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'''Microfibrillar-associated protein 2''' is a [[protein]] that in humans is encoded by the ''MFAP2'' [[gene]].<ref name="pmid7759096">{{cite journal |vauthors=Faraco J, Bashir M, Rosenbloom J, Francke U | title = Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170 | journal = Genomics | volume = 25 | issue = 3 | pages = 630–7 |date=Jun 1995 | pmid = 7759096 | pmc =  | doi =10.1016/0888-7543(95)80004-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MFAP2 microfibrillar-associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4237| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Microfibrillar-associated protein 2
| HGNCid = 7033
| Symbol = MFAP2
| AltSymbols =; MAGP; MAGP-1; MAGP1
| OMIM = 156790
| ECnumber = 
| Homologene = 1801
| MGIid = 99559
| GeneAtlas_image1 = PBB_GE_MFAP2_203417_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}}
| Component = {{GNF_GO|id=GO:0001527 |text = microfibril}} {{GNF_GO|id=GO:0005578 |text = proteinaceous extracellular matrix}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4237
    | Hs_Ensembl = ENSG00000117122
    | Hs_RefseqProtein = NP_002394
    | Hs_RefseqmRNA = NM_002403
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 17173584
    | Hs_GenLoc_end = 17179917
    | Hs_Uniprot = P55001
    | Mm_EntrezGene = 17150
    | Mm_Ensembl = ENSMUSG00000060572
    | Mm_RefseqmRNA = NM_008546
    | Mm_RefseqProtein = NP_032572
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 140282734
    | Mm_GenLoc_end = 140294976
    | Mm_Uniprot = P55002
  }}
}}
'''Microfibrillar-associated protein 2''', also known as '''MFAP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MFAP2 microfibrillar-associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4237| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. This gene encodes two transcripts with two alternatively spliced 5' untranslated exons. These two transcripts contain the same 8 coding exons, and therefore, encode the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: MFAP2 microfibrillar-associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4237| accessdate = }}</ref>
| summary_text = Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. This gene encodes two transcripts with two alternatively spliced 5' untranslated exons. These two transcripts contain the same 8 coding exons, and therefore, encode the same protein.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gibson MA, Hughes JL, Fanning JC, Cleary EG |title=The major antigen of elastin-associated microfibrils is a 31-kDa glycoprotein. |journal=J. Biol. Chem. |volume=261 |issue= 24 |pages= 11429-36 |year= 1986 |pmid= 3015971 |doi=  }}
*{{cite journal  |vauthors=Gibson MA, Hughes JL, Fanning JC, Cleary EG |title=The major antigen of elastin-associated microfibrils is a 31-kDa glycoprotein. |journal=J. Biol. Chem. |volume=261 |issue= 24 |pages= 11429–36 |year= 1986 |pmid= 3015971 |doi=  }}
*{{cite journal  | author=Faraco J, Bashir M, Rosenbloom J, Francke U |title=Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170. |journal=Genomics |volume=25 |issue= 3 |pages= 630-7 |year= 1995 |pmid= 7759096 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Brown-Augsburger P, Broekelmann T, Rosenbloom J, Mecham RP |title=Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly. |journal=Biochem. J. |volume=318 |issue=  1|pages= 149–55 |year= 1996 |pmid= 8761465 |doi= | pmc=1217601 }}
*{{cite journal  | author=Brown-Augsburger P, Broekelmann T, Rosenbloom J, Mecham RP |title=Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly. |journal=Biochem. J. |volume=318 ( Pt 1) |issue=  |pages= 149-55 |year= 1996 |pmid= 8761465 |doi=  }}
*{{cite journal  |vauthors=Finnis ML, Gibson MA |title=Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22817–23 |year= 1997 |pmid= 9278443 |doi=10.1074/jbc.272.36.22817 }}
*{{cite journal  | author=Finnis ML, Gibson MA |title=Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22817-23 |year= 1997 |pmid= 9278443 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Fujimoto N, Tajima S, Ishibashi A |title=Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes. |journal=Arch. Dermatol. Res. |volume=292 |issue= 1 |pages= 21–6 |year= 2000 |pmid= 10664011 |doi=10.1007/PL00007456 }}
*{{cite journal  | author=Fujimoto N, Tajima S, Ishibashi A |title=Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes. |journal=Arch. Dermatol. Res. |volume=292 |issue= 1 |pages= 21-6 |year= 2000 |pmid= 10664011 |doi=  }}
*{{cite journal   |vauthors=Trask BC, Broekelmann T, Ritty TM, etal |title=Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1). |journal=Biochemistry |volume=40 |issue= 14 |pages= 4372–80 |year= 2001 |pmid= 11284693 |doi=10.1021/bi002738z }}
*{{cite journal | author=Trask BC, Broekelmann T, Ritty TM, ''et al.'' |title=Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1). |journal=Biochemistry |volume=40 |issue= 14 |pages= 4372-80 |year= 2001 |pmid= 11284693 |doi=  }}
*{{cite journal  |vauthors=Jensen SA, Reinhardt DP, Gibson MA, Weiss AS |title=Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 39661–6 |year= 2001 |pmid= 11481325 |doi= 10.1074/jbc.M104533200 }}
*{{cite journal  | author=Jensen SA, Reinhardt DP, Gibson MA, Weiss AS |title=Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 39661-6 |year= 2001 |pmid= 11481325 |doi= 10.1074/jbc.M104533200 }}
*{{cite journal  |vauthors=Reinboth B, Hanssen E, Cleary EG, Gibson MA |title=Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 3950–7 |year= 2002 |pmid= 11723132 |doi= 10.1074/jbc.M109540200 }}
*{{cite journal  | author=Reinboth B, Hanssen E, Cleary EG, Gibson MA |title=Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 3950-7 |year= 2002 |pmid= 11723132 |doi= 10.1074/jbc.M109540200 }}
*{{cite journal   |vauthors=Segade F, Trask BC, Broekelmann TJ, etal |title=Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 11050–7 |year= 2002 |pmid= 11796718 |doi= 10.1074/jbc.M110347200 }}
*{{cite journal | author=Segade F, Trask BC, Broekelmann TJ, ''et al.'' |title=Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 11050-7 |year= 2002 |pmid= 11796718 |doi= 10.1074/jbc.M110347200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Werneck CC, Trask BC, Broekelmann TJ, etal |title=Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2. |journal=J. Biol. Chem. |volume=279 |issue= 22 |pages= 23045–51 |year= 2004 |pmid= 15044481 |doi= 10.1074/jbc.M402656200 }}
*{{cite journal | author=Werneck CC, Trask BC, Broekelmann TJ, ''et al.'' |title=Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2. |journal=J. Biol. Chem. |volume=279 |issue= 22 |pages= 23045-51 |year= 2004 |pmid= 15044481 |doi= 10.1074/jbc.M402656200 }}
*{{cite journal  |vauthors=Clarke AW, Weiss AS |title=Microfibril-associated glycoprotein-1 binding to tropoelastin: multiple binding sites and the role of divalent cations. |journal=Eur. J. Biochem. |volume=271 |issue= 14 |pages= 3085–90 |year= 2004 |pmid= 15233806 |doi= 10.1111/j.1432-1033.2004.04246.x }}
*{{cite journal  | author=Clarke AW, Weiss AS |title=Microfibril-associated glycoprotein-1 binding to tropoelastin: multiple binding sites and the role of divalent cations. |journal=Eur. J. Biochem. |volume=271 |issue= 14 |pages= 3085-90 |year= 2004 |pmid= 15233806 |doi= 10.1111/j.1432-1033.2004.04246.x }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Miyamoto A, Lau R, Hein PW, etal |title=Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 10089–97 |year= 2006 |pmid= 16492672 |doi= 10.1074/jbc.M600298200 }}
*{{cite journal | author=Miyamoto A, Lau R, Hein PW, ''et al.'' |title=Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 10089-97 |year= 2006 |pmid= 16492672 |doi= 10.1074/jbc.M600298200 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:25, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Microfibrillar-associated protein 2 is a protein that in humans is encoded by the MFAP2 gene.[1][2]

Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. This gene encodes two transcripts with two alternatively spliced 5' untranslated exons. These two transcripts contain the same 8 coding exons, and therefore, encode the same protein.[2]

References

  1. ↑ Faraco J, Bashir M, Rosenbloom J, Francke U (Jun 1995). "Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170". Genomics. 25 (3): 630–7. doi:10.1016/0888-7543(95)80004-6. PMID 7759096.
  2. ↑ 2.0 2.1 "Entrez Gene: MFAP2 microfibrillar-associated protein 2".

Further reading



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