Mycobacterium abscessus: Difference between revisions

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VisualWikitext

Latest revision as of 18:08, 18 September 2017

This page is about clinical aspects of the disease. For microbiologic aspects of the causative organism(s), see Mycobacterium abscessus causes.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]

Synonyms and keywords: M. abcessus, non tuberculous mycobacterium, NTM, rapidly growing mycobacterium, RGM

Overview

Historical Perspective

Causes

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Treatment

Medical Therapy | Surgery | Primary Prevention

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-{{Taxobox
+__NOTOC__
-| color = lightgrey
+{{Mycobacterium abscessus}}
-| name = ''Mycobacterium abscessus''
-| regnum = [[Bacterium|Bacteria]]
-| phylum = [[Actinobacteria]]
-| ordo = [[Actinomycetales]]
-| subordo = [[Corynebacterineae]]
-| familia = [[Mycobacterium|Mycobacteriaceae]]
-| genus = ''[[Mycobacterium]]''
-| species = '''''M. abscessus'''''
-| binomial = ''Mycobacterium abscessus''
-| binomial_authority = Kusonoki and Ezaki 1992 ATCC 19977
-}}
-{{SI}}
-{{CMG}}
+{{About1|Mycobacterium abscessus causes}}
+{{CMG}}; {{AE}} {{Rim}}
-{{SK}} M. abcessus
+{{SK}} M. abcessus, non tuberculous mycobacterium, NTM, rapidly growing mycobacterium, RGM
-==Overview==
+==[[Mycobacterium abscessus overview|Overview]]==
-Mycobacterium abscessus is a rapidly growing [[mycobacterium]] that is a common water contaminant.  It was until recently (1992) thought to be a subspecies of [[Mycobacterium chelonae]].  ''M. abcessus'' can cause chronic lung disease, post-traumatic wound infections, and disseminated cutaneous diseases, mostly in patients with suppressed immune systems.
-==Pathophysiology==
+==[[Mycobacterium abscessus historical perspective|Historical Perspective]]==
-===Microscopy===
+==[[Mycobacterium abscessus causes|Causes]]==
-*Gram-positive, nonmotile and acid-fast rods (1.0-2.5µm x 0.5µm).
-===Colony characteristics===
+==[[Mycobacterium abscessus epidemiology and demographics|Epidemiology and Demographics]]==
-*Colonies on Löwenstein-Jensen media may occur as smooth as well as rough, white or greyish and nonphotochromogenic.
-===Physiology===
+==[[Mycobacterium abscessus risk factors|Risk Factors]]==
-*Growth at 28°C and 37°C after 7 days but not at 43°C.
-*On MacConkey agar at 28°C and even 37°C.
-*Tolerance to 5% NaCl and 500mg/l hydroxylamine (Ogawa egg medium) and 0.2% picrate (Sauton agar medium).
-*Positive degradation of p-aminosalicylate.
-*Production of arylsulfatase but not of nitrate reductase and Tween 80 hydrolase.
-*Negative iron uptake test. No utilisation of fructose, glucose, oxalate and citrate as sole carbon sources.
-===Differential characteristics===
+==[[Mycobacterium abscessus natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-*M. abscessus and M. chelonae can be distinguished from M. fortuitum or M. peregrinum by their failure to reduce nitrate and to take up iron.
-*Tolerance to 5% NaCl in Löwenstein-Jensen media tolerance to 0.2% picrate in Sauton agar and non-utilisation of citrate as a sole carbon source are characteristics that distinguish M. abscessus from M. chelonae.
-*M. abscessus and M. chelonae sequevar I share an identical sequence in the 54-510 region of 16S rRNA, However, both species can be differentiated by their hsp65 or ITS sequences
-===Type Strain===
+==Diagnosis==
-ATCC 19977 = CCUG 20993 = CIP 104536 = DSM 44196 = JCM 13569 = NCTC 13031
+[[Mycobacterium abscessus diagnostic criteria|Diagnostic Criteria]] | [[Mycobacterium abscessus history and symptoms|History and Symptoms]] | [[Mycobacterium abscessus physical examination|Physical Examination]] | [[Mycobacterium abscessus laboratory findings|Laboratory Findings]] | [[Mycobacterium abscessus chest X ray|Chest X Ray]] | [[Mycobacterium abscessus other imaging findings|Other Imaging Findings]]
-==Risk Factors==
+==Treatment==
-The infection tends to occur in patients with chronic lung disease, post-traumatic wound infections, post-tympanostomy tube [[otitis media]], and as a disseminated cutaneous diseases in patients of immune suppression.
+[[Mycobacterium abscessus medical therapy|Medical Therapy]] | [[Mycobacterium abscessus surgery|Surgery]] | [[Mycobacterium abscessus primary prevention|Primary Prevention]]
-==References==
-{{Reflist|2}}
-*'''Kusunoki,S.,T. Ezaki.''' 1992. Proposal of Mycobacterium peregrinum sp. nov., nom. rev., and elevation of Mycobacterium chelonae subsp. abscessus (Kubica et al.) to species status: Mycobacterium abscessus comb. nov. Int. J. Syst. Bacteriol. 42, 240-245.
 [[Category:Acid fast bacilli]]
-[[Category:Corynebacterineae]]
 [[Category:Nontuberculous mycobacteria]]
-[[Category:Infectious disease]]
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