Glucagonoma (patient information): Difference between revisions
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'''For the WikiDoc page for this topic, click [[Glucagonoma|here]]''' | '''For the WikiDoc page for this topic, click [[Glucagonoma|here]]''' | ||
{{ | {{Glucagonoma (patient information)}} | ||
{{CMG}}; '''Associate Editor-In-Chief:''' Jinhui Wu, | {{CMG}}; '''Associate Editor-In-Chief:''' Jinhui Wu, M.D. | ||
==Overview== | ==Overview== | ||
Glucagonoma is a very rare tumor of the islet cells of the pancreas which is an organ in the abdomen that can make insulin and glucagon to regulate blood sugar level. A patient of insulinoma can produce too much glucagon. Patients may show a series of symptoms of hyperglucagonemia and hypoaminoacidemia, such as [[anemia]], [[diarrhea]], [[weight loss]], [[necrolytic migratory erythema]] and [[Diabetes Mellitus]]. Treatments | Glucagonoma is a very rare tumor of the islet cells of the [[pancreas]] which is an organ in the abdomen that can make [[insulin]] and [[glucagon]] to regulate blood sugar level. A patient of insulinoma can produce too much [[glucagon]]. Patients may show a series of symptoms of hyperglucagonemia and hypoaminoacidemia, such as [[anemia]], [[diarrhea]], [[weight loss]], [[necrolytic migratory erythema]], and [[Diabetes Mellitus|diabetes mellitus]]. Treatments involve surgery and medication. | ||
==What are the symptoms of | ==What are the symptoms of Glucagonoma?== | ||
Usual symptoms of glucagonoma | Usual symptoms of glucagonoma involve a series of signs of hyperglucagonemia and hypoaminoacidemia: | ||
*[[Diarrhea]] | *[[Diarrhea]] | ||
| Line 15: | Line 17: | ||
*Excess thirst | *Excess thirst | ||
*[[Frequent urination]] and [[nighttime urination]] | *[[Frequent urination]] and [[Nocturia|nighttime urination]] | ||
*Increased appetite | *Increased appetite | ||
| Line 27: | Line 29: | ||
Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible. | Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible. | ||
==Who is at risk | ==Who is at highest risk?== | ||
The cause of | The cause of glucagonoma is not clear. | ||
== | ==Diagnosis== | ||
*Fasting glucose level and serum glucagon level: In patients with glucagonoma, the level of fasting glucose level and serum glucagon level | *Fasting glucose level and serum glucagon level: In patients with glucagonoma, the level of fasting glucose level and serum glucagon level is higher than normal. | ||
*[[Oral glucose tolerance test]]: This is one of the tools used to diagnose [[Diabetes Mellitus]]. | *[[Oral glucose tolerance test]]: This is one of the tools used to diagnose [[Diabetes Mellitus|diabetes mellitus]]. | ||
*[[Complete blood count]]: A patient with glucagonoma may show [[anemia]]. | *[[Complete blood count]]: A patient with glucagonoma may show [[anemia]]. | ||
| Line 39: | Line 41: | ||
*Skin biopsy: Skin biopsy is a good test for skin lesions. Pathologists may find [[necrolytic migratory erythema]] in patients with glucagonoma. | *Skin biopsy: Skin biopsy is a good test for skin lesions. Pathologists may find [[necrolytic migratory erythema]] in patients with glucagonoma. | ||
*Computed tomography (CT) scan: CT scans are often used to diagnose glucagonoma. It can confirm the location of the tumor and show the organs nearby. These are helpful for determining the stage of | *Computed tomography (CT) scan: CT scans are often used to diagnose glucagonoma. It can confirm the location of the tumor and show the organs nearby. These are helpful for determining the stage of cancer and in determining whether surgery is a good treatment option. | ||
*Magnetic resonance imaging (MRI): An MRI uses magnetic fields but it is a different type of image than what is produced by computed tomography (CT) and produces detailed images of the body. Like computed tomography (CT), a contrast agent may be injected into a patient’s vein to create a better picture. | *Magnetic resonance imaging (MRI): An MRI uses magnetic fields but it is a different type of image than what is produced by computed tomography (CT) and produces detailed images of the body. Like computed tomography (CT), a contrast agent may be injected into a patient’s vein to create a better picture. | ||
*Positron emission tomography (PET) scan: When doing this test, a small amount of a radioactive medium is injected into your body and absorbed by the organs or tissues. This radioactive substance gives off energy which in turn is used to produce the images. PET can provide more helpful information than either CT or MRI scans. It is useful to see if | *Positron emission tomography (PET) scan: When doing this test, a small amount of a radioactive medium is injected into your body and absorbed by the organs or tissues. This radioactive substance gives off energy which in turn is used to produce the images. PET can provide more helpful information than either CT or MRI scans. It is useful to see if cancerr has spread to the lymph nodes and it is also useful for your doctor to locate where cancerrer has spread. | ||
==When to seek urgent medical care?== | ==When to seek urgent medical care?== | ||
| Line 55: | Line 57: | ||
*Surgery: The surgical measure may involve surgical removal of the glucagonoma. It is the first preferred treatment for the patients. | *Surgery: The surgical measure may involve surgical removal of the glucagonoma. It is the first preferred treatment for the patients. | ||
*Medication: For patients who may not accept surgery, medications such as octreotide, doxorubicin and streptozotocin can be used to block the release of | *Medication: For patients who may not accept surgery, medications such as [[octreotide]], [[doxorubicin]] and [[streptozotocin]] can be used to block the release of glucagon. | ||
==Diseases with similar symptoms== | ==Diseases with similar symptoms== | ||
''' | '''Skin lesions''' | ||
*[[Psoriasis]] | *[[Psoriasis]] | ||
| Line 68: | Line 70: | ||
*Severe [[infection]] | *Severe [[infection]] | ||
*[[Diabetes Mellitus]] | *[[Diabetes Mellitus|Diabetes mellitus]] | ||
*[[Cushing syndrome]] | *[[Cushing syndrome]] | ||
*[[Renal function failure]] | *[[Chronic renal failure|Renal function failure]] | ||
==Where to find medical care for | ==Where to find medical care for Glucagonoma?== | ||
[http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|glucagonoma}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating glucagonoma] | [http://maps.google.com/maps?f=q&hl=en&geocode=&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|glucagonoma}}}}&sll=37.0625,-95.677068&sspn=65.008093,112.148438&ie=UTF8&ll=37.0625,-95.677068&spn=91.690419,149.414063&z=2&source=embed Directions to Hospitals Treating glucagonoma] | ||
==Prevention of | ==Prevention of Glucagonoma== | ||
For the cause is not clear, there is no known method for prevention. | For the cause is not clear, there is no known method for prevention. | ||
==What to expect ( | ==What to expect (Outlook/Prognosis)?== | ||
Approximately 60% of these tumors are cancerous, therefore prognosis of glucagonoma depends on the following: | |||
*Whether or not the tumor can be removed by surgery | *Whether or not the tumor can be removed by surgery | ||
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==Source== | ==Source== | ||
http://www.nlm.nih.gov/medlineplus/ency/article/000326.htm | [http://www.nlm.nih.gov/medlineplus/ency/article/000326.htm Medlineplus] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Patient information]] | [[Category:Patient information]] | ||
[[Category:Oncology patient information]] | [[Category:Oncology patient information]] | ||
[[Category:Mature chapter]] | [[Category:Mature chapter]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 01:48, 27 November 2017
For the WikiDoc page for this topic, click here
|
Glucagonoma |
|
Glucagonoma On the Web |
|---|
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Jinhui Wu, M.D.
Overview
Glucagonoma is a very rare tumor of the islet cells of the pancreas which is an organ in the abdomen that can make insulin and glucagon to regulate blood sugar level. A patient of insulinoma can produce too much glucagon. Patients may show a series of symptoms of hyperglucagonemia and hypoaminoacidemia, such as anemia, diarrhea, weight loss, necrolytic migratory erythema, and diabetes mellitus. Treatments involve surgery and medication.
What are the symptoms of Glucagonoma?
Usual symptoms of glucagonoma involve a series of signs of hyperglucagonemia and hypoaminoacidemia:
- Excess thirst
- Increased appetite
- Inflamed mouth and tongue
- Skin rash
Other health problems may also cause these symptoms. Only a doctor can tell for sure. A person with any of these symptoms should tell the doctor so that the problems can be diagnosed and treated as early as possible.
Who is at highest risk?
The cause of glucagonoma is not clear.
Diagnosis
- Fasting glucose level and serum glucagon level: In patients with glucagonoma, the level of fasting glucose level and serum glucagon level is higher than normal.
- Oral glucose tolerance test: This is one of the tools used to diagnose diabetes mellitus.
- Complete blood count: A patient with glucagonoma may show anemia.
- Skin biopsy: Skin biopsy is a good test for skin lesions. Pathologists may find necrolytic migratory erythema in patients with glucagonoma.
- Computed tomography (CT) scan: CT scans are often used to diagnose glucagonoma. It can confirm the location of the tumor and show the organs nearby. These are helpful for determining the stage of cancer and in determining whether surgery is a good treatment option.
- Magnetic resonance imaging (MRI): An MRI uses magnetic fields but it is a different type of image than what is produced by computed tomography (CT) and produces detailed images of the body. Like computed tomography (CT), a contrast agent may be injected into a patient’s vein to create a better picture.
- Positron emission tomography (PET) scan: When doing this test, a small amount of a radioactive medium is injected into your body and absorbed by the organs or tissues. This radioactive substance gives off energy which in turn is used to produce the images. PET can provide more helpful information than either CT or MRI scans. It is useful to see if cancerr has spread to the lymph nodes and it is also useful for your doctor to locate where cancerrer has spread.
When to seek urgent medical care?
Call your health care provider if symptoms of glucagonoma develop. If you experience either of the following symptoms, seeking urgent medical care as soon as possible:
- Severe diarrhea
Treatment options
For patients with glucagonoma, surgery is the definitive management. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities.
- Surgery: The surgical measure may involve surgical removal of the glucagonoma. It is the first preferred treatment for the patients.
- Medication: For patients who may not accept surgery, medications such as octreotide, doxorubicin and streptozotocin can be used to block the release of glucagon.
Diseases with similar symptoms
Skin lesions
- Chronic eczema
Hyperglucagonemia
- Severe infection
Where to find medical care for Glucagonoma?
Directions to Hospitals Treating glucagonoma
Prevention of Glucagonoma
For the cause is not clear, there is no known method for prevention.
What to expect (Outlook/Prognosis)?
Approximately 60% of these tumors are cancerous, therefore prognosis of glucagonoma depends on the following:
- Whether or not the tumor can be removed by surgery
- The stage of the tumor: the size of the tumor, whether the cancer has spread outside the pancreas
- The patient’s general
- Whether the tumor has just been diagnosed or has recurred