Leptospirosis criteria: Difference between revisions
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Clinical presentation includes history of fever within the past two weeks and at least two of the following clinical findings: myalgia, headache, jaundice, conjunctival suffusion without purulent discharge, or rash (i.e. maculopapular or petechial); ORat least one of the following clinical findings: | Clinical presentation includes history of fever within the past two weeks and at least two of the following clinical findings: myalgia, headache, jaundice, conjunctival suffusion without purulent discharge, or rash (i.e. maculopapular or petechial); ORat least one of the following clinical findings: | ||
* Aseptic meningitis | * [[Aseptic meningitis]] | ||
* GI symptoms (e.g., abdominal pain, nausea, vomiting, diarrhea) | * GI symptoms (e.g., [[abdominal pain]], [[nausea]], [[vomiting]], [[diarrhea]]) | ||
* Pulmonary complications (e.g., cough, breathlessness, hemoptysis) | * Pulmonary complications (e.g., [[cough]], [[breathlessness]], [[hemoptysis]]) | ||
* Cardiac arrhythmias, ECG abnormalities | * [[Cardiac arrhythmias]], ECG abnormalities | ||
* Renal insufficiency (e.g., anuria, oliguria) | * Renal insufficiency (e.g., [[anuria]], [[oliguria]]) | ||
* Hemorrhage (e.g., intestinal, pulmonary, hematuria, hematemesis) | * [[Hemorrhage]] (e.g., intestinal, pulmonary, hematuria, hematemesis) | ||
* Jaundice with acute renal failure | * [[Jaundice]] with [[acute renal failure]] | ||
==Laboratory Criteria for Diagnosis== | ==Laboratory Criteria for Diagnosis== | ||
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'''Probable''' | '''Probable''' | ||
A clinically compatible case with at least one of the following: | A clinically compatible case with at least one of the following: | ||
Involvement in an exposure event (e.g., adventure race, triathlon, flooding) with known associated cases, or | * Involvement in an exposure event (e.g., adventure race, triathlon, flooding) with known associated cases, or | ||
Presumptive laboratory findings, but without confirmatory laboratory evidence of Leptospira infection. | * Presumptive laboratory findings, but without confirmatory laboratory evidence of Leptospira infection. | ||
'''Confirmed''' | '''Confirmed''' | ||
A case with confirmatory laboratory results, as listed above. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | |||
Latest revision as of 18:10, 18 September 2017
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Leptospirosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Leptospirosis criteria On the Web |
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American Roentgen Ray Society Images of Leptospirosis criteria |
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Risk calculators and risk factors for Leptospirosis criteria |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Clinical Criteria
An illness characterized by fever, headache, and myalgia, and less frequently by conjunctival suffusion, meningitis, rash, jaundice, or renal insufficiency. Symptoms may be biphasic.
Clinical presentation includes history of fever within the past two weeks and at least two of the following clinical findings: myalgia, headache, jaundice, conjunctival suffusion without purulent discharge, or rash (i.e. maculopapular or petechial); ORat least one of the following clinical findings:
- Aseptic meningitis
- GI symptoms (e.g., abdominal pain, nausea, vomiting, diarrhea)
- Pulmonary complications (e.g., cough, breathlessness, hemoptysis)
- Cardiac arrhythmias, ECG abnormalities
- Renal insufficiency (e.g., anuria, oliguria)
- Hemorrhage (e.g., intestinal, pulmonary, hematuria, hematemesis)
- Jaundice with acute renal failure
Laboratory Criteria for Diagnosis
Diagnostic testing should be requested for patients in whom there is a high index of suspicion for leptospirosis, based either on signs and symptoms, or on occupational, recreational or vocational exposure to animals or environments contaminated with animal urine.
Supportive:
- Leptospira agglutination titer of ≥ 200 but < 800 by Microscopic Agglutination Test (MAT) in one or more serum specimens, or
- Demonstration of anti-Leptospira antibodies in a clinical specimen by indirect immunofluorescence, or
- Demonstration of Leptospira in a clinical specimen by darkfield microscopy, or
- Detection of IgM antibodies against Leptospira in an in acute phase serum specimen.
Confirmed:
- Isolation of Leptospira from a clinical specimen, or
- Fourfold or greater increase in Leptospira agglutination titer between acute- and convalescent-phase serum specimens studied at the same laboratory, or
- Demonstration of Leptospira in tissue by direct immunofluorescence, or
- Leptospira agglutination titer of ≥ 800 by Microscopic Agglutination Test (MAT) in one or more serum specimens, or
- Detection of pathogenic Leptospira DNA (e.g., by PCR) from a clinical specimen.
Epidemiologic Linkage
Involvement in an exposure event (e.g., adventure race, triathlon, flooding) with associated laboratory-confirmed cases.
Case Classification
Probable
A clinically compatible case with at least one of the following:
- Involvement in an exposure event (e.g., adventure race, triathlon, flooding) with known associated cases, or
- Presumptive laboratory findings, but without confirmatory laboratory evidence of Leptospira infection.
Confirmed
A case with confirmatory laboratory results, as listed above.