Zollinger-Ellison syndrome causes: Difference between revisions

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{{CMG}} {{AE}} {{ARK}} {{MJK}}
{{CMG}} {{AE}} {{ARK}} {{MJK}}
==Overview==
==Overview==
The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of [[Gastrinoma|gastrinomas]], which can cause Zollinger-Ellison syndrome, are caused by  multiple endocrine [[neoplasia]] type 1 ([[MEN1]]).
The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of [[Gastrinoma|gastrinomas]], which can cause Zollinger-Ellison syndrome, are caused by  [[multiple endocrine neoplasia]] type 1 ([[MEN1]]).


==Causes==
==Causes==
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! style="background: #4479BA; padding: 5px 5px;" rowspan="1" | {{fontcolor|#FFFFFF|Appropriate Hypergastrinemia}}
! style="background: #4479BA; padding: 5px 5px;" rowspan="1" | {{fontcolor|#FFFFFF|Appropriate Hypergastrinemia}}
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Antisecretory therapeutic regimen (PPIs or high-dose histamine H2-receptor antagonist)
*Antisecretory therapeutic regimen (PPIs or high-dose [[histamine]] H2-receptor antagonist)
*Atrophic gastritis with or without pernicious anemia
*Atrophic gastritis with or without [[pernicious anemia]]
*Helicobacter pylori pangastritis
*[[Helicobacter pylori]] pangastritis
*Vagotomy
*Vagotomy
*Renal failure (Chronic)
*[[Chronic renal failure |Renal failure (Chronic)]]
|-
|-
! style="background: #4479BA; padding: 5px 5px;" rowspan="1" | {{fontcolor|#FFFFFF|Inappropriate Hypergastrinemia}}
! style="background: #4479BA; padding: 5px 5px;" rowspan="1" | {{fontcolor|#FFFFFF|Inappropriate Hypergastrinemia}}
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
*Antral-predominant Helicobacter pylori infection
*Antral-predominant [[Helicobacter pylori]] infection
*ZES (sporadic or associated with MEN-1)
*ZES (sporadic or associated with [[MEN-1]])
*Retained-antrum syndrome
*Retained-antrum syndrome
*Gastric-outlet obstruction
*[[Gastric outlet obstruction]]
*Small-bowel resection
*Small-bowel resection
|-
|-

Latest revision as of 16:09, 11 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2] Mohamad Alkateb, MBBCh [3]

Overview

The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).

Causes

  • Hypergastrinemia (an increased fasting serum gastrin level) is the hallmark of ZES. [2]
  • Causes of Hypergastrinemia: [2]
Causes of Hypergastrinemia
Appropriate Hypergastrinemia
Inappropriate Hypergastrinemia
Spurious hypergastrinemia
  • Inaccurate assay
  • Nonfasting patient

References

  1. National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes
  2. 2.0 2.1 Metz DC (2012). "Diagnosis of the Zollinger–Ellison syndrome". Clin. Gastroenterol. Hepatol. 10 (2): 126–30. doi:10.1016/j.cgh.2011.07.012. PMID 21806955.

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