Lymphatic filariasis laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
The standard method for diagnosing active infection is the identification of microfilariae in a blood smear by microscopic examination. The microfilariae that cause lymphatic filariasis circulate in the blood at night (called nocturnal periodicity). Blood collection should be done at night to coincide with the appearance of the microfilariae, and a thick smear should be made and stained with Giemsa or hematoxylin and eosin. For increased sensitivity, concentration techniques can be used. | * The standard method for diagnosing active [[infection]] is the identification of microfilariae in a [[blood smear]] by microscopic examination. The microfilariae that cause lymphatic filariasis circulate in the [[blood]] at night (called nocturnal periodicity). Blood collection should be done at night to coincide with the appearance of the microfilariae, and a thick smear should be made and stained with [[Giemsa]] or hematoxylin and eosin. For increased sensitivity, concentration techniques can be used. | ||
* Because [[lymphedema]] may develop many years after infection, lab tests are most likely to be negative with these patients. | |||
* The eosinophilia is often accompanied by high levels of [[IgE]] (Immunoglobulin E) and antifilarial [[antibodies]]. | |||
== References == | == References == | ||
{{reflist|2}} | {{reflist|2}} | ||
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[[Category:Zoonoses]] | [[Category:Zoonoses]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Needs overview]] | [[Category:Needs overview]] | ||
Latest revision as of 17:59, 18 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]
Laboratory Findings
- The standard method for diagnosing active infection is the identification of microfilariae in a blood smear by microscopic examination. The microfilariae that cause lymphatic filariasis circulate in the blood at night (called nocturnal periodicity). Blood collection should be done at night to coincide with the appearance of the microfilariae, and a thick smear should be made and stained with Giemsa or hematoxylin and eosin. For increased sensitivity, concentration techniques can be used.
- Because lymphedema may develop many years after infection, lab tests are most likely to be negative with these patients.
- The eosinophilia is often accompanied by high levels of IgE (Immunoglobulin E) and antifilarial antibodies.