Autoimmune polyendocrine syndrome classification: Difference between revisions
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{{Autoimmune polyendocrine syndrome}} | {{Autoimmune polyendocrine syndrome}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}}{{Akshun}} | ||
==Overview== | ==Overview== | ||
Autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3 on the basis of organ involvement. APS type 1 commonly presents with mucocutaneous [[candidiasis]], [[hypoparathyroidism]] and [[Addison's disease]]. APS type 2 most commonly presents with [[Addison's disease]], [[autoimmune thyroiditis]] and [[diabetes mellitus type 1]]. APS type 3 usually presents with [[autoimmune thyroiditis]], [[diabetes mellitus type 1]] and [[pernicious anemia]]. | |||
==Classification== | ==Classification== | ||
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3. | On the basis of [[Organ (anatomy)|organ]] involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3.<ref name="pmid12817789">{{cite journal |vauthors=Betterle C, Zanchetta R |title=Update on autoimmune polyendocrine syndromes (APS) |journal=Acta Biomed |volume=74 |issue=1 |pages=9–33 |year=2003 |pmid=12817789 |doi= |url=}}</ref><ref name="pmid5067225">{{cite journal |vauthors=Forcier RJ, McIntyre OR, Frey WG, Andrada JA, Streiff RR |title=Autoimmunity and multiple endocrine abnormalities |journal=Arch. Intern. Med. |volume=129 |issue=4 |pages=638–41 |year=1972 |pmid=5067225 |doi= |url=}}</ref><ref name="pmid15141045">{{cite journal |vauthors=Eisenbarth GS, Gottlieb PA |title=Autoimmune polyendocrine syndromes |journal=N. Engl. J. Med. |volume=350 |issue=20 |pages=2068–79 |year=2004 |pmid=15141045 |doi=10.1056/NEJMra030158 |url=}}</ref> | ||
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{{familytree | | C01 | | | | | C02 | | | | | C03 |C01=Autoimmune polyendocrine syndrome type 1|C02=Autoimmune polyendocrine syndrome type 2|C03=Autoimmune polyendocrine syndrome type 3}} | {{familytree | | C01 | | | | | C02 | | | | | C03 |C01=Autoimmune polyendocrine syndrome type 1|C02=Autoimmune polyendocrine syndrome type 2|C03=Autoimmune polyendocrine syndrome type 3}} | ||
{{familytree | | |!| | | | | | |!| | | | | | |!| }} | {{familytree | | |!| | | | | | |!| | | | | | |!| }} | ||
{{familytree | | D01 | | | | | D02 | | | | | D03 |D01=•Mucocutaneous candidiasis<br> | {{familytree | | D01 | | | | | D02 | | | | | D03 |D01=•Mucocutaneous [[candidiasis]]<br> •[[Hypoparathyroidism]]<br> •[[Addison's disease]]<br>|D02=•[[Addison's disease]]<br>•[[Autoimmune thyroiditis]]<br> •[[Diabetes mellitus type 1]]|D03=•[[Autoimmune thyroiditis]]<br> •[[Diabetes mellitus type 1]]<br> •[[Pernicious anemia]]<br>}} | ||
{{familytree | | | | | | | | | | |,|-|-|-|-|-|+|-|-|-|-|-|-|.|}} | |||
{{familytree | | | | | | | | | |F01| | | |F02| | | | | |F03| F01=Autoimmune polyendocrine syndrome type 3A|F02=Autoimmune polyendocrine syndrome type 3B|F03=Autoimmune polyendocrine syndrome type 3C}} | |||
{{familytree | | | | | | | | | | |!| | | | | |!| | | | | | | |!| }} | |||
{{familytree | | | | | | | | | |D01 | | | |D02 | | | | | | D03 |D01=•[[Autoimmune thyroiditis]]<br> •Immune mediated [[diabetes mellitus]]<br>|D02=•[[Autoimmune thyroiditis]]<br>•[[Pernicious anemia]]<br>|D03=•[[Autoimmune thyroiditis]]<br>•[[Vitiligo]]/[[Alopecia]]<br>}} | |||
{{familytree/end}} | {{familytree/end}} | ||
==References== | ==References== |
Latest revision as of 19:51, 27 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]
Overview
Autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3 on the basis of organ involvement. APS type 1 commonly presents with mucocutaneous candidiasis, hypoparathyroidism and Addison's disease. APS type 2 most commonly presents with Addison's disease, autoimmune thyroiditis and diabetes mellitus type 1. APS type 3 usually presents with autoimmune thyroiditis, diabetes mellitus type 1 and pernicious anemia.
Classification
On the basis of organ involvement, autoimmune polyendocrine syndrome (APS) can be classified into APS type 1, APS type 2 and APS type 3.[1][2][3]
Autoimmune polyendocrine syndrome (APS) | |||||||||||||||||||||||||||||||||||||||||||||||||||
Autoimmune polyendocrine syndrome type 1 | Autoimmune polyendocrine syndrome type 2 | Autoimmune polyendocrine syndrome type 3 | |||||||||||||||||||||||||||||||||||||||||||||||||
•Mucocutaneous candidiasis •Hypoparathyroidism •Addison's disease | •Addison's disease •Autoimmune thyroiditis •Diabetes mellitus type 1 | •Autoimmune thyroiditis •Diabetes mellitus type 1 •Pernicious anemia | |||||||||||||||||||||||||||||||||||||||||||||||||
Autoimmune polyendocrine syndrome type 3A | Autoimmune polyendocrine syndrome type 3B | Autoimmune polyendocrine syndrome type 3C | |||||||||||||||||||||||||||||||||||||||||||||||||
•Autoimmune thyroiditis •Immune mediated diabetes mellitus | •Autoimmune thyroiditis •Pernicious anemia | •Autoimmune thyroiditis •Vitiligo/Alopecia | |||||||||||||||||||||||||||||||||||||||||||||||||
References
- ↑ Betterle C, Zanchetta R (2003). "Update on autoimmune polyendocrine syndromes (APS)". Acta Biomed. 74 (1): 9–33. PMID 12817789.
- ↑ Forcier RJ, McIntyre OR, Frey WG, Andrada JA, Streiff RR (1972). "Autoimmunity and multiple endocrine abnormalities". Arch. Intern. Med. 129 (4): 638–41. PMID 5067225.
- ↑ Eisenbarth GS, Gottlieb PA (2004). "Autoimmune polyendocrine syndromes". N. Engl. J. Med. 350 (20): 2068–79. doi:10.1056/NEJMra030158. PMID 15141045.