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{{ | '''Regulator of G-protein signaling 5''' is a [[protein]] that in humans is encoded by the ''RGS5'' [[gene]].<ref name="pmid9747037">{{cite journal |vauthors=Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T | title = Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene | journal = J Hum Genet | volume = 43 | issue = 3 | pages = 202–5 |date=October 1998 | pmid = 9747037 | pmc = | doi = 10.1007/s100380050071 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS5 regulator of G-protein signalling 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8490| accessdate = }}</ref> | ||
}} | |||
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| summary_text = The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM]<ref name="entrez" | | summary_text = The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM]<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
RGS5 has been shown to [[Protein-protein interaction|interact]] with [[GNAO1]],<ref name=pmid9079700>{{cite journal |last=Chen |first=C |authorlink= |author2=Zheng B |author3=Han J |author4=Lin S C |date=March 1997 |title=Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast |journal=J. Biol. Chem. |volume=272 |issue=13 |pages=8679–85 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9079700 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.13.8679 }}</ref><ref name=pmid11253162>{{cite journal |last=Zhou |first=J |authorlink= |author2=Moroi K |author3=Nishiyama M |author4=Usui H |author5=Seki N |author6=Ishida J |author7=Fukamizu A |author8=Kimura S |date=February 2001 |title=Characterization of RGS5 in regulation of G protein-coupled receptor signaling |journal=Life Sci. |volume=68 |issue=13 |pages=1457–69 |publisher= |location = England| issn = 0024-3205| pmid = 11253162 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0024-3205(01)00939-0 }}</ref> [[GNAI2]]<ref name=pmid9079700/><ref name=pmid11253162/> and [[GNAI3]].<ref name=pmid9079700/><ref name=pmid11253162/> | |||
==References== | ==References== | ||
{{ | {{Reflist}} | ||
==Further reading== | ==Further reading== | ||
{{ | {{Refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Chen C, Zheng B, Han J, Lin SC |title=Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8679–85 |year= 1997 |pmid= 9079700 |doi=10.1074/jbc.272.13.8679 }} | ||
*{{cite journal | *{{cite journal |vauthors=Cismowski MJ, Takesono A, Ma C, etal |title=Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling |journal=Nat. Biotechnol. |volume=17 |issue= 9 |pages= 878–83 |year= 1999 |pmid= 10471929 |doi= 10.1038/12867 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Adams LD, Geary RL, McManus B, Schwartz SM |title=A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media |journal=Circ. Res. |volume=87 |issue= 7 |pages= 623–31 |year= 2000 |pmid= 11009569 |doi= 10.1161/01.res.87.7.623}} | ||
*{{cite journal | | *{{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }} | ||
*{{cite journal | *{{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }} | ||
*{{cite journal | *{{cite journal |vauthors=Zhou J, Moroi K, Nishiyama M, etal |title=Characterization of RGS5 in regulation of G protein-coupled receptor signaling |journal=Life Sci. |volume=68 |issue= 13 |pages= 1457–69 |year= 2001 |pmid= 11253162 |doi=10.1016/S0024-3205(01)00939-0 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Morris DW, Rodgers A, McGhee KA, etal |title=Confirming RGS4 as a susceptibility gene for schizophrenia |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=125 |issue= 1 |pages= 50–3 |year= 2005 |pmid= 14755443 |doi= 10.1002/ajmg.b.20109 }} | ||
*{{cite journal | *{{cite journal |vauthors=Berger M, Bergers G, Arnold B, etal |title=Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization |journal=Blood |volume=105 |issue= 3 |pages= 1094–101 |year= 2005 |pmid= 15459006 |doi= 10.1182/blood-2004-06-2315 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }} | ||
*{{cite journal | *{{cite journal |vauthors=Liang Y, Li C, Guzman VM, etal |title=Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues |journal=FEBS J. |volume=272 |issue= 3 |pages= 791–9 |year= 2005 |pmid= 15670159 |doi= 10.1111/j.1742-4658.2004.04516.x }} | ||
*{{cite journal | *{{cite journal |vauthors=Adams LD, Geary RL, Li J, etal |title=Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap |journal=Arterioscler. Thromb. Vasc. Biol. |volume=26 |issue= 2 |pages= 319–25 |year= 2006 |pmid= 16293795 |doi= 10.1161/01.ATV.0000196647.45718.d6 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rhee KH, Nam KH, Lee WH, etal |title=Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4- |journal=Protein Pept. Lett. |volume=13 |issue= 9 |pages= 945–9 |year= 2007 |pmid= 17100651 |doi=10.2174/092986606778256225 }} | ||
*{{cite journal |vauthors=Bodenstein J, Sunahara RK, Neubig RR |title=N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells |journal=Mol. Pharmacol. |volume=71 |issue= 4 |pages= 1040–50 |year= 2007 |pmid= 17220356 |doi= 10.1124/mol.106.029397 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Yang Z, Gaudio S, Song W, etal |title=Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5) |journal=Cell. Physiol. Biochem. |volume=20 |issue= 5 |pages= 303–10 |year= 2007 |pmid= 17762159 |doi= 10.1159/000107516 }} | ||
*{{cite journal | |||
}} | }} | ||
{{ | {{Refend}} | ||
{{PDB Gallery|geneid=8490}} | |||
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
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| Wikidata | |||||||
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Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.[1][2]
The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM][2]
Interactions
RGS5 has been shown to interact with GNAO1,[3][4] GNAI2[3][4] and GNAI3.[3][4]
References
- ↑ Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene". J Hum Genet. 43 (3): 202–5. doi:10.1007/s100380050071. PMID 9747037.
- ↑ 2.0 2.1 "Entrez Gene: RGS5 regulator of G-protein signalling 5".
- ↑ 3.0 3.1 3.2 Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. UNITED STATES. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700.
- ↑ 4.0 4.1 4.2 Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. England. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162.
Further reading
- Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
- Cismowski MJ, Takesono A, Ma C, et al. (1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling". Nat. Biotechnol. 17 (9): 878–83. doi:10.1038/12867. PMID 10471929.
- Adams LD, Geary RL, McManus B, Schwartz SM (2000). "A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media". Circ. Res. 87 (7): 623–31. doi:10.1161/01.res.87.7.623. PMID 11009569.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Zhou J, Moroi K, Nishiyama M, et al. (2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. PMID 11253162.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Morris DW, Rodgers A, McGhee KA, et al. (2005). "Confirming RGS4 as a susceptibility gene for schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 50–3. doi:10.1002/ajmg.b.20109. PMID 14755443.
- Berger M, Bergers G, Arnold B, et al. (2005). "Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization". Blood. 105 (3): 1094–101. doi:10.1182/blood-2004-06-2315. PMID 15459006.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Liang Y, Li C, Guzman VM, et al. (2005). "Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues". FEBS J. 272 (3): 791–9. doi:10.1111/j.1742-4658.2004.04516.x. PMID 15670159.
- Adams LD, Geary RL, Li J, et al. (2006). "Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap". Arterioscler. Thromb. Vasc. Biol. 26 (2): 319–25. doi:10.1161/01.ATV.0000196647.45718.d6. PMID 16293795.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Rhee KH, Nam KH, Lee WH, et al. (2007). "Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-". Protein Pept. Lett. 13 (9): 945–9. doi:10.2174/092986606778256225. PMID 17100651.
- Bodenstein J, Sunahara RK, Neubig RR (2007). "N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells". Mol. Pharmacol. 71 (4): 1040–50. doi:10.1124/mol.106.029397. PMID 17220356.
- Yang Z, Gaudio S, Song W, et al. (2007). "Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5)". Cell. Physiol. Biochem. 20 (5): 303–10. doi:10.1159/000107516. PMID 17762159.
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