /><ref name=" | Various kinds of diseases that cause elevated TSH (which all are categorized as hypothyroidism) can be differentiated from each other on the basis of history and symptoms and laboratory findings:<ref name="pmid19949140">{{cite journal |vauthors=McDermott MT |title=In the clinic. Hypothyroidism |journal=Ann. Intern. Med. |volume=151 |issue=11 |pages=ITC61 |year=2009 |pmid=19949140 |doi=10.7326/0003-4819-151-11-200912010-01006 |url=}}</ref><ref name="pmid18177256">{{cite journal |vauthors=Aoki Y, Belin RM, Clickner R, Jeffries R, Phillips L, Mahaffey KR |title=Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999-2002) |journal=Thyroid |volume=17 |issue=12 |pages=1211–23 |year=2007 |pmid=18177256 |doi=10.1089/thy.2006.0235 |url=}}</ref><ref name="pmid8371604">{{cite journal |vauthors=O'Brien T, Dinneen SF, O'Brien PC, Palumbo PJ |title=Hyperlipidemia in patients with primary and secondary hypothyroidism |journal=Mayo Clin. Proc. |volume=68 |issue=9 |pages=860–6 |year=1993 |pmid=8371604 |doi= |url=}}</ref> | ||
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! colspan="2" rowspan="2" align="center" style="background: #4479BA; color: #FFFFFF; " |Disease | ! colspan="2" rowspan="2" align="center" style="background: #4479BA; color: #FFFFFF; " |Disease | ||
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* Rare | * Rare | ||
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== References == | |||
{{Reflist|2}} | |||
Latest revision as of 12:35, 12 September 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]
Synonyms and keywords: Elevated thyroid stimulating hormone, High TSH, High thyroid stimulating hormone, TSH crisis, Thyroid stimulating hormone crisis.
Differentiating different causes of TSH elevation
Various kinds of diseases that cause elevated TSH (which all are categorized as hypothyroidism) can be differentiated from each other on the basis of history and symptoms and laboratory findings:[1][2][3]
| Disease | History and symptoms | Laboratory findings | Additional findings | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fever | Goiter | Pain | TSH | Free T4 | T3 | T3RU | Thyroglobin | TRH | TPOAb | |||
| Primary hypothyroidism | Autoimmune | + | +/-
Diffuse |
- | ↑ | ↓ | N/↓ | Normal | N/↑ | Normal | ↑ |
|
| Thyroiditis | + | +/- | + | ↑ | ↓ | Normal | Normal | N/↑ | Normal | Normal |
| |
| Others | - | +/- | - | ↑ | ↓ | Normal | Normal | N/↑ | Normal | Normal |
| |
| Transient hypothyroidism | +/- | - | +/- | ↑ | ↑ | Normal | Normal | ↑ | Normal | Normal |
| |
| Subclinical hypothyroidism | - | - | - | ↑ | Normal | Normal | Normal | ↑ | Normal | N/↑ |
| |
| Central Hypothyroidism | Pituitary | + | - | - | N/↓ | N/↓ | N/↓ | ↓ | Normal | Normal | Normal |
|
| Hypothalamus | + | - | - | ↑ | Normal | ↓ | Normal |
| ||||
| Resistance to TSH/TRH | - | - | - | ↑ | N/↓ | N/↓ | Normal | Normal | ↑/↓ | Normal |
| |
References
- ↑ McDermott MT (2009). "In the clinic. Hypothyroidism". Ann. Intern. Med. 151 (11): ITC61. doi:10.7326/0003-4819-151-11-200912010-01006. PMID 19949140.
- ↑ Aoki Y, Belin RM, Clickner R, Jeffries R, Phillips L, Mahaffey KR (2007). "Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999-2002)". Thyroid. 17 (12): 1211–23. doi:10.1089/thy.2006.0235. PMID 18177256.
- ↑ O'Brien T, Dinneen SF, O'Brien PC, Palumbo PJ (1993). "Hyperlipidemia in patients with primary and secondary hypothyroidism". Mayo Clin. Proc. 68 (9): 860–6. PMID 8371604.