SRRM1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Serine/arginine repetitive matrix protein 1''' is a [[protein]] that in humans is encoded by the ''SRRM1'' [[gene]].<ref name="pmid9531537">{{cite journal | vauthors = Blencowe BJ, Issner R, Nickerson JA, Sharp PA | title = A coactivator of pre-mRNA splicing | journal = Genes Dev. | volume = 12 | issue = 7 | pages = 996–1009  | date = May 1998 | pmid = 9531537 | pmc = 316672 | doi = 10.1101/gad.12.7.996 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SRRM1 serine/arginine repetitive matrix 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10250| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_SRRM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mp1.
| PDB = {{PDB2|1mp1}}
| Name = Serine/arginine repetitive matrix 1
| HGNCid = 16638
| Symbol = SRRM1
| AltSymbols =; 160-KD; MGC39488; POP101; SRM160
| OMIM = 605975
| ECnumber = 
| Homologene = 21187
| MGIid = 1858303
| GeneAtlas_image1 = PBB_GE_SRRM1_201225_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SRRM1_201224_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0031202 |text = RNA splicing factor activity, transesterification mechanism}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10250
    | Hs_Ensembl = ENSG00000133226
    | Hs_RefseqProtein = NP_005830
    | Hs_RefseqmRNA = NM_005839
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 24842179
    | Hs_GenLoc_end = 24872345
    | Hs_Uniprot = Q8IYB3
    | Mm_EntrezGene = 51796
    | Mm_Ensembl = ENSMUSG00000028809
    | Mm_RefseqmRNA = NM_016799
    | Mm_RefseqProtein = NP_058079
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 134592567
    | Mm_GenLoc_end = 134625221
    | Mm_Uniprot = Q52KI8
  }}
}}
'''Serine/arginine repetitive matrix 1''', also known as '''SRRM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SRRM1 serine/arginine repetitive matrix 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10250| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SRRM1 has been shown to [[Protein-protein interaction|interact]] with [[CDC5L]].<ref name=pmid11101529>{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81  | date = December 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD | title = SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells | journal = J. Cell Biol. | volume = 140 | issue = 4 | pages = 737–50 | year = 1998 | pmid = 9472028 | pmc = 2141757 | doi = 10.1083/jcb.140.4.737 }}
| citations =
* {{cite journal | vauthors = Wilson KF, Fortes P, Singh US, Ohno M, Mattaj IW, Cerione RA | title = The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction | journal = J. Biol. Chem. | volume = 274 | issue = 7 | pages = 4166–73 | year = 1999 | pmid = 9933612 | doi = 10.1074/jbc.274.7.4166 }}
*{{cite journal | author=Wang HY, Lin W, Dyck JA, ''et al.'' |title=SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. |journal=J. Cell Biol. |volume=140 |issue= 4 |pages= 737-50 |year= 1998 |pmid= 9472028 |doi= }}
* {{cite journal | vauthors = Eldridge AG, Li Y, Sharp PA, Blencowe BJ | title = The SRm160/300 splicing coactivator is required for exon-enhancer function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 11 | pages = 6125–30 | year = 1999 | pmid = 10339552 | pmc = 26846 | doi = 10.1073/pnas.96.11.6125 }}
*{{cite journal | author=Blencowe BJ, Issner R, Nickerson JA, Sharp PA |title=A coactivator of pre-mRNA splicing. |journal=Genes Dev. |volume=12 |issue= 7 |pages= 996-1009 |year= 1998 |pmid= 9531537 |doi= }}
* {{cite journal | vauthors = Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA | title = The SRm160/300 splicing coactivator subunits | journal = RNA | volume = 6 | issue = 1 | pages = 111–20 | year = 2000 | pmid = 10668804 | pmc = 1369899 | doi = 10.1017/S1355838200991982 }}
*{{cite journal | author=Wilson KF, Fortes P, Singh US, ''et al.'' |title=The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4166-73 |year= 1999 |pmid= 9933612 |doi= }}
* {{cite journal | vauthors = Le Hir H, Moore MJ, Maquat LE | title = Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions | journal = Genes Dev. | volume = 14 | issue = 9 | pages = 1098–108 | year = 2000 | pmid = 10809668 | pmc = 316578 | doi =  }}
*{{cite journal | author=Eldridge AG, Li Y, Sharp PA, Blencowe BJ |title=The SRm160/300 splicing coactivator is required for exon-enhancer function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6125-30 |year= 1999 |pmid= 10339552 |doi= }}
* {{cite journal | vauthors = McGarvey T, Rosonina E, McCracken S, Li Q, Arnaout R, Mientjes E, Nickerson JA, Awrey D, Greenblatt J, Grosveld G, Blencowe BJ | title = The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes | journal = J. Cell Biol. | volume = 150 | issue = 2 | pages = 309–20 | year = 2000 | pmid = 10908574 | pmc = 2180225 | doi = 10.1083/jcb.150.2.309 }}
*{{cite journal | author=Blencowe BJ, Baurén G, Eldridge AG, ''et al.'' |title=The SRm160/300 splicing coactivator subunits. |journal=RNA |volume=6 |issue= 1 |pages= 111-20 |year= 2000 |pmid= 10668804 |doi=  }}
* {{cite journal | vauthors = Le Hir H, Izaurralde E, Maquat LE, Moore MJ | title = The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions | journal = EMBO J. | volume = 19 | issue = 24 | pages = 6860–9 | year = 2000 | pmid = 11118221 | pmc = 305905 | doi = 10.1093/emboj/19.24.6860 }}
*{{cite journal | author=Le Hir H, Moore MJ, Maquat LE |title=Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. |journal=Genes Dev. |volume=14 |issue= 9 |pages= 1098-108 |year= 2000 |pmid= 10809668 |doi= }}
* {{cite journal | vauthors = Lykke-Andersen J, Shu MD, Steitz JA | title = Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1 | journal = Science | volume = 293 | issue = 5536 | pages = 1836–9 | year = 2001 | pmid = 11546874 | doi = 10.1126/science.1062786 }}
*{{cite journal  | author=McGarvey T, Rosonina E, McCracken S, ''et al.'' |title=The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 309-20 |year= 2000 |pmid= 10908574 |doi= }}
* {{cite journal | vauthors = McCracken S, Lambermon M, Blencowe BJ | title = SRm160 splicing coactivator promotes transcript 3'-end cleavage | journal = Mol. Cell. Biol. | volume = 22 | issue = 1 | pages = 148–60 | year = 2002 | pmid = 11739730 | pmc = 134228 | doi = 10.1128/MCB.22.1.148-160.2002 }}
*{{cite journal | author=Le Hir H, Izaurralde E, Maquat LE, Moore MJ |title=The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. |journal=EMBO J. |volume=19 |issue= 24 |pages= 6860-9 |year= 2001 |pmid= 11118221 |doi= 10.1093/emboj/19.24.6860 }}
* {{cite journal | vauthors = Szymczyna BR, Pineda-Lucena A, Mills JL, Szyperski T, Arrowsmith CH | title = 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR | journal = J. Biomol. NMR | volume = 22 | issue = 3 | pages = 299–300 | year = 2002 | pmid = 11991360 | doi = 10.1023/A:1014904502424 }}
*{{cite journal | author=Lykke-Andersen J, Shu MD, Steitz JA |title=Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. |journal=Science |volume=293 |issue= 5536 |pages= 1836-9 |year= 2001 |pmid= 11546874 |doi= 10.1126/science.1062786 }}
* {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | year = 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
*{{cite journal | author=McCracken S, Lambermon M, Blencowe BJ |title=SRm160 splicing coactivator promotes transcript 3'-end cleavage. |journal=Mol. Cell. Biol. |volume=22 |issue= 1 |pages= 148-60 |year= 2002 |pmid= 11739730 |doi= }}
* {{cite journal | vauthors = Lejeune F, Ishigaki Y, Li X, Maquat LE | title = The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling | journal = EMBO J. | volume = 21 | issue = 13 | pages = 3536–45 | year = 2002 | pmid = 12093754 | pmc = 126094 | doi = 10.1093/emboj/cdf345 }}
*{{cite journal | author=Szymczyna BR, Pineda-Lucena A, Mills JL, ''et al.'' |title=1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR. |journal=J. Biomol. NMR |volume=22 |issue= 3 |pages= 299-300 |year= 2002 |pmid= 11991360 |doi= }}
* {{cite journal | vauthors = Meissner M, Lopato S, Gotzmann J, Sauermann G, Barta A | title = Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins | journal = Exp. Cell Res. | volume = 283 | issue = 2 | pages = 184–95 | year = 2003 | pmid = 12581738 | doi = 10.1016/S0014-4827(02)00046-0 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi= }}
* {{cite journal | vauthors = Szymczyna BR, Bowman J, McCracken S, Pineda-Lucena A, Lu Y, Cox B, Lambermon M, Graveley BR, Arrowsmith CH, Blencowe BJ | title = Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing | journal = Genes Dev. | volume = 17 | issue = 4 | pages = 461–75 | year = 2003 | pmid = 12600940 | pmc = 196000 | doi = 10.1101/gad.1060403 }}
*{{cite journal | author=Lejeune F, Ishigaki Y, Li X, Maquat LE |title=The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3536-45 |year= 2002 |pmid= 12093754 |doi= 10.1093/emboj/cdf345 }}
* {{cite journal | vauthors = Wagner S, Chiosea S, Nickerson JA | title = The spatial targeting and nuclear matrix binding domains of SRm160 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 6 | pages = 3269–74 | year = 2003 | pmid = 12624182 | pmc = 152281 | doi = 10.1073/pnas.0438055100 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = McCracken S, Longman D, Johnstone IL, Cáceres JF, Blencowe BJ | title = An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation | journal = J. Biol. Chem. | volume = 278 | issue = 45 | pages = 44153–60 | year = 2003 | pmid = 12944400 | doi = 10.1074/jbc.M306856200 }}
*{{cite journal | author=Meissner M, Lopato S, Gotzmann J, ''et al.'' |title=Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins. |journal=Exp. Cell Res. |volume=283 |issue= 2 |pages= 184-95 |year= 2003 |pmid= 12581738 |doi= }}
* {{cite journal | vauthors = Wagner S, Chiosea S, Ivshina M, Nickerson JA | title = In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160 | journal = J. Cell Biol. | volume = 164 | issue = 6 | pages = 843–50 | year = 2004 | pmid = 15024032 | pmc = 2172284 | doi = 10.1083/jcb.200307002 }}
*{{cite journal | author=Szymczyna BR, Bowman J, McCracken S, ''et al.'' |title=Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing. |journal=Genes Dev. |volume=17 |issue= 4 |pages= 461-75 |year= 2003 |pmid= 12600940 |doi= 10.1101/gad.1060403 }}
* {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Anal. Chem. | volume = 76 | issue = 10 | pages = 2763–72 | year = 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
*{{cite journal | author=Wagner S, Chiosea S, Nickerson JA |title=The spatial targeting and nuclear matrix binding domains of SRm160. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 6 |pages= 3269-74 |year= 2003 |pmid= 12624182 |doi= 10.1073/pnas.0438055100 }}
*{{cite journal | author=McCracken S, Longman D, Johnstone IL, ''et al.'' |title=An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44153-60 |year= 2004 |pmid= 12944400 |doi= 10.1074/jbc.M306856200 }}
*{{cite journal  | author=Wagner S, Chiosea S, Ivshina M, Nickerson JA |title=In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160. |journal=J. Cell Biol. |volume=164 |issue= 6 |pages= 843-50 |year= 2004 |pmid= 15024032 |doi= 10.1083/jcb.200307002 }}
*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|SRRM1}}
* {{UCSC gene details|SRRM1}}
 
{{PDB Gallery|geneid=10250}}
 
 
{{gene-1-stub}}

Latest revision as of 06:59, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/arginine repetitive matrix protein 1 is a protein that in humans is encoded by the SRRM1 gene.[1][2]

Interactions

SRRM1 has been shown to interact with CDC5L.[3]

References

  1. ↑ Blencowe BJ, Issner R, Nickerson JA, Sharp PA (May 1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
  2. ↑ "Entrez Gene: SRRM1 serine/arginine repetitive matrix 1".
  3. ↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

External links


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