Diabetes insipidus risk factors: Difference between revisions

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{{Diabetes insipidus}}
{{Diabetes insipidus}}
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==Overview==
==Overview==
The risk factors in the development of diabetes insipidus vary depending on the type of diabetes insipidus being described. There are a few risk factors in the development of central diabetes which include [[genetic mutations]], [[Pituitary disease|pituitary disorders]], [[Hypothalamic dysfunction|hypothalamic injury,]] and head [[tumors]]. The most potent risk factor in the development of [[nephrogenic diabetes insipidus]] is [[lithium]] use as [[lithium]] has a very narrow [[therapeutic index]] of 0.4-0.8. Excessive water intake has been identified to be the only risk factor associated with psychogenic diabetes insipidus and pregnancy for gestational diabetes insipidus.
The [[risk factors]] for the development of diabetes insipidus vary among different types of DI. [[risk factors]] for the development of [[Central diabetes insipidus|central DI]] include [[genetic mutations]], [[Pituitary disease|pituitary disorders]], [[hypothalamic]] injury, and head [[tumors]]. The most potent [[risk factor]] for the development of [[nephrogenic diabetes insipidus]] is [[lithium]] use, as [[lithium]] has a very narrow [[therapeutic index]] of 0.4-0.8 mmol/L. Excessive water intake has been identified as the only [[risk factor]] associated with psychogenic DI, as [[pregnancy]] is the only risk factor for gestational DI.


==Risk Factors==
==Risk Factors==
*[[Genetic]] risk factors<ref name="pmid10749568">{{cite journal |vauthors=Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M |title=Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants |journal=J. Clin. Invest. |volume=105 |issue=7 |pages=887–95 |year=2000 |pmid=10749568 |pmc=377482 |doi=10.1172/JCI8688 |url=}}</ref>
===Common Risk Factors===
*[[Polycystic kidney disease|Polycystic Kidney Disease]]<ref name="pmid15153548">{{cite journal |vauthors=Devonald MA, Karet FE |title=Renal epithelial traffic jams and one-way streets |journal=J. Am. Soc. Nephrol. |volume=15 |issue=6 |pages=1370–81 |year=2004 |pmid=15153548 |doi= |url=}}</ref>
The following are some of the common [[risk factors]] associated with the development of diabetes insipidus:<ref name="pmid15806465">{{cite journal |vauthors=Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF |title=Causes of reversible nephrogenic diabetes insipidus: a systematic review |journal=Am. J. Kidney Dis. |volume=45 |issue=4 |pages=626–37 |year=2005 |pmid=15806465 |doi= |url=}}</ref><ref name="pmid15153548">{{cite journal |vauthors=Devonald MA, Karet FE |title=Renal epithelial traffic jams and one-way streets |journal=J. Am. Soc. Nephrol. |volume=15 |issue=6 |pages=1370–81 |year=2004 |pmid=15153548 |doi= |url=}}</ref><ref name="pmid16713495">{{cite journal |vauthors=Bichet DG |title=Hereditary polyuric disorders: new concepts and differential diagnosis |journal=Semin. Nephrol. |volume=26 |issue=3 |pages=224–33 |year=2006 |pmid=16713495 |doi=10.1016/j.semnephrol.2006.02.004 |url=}}</ref><ref name="pmid26077742">{{cite journal |vauthors=Bockenhauer D, Bichet DG |title=Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus |journal=Nat Rev Nephrol |volume=11 |issue=10 |pages=576–88 |year=2015 |pmid=26077742 |doi=10.1038/nrneph.2015.89 |url=}}</ref>
*[[Pituitary disease|Pituitary Disorders]]<ref name="pmid16713495">{{cite journal |vauthors=Bichet DG |title=Hereditary polyuric disorders: new concepts and differential diagnosis |journal=Semin. Nephrol. |volume=26 |issue=3 |pages=224–33 |year=2006 |pmid=16713495 |doi=10.1016/j.semnephrol.2006.02.004 |url=}}</ref>
 
*[[Genetics]]
*[[Polycystic kidney disease|Polycystic kidney disease]]
*[[Pituitary disease|Pituitary disorders]]
*[[Hypothalamic dysfunction|Hypothalamic injury]]
*[[Hypothalamic dysfunction|Hypothalamic injury]]
*[[Hypercalcemia]]
*[[Hypercalcemia]]
*Head [[Tumors]]<ref name="pmid10477148">{{cite journal |vauthors=van Lieburg AF, Knoers NV, Monnens LA |title=Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus |journal=J. Am. Soc. Nephrol. |volume=10 |issue=9 |pages=1958–64 |year=1999 |pmid=10477148 |doi= |url=}}</ref>
*Head [[tumors]]
*[[Pregnancy]]
*[[Pregnancy]]
*[[Sickle-cell disease|Sickle cell disease]]
*[[Sickle-cell disease|Sickle cell disease]]
*[[Amyloidosis]]<ref name="pmid26077742">{{cite journal |vauthors=Bockenhauer D, Bichet DG |title=Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus |journal=Nat Rev Nephrol |volume=11 |issue=10 |pages=576–88 |year=2015 |pmid=26077742 |doi=10.1038/nrneph.2015.89 |url=}}</ref>
*[[Amyloidosis]]
*Male Gender- some types of [[nephrogenic diabetes insipidus]] have a male predisposition i.e diabetes insipidus caused by [[Aquaporin 2|AQP2]] mutations
*[[Lithium]] use
*Family History of [[nephrogenic diabetes insipidus]]
===Less Common Risk Factors===
Less common [[risk factors]] include:<ref name="pmid10477148">{{cite journal |vauthors=van Lieburg AF, Knoers NV, Monnens LA |title=Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus |journal=J. Am. Soc. Nephrol. |volume=10 |issue=9 |pages=1958–64 |year=1999 |pmid=10477148 |doi= |url=}}</ref><ref name="pmid10749568">{{cite journal |vauthors=Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M |title=Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants |journal=J. Clin. Invest. |volume=105 |issue=7 |pages=887–95 |year=2000 |pmid=10749568 |pmc=377482 |doi=10.1172/JCI8688 |url=}}</ref>
*Male gender
*[[Family history]] of [[nephrogenic diabetes insipidus]]
*Excessive water consumption
*Excessive water consumption
*[[pregnancy]]
*[[Pregnancy]]
*Drugs like [[phenothiazine]]


==References==
==References==
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[[Category:Needs content]]
[[Category:Needs overview]]
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Latest revision as of 21:17, 27 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]

Overview

The risk factors for the development of diabetes insipidus vary among different types of DI. risk factors for the development of central DI include genetic mutations, pituitary disorders, hypothalamic injury, and head tumors. The most potent risk factor for the development of nephrogenic diabetes insipidus is lithium use, as lithium has a very narrow therapeutic index of 0.4-0.8 mmol/L. Excessive water intake has been identified as the only risk factor associated with psychogenic DI, as pregnancy is the only risk factor for gestational DI.

Risk Factors

Common Risk Factors

The following are some of the common risk factors associated with the development of diabetes insipidus:[1][2][3][4]

Less Common Risk Factors

Less common risk factors include:[5][6]

References

  1. Garofeanu CG, Weir M, Rosas-Arellano MP, Henson G, Garg AX, Clark WF (2005). "Causes of reversible nephrogenic diabetes insipidus: a systematic review". Am. J. Kidney Dis. 45 (4): 626–37. PMID 15806465.
  2. Devonald MA, Karet FE (2004). "Renal epithelial traffic jams and one-way streets". J. Am. Soc. Nephrol. 15 (6): 1370–81. PMID 15153548.
  3. Bichet DG (2006). "Hereditary polyuric disorders: new concepts and differential diagnosis". Semin. Nephrol. 26 (3): 224–33. doi:10.1016/j.semnephrol.2006.02.004. PMID 16713495.
  4. Bockenhauer D, Bichet DG (2015). "Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus". Nat Rev Nephrol. 11 (10): 576–88. doi:10.1038/nrneph.2015.89. PMID 26077742.
  5. van Lieburg AF, Knoers NV, Monnens LA (1999). "Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus". J. Am. Soc. Nephrol. 10 (9): 1958–64. PMID 10477148.
  6. Morello JP, Salahpour A, Laperrière A, Bernier V, Arthus MF, Lonergan M, Petäjä-Repo U, Angers S, Morin D, Bichet DG, Bouvier M (2000). "Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants". J. Clin. Invest. 105 (7): 887–95. doi:10.1172/JCI8688. PMC 377482. PMID 10749568.

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