Ewing's sarcoma epidemiology and demographics: Difference between revisions

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{{Ewing's sarcoma}}
{{Ewing's sarcoma}}
{{CMG}}; '''Assistant Editor(s)-In-Chief:''' [[User:Michael Maddaleni|Michael Maddaleni, B.S.]]
{{CMG}};{{AE}} {{PSK}};'''Assistant Editor(s)-In-Chief:''' [[User:Michael Maddaleni|Michael Maddaleni, B.S.]]
==Overview==
Ewing's sarcoma is the second most common malignant bone tumor in patients younger than 20 years. Ewing's sarcoma typically occurs in children and adolescents between 10 and 20 years of age.  The overall incidence of Ewing's sarcoma is 0.1 cases for 100,000 individuals. The incidence of Ewing's sarcoma in children aged 10 to 19 years is 1 case per 100,000 individuals. Males are more commonly affected with Ewing's sarcoma than females.
 
==Epidemiology and Demographics==
==Epidemiology and Demographics==
Ewing's sarcoma is the second most common malignant bone tumor in patients younger than 20 years. The most frequent is [[osteosarcoma]].<ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2011-12-21}}</ref>
===Incidence===
*The incidence of Ewing's sarcoma has remained unchanged for 30 years.<ref name=NIH>Ewing's sarcoma. National cancer institute.http://www.cancer.gov/types/bone/hp/ewing-treatment-pdq#section/_1</ref>
*The overall incidence of Ewing's sarcoma is 0.1 cases per 100,000 individuals.
*The incidence of Ewing's sarcoma in children aged 10 to 19 years is 1 case for 100,000 individuals.


===Prevalence===
===Race===
The frequency in the United States depends on the patient's age, with a rate of 0.3 case per 1,000,000 children in those younger than 3 years of age to as high as 4.6 cases per 1,000,000 in adolescents aged 15-19 years. Internationally the annual incidence rate averages less than 2 cases per 1,000,000 children. In the United Kingdom an average of six children per year are diagnosed, mainly males in early stages of puberty.
*Incidence of Ewing's sarcoma in the United States is nine times greater in whites than in African Americans, with an intermediate incidence in Asians.<ref name=NIH>Ewing's sarcoma. National cancer institute.http://www.cancer.gov/types/bone/hp/ewing-treatment-pdq#section/_1</ref>
Ewing's sarcoma is the second most frequent bone [[sarcoma]] in patients younger than 20. The most frequent is [[osteosarcoma]].<ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2011-12-21}}</ref>
*The relative paucity of Ewing's sarcoma in people of African or Asian descent may be explained, in part, by a specific polymorphism.
There are approximately 225 new diagnoses of Ewing's sarcoma in North America/year. <ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2011-12-21}}</ref>
*The polymorphism associated with the increased risk is found at a much higher frequency in whites than in blacks or Asians, possibly explaining the epidemiology of the relative infrequency of Ewing's sarcoma in the latter populations.
*Ewing's sarcoma usually affects individuals of the Caucasian race. African American individuals are less likely to develop chordoma.<ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2011-12-21}}</ref>


===Age===
===Age===
Due to the prevalence of diagnosis during teenage years, there may possibly be a link between the onset of puberty and the early stages of this disease, although no research is currently being conducted to confirm this theory.
*Ewing's sarcoma typically occurs in children and adolescents between 10 and 20 years of age (95% between 4 and 25 years of age).
*The median age at diagnosis of Ewing's sarcoma is 15 years.
*Well-characterized cases of Ewing's sarcoma in neonates and infants have been described.
*Review of the SEER database from 1973 to 2011 identified 1,957 patients with Ewing sarcoma. Thirty-nine of these patients (2.0%) were younger than 12 months at diagnosis.


===Gender===
===Gender===
Ewing's sarcoma is more common in males and usually presents in childhood or early adulthood, with a peak between 10 and 20 years of age.
*Males are more commonly affected with Ewing's sarcoma than females.
 
===Race===
Caucasians more frequently develop Ewing's sarcoma than Asians. Also, African Americans and Africans rarely suffer from this disease. There was a study done between 1973 and 1985, and out of 650 cases only three of them were from African descent.<ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2011-12-21}}</ref>


==References==
==References==
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Latest revision as of 23:19, 26 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2];Assistant Editor(s)-In-Chief: Michael Maddaleni, B.S.

Overview

Ewing's sarcoma is the second most common malignant bone tumor in patients younger than 20 years. Ewing's sarcoma typically occurs in children and adolescents between 10 and 20 years of age. The overall incidence of Ewing's sarcoma is 0.1 cases for 100,000 individuals. The incidence of Ewing's sarcoma in children aged 10 to 19 years is 1 case per 100,000 individuals. Males are more commonly affected with Ewing's sarcoma than females.

Epidemiology and Demographics

Ewing's sarcoma is the second most common malignant bone tumor in patients younger than 20 years. The most frequent is osteosarcoma.[1]

Incidence

  • The incidence of Ewing's sarcoma has remained unchanged for 30 years.[2]
  • The overall incidence of Ewing's sarcoma is 0.1 cases per 100,000 individuals.
  • The incidence of Ewing's sarcoma in children aged 10 to 19 years is 1 case for 100,000 individuals.

Race

  • Incidence of Ewing's sarcoma in the United States is nine times greater in whites than in African Americans, with an intermediate incidence in Asians.[2]
  • The relative paucity of Ewing's sarcoma in people of African or Asian descent may be explained, in part, by a specific polymorphism.
  • The polymorphism associated with the increased risk is found at a much higher frequency in whites than in blacks or Asians, possibly explaining the epidemiology of the relative infrequency of Ewing's sarcoma in the latter populations.
  • Ewing's sarcoma usually affects individuals of the Caucasian race. African American individuals are less likely to develop chordoma.[1]

Age

  • Ewing's sarcoma typically occurs in children and adolescents between 10 and 20 years of age (95% between 4 and 25 years of age).
  • The median age at diagnosis of Ewing's sarcoma is 15 years.
  • Well-characterized cases of Ewing's sarcoma in neonates and infants have been described.
  • Review of the SEER database from 1973 to 2011 identified 1,957 patients with Ewing sarcoma. Thirty-nine of these patients (2.0%) were younger than 12 months at diagnosis.

Gender

  • Males are more commonly affected with Ewing's sarcoma than females.

References

  1. ↑ 1.0 1.1 Iwamoto Y (2007). "Diagnosis and treatment of Ewing's sarcoma". Japanese Journal of Clinical Oncology. 37 (2): 79–89. doi:10.1093/jjco/hyl142. PMID 17272319. Retrieved 2011-12-21. Unknown parameter |month= ignored (help)
  2. ↑ 2.0 2.1 Ewing's sarcoma. National cancer institute.http://www.cancer.gov/types/bone/hp/ewing-treatment-pdq#section/_1

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