Kikuchi disease overview: Difference between revisions
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==Overview== | ==Overview== | ||
Kikuchi's disease (histiocytic necrotizing lymphadenitis) is a rare, non-cancerous enlargement of the [[lymph node]]s: the diagnosis can be confirmed by lymph node biopsy. | Kikuchi's disease (histiocytic necrotizing lymphadenitis) is a rare, non-[[cancerous]] enlargement of the [[lymph node]]s: the [[diagnosis]] can be confirmed by [[lymph node biopsy]]. | ||
==Historical Perspective== | |||
Kikuchi-Fujimoto disease (KFD) was described in 1972 in Japan by Dr Masahiro Kikuchi in 1972<ref>Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes. ''Acta Hematol Jpn'' 1972;35:379–80.<!--No PMID--></ref> and independently by Y. Fujimoto. | |||
==Causes== | |||
The cause for Kikuchi disease has not been established although [[infectious]] and [[autoimmune disease|autoimmune]] [[etiology|etiologies]] have been proposed. | |||
==Diagnosis== | |||
===Laboratory Findings=== | |||
Kikuchi disease is [[diagnose]]d by [[lymph node]] [[excisional biopsy]]. [[antinuclear antibody|ANA]], [[antiphospholipid antibody|APLA]], [[anti-dsDNA]], [[rheumatoid factor|RF]] are usually negative, and may help in differentiating from [[SLE]]. [[Laboratory]] findings may sometimes include positive results for [[IgM]], [[IgG]] or [[IgA]] [[antibodies]]. | |||
==Treatment== | |||
===Medical Therapy=== | |||
There is no specific cure for Kikuchi disease. Treatment is largely supportive. [[NSAID]]s are useful if [[patient]] presents with [[tenderness (medicine)|tender]] [[lymph node]]s and [[fever]]. [[Symptomatic]] measures aimed at relieving the distressing [[local]] and [[systemic]] [[chief complaint|complaints]] have been described as the main line of management of Kikuchi disease. [[Analgesic]]s, [[antipyretic]]s, [[nonsteroidal anti-inflammatory drug]]s ([[NSAID]]s) and corticosteroids have been used. [[Corticosteroid]]s are useful in severe extranodal or generalized disease. Multiple flares of bulky [[cervical]] [[lymphadenopathy]] and [[fever]] are treated with a low-dose corticosteroid. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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{{WS}} | {{WS}} | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
Latest revision as of 18:08, 18 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Kikuchi's disease (histiocytic necrotizing lymphadenitis) is a rare, non-cancerous enlargement of the lymph nodes: the diagnosis can be confirmed by lymph node biopsy.
Historical Perspective
Kikuchi-Fujimoto disease (KFD) was described in 1972 in Japan by Dr Masahiro Kikuchi in 1972[1] and independently by Y. Fujimoto.
Causes
The cause for Kikuchi disease has not been established although infectious and autoimmune etiologies have been proposed.
Diagnosis
Laboratory Findings
Kikuchi disease is diagnosed by lymph node excisional biopsy. ANA, APLA, anti-dsDNA, RF are usually negative, and may help in differentiating from SLE. Laboratory findings may sometimes include positive results for IgM, IgG or IgA antibodies.
Treatment
Medical Therapy
There is no specific cure for Kikuchi disease. Treatment is largely supportive. NSAIDs are useful if patient presents with tender lymph nodes and fever. Symptomatic measures aimed at relieving the distressing local and systemic complaints have been described as the main line of management of Kikuchi disease. Analgesics, antipyretics, nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids have been used. Corticosteroids are useful in severe extranodal or generalized disease. Multiple flares of bulky cervical lymphadenopathy and fever are treated with a low-dose corticosteroid.
References
- ↑ Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes. Acta Hematol Jpn 1972;35:379–80.