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{{Eosinophilic esophagitis}}
{{CMG}}, {{AE}}{{Ajay}}


{{SK}}: Eosinophilic oesophagitis


==Overview==
==[[Eosinophilic esophagitis overview|Overview]]==
{{SI}}
'''Eosinophilic esophagitis''' is an [[allergy|allergic]] inflammatory condition of the [[esophagus]]. Symptoms are [[chest pain]] or [[heartburn]] and occasionally [[dysphagia]], or difficulty in [[swallow]]ing.  The [[disease]] was first described in children but occurs in adults as well.


[[Image:Multi ring esophagus.jpg|thumb|center|[[Endoscopic]] image of [[esophagus]] in a case of eosinophilic esophagitis.  Concentric rings are termed [[Vertebrate trachea|trachealization]] of the esophagus.]]
==[[Eosinophilic esophagitis historical perspective|Historical Perspective]]==


Diagnosis is obtained during an upper GI endoscopy where [[biopsies]] are taken of the esophagus.  At the time of [[endoscopy]], ridges or [[furrow]]s may be seen in the esophagus wall.  Sometimes, multiple rings may occur in the esophagus, leading to the term "multi-ring esophagus" or "feline esophagus" due to the similarity in the rings of the cat esophagus.  A high number of eosinophils are seen on microscopic examination of the biopsy specimens.
==[[Eosinophilic esophagitis classification|Classification]]==
Skin testing can help identify which foods might contribute to this disease, but often skin testing implicates foods that are not involved.  Common [[allergen]]s in the GI tract are cow's milk, soy, egg and wheat.


[[Image:Eosinophilic esophagiits ba swallow.jpg|thumb|center|150px|[[Barium swallow]] of the esophagus, showing multiple rings associated with eosinophilic esophagitis.]]
==[[Eosinophilic esophagitis pathophysiology|Pathophysiology]]==


Treatment strategies include removal of the offending food, [[proton pump inhibitor]]s to decrease acidity in the stomach that may reflux into the esophagus, inhaled steroid puffers taken orally and swallowed, anti-histamines, H2-receptor blockers such as [[cimetidine]], [[leukotriene]] modifiers such as [[montelukast]], and, in investigational reports, the anti-IL5 [[monoclonal antibody]] [[mepolizumab]].  Refractory patients may require oral [[steroid]] medications.
==[[Eosinophilic esophagitis causes|Causes]]==


[[Image:Eosinophilic esophagiits path.jpg|thumb|center|150px|[[H&E]] stain of [[esophagus]] [[biopsy]] showing eosinophilic esophagitis, manifested by an infiltration of [[eosinophils]] in the [[lamina propria]]]]
==[[Eosinophilic esophagitis differential diagnosis|Differentiating Eosinophilic Esophagitis from other Diseases]]==


==External links==
==[[Eosinophilic esophagitis epidemiology and demographics|Epidemiology and Demographics]]==
*[http://www.apfed.org/ American Partnership for Eosinophilic Disorders]
*[http://www.cincinnatichildrens.org/svc/alpha/e/eosinophilic/ Cincinnati Center for Eosinophilic Disorders]


==[[Eosinophilic esophagitis risk factors|Risk Factors]]==
==[[Eosinophilic esophagitis screening|Screening]]==
==[[Eosinophilic esophagitis natural history|Natural History, Complications and Prognosis]]==
==Diagnosis==
[[Eosinophilic esophagitis history and symptoms|History and Symptoms]] | [[Eosinophilic esophagitis physical examination|Physical Examination]] | [[Eosinophilic esophagitis laboratory tests|Laboratory Findings]] | [[Eosinophilic esophagitis x ray|X Ray]] | [[Eosinophilic esophagitis CT|CT]] | [[Eosinophilic esophagitis MRI|MRI]] | [[Eosinophilic esophagitis other imaging findings|Other Imaging Findings]] | [[Eosinophilic esophagitis other diagnostic studies|Other Diagnostic Studies]]
==Treatment==
[[Eosinophilic esophagitis medical therapy|Medical Therapy]] | [[Eosinophilic esophagitis surgery|Surgery]] | [[Eosinophilic esophagitis primary prevention|Primary Prevention]]  |  [[Eosinophilic esophagitis secondary prevention|Secondary Prevention]]  |  [[Eosinophilic esophagitis future or investigational therapies|Future or Investigational Therapies]]


{{Gastroenterology}}
{{Gastroenterology}}


[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[he:אאוזנופיליק אזופגטיס]]


{{WH}}
{{WH}}
{{WikiDoc Sources}}
{{WS}}

Latest revision as of 19:31, 19 December 2017

Eosinophilic Esophagitis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Eosinophilic Esophagitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Future or Investigational Therapies

Case Studies

Case #1

Eosinophilic esophagitis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Eosinophilic esophagitis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Eosinophilic esophagitis

CDC on Eosinophilic esophagitis

Eosinophilic esophagitis in the news

Blogs on Eosinophilic esophagitis

Directions to Hospitals Treating Eosinophilic esophagitis

Risk calculators and risk factors for Eosinophilic esophagitis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Ajay Gade MD[2]]

Synonyms and keywords:: Eosinophilic oesophagitis

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Eosinophilic Esophagitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Future or Investigational Therapies

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