Adrenocortical carcinoma radiation therapy: Difference between revisions
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{{CMG}}; {{AE}} {{RT}} {{MAD}} | {{CMG}}; {{AE}} {{RT}} {{MAD}} | ||
==Overview== | ==Overview== | ||
[[Radiation therapy]]and [[radiofrequency ablation]] may be used for [[palliative care|palliation]] in patients who are not surgical candidates. Recurrence is lower in | [[Radiation therapy]] and [[radiofrequency ablation]] may be used for [[palliative care|palliation]] in patients who are not surgical candidates. Recurrence is lower in patients with [[Radiotherapy|adjuvant radiotherapy]] than in patients without [[Radiation therapy|radiotherapy]]. ACC with [[metastasis]] to [[bone]] experienced adequate [[pain relief]] after [[radiotherapy]]. | ||
==Radiation Therapy== | ==Radiation Therapy== | ||
[[Radiotherapy]] has shown improvement in both the [[Adjuvant treatment|adjuvant]] and [[Palliative care|palliative]] ACCs. | [[Radiotherapy]] has shown improvement in both the [[Adjuvant treatment|adjuvant]] and [[Palliative care|palliative]] ACCs. | ||
==== '''''Radiation therapy in non-[[metastatic]] ACC''''' ==== | ==== '''''Radiation therapy in non-[[metastatic]] ACC''''' ==== | ||
* According to the National Cancer Data Base and | * According to the National Cancer Data Base and the surveillance, epidemiology, and end results program, there is an evidence that [[radiotherapy]] might be effective.<ref name="pmid17188138">{{cite journal| author=Paton BL, Novitsky YW, Zerey M, Harrell AG, Norton HJ, Asbun H et al.| title=Outcomes of adrenal cortical carcinoma in the United States. | journal=Surgery | year= 2006 | volume= 140 | issue= 6 | pages= 914-20; discussion 919-20 | pmid=17188138 | doi=10.1016/j.surg.2006.07.035 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17188138 }}</ref> | ||
* Local recurrence-free survival was 86% in the group that received [[Radiation therapy|radiation]] compared | * Local recurrence-free survival was 86% in the group that received [[Radiation therapy|radiation]] compared with 11% in those that did not.<ref name="pmid16895957">{{cite journal| author=Fassnacht M, Hahner S, Polat B, Koschker AC, Kenn W, Flentje M et al.| title=Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma. | journal=J Clin Endocrinol Metab | year= 2006 | volume= 91 | issue= 11 | pages= 4501-4 | pmid=16895957 | doi=10.1210/jc.2006-1007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16895957 }}</ref> | ||
* [[Radiotherapy]] also can be used for treating unresectable [[Mass|masses]].<ref name="pmid20675074">{{cite journal| author=Sabolch A, Feng M, Griffith K, Hammer G, Doherty G, Ben-Josef E| title=Adjuvant and definitive radiotherapy for adrenocortical carcinoma. | journal=Int J Radiat Oncol Biol Phys | year= 2011 | volume= 80 | issue= 5 | pages= 1477-84 | pmid=20675074 | doi=10.1016/j.ijrobp.2010.04.030 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20675074 }}</ref> | * [[Radiotherapy]] also can be used for treating unresectable [[Mass|masses]].<ref name="pmid20675074">{{cite journal| author=Sabolch A, Feng M, Griffith K, Hammer G, Doherty G, Ben-Josef E| title=Adjuvant and definitive radiotherapy for adrenocortical carcinoma. | journal=Int J Radiat Oncol Biol Phys | year= 2011 | volume= 80 | issue= 5 | pages= 1477-84 | pmid=20675074 | doi=10.1016/j.ijrobp.2010.04.030 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20675074 }}</ref> | ||
==== '''''Radiation therapy for palliation''''' ==== | ==== '''''Radiation therapy for palliation''''' ==== | ||
* | * 77% of patients with [[Metastasis|metastatic]] ACCs to [[bone]] experienced adequate [[Palliative care|palliation]] of [[pain]] after [[radiotherapy]] with dosages totaling 10 to 60 Gyger.<ref name="pmid1709336">{{cite journal| author=Markoe AM, Serber W, Micaily B, Brady LW| title=Radiation therapy for adjunctive treatment of adrenal cortical carcinoma. | journal=Am J Clin Oncol | year= 1991 | volume= 14 | issue= 2 | pages= 170-4 | pmid=1709336 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1709336 }}</ref> | ||
* [[Radiofrequency ablation]] ([[RFA]]) and transarterial [[chemoembolization]] are | * [[Radiofrequency ablation]] ([[RFA]]) and transarterial [[chemoembolization]] are alternatives to surgery when surgery is not desired or [[contraindicated]]. | ||
* High local [[tumor]] [[regression]] | * High local [[tumor]] [[regression]] can be achieved with minimal [[systemic]] [[side effects]].<ref name="pmid21326571">{{cite journal| author=Thacker PG, Friese JL, Loe M, Biegler P, Larson M, Andrews J| title=Embolization of nonliver visceral tumors. | journal=Semin Intervent Radiol | year= 2009 | volume= 26 | issue= 3 | pages= 262-9 | pmid=21326571 | doi=10.1055/s-0029-1225667 | pmc=3036499 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21326571 }}</ref> | ||
* [[Bleeding]] is one of the complications as [[Adrenal tumor|adrenal tumors]] have a tendency to undergo [[hemorrhage]].<ref name="pmid20237856">{{cite journal| author=de Baere T, Teriitehau C, Deschamps F, Catherine L, Rao P, Hakime A et al.| title=Predictive factors for hypertrophy of the future remnant liver after selective portal vein embolization. | journal=Ann Surg Oncol | year= 2010 | volume= 17 | issue= 8 | pages= 2081-9 | pmid=20237856 | doi=10.1245/s10434-010-0979-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20237856 }}</ref> | * [[Bleeding]] is one of the [[complications]] as [[Adrenal tumor|adrenal tumors]] have a tendency to undergo [[hemorrhage]].<ref name="pmid20237856">{{cite journal| author=de Baere T, Teriitehau C, Deschamps F, Catherine L, Rao P, Hakime A et al.| title=Predictive factors for hypertrophy of the future remnant liver after selective portal vein embolization. | journal=Ann Surg Oncol | year= 2010 | volume= 17 | issue= 8 | pages= 2081-9 | pmid=20237856 | doi=10.1245/s10434-010-0979-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20237856 }}</ref> | ||
==References== | ==References== | ||
Latest revision as of 17:06, 19 October 2017
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Adrenocortical carcinoma radiation therapy On the Web |
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Risk calculators and risk factors for Adrenocortical carcinoma radiation therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Mohammed Abdelwahed M.D[3]
Overview
Radiation therapy and radiofrequency ablation may be used for palliation in patients who are not surgical candidates. Recurrence is lower in patients with adjuvant radiotherapy than in patients without radiotherapy. ACC with metastasis to bone experienced adequate pain relief after radiotherapy.
Radiation Therapy
Radiotherapy has shown improvement in both the adjuvant and palliative ACCs.
Radiation therapy in non-metastatic ACC
- According to the National Cancer Data Base and the surveillance, epidemiology, and end results program, there is an evidence that radiotherapy might be effective.[1]
- Local recurrence-free survival was 86% in the group that received radiation compared with 11% in those that did not.[2]
- Radiotherapy also can be used for treating unresectable masses.[3]
Radiation therapy for palliation
- 77% of patients with metastatic ACCs to bone experienced adequate palliation of pain after radiotherapy with dosages totaling 10 to 60 Gyger.[4]
- Radiofrequency ablation (RFA) and transarterial chemoembolization are alternatives to surgery when surgery is not desired or contraindicated.
- High local tumor regression can be achieved with minimal systemic side effects.[5]
- Bleeding is one of the complications as adrenal tumors have a tendency to undergo hemorrhage.[6]
References
- ↑ Paton BL, Novitsky YW, Zerey M, Harrell AG, Norton HJ, Asbun H; et al. (2006). "Outcomes of adrenal cortical carcinoma in the United States". Surgery. 140 (6): 914–20, discussion 919-20. doi:10.1016/j.surg.2006.07.035. PMID 17188138.
- ↑ Fassnacht M, Hahner S, Polat B, Koschker AC, Kenn W, Flentje M; et al. (2006). "Efficacy of adjuvant radiotherapy of the tumor bed on local recurrence of adrenocortical carcinoma". J Clin Endocrinol Metab. 91 (11): 4501–4. doi:10.1210/jc.2006-1007. PMID 16895957.
- ↑ Sabolch A, Feng M, Griffith K, Hammer G, Doherty G, Ben-Josef E (2011). "Adjuvant and definitive radiotherapy for adrenocortical carcinoma". Int J Radiat Oncol Biol Phys. 80 (5): 1477–84. doi:10.1016/j.ijrobp.2010.04.030. PMID 20675074.
- ↑ Markoe AM, Serber W, Micaily B, Brady LW (1991). "Radiation therapy for adjunctive treatment of adrenal cortical carcinoma". Am J Clin Oncol. 14 (2): 170–4. PMID 1709336.
- ↑ Thacker PG, Friese JL, Loe M, Biegler P, Larson M, Andrews J (2009). "Embolization of nonliver visceral tumors". Semin Intervent Radiol. 26 (3): 262–9. doi:10.1055/s-0029-1225667. PMC 3036499. PMID 21326571.
- ↑ de Baere T, Teriitehau C, Deschamps F, Catherine L, Rao P, Hakime A; et al. (2010). "Predictive factors for hypertrophy of the future remnant liver after selective portal vein embolization". Ann Surg Oncol. 17 (8): 2081–9. doi:10.1245/s10434-010-0979-2. PMID 20237856.