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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mitotic spindle assembly checkpoint protein MAD2B''' is a [[protein]] that in humans is encoded by the ''MAD2L2'' [[gene]].<ref name="pmid10366450">{{cite journal | vauthors = Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C | title = Characterization of MAD2B and other mitotic spindle checkpoint genes | journal = Genomics | volume = 58 | issue = 2 | pages = 181–7  | date = Aug 1999 | pmid = 10366450 | pmc =  | doi = 10.1006/geno.1999.5831 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10459| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MAD2 mitotic arrest deficient-like 2 (yeast)
| HGNCid = 6764
| Symbol = MAD2L2
| AltSymbols =; MAD2B; REV7
| OMIM = 604094
| ECnumber = 
| Homologene = 4624
| MGIid = 1919140
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007094 |text = mitotic cell cycle spindle assembly checkpoint}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10459
    | Hs_Ensembl = ENSG00000116670
    | Hs_RefseqProtein = NP_006332
    | Hs_RefseqmRNA = NM_006341
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 11657132
    | Hs_GenLoc_end = 11674294
    | Hs_Uniprot = Q9UI95
    | Mm_EntrezGene = 71890
    | Mm_Ensembl = ENSMUSG00000029003
    | Mm_RefseqmRNA = NM_027985
    | Mm_RefseqProtein = NP_082261
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 146974720
    | Mm_GenLoc_end = 146989496
    | Mm_Uniprot = Q9D752
  }}
}}
'''MAD2 mitotic arrest deficient-like 2 (yeast)''', also known as '''MAD2L2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10459| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate.  MAD2L2 is a homolog of MAD2L1.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate.  MAD2L2 is a homolog of MAD2L1.<ref name="entrez">{{cite web | title = Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10459| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAD2L2 has been shown to [[Protein-protein interaction|interact]] with:
* [[ADAM9]],<ref name = pmid10527948>{{cite journal | vauthors = Nelson KK, Schlöndorff J, Blobel CP | title = Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta | journal = Biochem. J. | volume = 343 | issue =  3| pages = 673–80  | date = Nov 1999 | pmid = 10527948 | pmc = 1220601 | doi =  10.1042/0264-6021:3430673| series = 343 }}</ref>
* [[MAD2L1]],<ref name = pmid10660610>{{cite journal | vauthors = Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R | title = A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 | journal = J. Biol. Chem. | volume = 275 | issue = 6 | pages = 4391–7  | date = Feb 2000 | pmid = 10660610 | doi =  10.1074/jbc.275.6.4391}}</ref>
* [[REV1]],<ref name = pmid11485998>{{cite journal | vauthors = Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M | title = Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 | journal = J. Biol. Chem. | volume = 276 | issue = 38 | pages = 35644–51  | date = Sep 2001 | pmid = 11485998 | doi = 10.1074/jbc.M102051200 }}</ref>  and
* [[REV3L]].<ref name = pmid10660610/><ref name = pmid11485998/>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nelson KK, Schlöndorff J, Blobel CP | title = Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta | journal = Biochem. J. | volume = 343 | issue =  3| pages = 673–80 | year = 1999 | pmid = 10527948 | pmc = 1220601 | doi = 10.1042/0264-6021:3430673 | series = 343 }}
| citations =
* {{cite journal | vauthors = Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R | title = A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 | journal = J. Biol. Chem. | volume = 275 | issue = 6 | pages = 4391–7 | year = 2000 | pmid = 10660610 | doi = 10.1074/jbc.275.6.4391 }}
*{{cite journal  | author=Cahill DP, da Costa LT, Carson-Walter EB, ''et al.'' |title=Characterization of MAD2B and other mitotic spindle checkpoint genes. |journal=Genomics |volume=58 |issue= 2 |pages= 181-7 |year= 1999 |pmid= 10366450 |doi= 10.1006/geno.1999.5831 }}
* {{cite journal | vauthors = Chan SH, Hung FS, Chan DS, Shaw PC | title = Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B | journal = Eur. J. Biochem. | volume = 268 | issue = 7 | pages = 2107–12 | year = 2001 | pmid = 11277934 | doi = 10.1046/j.1432-1327.2001.02091.x }}
*{{cite journal | author=Nelson KK, Schlöndorff J, Blobel CP |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. |journal=Biochem. J. |volume=343 Pt 3 |issue=  |pages= 673-80 |year= 2000 |pmid= 10527948 |doi= }}
* {{cite journal | vauthors = Chen J, Fang G | title = MAD2B is an inhibitor of the anaphase-promoting complex | journal = Genes Dev. | volume = 15 | issue = 14 | pages = 1765–70 | year = 2001 | pmid = 11459826 | pmc = 312737 | doi = 10.1101/gad.898701 }}
*{{cite journal | author=Murakumo Y, Roth T, Ishii H, ''et al.'' |title=A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4391-7 |year= 2000 |pmid= 10660610 |doi= }}
* {{cite journal | vauthors = Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M | title = Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 | journal = J. Biol. Chem. | volume = 276 | issue = 38 | pages = 35644–51 | year = 2001 | pmid = 11485998 | doi = 10.1074/jbc.M102051200 }}
*{{cite journal | author=Chan SH, Hung FS, Chan DS, Shaw PC |title=Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B. |journal=Eur. J. Biochem. |volume=268 |issue= 7 |pages= 2107-12 |year= 2001 |pmid= 11277934 |doi= }}
* {{cite journal | vauthors = Weterman MA, van Groningen JJ, Tertoolen L, van Kessel AG | title = Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 24 | pages = 13808–13 | year = 2001 | pmid = 11717438 | pmc = 61123 | doi = 10.1073/pnas.241304198 }}
*{{cite journal | author=Chen J, Fang G |title=MAD2B is an inhibitor of the anaphase-promoting complex. |journal=Genes Dev. |volume=15 |issue= 14 |pages= 1765-70 |year= 2001 |pmid= 11459826 |doi= 10.1101/gad.898701 }}
* {{cite journal | vauthors = Masuda Y, Ohmae M, Masuda K, Kamiya K | title = Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins | journal = J. Biol. Chem. | volume = 278 | issue = 14 | pages = 12356–60 | year = 2003 | pmid = 12529368 | doi = 10.1074/jbc.M211765200 }}
*{{cite journal | author=Murakumo Y, Ogura Y, Ishii H, ''et al.'' |title=Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35644-51 |year= 2001 |pmid= 11485998 |doi= 10.1074/jbc.M102051200 }}
* {{cite journal | vauthors = Ying B, Wold WS | title = Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B | journal = Virology | volume = 313 | issue = 1 | pages = 224–34 | year = 2003 | pmid = 12951035 | doi = 10.1016/S0042-6822(03)00287-3 }}
*{{cite journal | author=Weterman MA, van Groningen JJ, Tertoolen L, van Kessel AG |title=Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 24 |pages= 13808-13 |year= 2002 |pmid= 11717438 |doi= 10.1073/pnas.241304198 }}
* {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | year = 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ohashi E, Murakumo Y, Kanjo N, Akagi J, Masutani C, Hanaoka F, Ohmori H | title = Interaction of hREV1 with three human Y-family DNA polymerases | journal = Genes Cells | volume = 9 | issue = 6 | pages = 523–31 | year = 2004 | pmid = 15189446 | doi = 10.1111/j.1356-9597.2004.00747.x }}
*{{cite journal | author=Masuda Y, Ohmae M, Masuda K, Kamiya K |title=Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins. |journal=J. Biol. Chem. |volume=278 |issue= 14 |pages= 12356-60 |year= 2003 |pmid= 12529368 |doi= 10.1074/jbc.M211765200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Ying B, Wold WS |title=Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B. |journal=Virology |volume=313 |issue= 1 |pages= 224-34 |year= 2003 |pmid= 12951035 |doi= }}
* {{cite journal | vauthors = Rimkus C, Friederichs J, Rosenberg R, Holzmann B, Siewert JR, Janssen KP | title = Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer | journal = Int. J. Cancer | volume = 120 | issue = 1 | pages = 207–11 | year = 2007 | pmid = 17044027 | doi = 10.1002/ijc.22155 }}
*{{cite journal | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi= }}
* {{cite journal | vauthors = Zhang L, Yang SH, Sharrocks AD | title = Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1 | journal = Mol. Cell. Biol. | volume = 27 | issue = 8 | pages = 2861–9 | year = 2007 | pmid = 17296730 | pmc = 1899940 | doi = 10.1128/MCB.02276-06 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Pinto M, Soares MJ, Cerveira N, Henrique R, Ribeiro FR, Oliveira J, Jerónimo C, Teixeira MR | title = Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes | journal = Virchows Arch. | volume = 450 | issue = 4 | pages = 379–85 | year = 2007 | pmid = 17333263 | doi = 10.1007/s00428-007-0386-7 }}
*{{cite journal | author=Ohashi E, Murakumo Y, Kanjo N, ''et al.'' |title=Interaction of hREV1 with three human Y-family DNA polymerases. |journal=Genes Cells |volume=9 |issue= 6 |pages= 523-31 |year= 2005 |pmid= 15189446 |doi= 10.1111/j.1356-9597.2004.00747.x }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Rimkus C, Friederichs J, Rosenberg R, ''et al.'' |title=Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer. |journal=Int. J. Cancer |volume=120 |issue= 1 |pages= 207-11 |year= 2007 |pmid= 17044027 |doi= 10.1002/ijc.22155 }}
*{{cite journal | author=Zhang L, Yang SH, Sharrocks AD |title=Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. |journal=Mol. Cell. Biol. |volume=27 |issue= 8 |pages= 2861-9 |year= 2007 |pmid= 17296730 |doi= 10.1128/MCB.02276-06 }}
*{{cite journal | author=Pinto M, Soares MJ, Cerveira N, ''et al.'' |title=Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes. |journal=Virchows Arch. |volume=450 |issue= 4 |pages= 379-85 |year= 2007 |pmid= 17333263 |doi= 10.1007/s00428-007-0386-7 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 05:59, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.[1][2]

Function

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.[2]

Interactions

MAD2L2 has been shown to interact with:

References

  1. ↑ Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C (Aug 1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
  2. ↑ 2.0 2.1 "Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)".
  3. ↑ Nelson KK, Schlöndorff J, Blobel CP (Nov 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343. 343 (3): 673–80. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948.
  4. ↑ 4.0 4.1 Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R (Feb 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–7. doi:10.1074/jbc.275.6.4391. PMID 10660610.
  5. ↑ 5.0 5.1 Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M (Sep 2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38): 35644–51. doi:10.1074/jbc.M102051200. PMID 11485998.

Further reading


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