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{{otheruses|Rere (disambiguation){{!}}Rere}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Arginine-glutamic acid dipeptide repeats protein''' is a [[protein]] that in humans is encoded by the ''RERE'' [[gene]].<ref name="pmid10814707">{{cite journal | vauthors = Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M | title = Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine | journal = Human Molecular Genetics | volume = 9 | issue = 9 | pages = 1433–42 | date = May 2000 | pmid = 10814707 | pmc =  | doi = 10.1093/hmg/9.9.1433 }}</ref><ref name="pmid10729226">{{cite journal | vauthors = Amler LC, Bauer A, Corvi R, Dihlmann S, Praml C, Cavenee WK, Schwab M, Hampton GM | title = Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP | journal = Genomics | volume = 64 | issue = 2 | pages = 195–202 | date = Mar 2000 | pmid = 10729226 | pmc = | doi = 10.1006/geno.1999.6097 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RERE arginine-glutamic acid dipeptide (RE) repeats| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=473| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Arginine-glutamic acid dipeptide (RE) repeats
| HGNCid = 9965
| Symbol = RERE
| AltSymbols =; ARG; ARP; ATN1L; DNB1; FLJ38775; KIAA0458
| OMIM = 605226
| ECnumber = 
| Homologene = 8101
| MGIid = 2683486
| GeneAtlas_image1 = PBB_GE_RERE_200940_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RERE_200938_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RERE_200939_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008267 |text = poly-glutamine tract binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000118 |text = histone deacetylase complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006607 |text = NLS-bearing substrate import into nucleus}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 473
    | Hs_Ensembl = ENSG00000142599
    | Hs_RefseqProtein = NP_001036146
    | Hs_RefseqmRNA = NM_001042681
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 8335044
    | Hs_GenLoc_end = 8800111
    | Hs_Uniprot = Q9P2R6
    | Mm_EntrezGene = 68703
    | Mm_Ensembl = ENSMUSG00000039852
    | Mm_RefseqmRNA = XM_001003134
    | Mm_RefseqProtein = XP_001003134
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 149250140
    | Mm_GenLoc_end = 149463289
    | Mm_Uniprot = Q2NLC0
  }}
}}
'''Arginine-glutamic acid dipeptide (RE) repeats''', also known as '''RERE''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RERE arginine-glutamic acid dipeptide (RE) repeats| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=473| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Recent reports also indicate that RERE and its Drosophila homolog associate with histone methyltransferases in regulating gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: RERE arginine-glutamic acid dipeptide (RE) repeats| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=473| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RERE has been shown to [[Protein-protein interaction|interact]] with [[ATN1]].<ref name=pmid10814707 />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wang L, Rajan H, Pitman JL, McKeown M, Tsai CC | title = Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors | journal = Genes & Development | volume = 20 | issue = 5 | pages = 525–30 | date = Mar 2006 | pmid = 16481466 | pmc = 1410805 | doi = 10.1101/gad.1393506 }}
| citations =
* {{cite journal | vauthors = Wang L, Charroux B, Kerridge S, Tsai CC | title = Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates | journal = EMBO Reports | volume = 9 | issue = 6 | pages = 555–62 | date = Jun 2008 | pmid = 18451879 | pmc = 2427389 | doi = 10.1038/embor.2008.67 }}
*{{cite journal | author=Seki N, Ohira M, Nagase T, ''et al.'' |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=4 |issue= 5 |pages= 345-9 |year= 1998 |pmid= 9455484 |doi= }}
* {{cite journal | vauthors = Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O | title = Characterization of cDNA clones in size-fractionated cDNA libraries from human brain | journal = DNA Research | volume = 4 | issue = 5 | pages = 345–9 | date = Oct 1997 | pmid = 9455484 | doi = 10.1093/dnares/4.5.345 }}
*{{cite journal | author=Amler LC, Bauer A, Corvi R, ''et al.'' |title=Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP. |journal=Genomics |volume=64 |issue= 2 |pages= 195-202 |year= 2000 |pmid= 10729226 |doi= 10.1006/geno.1999.6097 }}
* {{cite journal | vauthors = Waerner T, Gardellin P, Pfizenmaier K, Weith A, Kraut N | title = Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis | journal = Cell Growth & Differentiation | volume = 12 | issue = 4 | pages = 201–10 | date = Apr 2001 | pmid = 11331249 | doi =  }}
*{{cite journal | author=Yanagisawa H, Bundo M, Miyashita T, ''et al.'' |title=Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine. |journal=Hum. Mol. Genet. |volume=9 |issue= 9 |pages= 1433-42 |year= 2000 |pmid= 10814707 |doi= }}
* {{cite journal | vauthors = Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC | title = Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 9580–9 | date = Mar 2002 | pmid = 11782456 | doi = 10.1074/jbc.M106922200 }}
*{{cite journal | author=Waerner T, Gardellin P, Pfizenmaier K, ''et al.'' |title=Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis. |journal=Cell Growth Differ. |volume=12 |issue= 4 |pages= 201-10 |year= 2003 |pmid= 11331249 |doi=  }}
* {{cite journal | vauthors = Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K | title = Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants | journal = Molecular Vision | volume = 8 | issue =  | pages = 171–84 | date = Jun 2002 | pmid = 12107413 | doi =  }}
*{{cite journal | author=Yi J, Kloeker S, Jensen CC, ''et al.'' |title=Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9580-9 |year= 2002 |pmid= 11782456 |doi= 10.1074/jbc.M106922200 }}
* {{cite journal | vauthors = Tomarev SI, Wistow G, Raymond V, Dubois S, Malyukova I | title = Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis | journal = Investigative Ophthalmology & Visual Science | volume = 44 | issue = 6 | pages = 2588–96 | date = Jun 2003 | pmid = 12766061 | doi = 10.1167/iovs.02-1099 }}
*{{cite journal | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue=  |pages= 171-84 |year= 2002 |pmid= 12107413 |doi=  }}
* {{cite journal | vauthors = Zoltewicz JS, Stewart NJ, Leung R, Peterson AS | title = Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis | journal = Development | volume = 131 | issue = 1 | pages = 3–14 | date = Jan 2004 | pmid = 14645126 | doi = 10.1242/dev.00908 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Tomarev SI, Wistow G, Raymond V, ''et al.'' |title=Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 6 |pages= 2588-96 |year= 2003 |pmid= 12766061 |doi= }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Zoltewicz JS, Stewart NJ, Leung R, Peterson AS |title=Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. |journal=Development |volume=131 |issue= 1 |pages= 3-14 |year= 2004 |pmid= 14645126 |doi= 10.1242/dev.00908 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:06, 10 September 2017

For other uses, see Rere.
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Arginine-glutamic acid dipeptide repeats protein is a protein that in humans is encoded by the RERE gene.[1][2][3]

Function

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Recent reports also indicate that RERE and its Drosophila homolog associate with histone methyltransferases in regulating gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

RERE has been shown to interact with ATN1.[1]

References

  1. ↑ 1.0 1.1 Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M (May 2000). "Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine". Human Molecular Genetics. 9 (9): 1433–42. doi:10.1093/hmg/9.9.1433. PMID 10814707.
  2. ↑ Amler LC, Bauer A, Corvi R, Dihlmann S, Praml C, Cavenee WK, Schwab M, Hampton GM (Mar 2000). "Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP". Genomics. 64 (2): 195–202. doi:10.1006/geno.1999.6097. PMID 10729226.
  3. ↑ 3.0 3.1 "Entrez Gene: RERE arginine-glutamic acid dipeptide (RE) repeats".

Further reading


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