Croup future or investigational therapies: Difference between revisions
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==Overview== | ==Overview== | ||
[[Heliox]] - a combination of [[helium]] and [[oxygen]] - is currently being studied for efficacy in treating croup. It works by reducing [[upper airway]] resistance to gas flow, relieving [[respiratory distress]]. There is early evidence that it is as effective as [[racemic]] [[epinephrine]] in treating moderate and severe croup. Further randomized trials and investigational studies are being pursued. | |||
==Future or Investigational Therapies== | ==Future or Investigational Therapies== | ||
=== | ===Heliox=== | ||
*[[Helium]] and [[oxygen]] combined into "[[heliox]]" breathing gas can be used to alleviate croup symptoms by reducing upper airway obstruction.<ref name="MoraaSturman2013">{{cite journal|last1=Moraa|first1=Irene|last2=Sturman|first2=Nancy|last3=McGuire|first3=Treasure|last4=van Driel|first4=Mieke L|last5=Moraa|first5=Irene|title=Heliox for croup in children|year=2013|doi=10.1002/14651858.CD006822.pub4}}</ref> | *[[Helium]] and [[oxygen]] combined into "[[heliox]]" breathing gas can be used to alleviate croup symptoms by reducing [[upper airway]] obstruction.<ref name="MoraaSturman2013">{{cite journal|last1=Moraa|first1=Irene|last2=Sturman|first2=Nancy|last3=McGuire|first3=Treasure|last4=van Driel|first4=Mieke L|last5=Moraa|first5=Irene|title=Heliox for croup in children|year=2013|doi=10.1002/14651858.CD006822.pub4}}</ref> | ||
**Upper airway resistance to gas flow is reduced to relieve [[respiratory distress]]. | **[[Upper airway]] resistance to gas flow is reduced to relieve [[respiratory distress]]. | ||
*There is evidence that suggests [[heliox]] can be as effective as [[racemic]] [[epinephrine]] in relieving moderate to severe croup symptoms.<ref name="WeberChudnofsky2001">{{cite journal|last1=Weber|first1=J. E.|last2=Chudnofsky|first2=C. R.|last3=Younger|first3=J. G.|last4=Larkin|first4=G. L.|last5=Boczar|first5=M.|last6=Wilkerson|first6=M. D.|last7=Zuriekat|first7=G. Y.|last8=Nolan|first8=B.|last9=Eicke|first9=D. M.|title=A Randomized Comparison of Helium-Oxygen Mixture (Heliox) and Racemic Epinephrine for the Treatment of Moderate to Severe Croup|journal=PEDIATRICS|volume=107|issue=6|year=2001|pages=e96–e96|issn=0031-4005|doi=10.1542/peds.107.6.e96}}</ref> | *There is evidence that suggests [[heliox]] can be as effective as [[racemic]] [[epinephrine]] in relieving moderate to severe croup symptoms.<ref name="WeberChudnofsky2001">{{cite journal|last1=Weber|first1=J. E.|last2=Chudnofsky|first2=C. R.|last3=Younger|first3=J. G.|last4=Larkin|first4=G. L.|last5=Boczar|first5=M.|last6=Wilkerson|first6=M. D.|last7=Zuriekat|first7=G. Y.|last8=Nolan|first8=B.|last9=Eicke|first9=D. M.|title=A Randomized Comparison of Helium-Oxygen Mixture (Heliox) and Racemic Epinephrine for the Treatment of Moderate to Severe Croup|journal=PEDIATRICS|volume=107|issue=6|year=2001|pages=e96–e96|issn=0031-4005|doi=10.1542/peds.107.6.e96}}</ref>. | ||
*Studies have not yet consistently determined if [[heliox]] is effective in treating all forms of croup and further investigational randomized trials are being pursued.<ref name="MoraaSturman2013">{{cite journal|last1=Moraa|first1=Irene|last2=Sturman|first2=Nancy|last3=McGuire|first3=Treasure|last4=van Driel|first4=Mieke L|last5=Moraa|first5=Irene|title=Heliox for croup in children|year=2013|doi=10.1002/14651858.CD006822.pub4}}</ref> | *Studies have not yet consistently determined if [[heliox]] is effective in treating all forms of croup and further investigational randomized trials are being pursued.<ref name="MoraaSturman2013">{{cite journal|last1=Moraa|first1=Irene|last2=Sturman|first2=Nancy|last3=McGuire|first3=Treasure|last4=van Driel|first4=Mieke L|last5=Moraa|first5=Irene|title=Heliox for croup in children|year=2013|doi=10.1002/14651858.CD006822.pub4}}</ref> | ||
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[[Category:Pediatrics]] | [[Category:Pediatrics]] | ||
[[Category:Pulmonology]] | [[Category:Pulmonology]] | ||
[[Category:Emergency medicine]] | [[Category:Emergency medicine]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Latest revision as of 17:30, 18 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Heliox - a combination of helium and oxygen - is currently being studied for efficacy in treating croup. It works by reducing upper airway resistance to gas flow, relieving respiratory distress. There is early evidence that it is as effective as racemic epinephrine in treating moderate and severe croup. Further randomized trials and investigational studies are being pursued.
Future or Investigational Therapies
Heliox
- Helium and oxygen combined into "heliox" breathing gas can be used to alleviate croup symptoms by reducing upper airway obstruction.[1]
- Upper airway resistance to gas flow is reduced to relieve respiratory distress.
- There is evidence that suggests heliox can be as effective as racemic epinephrine in relieving moderate to severe croup symptoms.[2].
- Studies have not yet consistently determined if heliox is effective in treating all forms of croup and further investigational randomized trials are being pursued.[1]
References
- ↑ 1.0 1.1 Moraa, Irene; Sturman, Nancy; McGuire, Treasure; van Driel, Mieke L; Moraa, Irene (2013). "Heliox for croup in children". doi:10.1002/14651858.CD006822.pub4.
- ↑ Weber, J. E.; Chudnofsky, C. R.; Younger, J. G.; Larkin, G. L.; Boczar, M.; Wilkerson, M. D.; Zuriekat, G. Y.; Nolan, B.; Eicke, D. M. (2001). "A Randomized Comparison of Helium-Oxygen Mixture (Heliox) and Racemic Epinephrine for the Treatment of Moderate to Severe Croup". PEDIATRICS. 107 (6): e96–e96. doi:10.1542/peds.107.6.e96. ISSN 0031-4005.