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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Glucocorticoid modulatory element-binding protein 1''' is a [[protein]] that in humans is encoded by the ''GMEB1'' [[gene]].<ref name="pmid10386584">{{cite journal | vauthors = Thériault JR, Charette SJ, Lambert H, Landry J | title = Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein | journal = FEBS Lett | volume = 452 | issue = 3 | pages = 170–176 | date = Jul 1999 | pmid = 10386584 | pmc =  | doi = 10.1016/S0014-5793(99)00634-1 }}</ref><ref name="pmid10523663">{{cite journal | vauthors = Christensen J, Cotmore SF, Tattersall P | title = Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites | journal = Mol Cell Biol | volume = 19 | issue = 11 | pages = 7741–50 | date = Nov 1999 | pmid = 10523663 | pmc = 84824 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GMEB1 glucocorticoid modulatory element binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10691| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GMEB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1oqj.
| PDB = {{PDB2|1oqj}}
| Name = Glucocorticoid modulatory element binding protein 1
| HGNCid = 4370
| Symbol = GMEB1
| AltSymbols =; P96PIF; PIF96
| OMIM = 604409
| ECnumber = 
| Homologene = 10647
| MGIid = 2135604
| GeneAtlas_image1 = PBB_GE_GMEB1_220938_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10691
    | Hs_Ensembl = ENSG00000162419
    | Hs_RefseqProtein = NP_006573
    | Hs_RefseqmRNA = NM_006582
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 28867831
    | Hs_GenLoc_end = 28918452
    | Hs_Uniprot = Q9Y692
    | Mm_EntrezGene = 56809
    | Mm_Ensembl = ENSMUSG00000028901
    | Mm_RefseqmRNA = NM_020273
    | Mm_RefseqProtein = NP_064669
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 131497095
    | Mm_GenLoc_end = 131523928
    | Mm_Uniprot = Q3UYV4
  }}
}}
'''Glucocorticoid modulatory element binding protein 1''', also known as '''GMEB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GMEB1 glucocorticoid modulatory element binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10691| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of KDWK gene family. The product of this gene associates with GMEB2 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of KDWK gene family. The product of this gene associates with GMEB2 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.<ref name="entrez">{{cite web | title = Entrez Gene: GMEB1 glucocorticoid modulatory element binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10691| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
GMEB1 has been shown to [[Protein-protein interaction|interact]] with [[TRIM63]].<ref name="pmid11927605">{{cite journal | vauthors = McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC | title = Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1 | journal = J Cell Biol | volume = 157 | issue = 1 | pages = 125–136 | year = 2002 | pmid = 11927605 | pmc = 2173255 | doi = 10.1083/jcb.200108089 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jimenez-Lara AM, Heine MJ, Gronemeyer H | title = Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family | journal = FEBS Lett. | volume = 468 | issue = 2–3 | pages = 203–210 | year = 2000 | pmid = 10692587 | doi = 10.1016/S0014-5793(00)01209-6 }}
| citations =
* {{cite journal | vauthors = Zeng H, Kaul S, Simons SS | title = Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins | journal = Nucleic Acids Res. | volume = 28 | issue = 8 | pages = 1819–1829 | year = 2000 | pmid = 10734202 | pmc = 102812 | doi = 10.1093/nar/28.8.1819 }}
*{{cite journal | author=Thériault JR, Charette SJ, Lambert H, Landry J |title=Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein. |journal=FEBS Lett. |volume=452 |issue= 3 |pages= 170-6 |year= 1999 |pmid= 10386584 |doi=  }}
* {{cite journal | vauthors = Kaul S, Blackford JA, Chen J, Ogryzko VV, Simons SS | title = Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins | journal = Mol. Endocrinol. | volume = 14 | issue = 7 | pages = 1010–1027 | year = 2000 | pmid = 10894151 | doi = 10.1210/me.14.7.1010 }}
*{{cite journal  | author=Christensen J, Cotmore SF, Tattersall P |title=Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7741-50 |year= 1999 |pmid= 10523663 |doi=  }}
* {{cite journal | vauthors = Burnett E, Christensen J, Tattersall P | title = A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters | journal = J. Mol. Biol. | volume = 314 | issue = 5 | pages = 1029–1039 | year = 2002 | pmid = 11743720 | doi = 10.1006/jmbi.2000.5198 }}
*{{cite journal  | author=Jimenez-Lara AM, Heine MJ, Gronemeyer H |title=Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family. |journal=FEBS Lett. |volume=468 |issue= 2-3 |pages= 203-10 |year= 2000 |pmid= 10692587 |doi= }}
* {{cite journal | vauthors = Kaul S, Blackford JA, Cho S, Simons SS | title = Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors | journal = J. Biol. Chem. | volume = 277 | issue = 15 | pages = 12541–12549 | year = 2002 | pmid = 11812797 | doi = 10.1074/jbc.M112330200 }}
*{{cite journal | author=Zeng H, Kaul S, Simons SS |title=Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins. |journal=Nucleic Acids Res. |volume=28 |issue= 8 |pages= 1819-29 |year= 2000 |pmid= 10734202 |doi= }}
* {{cite journal | vauthors = Surdo PL, Bottomley MJ, Sattler M, Scheffzek K | title = Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions | journal = Mol. Endocrinol. | volume = 17 | issue = 7 | pages = 1283–1295 | year = 2004 | pmid = 12702733 | doi = 10.1210/me.2002-0409 }}
*{{cite journal | author=Kaul S, Blackford JA, Chen J, ''et al.'' |title=Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. |journal=Mol. Endocrinol. |volume=14 |issue= 7 |pages= 1010-27 |year= 2000 |pmid= 10894151 |doi= }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–1332 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Burnett E, Christensen J, Tattersall P |title=A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters. |journal=J. Mol. Biol. |volume=314 |issue= 5 |pages= 1029-39 |year= 2002 |pmid= 11743720 |doi= 10.1006/jmbi.2000.5198 }}
* {{cite journal | vauthors = Tsuruma K, Nakagawa T, Shirakura H, Hayashi N, Uehara T, Nomura Y | title = Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain | journal = Biochem. Biophys. Res. Commun. | volume = 325 | issue = 4 | pages = 1246–1251 | year = 2005 | pmid = 15555560 | doi = 10.1016/j.bbrc.2004.10.145 }}
*{{cite journal | author=Kaul S, Blackford JA, Cho S, Simons SS |title=Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12541-9 |year= 2002 |pmid= 11812797 |doi= 10.1074/jbc.M112330200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=McElhinny AS, Kakinuma K, Sorimachi H, ''et al.'' |title=Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. |journal=J. Cell Biol. |volume=157 |issue= 1 |pages= 125-36 |year= 2002 |pmid= 11927605 |doi= 10.1083/jcb.200108089 }}
* {{cite journal | vauthors = Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y | title = Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury | journal = J. Biol. Chem. | volume = 281 | issue = 16 | pages = 11397–11404 | year = 2006 | pmid = 16497673 | doi = 10.1074/jbc.M510597200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–1292 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal  | author=Surdo PL, Bottomley MJ, Sattler M, Scheffzek K |title=Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions. |journal=Mol. Endocrinol. |volume=17 |issue= 7 |pages= 1283-95 |year= 2004 |pmid= 12702733 |doi= 10.1210/me.2002-0409 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Tsuruma K, Nakagawa T, Shirakura H, ''et al.'' |title=Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain. |journal=Biochem. Biophys. Res. Commun. |volume=325 |issue= 4 |pages= 1246-51 |year= 2005 |pmid= 15555560 |doi= 10.1016/j.bbrc.2004.10.145 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Tsuruma K, Nakagawa T, Morimoto N, ''et al.'' |title=Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury. |journal=J. Biol. Chem. |volume=281 |issue= 16 |pages= 11397-404 |year= 2006 |pmid= 16497673 |doi= 10.1074/jbc.M510597200 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=10691}}
{{WikiDoc Sources}}
 
 
{{gene-1-stub}}

Latest revision as of 08:49, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glucocorticoid modulatory element-binding protein 1 is a protein that in humans is encoded by the GMEB1 gene.[1][2][3]

Function

This gene is a member of KDWK gene family. The product of this gene associates with GMEB2 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist.[3]

Interactions

GMEB1 has been shown to interact with TRIM63.[4]

References

  1. ↑ Thériault JR, Charette SJ, Lambert H, Landry J (Jul 1999). "Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein". FEBS Lett. 452 (3): 170–176. doi:10.1016/S0014-5793(99)00634-1. PMID 10386584.
  2. ↑ Christensen J, Cotmore SF, Tattersall P (Nov 1999). "Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites". Mol Cell Biol. 19 (11): 7741–50. PMC 84824. PMID 10523663.
  3. ↑ 3.0 3.1 "Entrez Gene: GMEB1 glucocorticoid modulatory element binding protein 1".
  4. ↑ McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1". J Cell Biol. 157 (1): 125–136. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605.

Further reading

  • Jimenez-Lara AM, Heine MJ, Gronemeyer H (2000). "Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family". FEBS Lett. 468 (2–3): 203–210. doi:10.1016/S0014-5793(00)01209-6. PMID 10692587.
  • Zeng H, Kaul S, Simons SS (2000). "Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins". Nucleic Acids Res. 28 (8): 1819–1829. doi:10.1093/nar/28.8.1819. PMC 102812. PMID 10734202.
  • Kaul S, Blackford JA, Chen J, Ogryzko VV, Simons SS (2000). "Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins". Mol. Endocrinol. 14 (7): 1010–1027. doi:10.1210/me.14.7.1010. PMID 10894151.
  • Burnett E, Christensen J, Tattersall P (2002). "A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters". J. Mol. Biol. 314 (5): 1029–1039. doi:10.1006/jmbi.2000.5198. PMID 11743720.
  • Kaul S, Blackford JA, Cho S, Simons SS (2002). "Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors". J. Biol. Chem. 277 (15): 12541–12549. doi:10.1074/jbc.M112330200. PMID 11812797.
  • Surdo PL, Bottomley MJ, Sattler M, Scheffzek K (2004). "Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions". Mol. Endocrinol. 17 (7): 1283–1295. doi:10.1210/me.2002-0409. PMID 12702733.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Tsuruma K, Nakagawa T, Shirakura H, Hayashi N, Uehara T, Nomura Y (2005). "Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain". Biochem. Biophys. Res. Commun. 325 (4): 1246–1251. doi:10.1016/j.bbrc.2004.10.145. PMID 15555560.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
  • Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y (2006). "Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury". J. Biol. Chem. 281 (16): 11397–11404. doi:10.1074/jbc.M510597200. PMID 16497673.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243.


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