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{{Infobox_gene}}
{{PBB_Controls
'''Nuclear autoantigenic sperm protein''' is a [[protein]] that in humans is encoded by the ''NASP'' [[gene]].<ref name="pmid1426632">{{cite journal | vauthors = O'Rand MG, Richardson RT, Zimmerman LJ, Widgren EE | title = Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein | journal = Dev Biol | volume = 154 | issue = 1 | pages = 37–44 |date=Dec 1992 | pmid = 1426632 | pmc =  | doi =10.1016/0012-1606(92)90045-I  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NASP nuclear autoantigenic sperm protein (histone-binding)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4678| accessdate = }}</ref> Multiple isoforms are encoded by transcript variants of this gene.
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear autoantigenic sperm protein (histone-binding)
| HGNCid = 7644
| Symbol = NASP
| AltSymbols =; DKFZp547F162; FLB7527; FLJ31599; FLJ35510; MGC19722; MGC20372; MGC2297; PRO1999
| OMIM = 603185
| ECnumber = 
| Homologene = 1856
| MGIid = 1355328
| GeneAtlas_image1 = PBB_GE_NASP_201969_at_tn.png
| GeneAtlas_image2 = PBB_GE_NASP_201970_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0051879 |text = Hsp90 protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001824 |text = blastocyst development}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0043486 |text = histone exchange}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4678
    | Hs_Ensembl = ENSG00000132780
    | Hs_RefseqProtein = NP_002473
    | Hs_RefseqmRNA = NM_002482
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 45822304
    | Hs_GenLoc_end = 45857145
    | Hs_Uniprot = P49321
    | Mm_EntrezGene = 50927
    | Mm_Ensembl = ENSMUSG00000028693
    | Mm_RefseqmRNA = NM_001081475
    | Mm_RefseqProtein = NP_001074944
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 116098984
    | Mm_GenLoc_end = 116125873
    | Mm_Uniprot = Q3TTH5
  }}
}}
'''Nuclear autoantigenic sperm protein (histone-binding)''', also known as '''NASP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NASP nuclear autoantigenic sperm protein (histone-binding)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4678| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a [[histone H1]] binding protein that is involved in transporting histones into the nucleus of dividing cells.<ref name="pmid15533935">{{cite journal | vauthors = Alekseev OM, Widgren EE, Richardson RT, O'Rand MG | title = Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei | journal = J. Biol. Chem. | volume = 280 | issue = 4 | pages = 2904–11 |date=January 2005 | pmid = 15533935 | doi = 10.1074/jbc.M410397200 | url = | issn = }}</ref>  The [[Somatic (biology)|somatic]] form is expressed in all [[mitosis|mitotic]] cells, is localized to the [[cell nucleus|nucleus]], and is coupled to the [[cell cycle]]. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary [[spermatocyte]]s, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.<ref name="entrez">{{cite web | title = Entrez Gene: NASP nuclear autoantigenic sperm protein (histone-binding)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4678| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Welch JE, Zimmerman LJ, Joseph DR, O'Rand MG |title=Characterization of a sperm-specific nuclear autoantigenic protein. I. Complete sequence and homology with the Xenopus protein, N1/N2. |journal=Biol. Reprod. |volume=43 |issue= 4 |pages= 559–68 |year= 1991 |pmid= 2289010 |doi=10.1095/biolreprod43.4.559 }}
| citations =
*{{cite journal  | vauthors=Welch JE, O'Rand MG |title=Characterization of a sperm-specific nuclear autoantigenic protein. II. Expression and localization in the testis. |journal=Biol. Reprod. |volume=43 |issue= 4 |pages= 569–78 |year= 1991 |pmid= 2289011 |doi=10.1095/biolreprod43.4.569 }}
*{{cite journal  | author=O'Rand MG, Richardson RT, Zimmerman LJ, Widgren EE |title=Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein. |journal=Dev. Biol. |volume=154 |issue= 1 |pages= 37-44 |year= 1992 |pmid= 1426632 |doi=  }}
*{{cite journal  | vauthors=Kleinschmidt JA, Dingwall C, Maier G, Franke WW |title=Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis. |journal=EMBO J. |volume=5 |issue= 13 |pages= 3547–52 |year= 1987 |pmid= 3549279 |doi= | pmc=1167392 }}
*{{cite journal  | author=Welch JE, Zimmerman LJ, Joseph DR, O'Rand MG |title=Characterization of a sperm-specific nuclear autoantigenic protein. I. Complete sequence and homology with the Xenopus protein, N1/N2. |journal=Biol. Reprod. |volume=43 |issue= 4 |pages= 559-68 |year= 1991 |pmid= 2289010 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Welch JE, O'Rand MG |title=Characterization of a sperm-specific nuclear autoantigenic protein. II. Expression and localization in the testis. |journal=Biol. Reprod. |volume=43 |issue= 4 |pages= 569-78 |year= 1991 |pmid= 2289011 |doi=  }}
*{{cite journal  | vauthors=Lee YH, O'Rand MG |title=Ultrastructural localization of a nuclear autoantigenic sperm protein in spermatogenic cells and spermatozoa |journal=Anat. Rec. |volume=236 |issue= 3 |pages= 442–8 |year= 1993 |pmid= 8363049 |doi= 10.1002/ar.1092360304 }}
*{{cite journal  | author=Kleinschmidt JA, Dingwall C, Maier G, Franke WW |title=Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis. |journal=EMBO J. |volume=5 |issue= 13 |pages= 3547-52 |year= 1987 |pmid= 3549279 |doi= }}
*{{cite journal  | vauthors=Batova I, O'Rand MG |title=Histone-binding domains in a human nuclear autoantigenic sperm protein |journal=Biol. Reprod. |volume=54 |issue= 6 |pages= 1238–44 |year= 1996 |pmid= 8724350 |doi=10.1095/biolreprod54.6.1238  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Lee YH, O'Rand MG |title=Ultrastructural localization of a nuclear autoantigenic sperm protein in spermatogenic cells and spermatozoa. |journal=Anat. Rec. |volume=236 |issue= 3 |pages= 442-8 |year= 1993 |pmid= 8363049 |doi= 10.1002/ar.1092360304 }}
*{{cite journal   |vauthors=Richardson RT, Batova IN, Widgren EE, etal |title=Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30378–86 |year= 2000 |pmid= 10893414 |doi= 10.1074/jbc.M003781200 }}
*{{cite journal | author=Batova I, O'Rand MG |title=Histone-binding domains in a human nuclear autoantigenic sperm protein. |journal=Biol. Reprod. |volume=54 |issue= 6 |pages= 1238-44 |year= 1996 |pmid= 8724350 |doi=  }}
*{{cite journal  | vauthors=Batova IN, Richardson RT, Widgren EE, O'Rand MG |title=Analysis of the autoimmune epitopes on human testicular NASP using recombinant and synthetic peptides |journal=Clin. Exp. Immunol. |volume=121 |issue= 2 |pages= 201–9 |year= 2000 |pmid= 10931132 |doi=10.1046/j.1365-2249.2000.01303.x  | pmc=1905703  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Minami N, Sasaki K, Aizawa A, etal |title=Analysis of gene expression in mouse 2-cell embryos using fluorescein differential display: comparison of culture environments |journal=Biol. Reprod. |volume=64 |issue= 1 |pages= 30–5 |year= 2001 |pmid= 11133655 |doi=10.1095/biolreprod64.1.30 }}
*{{cite journal  | author=Richardson RT, Batova IN, Widgren EE, ''et al.'' |title=Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30378-86 |year= 2000 |pmid= 10893414 |doi= 10.1074/jbc.M003781200 }}
*{{cite journal  | vauthors=Richardson RT, Bencic DC, O'Rand MG |title=Comparison of mouse and human NASP genes and expression in human transformed and tumor cell lines |journal=Gene |volume=274 |issue= 1–2 |pages= 67–75 |year= 2001 |pmid= 11674998 |doi=10.1016/S0378-1119(01)00605-9 }}
*{{cite journal | author=Batova IN, Richardson RT, Widgren EE, O'Rand MG |title=Analysis of the autoimmune epitopes on human testicular NASP using recombinant and synthetic peptides. |journal=Clin. Exp. Immunol. |volume=121 |issue= 2 |pages= 201-9 |year= 2000 |pmid= 10931132 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Minami N, Sasaki K, Aizawa A, ''et al.'' |title=Analysis of gene expression in mouse 2-cell embryos using fluorescein differential display: comparison of culture environments. |journal=Biol. Reprod. |volume=64 |issue= 1 |pages= 30-5 |year= 2001 |pmid= 11133655 |doi=  }}
*{{cite journal   |vauthors=Alekseev OM, Bencic DC, Richardson RT, etal |title=Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8846–52 |year= 2003 |pmid= 12509435 |doi= 10.1074/jbc.M210352200 }}
*{{cite journal | author=Richardson RT, Bencic DC, O'Rand MG |title=Comparison of mouse and human NASP genes and expression in human transformed and tumor cell lines. |journal=Gene |volume=274 |issue= 1-2 |pages= 67-75 |year= 2001 |pmid= 11674998 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Silva AP, Chen J, Carraro DM, etal |title=Generation of longer 3' cDNA fragments from massively parallel signature sequencing tags |journal=Nucleic Acids Res. |volume=32 |issue= 12 |pages= e94 |year= 2004 |pmid= 15247327 |doi= 10.1093/nar/gnh095  | pmc=484194 }}
*{{cite journal | author=Alekseev OM, Bencic DC, Richardson RT, ''et al.'' |title=Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8846-52 |year= 2003 |pmid= 12509435 |doi= 10.1074/jbc.M210352200 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Silva AP, Chen J, Carraro DM, ''et al.'' |title=Generation of longer 3' cDNA fragments from massively parallel signature sequencing tags. |journal=Nucleic Acids Res. |volume=32 |issue= 12 |pages= e94 |year= 2004 |pmid= 15247327 |doi= 10.1093/nar/gnh095 }}
*{{cite journal   |vauthors=Groth A, Ray-Gallet D, Quivy JP, etal |title=Human Asf1 regulates the flow of S phase histones during replicational stress |journal=Mol. Cell |volume=17 |issue= 2 |pages= 301–11 |year= 2005 |pmid= 15664198 |doi= 10.1016/j.molcel.2004.12.018 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Groth A, Ray-Gallet D, Quivy JP, ''et al.'' |title=Human Asf1 regulates the flow of S phase histones during replicational stress. |journal=Mol. Cell |volume=17 |issue= 2 |pages= 301-11 |year= 2005 |pmid= 15664198 |doi= 10.1016/j.molcel.2004.12.018 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Human proteins]]
{{WikiDoc Sources}}
 
 
{{gene-1-stub}}

Latest revision as of 12:29, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear autoantigenic sperm protein is a protein that in humans is encoded by the NASP gene.[1][2] Multiple isoforms are encoded by transcript variants of this gene.

Function

This gene encodes a histone H1 binding protein that is involved in transporting histones into the nucleus of dividing cells.[3] The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.[2]

References

  1. ↑ O'Rand MG, Richardson RT, Zimmerman LJ, Widgren EE (Dec 1992). "Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein". Dev Biol. 154 (1): 37–44. doi:10.1016/0012-1606(92)90045-I. PMID 1426632.
  2. ↑ 2.0 2.1 "Entrez Gene: NASP nuclear autoantigenic sperm protein (histone-binding)".
  3. ↑ Alekseev OM, Widgren EE, Richardson RT, O'Rand MG (January 2005). "Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei". J. Biol. Chem. 280 (4): 2904–11. doi:10.1074/jbc.M410397200. PMID 15533935.

Further reading


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