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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Small proline-rich protein 2A''' is a [[protein]] that in humans is encoded by the ''SPRR2A'' [[gene]].<ref name="pmid8325635">{{cite journal | vauthors = Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C | title = Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins | journal = Genomics | volume = 16 | issue = 3 | pages = 630–7 |date=Aug 1993 | pmid = 8325635 | pmc =  | doi = 10.1006/geno.1993.1240 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SPRR2A small proline-rich protein 2A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6700| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Small proline-rich protein 2A
| HGNCid = 11261
| Symbol = SPRR2A
| AltSymbols =;
| OMIM = 182267
| ECnumber = 
| Homologene = 31413
| MGIid = 1330344
| GeneAtlas_image1 = PBB_GE_SPRR2A_208539_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}{{GNF_GO|id=GO:0005488 |text = binding}}{{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0001533 |text = cornified envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}} {{GNF_GO|id=GO:0031424 |text = keratinization}} {{GNF_GO|id=GO:0042698 |text = menstrual cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6700
    | Hs_Ensembl = ENSG00000196805
    | Hs_RefseqProtein = NP_005979
    | Hs_RefseqmRNA = NM_005988
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 151295213
    | Hs_GenLoc_end = 151296637
    | Hs_Uniprot = P35326
    | Mm_EntrezGene = 20765
    | Mm_Ensembl = ENSMUSG00000054215
    | Mm_RefseqmRNA = NM_011477
    | Mm_RefseqProtein = NP_035607
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 92517985
    | Mm_GenLoc_end = 92519330
    | Mm_Uniprot = O70562
  }}
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'''Small proline-rich protein 2A''', also known as '''SPRR2A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPRR2A small proline-rich protein 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6700| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Tong L, Corrales RM, Chen Z, ''et al.'' |title=Expression and regulation of cornified envelope proteins in human corneal epithelium. |journal=Invest. Ophthalmol. Vis. Sci. |volume=47 |issue= 5 |pages= 1938-46 |year= 2006 |pmid= 16639001 |doi= 10.1167/iovs.05-1129 }}
*{{cite journal   |vauthors=Tong L, Corrales RM, Chen Z, etal |title=Expression and Regulation of Cornified Envelope Proteins in Human Corneal Epithelium |journal=Invest. Ophthalmol. Vis. Sci. |volume=47 |issue= 5 |pages= 1938–46 |year= 2006 |pmid= 16639001 | pmc=2906387 |doi= 10.1167/iovs.05-1129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Hong SH, Nah HY, Lee JY, ''et al.'' |title=Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus. |journal=Mol. Cells |volume=17 |issue= 3 |pages= 477-84 |year= 2004 |pmid= 15232223 |doi=  }}
*{{cite journal   |vauthors=Hong SH, Nah HY, Lee JY, etal |title=Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus |journal=Mol. Cells |volume=17 |issue= 3 |pages= 477–84 |year= 2004 |pmid= 15232223 |doi=  }}
*{{cite journal  | author=Cabral A, Fischer DF, Vermeij WP, Backendorf C |title=Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17792-9 |year= 2003 |pmid= 12624109 |doi= 10.1074/jbc.M300508200 }}
*{{cite journal  | vauthors=Cabral A, Fischer DF, Vermeij WP, Backendorf C |title=Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17792–9 |year= 2003 |pmid= 12624109 |doi= 10.1074/jbc.M300508200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal   |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267 }}
*{{cite journal | author=Fischer DF, van Drunen CM, Winkler GS, ''et al.'' |title=Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker. |journal=Nucleic Acids Res. |volume=26 |issue= 23 |pages= 5288-94 |year= 1999 |pmid= 9826750 |doi=  }}
*{{cite journal   |vauthors=Fischer DF, van Drunen CM, Winkler GS, etal |title=Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker |journal=Nucleic Acids Res. |volume=26 |issue= 23 |pages= 5288–94 |year= 1999 |pmid= 9826750 |doi=10.1093/nar/26.23.5288  | pmc=147987 }}
*{{cite journal  | author=Steinert PM, Marekov LN |title=Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 2021-30 |year= 1997 |pmid= 8999895 |doi=  }}
*{{cite journal  | vauthors=Steinert PM, Marekov LN |title=Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 2021–30 |year= 1997 |pmid= 8999895 |doi=10.1074/jbc.272.3.2021 }}
*{{cite journal  | author=Fischer DF, Gibbs S, van De Putte P, Backendorf C |title=Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5365-74 |year= 1996 |pmid= 8816448 |doi= }}
*{{cite journal  | vauthors=Fischer DF, Gibbs S, van De Putte P, Backendorf C |title=Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5365–74 |year= 1996 |pmid= 8816448 |doi=  | pmc=231535  }}
*{{cite journal | author=Gibbs S, Fijneman R, Wiegant J, ''et al.'' |title=Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. |journal=Genomics |volume=16 |issue= 3 |pages= 630-7 |year= 1993 |pmid= 8325635 |doi= 10.1006/geno.1993.1240 }}
*{{cite journal   |vauthors=Gibbs S, Lohman F, Teubel W, etal |title=Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes |journal=Nucleic Acids Res. |volume=18 |issue= 15 |pages= 4401–7 |year= 1990 |pmid= 2388825 |doi=10.1093/nar/18.15.4401  | pmc=331257 }}
*{{cite journal | author=Gibbs S, Lohman F, Teubel W, ''et al.'' |title=Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes. |journal=Nucleic Acids Res. |volume=18 |issue= 15 |pages= 4401-7 |year= 1990 |pmid= 2388825 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:56, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Small proline-rich protein 2A is a protein that in humans is encoded by the SPRR2A gene.[1][2]


References

  1. ↑ Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (Aug 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins". Genomics. 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
  2. ↑ "Entrez Gene: SPRR2A small proline-rich protein 2A".

Further reading



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