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{{Infobox_gene}}
{{PBB_Controls
'''Interferon-induced guanylate-binding protein 1''' is a [[protein]] that in humans is encoded by the ''GBP1'' [[gene]].<ref name="pmid7518790">{{cite journal |vauthors=Strehlow I, Lohmann-Matthes ML, Decker T | title = The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1 | journal = Gene | volume = 144 | issue = 2 | pages = 295–9 |date=Aug 1994 | pmid = 7518790 | pmc =  | doi =10.1016/0378-1119(94)90393-X  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2633| accessdate = }}</ref> It belongs to the [[dynamin]] superfamily of large [[GTPase]]s.<ref name="pmid15040446">{{cite journal |vauthors=Praefcke GJ, McMahon HT | title = The dynamin superfamily: universal membrane tubulation and fission molecules? | journal = Nat. Rev. Mol. Cell Biol. | volume = 5 | issue = 2 | pages = 133–47 |date=February 2004 | pmid = 15040446 | doi = 10.1038/nrm1313| url = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GBP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dg3.
| PDB = {{PDB2|1dg3}}, {{PDB2|1f5n}}, {{PDB2|2b8w}}, {{PDB2|2b92}}, {{PDB2|2bc9}}, {{PDB2|2d4h}}
| Name = Guanylate binding protein 1, interferon-inducible, 67kDa
| HGNCid = 4182
| Symbol = GBP1
| AltSymbols =;
| OMIM = 600411
| ECnumber = 
| Homologene = 55626
| MGIid = 
| GeneAtlas_image1 = PBB_GE_GBP1_202270_at_tn.png
| GeneAtlas_image2 = PBB_GE_GBP1_202269_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2633
    | Hs_Ensembl = ENSG00000117228
    | Hs_RefseqProtein = NP_002044
    | Hs_RefseqmRNA = NM_002053
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 89290590
    | Hs_GenLoc_end = 89303631
    | Hs_Uniprot = P32455
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Guanylate binding protein 1, interferon-inducible, 67kDa''', also known as '''GBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2633| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Guanosine monophosphate|Guanylate]] binding protein expression is induced by [[interferon]].  Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Guanylate binding protein expression is induced by interferon.  Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3<ref name="entrez">{{cite web | title = Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2633| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Anderson NL, Anderson NG |title=The human plasma proteome: history, character, and diagnostic prospects. |journal=Mol. Cell Proteomics |volume=1 |issue= 11 |pages= 845-67 |year= 2003 |pmid= 12488461 |doi=  }}
*{{cite journal  |vauthors=Anderson NL, Anderson NG |title=The human plasma proteome: history, character, and diagnostic prospects. |journal=Mol. Cell. Proteomics |volume=1 |issue= 11 |pages= 845–67 |year= 2003 |pmid= 12488461 |doi=  10.1074/mcp.R200007-MCP200}}
*{{cite journal  | author=Naschberger E, Bauer M, Stürzl M |title=Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases. |journal=Adv. Enzyme Regul. |volume=45 |issue=  |pages= 215-27 |year= 2006 |pmid= 16005050 |doi= 10.1016/j.advenzreg.2005.02.011 }}
*{{cite journal  |vauthors=Naschberger E, Bauer M, Stürzl M |title=Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases. |journal=Adv. Enzyme Regul. |volume=45 |issue=  |pages= 215–27 |year= 2006 |pmid= 16005050 |doi= 10.1016/j.advenzreg.2005.02.011 }}
*{{cite journal  | author=Cheng YS, Patterson CE, Staeheli P |title=Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. |journal=Mol. Cell. Biol. |volume=11 |issue= 9 |pages= 4717-25 |year= 1991 |pmid= 1715024 |doi=  }}
*{{cite journal  |vauthors=Cheng YS, Patterson CE, Staeheli P |title=Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP |journal=Mol. Cell. Biol. |volume=11 |issue= 9 |pages= 4717–25 |year= 1991 |pmid= 1715024 |doi= | pmc=361367 }}
*{{cite journal  | author=Strehlow I, Lohmann-Matthes ML, Decker T |title=The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1. |journal=Gene |volume=144 |issue= 2 |pages= 295-9 |year= 1994 |pmid= 7518790 |doi=  }}
*{{cite journal  |vauthors=Nantais DE, Schwemmle M, Stickney JT |title=Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1 |journal=J. Leukoc. Biol. |volume=60 |issue= 3 |pages= 423–31 |year= 1996 |pmid= 8830800 |doi=  |display-authors=etal}}
*{{cite journal  | author=Nantais DE, Schwemmle M, Stickney JT, ''et al.'' |title=Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1. |journal=J. Leukoc. Biol. |volume=60 |issue= 3 |pages= 423-31 |year= 1996 |pmid= 8830800 |doi= }}
*{{cite journal  |vauthors=Saunders NA, Smith RJ, Jetten AM |title=Regulation of guanylate-binding protein expression in interferon-gamma-treated human epidermal keratinocytes and squamous cell carcinoma cells |journal=J. Invest. Dermatol. |volume=112 |issue= 6 |pages= 977–83 |year= 1999 |pmid= 10383748 |doi= 10.1046/j.1523-1747.1999.00611.x }}
*{{cite journal  | author=Saunders NA, Smith RJ, Jetten AM |title=Regulation of guanylate-binding protein expression in interferon-gamma-treated human epidermal keratinocytes and squamous cell carcinoma cells. |journal=J. Invest. Dermatol. |volume=112 |issue= 6 |pages= 977-83 |year= 1999 |pmid= 10383748 |doi= 10.1046/j.1523-1747.1999.00611.x }}
*{{cite journal  |vauthors=Prakash B, Praefcke GJ, Renault L |title=Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins |journal=Nature |volume=403 |issue= 6769 |pages= 567–71 |year= 2000 |pmid= 10676968 |doi= 10.1038/35000617 |display-authors=etal}}
*{{cite journal  | author=Prakash B, Praefcke GJ, Renault L, ''et al.'' |title=Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. |journal=Nature |volume=403 |issue= 6769 |pages= 567-71 |year= 2000 |pmid= 10676968 |doi= 10.1038/35000617 }}
*{{cite journal  |vauthors=Kumar S, Li Q, Dua A |title=Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 6 |pages= 2420–7 |year= 2001 |pmid= 11397834 |doi=10.1210/jc.86.6.2420  |display-authors=etal}}
*{{cite journal  | author=Kumar S, Li Q, Dua A, ''et al.'' |title=Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 6 |pages= 2420-7 |year= 2001 |pmid= 11397834 |doi= }}
*{{cite journal  |vauthors=Guenzi E, Töpolt K, Cornali E |title=The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines |journal=EMBO J. |volume=20 |issue= 20 |pages= 5568–77 |year= 2001 |pmid= 11598000 |doi= 10.1093/emboj/20.20.5568  | pmc=125279 |display-authors=etal}}
*{{cite journal  | author=Guenzi E, Töpolt K, Cornali E, ''et al.'' |title=The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines. |journal=EMBO J. |volume=20 |issue= 20 |pages= 5568-77 |year= 2001 |pmid= 11598000 |doi= 10.1093/emboj/20.20.5568 }}
*{{cite journal  |vauthors=Lubeseder-Martellato C, Guenzi E, Jörg A |title=Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases |journal=Am. J. Pathol. |volume=161 |issue= 5 |pages= 1749–59 |year= 2002 |pmid= 12414522 |doi= 10.1016/S0002-9440(10)64452-5| pmc=1850787  |display-authors=etal}}
*{{cite journal  | author=Lubeseder-Martellato C, Guenzi E, Jörg A, ''et al.'' |title=Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases. |journal=Am. J. Pathol. |volume=161 |issue= 5 |pages= 1749-59 |year= 2002 |pmid= 12414522 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Adkins JN, Varnum SM, Auberry KJ |title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry |journal=Mol. Cell. Proteomics |volume=1 |issue= 12 |pages= 947–55 |year= 2003 |pmid= 12543931 |doi= 10.1074/mcp.M200066-MCP200|display-authors=etal}}
*{{cite journal  | author=Adkins JN, Varnum SM, Auberry KJ, ''et al.'' |title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. |journal=Mol. Cell Proteomics |volume=1 |issue= 12 |pages= 947-55 |year= 2003 |pmid= 12543931 |doi=  }}
*{{cite journal  |vauthors=Guenzi E, Töpolt K, Lubeseder-Martellato C |title=The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression |journal=EMBO J. |volume=22 |issue= 15 |pages= 3772–82 |year= 2003 |pmid= 12881412 |doi= 10.1093/emboj/cdg382 | pmc=169055 |display-authors=etal}}
*{{cite journal  | author=Guenzi E, Töpolt K, Lubeseder-Martellato C, ''et al.'' |title=The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression. |journal=EMBO J. |volume=22 |issue= 15 |pages= 3772-82 |year= 2003 |pmid= 12881412 |doi= 10.1093/emboj/cdg382 }}
*{{cite journal  |vauthors=Naschberger E, Werner T, Vicente AB |title=Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells |journal=Biochem. J. |volume=379 |issue= Pt 2 |pages= 409–20 |year= 2004 |pmid= 14741045 |doi= 10.1042/BJ20031873  | pmc=1224089 |display-authors=etal}}
*{{cite journal  | author=Naschberger E, Werner T, Vicente AB, ''et al.'' |title=Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells. |journal=Biochem. J. |volume=379 |issue= Pt 2 |pages= 409-20 |year= 2004 |pmid= 14741045 |doi= 10.1042/BJ20031873 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Praefcke GJ, Kloep S, Benscheid U |title=Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis |journal=J. Mol. Biol. |volume=344 |issue= 1 |pages= 257–69 |year= 2004 |pmid= 15504415 |doi= 10.1016/j.jmb.2004.09.026 |display-authors=etal}}
*{{cite journal  | author=Praefcke GJ, Kloep S, Benscheid U, ''et al.'' |title=Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis. |journal=J. Mol. Biol. |volume=344 |issue= 1 |pages= 257-69 |year= 2004 |pmid= 15504415 |doi= 10.1016/j.jmb.2004.09.026 }}
*{{cite journal  |vauthors=Modiano N, Lu YE, Cresswell P |title=Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-γ-inducible cofactor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 24 |pages= 8680–5 |year= 2005 |pmid= 15937107 |doi= 10.1073/pnas.0503227102  | pmc=1150846 }}
*{{cite journal  | author=Modiano N, Lu YE, Cresswell P |title=Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 24 |pages= 8680-5 |year= 2005 |pmid= 15937107 |doi= 10.1073/pnas.0503227102 }}
*{{cite journal  |vauthors=Ghosh A, Praefcke GJ, Renault L |title=How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP |journal=Nature |volume=440 |issue= 7080 |pages= 101–4 |year= 2006 |pmid= 16511497 |doi= 10.1038/nature04510 |display-authors=etal}}
*{{cite journal  | author=Ghosh A, Praefcke GJ, Renault L, ''et al.'' |title=How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. |journal=Nature |volume=440 |issue= 7080 |pages= 101-4 |year= 2006 |pmid= 16511497 |doi= 10.1038/nature04510 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2633}}
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{{protein-stub}}
{{gene-1-stub}}
{{WikiDoc Sources}}

Latest revision as of 08:41, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene.[1][2] It belongs to the dynamin superfamily of large GTPases.[3]

Function

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.[2]

References

  1. ↑ Strehlow I, Lohmann-Matthes ML, Decker T (Aug 1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene. 144 (2): 295–9. doi:10.1016/0378-1119(94)90393-X. PMID 7518790.
  2. ↑ 2.0 2.1 "Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa".
  3. ↑ Praefcke GJ, McMahon HT (February 2004). "The dynamin superfamily: universal membrane tubulation and fission molecules?". Nat. Rev. Mol. Cell Biol. 5 (2): 133–47. doi:10.1038/nrm1313. PMID 15040446.

Further reading



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