CFHR1: Difference between revisions

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Latest revision as of 09:36, 30 August 2017

Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene.^[1]^[2]^[3]

References

↑ Skerka C, Horstmann RD, Zipfel PF (Jul 1991). "Molecular cloning of a human serum protein structurally related to complement factor H". J Biol Chem. 266 (18): 12015–20. PMID 1711047.
↑ Estaller C, Koistinen V, Schwaeble W, Dierich MP, Weiss EH (May 1991). "Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule". J Immunol. 146 (9): 3190–6. PMID 1826708.
↑ "Entrez Gene: CFHR1 complement factor H-related 1".

Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins?". Immunol. Today. 15 (3): 121–6. doi:10.1016/0167-5699(94)90155-4. PMID 8172644.
Zipfel PF, Jokiranta TS, Hellwage J, et al. (1999). "The factor H protein family". Immunopharmacology. 42 (1–3): 53–60. doi:10.1016/S0162-3109(99)00015-6. PMID 10408366.
Timmann C, Leippe M, Horstmann RD (1991). "Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions". J. Immunol. 146 (4): 1265–70. PMID 1825108.
Park CT, Wright SD (1996). "Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins". J. Biol. Chem. 271 (30): 18054–60. doi:10.1074/jbc.271.30.18054. PMID 8663389.
Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D (1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. doi:10.1007/s002510050534. PMID 10380701.
Male DA, Ormsby RJ, Ranganathan S, et al. (2000). "Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes". Mol. Immunol. 37 (1–2): 41–52. doi:10.1016/S0161-5890(00)00024-9. PMID 10781834.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pérez-Caballero D, García-Laorden I, Cortés G, et al. (2005). "Interaction between complement regulators and Streptococcus pyogenes: binding of C4b-binding protein and factor H/factor H-like protein 1 to M18 strains involves two different cell surface molecules". J. Immunol. 173 (11): 6899–904. doi:10.4049/jimmunol.173.11.6899. PMID 15557185.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
McDowell JV, Lankford J, Stamm L, et al. (2005). "Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans". Infect. Immun. 73 (11): 7126–32. doi:10.1128/IAI.73.11.7126-7132.2005. PMC 1273895. PMID 16239506.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Zipfel PF, Edey M, Heinen S, et al. (2007). "Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome". PLoS Genet. 3 (3): e41. doi:10.1371/journal.pgen.0030041. PMC 1828695. PMID 17367211.
Haupt K, Kraiczy P, Wallich R, et al. (2007). "Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins". J. Infect. Dis. 196 (1): 124–33. doi:10.1086/518509. PMID 17538892.

External links

Human CFHR1 genome location and CFHR1 gene details page in the UCSC Genome Browser.
GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
OMIM entries on Atypical Hemolytic-Uremic Syndrome

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid1711047-1] Skerka C, Horstmann RD, Zipfel PF (Jul 1991). "Molecular cloning of a human serum protein structurally related to complement factor H". J Biol Chem. 266 (18): 12015–20. PMID 1711047.

[pmid1826708-2] Estaller C, Koistinen V, Schwaeble W, Dierich MP, Weiss EH (May 1991). "Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule". J Immunol. 146 (9): 3190–6. PMID 1826708.

[entrez-3] "Entrez Gene: CFHR1 complement factor H-related 1".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=May 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Complement factor H-related protein 1''' is a [[protein]] that in humans is encoded by the ''CFHR1'' [[gene]].<ref name="pmid1711047">{{cite journal | vauthors = Skerka C, Horstmann RD, Zipfel PF | title = Molecular cloning of a human serum protein structurally related to complement factor H | journal = J Biol Chem | volume = 266 | issue = 18 | pages = 12015–20 |date=Jul 1991 | pmid = 1711047 | pmc =  | doi =  }}</ref><ref name="pmid1826708">{{cite journal | vauthors = Estaller C, Koistinen V, Schwaeble W, Dierich MP, Weiss EH | title = Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule | journal = J Immunol | volume = 146 | issue = 9 | pages = 3190–6 |date=May 1991 | pmid = 1826708 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CFHR1 complement factor H-related 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3078| accessdate = }}</ref>
-| require_manual_inspection = no
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-{{GNF_Protein_box
- | image = PBB_Protein_CFHR1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bzm.
- | PDB = {{PDB2|2bzm}}, {{PDB2|2g7i}}
- | Name = Complement factor H-related 1
- | HGNCid = 4888
- | Symbol = CFHR1
- | AltSymbols =; CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; H36-1; H36-2; HFL1; HFL2; MGC104329
- | OMIM = 134371
- | ECnumber =
- | Homologene = 55632
- | MGIid = 2138169
- | GeneAtlas_image1 = PBB_GE_CFHR1_215388_s_at_tn.png
- | Function =
-  | Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
-  | Process = {{GNF_GO|id=GO:0006956 |text = complement activation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3078
-    | Hs_Ensembl = ENSG00000080910
-    | Hs_RefseqProtein = NP_002104
-    | Hs_RefseqmRNA = NM_002113
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 195055498
-    | Hs_GenLoc_end = 195067942
-    | Hs_Uniprot = Q03591
-    | Mm_EntrezGene = 50702
-    | Mm_Ensembl = ENSMUSG00000057037
-    | Mm_RefseqmRNA = NM_015780
-    | Mm_RefseqProtein = NP_056595
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 141363396
-    | Mm_GenLoc_end = 141597579
-    | Mm_Uniprot =
-  }}
-}}
-'''Complement factor H-related 1''', also known as '''CFHR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CFHR1 complement factor H-related 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3078| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 55: / Line 10: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Zipfel PF, Skerka C |title=Complement factor H and related proteins: an expanding family of complement-regulatory proteins? |journal=Immunol. Today |volume=15 |issue= 3 |pages= 121-6 |year= 1994 |pmid= 8172644 |doi=  }}
+*{{cite journal  | vauthors=Zipfel PF, Skerka C |title=Complement factor H and related proteins: an expanding family of complement-regulatory proteins? |journal=Immunol. Today |volume=15 |issue= 3 |pages= 121–6 |year= 1994 |pmid= 8172644 |doi=10.1016/0167-5699(94)90155-4  }}
-*{{cite journal  | author=Zipfel PF, Jokiranta TS, Hellwage J, ''et al.'' |title=The factor H protein family. |journal=Immunopharmacology |volume=42 |issue= 1-3 |pages= 53-60 |year= 1999 |pmid= 10408366 |doi=  }}
+*{{cite journal  | vauthors=Zipfel PF, Jokiranta TS, Hellwage J |title=The factor H protein family. |journal=Immunopharmacology |volume=42 |issue= 1-3 |pages= 53–60 |year= 1999 |pmid= 10408366 |doi=10.1016/S0162-3109(99)00015-6  |display-authors=etal}}
-*{{cite journal  | author=Skerka C, Horstmann RD, Zipfel PF |title=Molecular cloning of a human serum protein structurally related to complement factor H. |journal=J. Biol. Chem. |volume=266 |issue= 18 |pages= 12015-20 |year= 1991 |pmid= 1711047 |doi=  }}
+*{{cite journal  | vauthors=Timmann C, Leippe M, Horstmann RD |title=Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions. |journal=J. Immunol. |volume=146 |issue= 4 |pages= 1265–70 |year= 1991 |pmid= 1825108 |doi=  }}
-*{{cite journal  | author=Timmann C, Leippe M, Horstmann RD |title=Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions. |journal=J. Immunol. |volume=146 |issue= 4 |pages= 1265-70 |year= 1991 |pmid= 1825108 |doi=  }}
+*{{cite journal  | vauthors=Park CT, Wright SD |title=Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 18054–60 |year= 1996 |pmid= 8663389 |doi=10.1074/jbc.271.30.18054  }}
-*{{cite journal  | author=Estaller C, Koistinen V, Schwaeble W, ''et al.'' |title=Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule. |journal=J. Immunol. |volume=146 |issue= 9 |pages= 3190-6 |year= 1991 |pmid= 1826708 |doi=  }}
+*{{cite journal  | vauthors=Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D |title=A radiation hybrid map of complement factor H and factor H-related genes. |journal=Immunogenetics |volume=49 |issue= 6 |pages= 549–52 |year= 1999 |pmid= 10380701 |doi=10.1007/s002510050534  }}
-*{{cite journal  | author=Park CT, Wright SD |title=Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 18054-60 |year= 1996 |pmid= 8663389 |doi=  }}
+*{{cite journal  | vauthors=Male DA, Ormsby RJ, Ranganathan S |title=Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes. |journal=Mol. Immunol. |volume=37 |issue= 1-2 |pages= 41–52 |year= 2000 |pmid= 10781834 |doi=10.1016/S0161-5890(00)00024-9  |display-authors=etal}}
-*{{cite journal  | author=Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D |title=A radiation hybrid map of complement factor H and factor H-related genes. |journal=Immunogenetics |volume=49 |issue= 6 |pages= 549-52 |year= 1999 |pmid= 10380701 |doi=  }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Male DA, Ormsby RJ, Ranganathan S, ''et al.'' |title=Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes. |journal=Mol. Immunol. |volume=37 |issue= 1-2 |pages= 41-52 |year= 2000 |pmid= 10781834 |doi=  }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Pérez-Caballero D, García-Laorden I, Cortés G |title=Interaction between complement regulators and Streptococcus pyogenes: binding of C4b-binding protein and factor H/factor H-like protein 1 to M18 strains involves two different cell surface molecules. |journal=J. Immunol. |volume=173 |issue= 11 |pages= 6899–904 |year= 2005 |pmid= 15557185 |doi=  10.4049/jimmunol.173.11.6899|display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
-*{{cite journal  | author=Pérez-Caballero D, García-Laorden I, Cortés G, ''et al.'' |title=Interaction between complement regulators and Streptococcus pyogenes: binding of C4b-binding protein and factor H/factor H-like protein 1 to M18 strains involves two different cell surface molecules. |journal=J. Immunol. |volume=173 |issue= 11 |pages= 6899-904 |year= 2005 |pmid= 15557185 |doi=  }}
+*{{cite journal  | vauthors=McDowell JV, Lankford J, Stamm L |title=Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans. |journal=Infect. Immun. |volume=73 |issue= 11 |pages= 7126–32 |year= 2005 |pmid= 16239506 |doi= 10.1128/IAI.73.11.7126-7132.2005  | pmc=1273895 |display-authors=etal}}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065  | pmc=1850943 |display-authors=etal}}
-*{{cite journal  | author=McDowell JV, Lankford J, Stamm L, ''et al.'' |title=Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans. |journal=Infect. Immun. |volume=73 |issue= 11 |pages= 7126-32 |year= 2005 |pmid= 16239506 |doi= 10.1128/IAI.73.11.7126-7132.2005 }}
+*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
-*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
+*{{cite journal  | vauthors=Zipfel PF, Edey M, Heinen S |title=Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. |journal=PLoS Genet. |volume=3 |issue= 3 |pages= e41 |year= 2007 |pmid= 17367211 |doi= 10.1371/journal.pgen.0030041  | pmc=1828695 |display-authors=etal}}
-*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
+*{{cite journal  | vauthors=Haupt K, Kraiczy P, Wallich R |title=Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins. |journal=J. Infect. Dis. |volume=196 |issue= 1 |pages= 124–33 |year= 2007 |pmid= 17538892 |doi= 10.1086/518509 |display-authors=etal}}
-*{{cite journal  | author=Zipfel PF, Edey M, Heinen S, ''et al.'' |title=Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. |journal=PLoS Genet. |volume=3 |issue= 3 |pages= e41 |year= 2007 |pmid= 17367211 |doi= 10.1371/journal.pgen.0030041 }}
-*{{cite journal  | author=Haupt K, Kraiczy P, Wallich R, ''et al.'' |title=Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins. |journal=J. Infect. Dis. |volume=196 |issue= 1 |pages= 124-33 |year= 2007 |pmid= 17538892 |doi= 10.1086/518509 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=3078}}
+==External links==
+* {{UCSC gene info|CFHR1}}
+* [https://www.ncbi.nlm.nih.gov/books/NBK1367/  GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome]
+* [https://www.ncbi.nlm.nih.gov/omim/277400,120700,120920,134370,134371,138470,188040,217030,235400,605336,605337,612922,612923,612924,612925,612926,120700,120920,134370,134371,138470,188040,217030,235400,605336,605337,612922,612923,612924,612925,612926  OMIM entries on Atypical Hemolytic-Uremic Syndrome]
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-1-stub}}
-{{WikiDoc Sources}}

CFHR1: Difference between revisions

Latest revision as of 09:36, 30 August 2017

References

Further reading

External links

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