Herpes labialis: Difference between revisions
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==Overview== | ==Overview== | ||
'''Herpes labialis''' (also known as "Orolabial herpes"<ref name="Andrews">{{cite book |author=James, William D.; Berger, Timothy G.; et al. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages= |isbn=0-7216-2921-0 |oclc= |doi= |accessdate=}}</ref>{{rp|368}}) is an infection of the [[lip]] by [[herpes simplex virus]]. In many cases, it causes small blisters or sores on or around the mouth that are commonly known as | '''Herpes labialis''' (also known as "Orolabial herpes"<ref name="Andrews">{{cite book |author=James, William D.; Berger, Timothy G.; et al. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages= |isbn=0-7216-2921-0 |oclc= |doi= |accessdate=}}</ref>{{rp|368}}) is an infection of the [[lip]] by [[herpes simplex virus]]. In many cases, it causes small blisters or sores on or around the mouth that are commonly known as cold sores or fever blisters. (In medical contexts, "labia" is a general term for "lip"; "herpes labialis" does not refer to the [[Labium (genitalia)|labia]] of the [[genitals]], though the [[etymology]] is the same.) When the viral infection affects both face and mouth, the broader term "orofacial herpes" is used to describe the condition, whereas the term "herpetic stomatitis" is used to specifically describe infection of the mouth; "stomatitis" is derived from the Greek word [[stoma]] that means "mouth". Sores associated with herpes labialis typically heal within 2-3 weeks, but the virus that causes them is not removed from the body. The herpes virus infects and becomes [[dormant]] in the facial [[nerve]]s, following orofacial infection, periodically reactivating (in symptomatic people) to create sores in the same area of the mouth or face that the original infection occurred. | ||
==Causes== | ==Causes== | ||
Herpes labialis infection occurs when the herpes simplex virus comes into contact with [[oral mucosa]]l tissue or [[abrasion (medical)|abraded]] skin of the mouth. Infection by the type 1 strain of herpes simplex virus (HSV-1) is most common, though cases of oral infection by the type 2 strain are increasing.<ref name="pmid15596324">{{cite journal |author=Bruce AJ, Rogers RS |title=Oral manifestations of sexually transmitted diseases |journal=Clin. Dermatol. |volume=22 |issue=6 |pages=520–7 |year=2004 |pmid=15596324 |doi=10.1016/j.clindermatol.2004.07.005}}</ref> | Herpes labialis infection occurs when the herpes simplex virus comes into contact with [[oral mucosa]]l tissue or [[abrasion (medical)|abraded]] skin of the mouth. Infection by the type 1 strain of herpes simplex virus (HSV-1) is most common, though cases of oral infection by the type 2 strain are increasing.<ref name="pmid15596324">{{cite journal |author=Bruce AJ, Rogers RS |title=Oral manifestations of sexually transmitted diseases |journal=Clin. Dermatol. |volume=22 |issue=6 |pages=520–7 |year=2004 |pmid=15596324 |doi=10.1016/j.clindermatol.2004.07.005}}</ref> | ||
===Drugs=== | |||
[[Azficel-T]] | |||
== | ==History and Symptoms== | ||
Herpes infections often show no symptoms;<ref name="pmid19074705">{{cite journal |author=Opstelten W, Neven AK, Eekhof J |title=Treatment and prevention of herpes labialis |journal=Can Fam Physician |volume=54 |issue=12 |pages=1683–7 |year=2008 |month=December |pmid=19074705 |pmc=2602638 |doi= |url=http://www.cfp.ca/cgi/pmidlookup?view=long&pmid=19074705}}</ref> when symptoms do appear they typically resolve within two weeks.<ref name="pmid15596324"/> The main symptom of oral infection is inflammation of the mucosa of the cheek and gums -- known as acute herpetic [[gingivostomatitis]] -- which occurs within 5–10 days of infection. Other symptoms may also develop, including painful [[Oral ulcer|ulcers]]—sometimes confused with [[canker sores]]—fever, and sore throat.<ref name="pmid15596324"/> [[primary infection|Primary]] HSV infection in [[adolescent]]s frequently manifests as severe [[pharyngitis]] with [[lesion]]s developing on the cheek and gums. Some individuals develop difficulty in swallowing ([[dysphagia]]) and swollen [[lymph node]]s ([[lymphadenopathy]]).<ref name="pmid15596324"/> Primary HSV infections in adults often results in pharyngitis similar to that observed in glandular fever ([[infectious mononucleosis]]), but gingivostomatitis is less likely. | Herpes infections often show no symptoms;<ref name="pmid19074705">{{cite journal |author=Opstelten W, Neven AK, Eekhof J |title=Treatment and prevention of herpes labialis |journal=Can Fam Physician |volume=54 |issue=12 |pages=1683–7 |year=2008 |month=December |pmid=19074705 |pmc=2602638 |doi= |url=http://www.cfp.ca/cgi/pmidlookup?view=long&pmid=19074705}}</ref> when symptoms do appear they typically resolve within two weeks.<ref name="pmid15596324"/> The main symptom of oral infection is inflammation of the mucosa of the cheek and gums -- known as acute herpetic [[gingivostomatitis]] -- which occurs within 5–10 days of infection. Other symptoms may also develop, including painful [[Oral ulcer|ulcers]]—sometimes confused with [[canker sores]]—fever, and sore throat.<ref name="pmid15596324"/> [[primary infection|Primary]] HSV infection in [[adolescent]]s frequently manifests as severe [[pharyngitis]] with [[lesion]]s developing on the cheek and gums. Some individuals develop difficulty in swallowing ([[dysphagia]]) and swollen [[lymph node]]s ([[lymphadenopathy]]).<ref name="pmid15596324"/> Primary HSV infections in adults often results in pharyngitis similar to that observed in glandular fever ([[infectious mononucleosis]]), but gingivostomatitis is less likely. | ||
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==Treatment== | ==Treatment== | ||
{{main|Herpes simplex#Treatment}} | {{main|Herpes simplex#Treatment}} | ||
[[Acyclovir]] has been used in some cases.<ref name="pmid14959874">{{cite journal |author=Raborn GW, Chan KS, Grace M |title=Treatment modalities and medication recommended by health care professionals for treating recurrent herpes labialis |journal=J Am Dent Assoc |volume=135 |issue=1 |pages=48–54 |year=2004 |month=January |pmid=14959874 |doi= |url=http://jada.ada.org/cgi/pmidlookup?view=long&pmid=14959874}}</ref> | Placing cool, wet towel or ice on the sore. | ||
For pain-Advil or Motrin (Ibuprofen) or Tylenol(Acetaminophen). If very severe pain and not able to take any medicine per oral, Anbesol or Orajel( Benzocaine ointment or gel in 7.5 or 10 or 20% formulation). Due to pain, patient is not able to take any solid foods, but they should at least make sure that they are hydrated, should take a lot of fruit smoothie with protein powder added to it. Vitamin supplements recommended. Avoid Citrus foods like tomato, lemon as it increases pain of the blister. Zinc oxide cream on the cold sore can help reduce the duration of the blister. <ref name="webMD">|url=http://www.webmd.com/skin-problems-and-treatments/tc/cold-sores-home-treatment}}</ref> | |||
[[Acyclovir]] has been used in some cases. In primary lesion, Acyclovir Per oral or Abreva/ Docosanol antiviral cream available as 10% cream over the counter five times a day helps to reduce the duration of symptoms. <ref name="pmid14959874">{{cite journal |author=Raborn GW, Chan KS, Grace M |title=Treatment modalities and medication recommended by health care professionals for treating recurrent herpes labialis |journal=J Am Dent Assoc |volume=135 |issue=1 |pages=48–54 |year=2004 |month=January |pmid=14959874 |doi= |url=http://jada.ada.org/cgi/pmidlookup?view=long&pmid=14959874}}</ref> | |||
===Antiviral regimen=== | |||
:*[[Acyclovir]] 15 mg/kg PO q5h For 7 days | |||
==References== | ==References== | ||
{{reflist}} | {{reflist|2}} | ||
{{Viral diseases}} | {{Viral diseases}} | ||
{{Oral pathology}} | {{Oral pathology}} | ||
[[cy:Dolur annwyd]] | [[cy:Dolur annwyd]] | ||
[[de:Herpes simplex#Herpes labialis]] | [[de:Herpes simplex#Herpes labialis]] | ||
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Latest revision as of 17:58, 18 September 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Herpes labialis (also known as "Orolabial herpes"[1]:368) is an infection of the lip by herpes simplex virus. In many cases, it causes small blisters or sores on or around the mouth that are commonly known as cold sores or fever blisters. (In medical contexts, "labia" is a general term for "lip"; "herpes labialis" does not refer to the labia of the genitals, though the etymology is the same.) When the viral infection affects both face and mouth, the broader term "orofacial herpes" is used to describe the condition, whereas the term "herpetic stomatitis" is used to specifically describe infection of the mouth; "stomatitis" is derived from the Greek word stoma that means "mouth". Sores associated with herpes labialis typically heal within 2-3 weeks, but the virus that causes them is not removed from the body. The herpes virus infects and becomes dormant in the facial nerves, following orofacial infection, periodically reactivating (in symptomatic people) to create sores in the same area of the mouth or face that the original infection occurred.
Causes
Herpes labialis infection occurs when the herpes simplex virus comes into contact with oral mucosal tissue or abraded skin of the mouth. Infection by the type 1 strain of herpes simplex virus (HSV-1) is most common, though cases of oral infection by the type 2 strain are increasing.[2]
Drugs
History and Symptoms
Herpes infections often show no symptoms;[3] when symptoms do appear they typically resolve within two weeks.[2] The main symptom of oral infection is inflammation of the mucosa of the cheek and gums -- known as acute herpetic gingivostomatitis -- which occurs within 5–10 days of infection. Other symptoms may also develop, including painful ulcers—sometimes confused with canker sores—fever, and sore throat.[2] Primary HSV infection in adolescents frequently manifests as severe pharyngitis with lesions developing on the cheek and gums. Some individuals develop difficulty in swallowing (dysphagia) and swollen lymph nodes (lymphadenopathy).[2] Primary HSV infections in adults often results in pharyngitis similar to that observed in glandular fever (infectious mononucleosis), but gingivostomatitis is less likely.
Recurrent oral infection is more common with HSV-1 infections than with HSV-2. Prodromal symptoms often precede a recurrence. Symptoms typically begin with tingling (itching) and reddening of the skin around the infected site. Eventually, fluid-filled blisters form on the lip (labial) tissue and the area between the lip and skin (vermilion border). The recurrent infection is thus often called herpes simplex labialis. Rare reinfections occur inside the mouth (intraoral HSV stomatitis) affecting the gums, alveolar ridge, hard palate, and the back of the tongue, possibly accompanied by herpes labialis.[2]
Treatment
Placing cool, wet towel or ice on the sore. For pain-Advil or Motrin (Ibuprofen) or Tylenol(Acetaminophen). If very severe pain and not able to take any medicine per oral, Anbesol or Orajel( Benzocaine ointment or gel in 7.5 or 10 or 20% formulation). Due to pain, patient is not able to take any solid foods, but they should at least make sure that they are hydrated, should take a lot of fruit smoothie with protein powder added to it. Vitamin supplements recommended. Avoid Citrus foods like tomato, lemon as it increases pain of the blister. Zinc oxide cream on the cold sore can help reduce the duration of the blister. [4] Acyclovir has been used in some cases. In primary lesion, Acyclovir Per oral or Abreva/ Docosanol antiviral cream available as 10% cream over the counter five times a day helps to reduce the duration of symptoms. [5]
Antiviral regimen
- Acyclovir 15 mg/kg PO q5h For 7 days
References
- ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ↑ 2.0 2.1 2.2 2.3 2.4 Bruce AJ, Rogers RS (2004). "Oral manifestations of sexually transmitted diseases". Clin. Dermatol. 22 (6): 520–7. doi:10.1016/j.clindermatol.2004.07.005. PMID 15596324.
- ↑ Opstelten W, Neven AK, Eekhof J (2008). "Treatment and prevention of herpes labialis". Can Fam Physician. 54 (12): 1683–7. PMC 2602638. PMID 19074705. Unknown parameter
|month=ignored (help) - ↑ |url=http://www.webmd.com/skin-problems-and-treatments/tc/cold-sores-home-treatment}}
- ↑ Raborn GW, Chan KS, Grace M (2004). "Treatment modalities and medication recommended by health care professionals for treating recurrent herpes labialis". J Am Dent Assoc. 135 (1): 48–54. PMID 14959874. Unknown parameter
|month=ignored (help)
Template:Viral diseases
Template:Oral pathology
cy:Dolur annwyd
de:Herpes simplex#Herpes labialis
nl:Koortslip