ATP6V1G3: Difference between revisions
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{{ | '''V-type proton ATPase subunit G 3''' is an [[enzyme]] that in humans is encoded by the ''ATP6V1G3'' [[gene]].<ref name="pmid9442887">{{cite journal | vauthors = Stevens TH, Forgac M | title = Structure, function and regulation of the vacuolar (H+)-ATPase | journal = Annual Review of Cell and Developmental Biology | volume = 13 | issue = | pages = 779–808 | date = Feb 1998 | pmid = 9442887 | pmc = | doi = 10.1146/annurev.cellbio.13.1.779 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127124| accessdate = }}</ref> | ||
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== Function == | |||
This gene encodes a component of [[vacuolar]] [[ATPase]] (V-ATPase), a multisubunit enzyme that mediates acidification of [[eukaryotic]] intracellular [[organelle]]s. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, [[zymogen]] activation, receptor-mediated [[endocytosis]], and [[synaptic vesicle]] proton gradient generation. V-ATPase is composed of a [[cytosolic]] V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c<nowiki>''</nowiki> and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" /> | |||
==References== | == References == | ||
{{reflist| | {{reflist}} | ||
==Further reading== | |||
==External links== | |||
* {{UCSC gene info|ATP6V1G3}} | |||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Finbow ME, Harrison MA | title = The vacuolar H+-ATPase: a universal proton pump of eukaryotes | journal = The Biochemical Journal | volume = 324 | issue = Pt 3 | pages = 697–712 | date = Jun 1997 | pmid = 9210392 | pmc = 1218484 | doi = 10.1042/bj3240697}} | |||
* {{cite journal | vauthors = Nelson N, Harvey WR | title = Vacuolar and plasma membrane proton-adenosinetriphosphatases | journal = Physiological Reviews | volume = 79 | issue = 2 | pages = 361–85 | date = Apr 1999 | pmid = 10221984 | doi = }} | |||
*{{cite journal | * {{cite journal | vauthors = Forgac M | title = Structure and properties of the vacuolar (H+)-ATPases | journal = The Journal of Biological Chemistry | volume = 274 | issue = 19 | pages = 12951–4 | date = May 1999 | pmid = 10224039 | doi = 10.1074/jbc.274.19.12951 }} | ||
* {{cite journal | vauthors = Kane PM | title = Introduction: V-ATPases 1992-1998 | journal = Journal of Bioenergetics and Biomembranes | volume = 31 | issue = 1 | pages = 3–5 | date = Feb 1999 | pmid = 10340843 | doi = 10.1023/A:1001884227654 }} | |||
*{{cite journal | * {{cite journal | vauthors = Wieczorek H, Brown D, Grinstein S, Ehrenfeld J, Harvey WR | title = Animal plasma membrane energization by proton-motive V-ATPases | journal = BioEssays | volume = 21 | issue = 8 | pages = 637–48 | date = Aug 1999 | pmid = 10440860 | doi = 10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W }} | ||
*{{cite journal | * {{cite journal | vauthors = Nishi T, Forgac M | title = The vacuolar (H+)-ATPases--nature's most versatile proton pumps | journal = Nature Reviews Molecular Cell Biology | volume = 3 | issue = 2 | pages = 94–103 | date = Feb 2002 | pmid = 11836511 | doi = 10.1038/nrm729 }} | ||
*{{cite journal | * {{cite journal | vauthors = Kawasaki-Nishi S, Nishi T, Forgac M | title = Proton translocation driven by ATP hydrolysis in V-ATPases | journal = FEBS Letters | volume = 545 | issue = 1 | pages = 76–85 | date = Jun 2003 | pmid = 12788495 | doi = 10.1016/S0014-5793(03)00396-X }} | ||
*{{cite journal | * {{cite journal | vauthors = Morel N | title = Neurotransmitter release: the dark side of the vacuolar-H+ATPase | journal = Biology of the Cell / Under the Auspices of the European Cell Biology Organization | volume = 95 | issue = 7 | pages = 453–7 | date = Oct 2003 | pmid = 14597263 | doi = 10.1016/S0248-4900(03)00075-3 }} | ||
*{{cite journal | * {{cite journal | vauthors = Brown D, Lui B, Gluck S, Sabolić I | title = A plasma membrane proton ATPase in specialized cells of rat epididymis | journal = The American Journal of Physiology | volume = 263 | issue = 4 Pt 1 | pages = C913–6 | date = Oct 1992 | pmid = 1415677 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Smith AN, Borthwick KJ, Karet FE | title = Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis | journal = Gene | volume = 297 | issue = 1-2 | pages = 169–77 | date = Sep 2002 | pmid = 12384298 | doi = 10.1016/S0378-1119(02)00884-3 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
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Latest revision as of 18:28, 29 August 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.[1][2]
Function
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.[2]
References
- ↑ Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
- ↑ 2.0 2.1 "Entrez Gene: ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3".
External links
- Human ATP6V1G3 genome location and ATP6V1G3 gene details page in the UCSC Genome Browser.
Further reading
- Finbow ME, Harrison MA (Jun 1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". The Biochemical Journal. 324 (Pt 3): 697–712. doi:10.1042/bj3240697. PMC 1218484. PMID 9210392.
- Nelson N, Harvey WR (Apr 1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiological Reviews. 79 (2): 361–85. PMID 10221984.
- Forgac M (May 1999). "Structure and properties of the vacuolar (H+)-ATPases". The Journal of Biological Chemistry. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
- Kane PM (Feb 1999). "Introduction: V-ATPases 1992-1998". Journal of Bioenergetics and Biomembranes. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
- Wieczorek H, Brown D, Grinstein S, Ehrenfeld J, Harvey WR (Aug 1999). "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860.
- Nishi T, Forgac M (Feb 2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nature Reviews Molecular Cell Biology. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511.
- Kawasaki-Nishi S, Nishi T, Forgac M (Jun 2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Letters. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495.
- Morel N (Oct 2003). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263.
- Brown D, Lui B, Gluck S, Sabolić I (Oct 1992). "A plasma membrane proton ATPase in specialized cells of rat epididymis". The American Journal of Physiology. 263 (4 Pt 1): C913–6. PMID 1415677.
- Smith AN, Borthwick KJ, Karet FE (Sep 2002). "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis". Gene. 297 (1–2): 169–77. doi:10.1016/S0378-1119(02)00884-3. PMID 12384298.
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