Granulomatous amoebic encephalitis laboratory tests: Difference between revisions
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{{Granulomatous amoebic encephalitis}} | {{Granulomatous amoebic encephalitis}} | ||
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==Overview== | ==Overview== | ||
The [[indirect immunofluorescence assay]] (IFA) is a test used to detect antibodies attached to Balamuthia amebas in body tissues. In contrast, [[immunohistochemistry]] (IHC) uses specific antibodies against Balamuthia to detect the amoebas. Finally, a [[polymerase chain reaction]] (PCR) molecular assay can detect Balamuthia DNA. | |||
==Laboratory Findings== | |||
Balamuthia Granulomatous Amebic Encephalitis (GAE) is a serious infection of the [[brain]] and [[spinal cord]] caused by Balamuthia. GAE is often diagnosed only after death. However, it can be diagnosed by examining [[blood]], [[cerebrospinal fluid]], and tissue samples from a living patient as well. Diagnosis of GAE in a living patient is less common because the amoebas are difficult to identify under the microscope, even with commonly used stains[5]. | |||
However, there are three types of tests that can help confirm the diagnosis of GAE. The [[indirect immunofluorescence assay]] (IFA) is a test used to detect antibodies attached to Balamuthia amebas in body tissues. In contrast, [[immunohistochemistry]] (IHC) uses specific antibodies against Balamuthia to detect the amoebas. Finally, a [[polymerase chain reaction]] (PCR) molecular assay can detect Balamuthia DNA. | |||
However, there are three types of tests that can help confirm the diagnosis of GAE. The [[indirect immunofluorescence assay]] (IFA) is a test used to detect antibodies attached to Balamuthia amebas in body tissues. In contrast, [[immunohistochemistry]] (IHC) uses specific antibodies against Balamuthia to detect the amoebas. Finally, a [[polymerase chain reaction]] (PCR) molecular assay can detect Balamuthia DNA | |||
The [[Centers for Disease Control and Prevention]] (CDC) offers diagnostic assistance for Balamuthia to physicians and scientists through DPDx. | The [[Centers for Disease Control and Prevention]] (CDC) offers diagnostic assistance for Balamuthia to physicians and scientists through DPDx. | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | |||
[[Category:Neurology]] | |||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{wikiDoc Sources}} | {{wikiDoc Sources}} | ||
Latest revision as of 17:50, 18 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The indirect immunofluorescence assay (IFA) is a test used to detect antibodies attached to Balamuthia amebas in body tissues. In contrast, immunohistochemistry (IHC) uses specific antibodies against Balamuthia to detect the amoebas. Finally, a polymerase chain reaction (PCR) molecular assay can detect Balamuthia DNA.
Laboratory Findings
Balamuthia Granulomatous Amebic Encephalitis (GAE) is a serious infection of the brain and spinal cord caused by Balamuthia. GAE is often diagnosed only after death. However, it can be diagnosed by examining blood, cerebrospinal fluid, and tissue samples from a living patient as well. Diagnosis of GAE in a living patient is less common because the amoebas are difficult to identify under the microscope, even with commonly used stains[5].
However, there are three types of tests that can help confirm the diagnosis of GAE. The indirect immunofluorescence assay (IFA) is a test used to detect antibodies attached to Balamuthia amebas in body tissues. In contrast, immunohistochemistry (IHC) uses specific antibodies against Balamuthia to detect the amoebas. Finally, a polymerase chain reaction (PCR) molecular assay can detect Balamuthia DNA.
The Centers for Disease Control and Prevention (CDC) offers diagnostic assistance for Balamuthia to physicians and scientists through DPDx.
References