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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''[[S100 protein|S100]] calcium-binding protein A6''' ('''S100A6''') is a [[protein]] that in humans is encoded by the ''S100A6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: S100A6 S100 calcium binding protein A6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6277| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_S100A6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a03.
| PDB = {{PDB2|1a03}}, {{PDB2|1cnp}}, {{PDB2|1jwd}}, {{PDB2|1k8u}}, {{PDB2|1k96}}, {{PDB2|1k9k}}, {{PDB2|1k9p}}, {{PDB2|2cnp}}
| Name = S100 calcium binding protein A6
| HGNCid = 10496
| Symbol = S100A6
| AltSymbols =; 2A9; 5B10; CABP; CACY; PRA
| OMIM = 114110
| ECnumber = 
| Homologene = 7925
| MGIid = 1339467
| GeneAtlas_image1 = PBB_GE_S100A6_217728_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0048154 |text = S100 beta binding}} {{GNF_GO|id=GO:0048306 |text = calcium-dependent protein binding}}
| Component = {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0048146 |text = positive regulation of fibroblast proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6277
    | Hs_Ensembl = ENSG00000197956
    | Hs_RefseqProtein = NP_055439
    | Hs_RefseqmRNA = NM_014624
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 151773699
    | Hs_GenLoc_end = 151775344
    | Hs_Uniprot = P06703
    | Mm_EntrezGene = 20200
    | Mm_Ensembl = ENSMUSG00000001025
    | Mm_RefseqmRNA = NM_011313
    | Mm_RefseqProtein = NP_035443
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 90699108
    | Mm_GenLoc_end = 90700341
    | Mm_Uniprot = Q545I9
  }}
}}
'''S100 calcium binding protein A6''', also known as '''S100A6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: S100A6 S100 calcium binding protein A6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6277| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.<ref name="entrez">{{cite web | title = Entrez Gene: S100A6 S100 calcium binding protein A6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6277| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
S100A6 has been shown to [[Protein-protein interaction|interact]] with [[S100B]]<ref name=pmid10913138>{{cite journal | vauthors = Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J | title = S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 35302–10  | date = November 2000 | pmid = 10913138 | doi = 10.1074/jbc.M003943200 }}</ref><ref name=pmid9925766>{{cite journal | vauthors = Yang Q, O'Hanlon D, Heizmann CW, Marks A | title = Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma | journal = Exp. Cell Res. | volume = 246 | issue = 2 | pages = 501–9  | date = February 1999 | pmid = 9925766 | doi = 10.1006/excr.1998.4314 }}</ref> and [[SUGT1]].<ref name=pmid12746458>{{cite journal | vauthors = Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J | title = Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins | journal = J. Biol. Chem. | volume = 278 | issue = 29 | pages = 26923–8  | date = July 2003 | pmid = 12746458 | doi = 10.1074/jbc.M211518200 }}</ref>
 
==Pathology==
S100A6 to be reported as possible diagnostic marker of [[papillary thyroid carcinoma]].<ref>{{cite journal | vauthors = Sofiadis A, Dinets A, Orre LM, Branca RM, Juhlin CC, Foukakis T, Wallin G, Höög A, Hulchiy M, Zedenius J, Larsson C, Lehtiö J | title = Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma | journal = Thyroid | volume = 20 | issue = 10 | pages = 1067–76  | date = October 2010 | pmid = 20629554 | doi = 10.1089/thy.2009.0400 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Schäfer BW, Heizmann CW | title = The S100 family of EF-hand calcium-binding proteins: functions and pathology | journal = Trends Biochem. Sci. | volume = 21 | issue = 4 | pages = 134–40 | year = 1996 | pmid = 8701470 | doi = 10.1016/S0968-0004(96)80167-8 }}
| citations =
* {{cite journal | vauthors = Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H | title = Specific binding of CAP-50 to calcyclin | journal = FEBS Lett. | volume = 305 | issue = 3 | pages = 217–9 | year = 1992 | pmid = 1299619 | doi = 10.1016/0014-5793(92)80671-3 }}
*{{cite journal | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi= }}
* {{cite journal | vauthors = Engelkamp D, Schäfer BW, Erne P, Heizmann CW | title = S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart | journal = Biochemistry | volume = 31 | issue = 42 | pages = 10258–64 | year = 1992 | pmid = 1384693 | doi = 10.1021/bi00157a012 }}
*{{cite journal | author=Minami H, Tokumitsu H, Mizutani A, ''et al.'' |title=Specific binding of CAP-50 to calcyclin. |journal=FEBS Lett. |volume=305 |issue= 3 |pages= 217-9 |year= 1993 |pmid= 1299619 |doi= }}
* {{cite journal | vauthors = Tomida Y, Terasawa M, Kobayashi R, Hidaka H | title = Calcyclin and calvasculin exist in human platelets | journal = Biochem. Biophys. Res. Commun. | volume = 189 | issue = 3 | pages = 1310–6 | year = 1992 | pmid = 1482346 | doi = 10.1016/0006-291X(92)90216-8 }}
*{{cite journal | author=Engelkamp D, Schäfer BW, Erne P, Heizmann CW |title=S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart. |journal=Biochemistry |volume=31 |issue= 42 |pages= 10258-64 |year= 1992 |pmid= 1384693 |doi= }}
* {{cite journal | vauthors = Filipek A, Gerke V, Weber K, Kuźnicki J | title = Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding proteins obtained by Ca2(+)-dependent affinity chromatography | journal = Eur. J. Biochem. | volume = 195 | issue = 3 | pages = 795–800 | year = 1991 | pmid = 1999197 | doi = 10.1111/j.1432-1033.1991.tb15768.x }}
*{{cite journal | author=Tomida Y, Terasawa M, Kobayashi R, Hidaka H |title=Calcyclin and calvasculin exist in human platelets. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 3 |pages= 1310-6 |year= 1993 |pmid= 1482346 |doi= }}
* {{cite journal | vauthors = Murphy LC, Murphy LJ, Tsuyuki D, Duckworth ML, Shiu RP | title = Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum | journal = J. Biol. Chem. | volume = 263 | issue = 5 | pages = 2397–401 | year = 1988 | pmid = 2448309 | doi =  }}
*{{cite journal | author=Filipek A, Gerke V, Weber K, Kuźnicki J |title=Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding proteins obtained by Ca2(+)-dependent affinity chromatography. |journal=Eur. J. Biochem. |volume=195 |issue= 3 |pages= 795-800 |year= 1991 |pmid= 1999197 |doi= }}
* {{cite journal | vauthors = Gabius HJ, Bardosi A, Gabius S, Hellmann KP, Karas M, Kratzin H | title = Identification of a cell cycle-dependent gene product as a sialic acid-binding protein | journal = Biochem. Biophys. Res. Commun. | volume = 163 | issue = 1 | pages = 506–12 | year = 1989 | pmid = 2775283 | doi = 10.1016/0006-291X(89)92166-9 }}
*{{cite journal | author=Murphy LC, Murphy LJ, Tsuyuki D, ''et al.'' |title=Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum. |journal=J. Biol. Chem. |volume=263 |issue= 5 |pages= 2397-401 |year= 1988 |pmid= 2448309 |doi=  }}
* {{cite journal | vauthors = Ferrari S, Calabretta B, deRiel JK, Battini R, Ghezzo F, Lauret E, Griffin C, Emanuel BS, Gurrieri F, Baserga R | title = Structural and functional analysis of a growth-regulated gene, the human calcyclin | journal = J. Biol. Chem. | volume = 262 | issue = 17 | pages = 8325–32 | year = 1987 | pmid = 3036810 | doi =  }}
*{{cite journal | author=Gabius HJ, Bardosi A, Gabius S, ''et al.'' |title=Identification of a cell cycle-dependent gene product as a sialic acid-binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=163 |issue= 1 |pages= 506-12 |year= 1989 |pmid= 2775283 |doi= }}
* {{cite journal | vauthors = Calabretta B, Battini R, Kaczmarek L, de Riel JK, Baserga R | title = Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein | journal = J. Biol. Chem. | volume = 261 | issue = 27 | pages = 12628–32 | year = 1986 | pmid = 3755724 | doi =  }}
*{{cite journal | author=Ferrari S, Calabretta B, deRiel JK, ''et al.'' |title=Structural and functional analysis of a growth-regulated gene, the human calcyclin. |journal=J. Biol. Chem. |volume=262 |issue= 17 |pages= 8325-32 |year= 1987 |pmid= 3036810 |doi=  }}
* {{cite journal | vauthors = Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW | title = Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family | journal = Genomics | volume = 25 | issue = 3 | pages = 638–43 | year = 1995 | pmid = 7759097 | doi = 10.1016/0888-7543(95)80005-7 }}
*{{cite journal | author=Calabretta B, Battini R, Kaczmarek L, ''et al.'' |title=Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein. |journal=J. Biol. Chem. |volume=261 |issue= 27 |pages= 12628-32 |year= 1986 |pmid= 3755724 |doi=  }}
* {{cite journal | vauthors = Engelkamp D, Schäfer BW, Mattei MG, Erne P, Heizmann CW | title = Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 14 | pages = 6547–51 | year = 1993 | pmid = 8341667 | pmc = 46969 | doi = 10.1073/pnas.90.14.6547 }}
*{{cite journal | author=Schäfer BW, Wicki R, Engelkamp D, ''et al.'' |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638-43 |year= 1995 |pmid= 7759097 |doi= }}
* {{cite journal | vauthors = Filipek A, Wojda U | title = p30, a novel protein target of mouse calcyclin (S100A6) | journal = Biochem. J. | volume = 320 ( Pt 2) | issue = Pt 2 | pages = 585–7 | year = 1996 | pmid = 8973570 | pmc = 1217969 | doi =  }}
*{{cite journal | author=Engelkamp D, Schäfer BW, Mattei MG, ''et al.'' |title=Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6547-51 |year= 1993 |pmid= 8341667 |doi= }}
* {{cite journal | vauthors = Kordowska J, Stafford WF, Wang CL | title = Ca2+ and Zn2+ bind to different sites and induce different conformational changes in human calcyclin | journal = Eur. J. Biochem. | volume = 253 | issue = 1 | pages = 57–66 | year = 1998 | pmid = 9578461 | doi = 10.1046/j.1432-1327.1998.2530057.x }}
*{{cite journal | author=Filipek A, Wojda U |title=p30, a novel protein target of mouse calcyclin (S100A6). |journal=Biochem. J. |volume=320 ( Pt 2) |issue= |pages= 585-7 |year= 1997 |pmid= 8973570 |doi=  }}
* {{cite journal | vauthors = Yang Q, O'Hanlon D, Heizmann CW, Marks A | title = Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma | journal = Exp. Cell Res. | volume = 246 | issue = 2 | pages = 501–9 | year = 1999 | pmid = 9925766 | doi = 10.1006/excr.1998.4314 }}
*{{cite journal | author=Kordowska J, Stafford WF, Wang CL |title=Ca2+ and Zn2+ bind to different sites and induce different conformational changes in human calcyclin. |journal=Eur. J. Biochem. |volume=253 |issue= 1 |pages= 57-66 |year= 1998 |pmid= 9578461 |doi= }}
* {{cite journal | vauthors = Sudo T, Hidaka H | title = Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis | journal = FEBS Lett. | volume = 444 | issue = 1 | pages = 11–4 | year = 1999 | pmid = 10037139 | doi = 10.1016/S0014-5793(99)00014-9 }}
*{{cite journal | author=Yang Q, O'Hanlon D, Heizmann CW, Marks A |title=Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma. |journal=Exp. Cell Res. |volume=246 |issue= 2 |pages= 501-9 |year= 1999 |pmid= 9925766 |doi= 10.1006/excr.1998.4314 }}
* {{cite journal | vauthors = Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J | title = S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 35302–10 | year = 2000 | pmid = 10913138 | doi = 10.1074/jbc.M003943200 }}
*{{cite journal | author=Sudo T, Hidaka H |title=Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis. |journal=FEBS Lett. |volume=444 |issue= 1 |pages= 11-4 |year= 1999 |pmid= 10037139 |doi= }}
* {{cite journal | vauthors = Li Y, Yang L, Cui JT, Li WM, Guo RF, Lu YY | title = Construction of cDNA representational difference analysis based on two cDNA libraries and identification of garlic inducible expression genes in human gastric cancer cells | journal = World J. Gastroenterol. | volume = 8 | issue = 2 | pages = 208–12 | year = 2002 | pmid = 11925593 | doi =  }}
*{{cite journal | author=Deloulme JC, Assard N, Mbele GO, ''et al.'' |title=S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35302-10 |year= 2001 |pmid= 10913138 |doi= 10.1074/jbc.M003943200 }}
* {{cite journal | vauthors = Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R | title = Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution | journal = Structure | volume = 10 | issue = 4 | pages = 557–67 | year = 2002 | pmid = 11937060 | doi = 10.1016/S0969-2126(02)00740-2 }}
*{{cite journal | author=Li Y, Yang L, Cui JT, ''et al.'' |title=Construction of cDNA representational difference analysis based on two cDNA libraries and identification of garlic inducible expression genes in human gastric cancer cells. |journal=World J. Gastroenterol. |volume=8 |issue= 2 |pages= 208-12 |year= 2002 |pmid= 11925593 |doi=  }}
* {{cite journal | vauthors = Filipek A, Jastrzebska B, Nowotny M, Kuznicki J | title = CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family | journal = J. Biol. Chem. | volume = 277 | issue = 32 | pages = 28848–52 | year = 2002 | pmid = 12042313 | doi = 10.1074/jbc.M203602200 }}
*{{cite journal | author=Otterbein LR, Kordowska J, Witte-Hoffmann C, ''et al.'' |title=Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. |journal=Structure |volume=10 |issue= 4 |pages= 557-67 |year= 2002 |pmid= 11937060 |doi=  }}
*{{cite journal | author=Filipek A, Jastrzebska B, Nowotny M, Kuznicki J |title=CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28848-52 |year= 2002 |pmid= 12042313 |doi= 10.1074/jbc.M203602200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=6277}}
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{{gene-1-stub}}
 
[[Category:S100 proteins]]

Latest revision as of 05:50, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene.[1]

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.[1]

Interactions

S100A6 has been shown to interact with S100B[2][3] and SUGT1.[4]

Pathology

S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma.[5]

References

  1. ↑ 1.0 1.1 "Entrez Gene: S100A6 S100 calcium binding protein A6".
  2. ↑ Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J (November 2000). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". J. Biol. Chem. 275 (45): 35302–10. doi:10.1074/jbc.M003943200. PMID 10913138.
  3. ↑ Yang Q, O'Hanlon D, Heizmann CW, Marks A (February 1999). "Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma". Exp. Cell Res. 246 (2): 501–9. doi:10.1006/excr.1998.4314. PMID 9925766.
  4. ↑ Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". J. Biol. Chem. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.
  5. ↑ Sofiadis A, Dinets A, Orre LM, Branca RM, Juhlin CC, Foukakis T, Wallin G, Höög A, Hulchiy M, Zedenius J, Larsson C, Lehtiö J (October 2010). "Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma". Thyroid. 20 (10): 1067–76. doi:10.1089/thy.2009.0400. PMID 20629554.

Further reading

  • Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. doi:10.1016/S0968-0004(96)80167-8. PMID 8701470.
  • Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H (1992). "Specific binding of CAP-50 to calcyclin". FEBS Lett. 305 (3): 217–9. doi:10.1016/0014-5793(92)80671-3. PMID 1299619.
  • Engelkamp D, Schäfer BW, Erne P, Heizmann CW (1992). "S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart". Biochemistry. 31 (42): 10258–64. doi:10.1021/bi00157a012. PMID 1384693.
  • Tomida Y, Terasawa M, Kobayashi R, Hidaka H (1992). "Calcyclin and calvasculin exist in human platelets". Biochem. Biophys. Res. Commun. 189 (3): 1310–6. doi:10.1016/0006-291X(92)90216-8. PMID 1482346.
  • Filipek A, Gerke V, Weber K, Kuźnicki J (1991). "Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding proteins obtained by Ca2(+)-dependent affinity chromatography". Eur. J. Biochem. 195 (3): 795–800. doi:10.1111/j.1432-1033.1991.tb15768.x. PMID 1999197.
  • Murphy LC, Murphy LJ, Tsuyuki D, Duckworth ML, Shiu RP (1988). "Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum". J. Biol. Chem. 263 (5): 2397–401. PMID 2448309.
  • Gabius HJ, Bardosi A, Gabius S, Hellmann KP, Karas M, Kratzin H (1989). "Identification of a cell cycle-dependent gene product as a sialic acid-binding protein". Biochem. Biophys. Res. Commun. 163 (1): 506–12. doi:10.1016/0006-291X(89)92166-9. PMID 2775283.
  • Ferrari S, Calabretta B, deRiel JK, Battini R, Ghezzo F, Lauret E, Griffin C, Emanuel BS, Gurrieri F, Baserga R (1987). "Structural and functional analysis of a growth-regulated gene, the human calcyclin". J. Biol. Chem. 262 (17): 8325–32. PMID 3036810.
  • Calabretta B, Battini R, Kaczmarek L, de Riel JK, Baserga R (1986). "Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein". J. Biol. Chem. 261 (27): 12628–32. PMID 3755724.
  • Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
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