Adrenocortical carcinoma history and symptoms: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
 
(14 intermediate revisions by 3 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Adrenocortical carcinoma}}
{{Adrenocortical carcinoma}}
{{CMG}}; {{AE}} {{RT}}{{AAM}}
{{CMG}}; {{AE}} {{RT}} {{AAM}} {{MAD}}
==Overview==
==Overview==
Symptoms of [[adrenocortical carcinoma]] include symptoms of [[androgen]], [[glucocorticoid]], [[mineralocorticoid]], or [[estrogen]] excess.
Symptoms of [[adrenocortical carcinoma]] include symptoms of [[androgen]], [[glucocorticoid]], [[mineralocorticoid]], or [[estrogen]] excess. Symptoms of [[glucocorticoid]] excess include [[Weight gain]], [[Acne]], irritability. Symptoms of [[androgen]] excess include [[hirsuitism|hirsutism]], [[Irritability|acne]], and [[Irritability|deepening of the voice.]] Symptoms [[Irritability|of]] [[mineralcorticoid|mineralocorticoid]] excess include [[headache]], [[Muscle weakness|muscle weakness,]] [[Confusion]], and [[Palpitations|palpitations.]]
==Common Symptoms==
==Common Symptoms==
All patients with suspected adrenocortical carcinoma should be carefully evaluated for signs and symptoms of hormonal syndromes.
60 percent of [[adrenocortical carcinoma]] (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.<ref name="pmid16551738">{{cite journal| author=Allolio B, Fassnacht M| title=Clinical review: Adrenocortical carcinoma: clinical update. | journal=J Clin Endocrinol Metab | year= 2006 | volume= 91 | issue= 6 | pages= 2027-37 | pmid=16551738 | doi=10.1210/jc.2005-2639 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16551738  }}</ref>
This may include the followings:
* 45% of ACCs show symptoms of [[Cushing's syndrome]] alone.
* 25% present with mixed overproduction of both [[glucocorticoids]] and [[androgens]]. <ref name="pmid10679640">{{cite journal| author=Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA et al.| title=Adrenocortical carcinoma: clinical and laboratory observations. | journal=Cancer | year= 2000 | volume= 88 | issue= 4 | pages= 711-36 | pmid=10679640 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10679640  }}</ref>
* 10% present with [[virilization]] alone.
1- Symptoms of [[glucocorticoid]] excess include: <ref>{{Cite journal


1- [[Glucocorticoid]] excess symptoms include:
| author = [[Bibek Bista]] & [[Nancy Beck]]
:*[[Weight gain]]
| title = Cushing syndrome
:*[[Acne]]
| journal = [[Indian journal of pediatrics]]
:*[[Irritability]]
| volume = 81
:*[[Insomnia]]  
| issue = 2
| pages = 158–164
| year = 2014
  | doi = 10.1007/s12098-013-1203-8
| pmid = 24062268
}}</ref>
*[[Weight gain]]
*[[Acne]]
*[[Irritability]]
*[[Insomnia]]  


2- [[Androgen]] excess symptoms (most readily noted among females) include:
2- Symptoms of [[androgen]] excess [[symptoms]] in women include: <ref>{{Cite journal
:*[[Hirsutism|Excess facial and body hair]]
:*[[Acne]]
:*Deepening of the voice
:*Coarsening of facial features
:*[[Amenorrhea|Cessation of menstruation]]
3- [[Mineralcorticoid]] excess symptoms include:
:*[[Headache]]
:*[[Muscle weakness]]
:*[[Confusion]]
:*[[Palpitations]]
4- [[Estrogen]] excess symptoms (most readily noted in males) include:
:*[[Gynecomastia]]
:*Decreased [[libido]]
:*[[Impotence]]
5- Other symptoms may include:<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1</ref>
:*Abdominal mass
:*Abdominal or back pain
:*Abdominal fullness


==Less Common Symptoms==
| author = [[Lourdes Ibanez]], [[Ken K. Ong]], [[Abel Lopez-Bermejo]], [[David B. Dunger]] & [[Francis de Zegher]]
Rarely, [[catecholamine]]s excess has been reported in adrenocortical cancers symptoms include:<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref>
| title = Hyperinsulinaemic androgen excess in adolescent girls
| journal = [[Nature reviews. Endocrinology]]
| volume = 10
| issue = 8
| pages = 499–508
| year = 2014
| doi = 10.1038/nrendo.2014.58
| pmid = 24776733
}}</ref>
*[[Hirsutism|Excess facial and body hair]]
*[[Acne]]
*Deepening of the voice
*Coarsening of [[facial]] features
*[[Amenorrhea|Cessation of menstruation]]
3- Symptoms of [[mineralcorticoid|mineralocorticoid]] excess include: <ref>{{Cite journal
 
| author = [[Valeria Bisogni]], [[Gian Paolo Rossi]] & [[Lorenzo A. Calo]]
| title = Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology
| journal = [[Blood pressure]]
| volume = 23
| issue = 3
| pages = 189–192
| year = 2014
| doi = 10.3109/08037051.2013.832967
| pmid = 24053336
}}</ref>
*[[Headache]]
*[[Muscle weakness]]
*[[Confusion]]
*[[Palpitations]]
4- Symptoms of [[estrogen]] excess in men include: <ref>{{Cite journal
 
| author = [[G. M. Zanetta]], [[M. J. Webb]], [[H. Li]] & [[G. L. Keeney]]
| title = Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis
| journal = [[Gynecologic oncology]]
| volume = 79
| issue = 1
| pages = 18–22
| year = 2000
| doi = 10.1006/gyno.2000.5905
| pmid = 11006024
}}</ref>
*[[Gynecomastia]]
*Decreased [[libido]]
*[[Impotence]]
 
5- Symptoms of [[catecholamine]]s excess has been reported in adrenocortical cancers: <ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref>
*[[Headache]]
*[[Headache]]
*[[Sweating]]
*[[Sweating]]
*[[Palpitation]]
*[[Palpitation]]
6- Other symptoms may include: <ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1</ref>
*[[Abdominal mass|Abdominal lump]]
*[[Abdominal]] or [[back pain]]
*[[Abdominal]] fullness
7- Children usually present with [[virilization]] (84%), while isolated [[glucocorticoid]] excess is much less common (6%). <ref name="pmid15137014">{{cite journal| author=Stewart JN, Flageole H, Kavan P| title=A surgical approach to adrenocortical tumors in children: the mainstay of treatment. | journal=J Pediatr Surg | year= 2004 | volume= 39 | issue= 5 | pages= 759-63 | pmid=15137014 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15137014  }}</ref>
==References==
==References==
{{reflist|2}}
{{reflist|2}}
[[Category:Endocrinology]]
[[Category:Types of cancer]]
[[Category:Disease]]
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}

Latest revision as of 18:58, 30 October 2017

Adrenocortical carcinoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Adrenocortical carcinoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

MRI

CT

Ultrasound

Other Imaging Studies

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Radiation Therapy

Primary prevention

Secondary prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Study

Case #1

Adrenocortical carcinoma history and symptoms On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Adrenocortical carcinoma history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Adrenocortical carcinoma history and symptoms

CDC on Adrenocortical carcinoma history and symptoms

Adrenocortical carcinoma history and symptoms in the news

Blogs on Adrenocortical carcinoma history and symptoms

Hospitals Treating Adrenocortical carcinoma

Risk calculators and risk factors for Adrenocortical carcinoma history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]

Overview

Symptoms of adrenocortical carcinoma include symptoms of androgen, glucocorticoid, mineralocorticoid, or estrogen excess. Symptoms of glucocorticoid excess include Weight gain, Acne, irritability. Symptoms of androgen excess include hirsutism, acne, and deepening of the voice. Symptoms of mineralocorticoid excess include headache, muscle weakness, Confusion, and palpitations.

Common Symptoms

60 percent of adrenocortical carcinoma (ACC) are sufficiently secretory to present clinical syndrome of hormone excess.[1]

1- Symptoms of glucocorticoid excess include: [3]

2- Symptoms of androgen excess symptoms in women include: [4]

3- Symptoms of mineralocorticoid excess include: [5]

4- Symptoms of estrogen excess in men include: [6]

5- Symptoms of catecholamines excess has been reported in adrenocortical cancers: [7]

6- Other symptoms may include: [8]

7- Children usually present with virilization (84%), while isolated glucocorticoid excess is much less common (6%). [9]

References

  1. ↑ Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update". J Clin Endocrinol Metab. 91 (6): 2027–37. doi:10.1210/jc.2005-2639. PMID 16551738.
  2. ↑ Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos Carneiro P, Alves VA; et al. (2000). "Adrenocortical carcinoma: clinical and laboratory observations". Cancer. 88 (4): 711–36. PMID 10679640.
  3. ↑ Bibek Bista & Nancy Beck (2014). "Cushing syndrome". Indian journal of pediatrics. 81 (2): 158–164. doi:10.1007/s12098-013-1203-8. PMID 24062268.
  4. ↑ Lourdes Ibanez, Ken K. Ong, Abel Lopez-Bermejo, David B. Dunger & Francis de Zegher (2014). "Hyperinsulinaemic androgen excess in adolescent girls". Nature reviews. Endocrinology. 10 (8): 499–508. doi:10.1038/nrendo.2014.58. PMID 24776733.
  5. ↑ Valeria Bisogni, Gian Paolo Rossi & Lorenzo A. Calo (2014). "Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology". Blood pressure. 23 (3): 189–192. doi:10.3109/08037051.2013.832967. PMID 24053336.
  6. ↑ G. M. Zanetta, M. J. Webb, H. Li & G. L. Keeney (2000). "Hyperestrogenism: a relevant risk factor for the development of cancer from endometriosis". Gynecologic oncology. 79 (1): 18–22. doi:10.1006/gyno.2000.5905. PMID 11006024.
  7. ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
  8. ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/adrenocortical/patient/adrenocortical-treatment-pdq#section/_1
  9. ↑ Stewart JN, Flageole H, Kavan P (2004). "A surgical approach to adrenocortical tumors in children: the mainstay of treatment". J Pediatr Surg. 39 (5): 759–63. PMID 15137014.
Retrieved from "https://www.wikidoc.org/index.php?title=Adrenocortical_carcinoma_history_and_symptoms&oldid=1381658"