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{{Toxic multinodular goiter}}


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{{CMG}}; {{AE}} {{Ajay}} {{ARK}} {{Mazia}}{{SKA}}


== Overview ==
{{SK}}


'''Toxic multinodular goitre''' (also known as '''toxic nodular goitre''', '''toxic nodular struma''') is a form of [[hyperthyroidism]] - where there is excess production of [[thyroid hormones]].
==[[Toxic multinodular goiter overview|Overview]]==


It is the second most common cause of [[hyperthyroidism]] after [[Graves disease]].
==[[Toxic multinodular goiter historical perspective|Historical Perspective]]==


==Symptoms==
==[[Toxic multinodular goiter classification|Classification]]==
Symptoms of toxic multinodular goitre are similar to that of [[hyperthyroidism]], including:
* heat intolerance
* [[hyperkinesis]]
* [[tremor]]
* irritability
* [[weight loss]]
* [[increased appetite]]
* [[goitre]] (swelling of the thyroid gland)
* [[tachycardia]] (high heart rate - above 180 bpm at rest)


==Related eponym==
==[[Toxic multinodular goiter pathophysiology|Pathophysiology]]==
'''Plummer's disease''' is named after an American [[physician]] [[Henry Stanley Plummer]] but refers to a '''single toxic nodule''' (adenoma) which may present with the background of a suppressed multinodular goitre.<ref>{{WhoNamedIt2|synd|1094|Plummer's disease}} eponymously named after {{WhoNamedIt|doctor|1074|Henry Stanley Plummer}}</ref>
The progression to Toxic multinodular goiter usually involves the somatic gain-of-function mutations in the TSH receptor in autonomously functioning thyroid nodules.


==Footnotes==
==[[Toxic multinodular goiter causes|Causes]]==
<references/>


==External links==
==[[Toxic multinodular goiter differential diagnosis|Differentiating Toxic multinodular goiter from other Diseases]]==
* [http://www.thyroidimaging.com/pic_gozzonod2.htm Photo of patient]
 
* [http://www.thyroidimaging.com/surg_gozimm2.htm Photo of goitre]
==[[Toxic multinodular goiter epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Toxic multinodular goiter risk factors|Risk Factors]]==


== Acknowledgements ==
==[[Toxic multinodular goiter screening|Screening]]==
The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.


Initial content for this page in some instances came from [http://www.wikipedia.org Wikipedia]
==[[Toxic multinodular goiter natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


'''List of contributors:'''
==Diagnosis==
[[Toxic multinodular goiter history and symptoms|History and Symptoms]] | [[Toxic multinodular goiter physical examination|Physical Examination]] | [[Toxic multinodular goiter laboratory findings|Laboratory Findings]] | [[Toxic multinodular goiter electrocardiogram|Electrocardiogram]] | [[Toxic multinodular goiter x ray|X-Ray Findings]] | [[Toxic multinodular goiter CT|CT-Scan Findings]] | [[Toxic multinodular goiter MRI|MRI Findings]] | [[Toxic multinodular goiter other diagnostic studies|Other Diagnostic Studies]] | [[Toxic multinodular goiter other imaging findings|Other Imaging Findings]]


== Suggested Reading and Key General References ==
==Treatment==
[[Toxic multinodular goiter medical therapy|Medical Therapy]] | [[Toxic multinodular goiter surgery|Surgery]] | | [[Toxic multinodular goiter surgery|Radiation Therapy]] |[[Toxic multinodular goiter primary prevention|Primary Prevention]] | [[Toxic multinodular goiter secondary prevention|Secondary Prevention]] | [[Toxic multinodular goiter cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Toxic multinodular goiter future or investigational therapies|Future or Investigational Therapies]]


== Suggested Links and Web Resources ==
==Case Studies==
[[Toxic multi nodular goiter case study one|Case #1]]


== For Patients ==


==External links==
* [http://www.thyroidimaging.com/pic_gozzonod2.htm Photo of patient]
* [http://www.thyroidimaging.com/surg_gozimm2.htm Photo of goitre]


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[[pt:Doença de Plummer]]
[[pt:Doença de Plummer]]
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[[Category:Disease]]
[[Category:Endocrinology]]
[[Category:Endocrinology]]
{{WikiDoc Sources}}

Latest revision as of 16:28, 6 December 2017

Toxic multinodular goiter Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Toxic multinodular goiter from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Toxic multinodular goiter On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Toxic multinodular goiter

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Toxic multinodular goiter

CDC on Toxic multinodular goiter

Toxic multinodular goiter in the news

Blogs on Toxic multinodular goiter

Directions to Hospitals Treating Toxic multinodular goiter

Risk calculators and risk factors for Toxic multinodular goiter

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ajay Gade MD[2]] Aravind Reddy Kothagadi M.B.B.S[3] Mazia Fatima, MBBS [4]Sunny Kumar MD [5]

Synonyms and keywords:

Overview

Historical Perspective

Classification

Pathophysiology

The progression to Toxic multinodular goiter usually involves the somatic gain-of-function mutations in the TSH receptor in autonomously functioning thyroid nodules.

Causes

Differentiating Toxic multinodular goiter from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray Findings | CT-Scan Findings | MRI Findings | Other Diagnostic Studies | Other Imaging Findings

Treatment

Medical Therapy | Surgery | | Radiation Therapy |Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1


External links

Template:WH Template:WikiDoc Sources