Osteonecrosis of the jaw overview: Difference between revisions
Rim Halaby (talk | contribs) Created page with "__NOTOC__ {{Osteonecrosis of the jaw}} {{CMG}} ==Overview== Osteonecrosis of the jaws (ONJ) is a severe bone disease that affects the jaws, including the maxilla and..." |
m Changes made per Mahshid's request |
||
(One intermediate revision by one other user not shown) | |||
Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
Osteonecrosis of the jaws (ONJ) is a severe [[bone]] disease that affects the jaws, including the [[maxilla]] and the [[mandible]]. Jaw bone (''[[bone|osteo]]-'') damage and death (''-[[necrosis]]'') occurs as a result of reduced local blood supply ([[ischemia]]). The condition is thus included in the general category of ischemic or [[Avascular necrosis|avascular osteonecrosis]] (literally "dead bone from poor blood flow."). | Osteonecrosis of the jaws (ONJ) is a severe [[bone]] disease that affects the jaws, including the [[maxilla]] and the [[mandible]]. Jaw bone (''[[bone|osteo]]-'') damage and death (''-[[necrosis]]'') occurs as a result of reduced local blood supply ([[ischemia]]). The condition is thus included in the general category of ischemic or [[Avascular necrosis|avascular osteonecrosis]] (literally "dead bone from poor blood flow."). Various forms of ONJ have been described over the last 160 years, and a number of causes have been suggested in the literature. In recent years, an increased incidence of ONJ has been associated with the use of high dosages of [[bisphosphonate]]s, required by some cancer treatment regimens, especially when the patient undergoes subsequent dental procedures. The possible risk from lower oral doses of bisphosphonates, taken by patients to prevent or treat [[osteoporosis]], remains uncertain.<ref name="Woo2006">{{cite journal | author = Woo S, Hellstein J, Kalmar J | title = Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. | journal = Ann Intern Med | volume = 144 | issue = 10 | pages = 753-61 | year = 2006 | id = PMID 16702591}}</ref> Various treatment options have been explored, however severe cases of ONJ still require surgical removal of the affected bone.<ref name="Bouquot1995"> Bouquot JE, Christian J. Long-term effects of jawbone curettage on the pain of facial neuralgia. J Oral Maxillofac Surg 1995; 53:387-397. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7699492&query_hl=24&itool=pubmed_docsum PMID: 7699492]</ref> Careful [[anamnesis]] (patient history) and assessement of pre-existing systemic problems and possible sites of dental infection are required to help prevent the condition, especially if bisphosphonate therapy is considered.<ref name="Woo2006">{{cite journal | author = Woo S, Hellstein J, Kalmar J | title = Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. | journal = Ann Intern Med | volume = 144 | issue = 10 | pages = 753-61 | year = 2006 | id = PMID 16702591}}</ref> | ||
Various forms of ONJ have been described over the last 160 years, and a number of causes have been suggested in the literature. In recent years, an increased incidence of ONJ has been associated with the use of high dosages of [[bisphosphonate]]s, required by some cancer treatment regimens, especially when the patient undergoes subsequent dental procedures. The possible risk from lower oral doses of bisphosphonates, taken by patients to prevent or treat [[osteoporosis]], remains uncertain.<ref name="Woo2006">{{cite journal | author = Woo S, Hellstein J, Kalmar J | title = Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. | journal = Ann Intern Med | volume = 144 | issue = 10 | pages = 753-61 | year = 2006 | id = PMID 16702591}}</ref> | |||
Various treatment options have been explored, however severe cases of ONJ still require surgical removal of the affected bone.<ref name="Bouquot1995"> Bouquot JE, Christian J. Long-term effects of jawbone curettage on the pain of facial neuralgia. J Oral Maxillofac Surg 1995; 53:387-397. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=7699492&query_hl=24&itool=pubmed_docsum PMID: 7699492]</ref> Careful [[anamnesis]] (patient history) and assessement of pre-existing systemic problems and possible sites of dental infection are required to help prevent the condition, especially if bisphosphonate therapy is considered.<ref name="Woo2006">{{cite journal | author = Woo S, Hellstein J, Kalmar J | title = Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. | journal = Ann Intern Med | volume = 144 | issue = 10 | pages = 753-61 | year = 2006 | id = PMID 16702591}}</ref> | |||
==References== | ==References== | ||
Line 15: | Line 11: | ||
[[Category:Skeletal disorders]] | [[Category:Skeletal disorders]] | ||
[[Category:Dentistry]] | [[Category:Dentistry]] | ||
Latest revision as of 18:34, 18 September 2017
Osteonecrosis of the Jaw Microchapters |
Differentiating Osteonecrosis of the jaw from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
Osteonecrosis of the jaw overview On the Web |
American Roentgen Ray Society Images of Osteonecrosis of the jaw overview |
Risk calculators and risk factors for Osteonecrosis of the jaw overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Osteonecrosis of the jaws (ONJ) is a severe bone disease that affects the jaws, including the maxilla and the mandible. Jaw bone (osteo-) damage and death (-necrosis) occurs as a result of reduced local blood supply (ischemia). The condition is thus included in the general category of ischemic or avascular osteonecrosis (literally "dead bone from poor blood flow."). Various forms of ONJ have been described over the last 160 years, and a number of causes have been suggested in the literature. In recent years, an increased incidence of ONJ has been associated with the use of high dosages of bisphosphonates, required by some cancer treatment regimens, especially when the patient undergoes subsequent dental procedures. The possible risk from lower oral doses of bisphosphonates, taken by patients to prevent or treat osteoporosis, remains uncertain.[1] Various treatment options have been explored, however severe cases of ONJ still require surgical removal of the affected bone.[2] Careful anamnesis (patient history) and assessement of pre-existing systemic problems and possible sites of dental infection are required to help prevent the condition, especially if bisphosphonate therapy is considered.[1]
References
- ↑ 1.0 1.1 Woo S, Hellstein J, Kalmar J (2006). "Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws". Ann Intern Med. 144 (10): 753–61. PMID 16702591.
- ↑ Bouquot JE, Christian J. Long-term effects of jawbone curettage on the pain of facial neuralgia. J Oral Maxillofac Surg 1995; 53:387-397. PMID: 7699492