UBE4B: Difference between revisions

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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Ubiquitin conjugation factor E4 B''' is a [[protein]] that in humans is encoded by the ''UBE4B'' [[gene]].<ref name="pmid9734811">{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 |date=Dec 1998 | pmid = 9734811 | pmc =  | doi =10.1093/dnares/5.3.169 }}</ref><ref name="pmid10089879">{{cite journal | vauthors = Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S | title = A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly | journal = Cell | volume = 96 | issue = 5 | pages = 635–44 |date=Apr 1999 | pmid = 10089879 | pmc =  | doi =10.1016/S0092-8674(00)80574-7 }}</ref><ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Ubiquitination factor E4B (UFD2 homolog, yeast)
| HGNCid = 12500
| Symbol = UBE4B
| AltSymbols =; E4; UFD2; HDNB1; KIAA0684; UBOX3
| OMIM =
| ECnumber =
  | Homologene = 4413
| MGIid = 1927086
| GeneAtlas_image1 = PBB_GE_UBE4B_202317_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_UBE4B_202316_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_UBE4B_210685_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
  | Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0009411 |text = response to UV}} {{GNF_GO|id=GO:0042787 |text = protein ubiquitination during ubiquitin-dependent protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10277
    | Hs_Ensembl = ENSG00000130939
    | Hs_RefseqProtein = NP_006039
    | Hs_RefseqmRNA = NM_006048
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 10015630
    | Hs_GenLoc_end = 10163884
    | Hs_Uniprot = O95155
    | Mm_EntrezGene = 63958
    | Mm_Ensembl = ENSMUSG00000028960
    | Mm_RefseqmRNA = NM_022022
    | Mm_RefseqProtein = NP_071305
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 148172216
    | Mm_GenLoc_end = 148270549
    | Mm_Uniprot = Q3V426
  }}
}}
'''Ubiquitination factor E4B (UFD2 homolog, yeast)''', also known as '''UBE4B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE4B ubiquitination factor E4B (UFD2 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10277| accessdate = }}</ref>
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.<ref name="entrez">{{cite web | title = Entrez Gene: UBE4B ubiquitination factor E4B (UFD2 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10277| accessdate = }}</ref>
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.<ref name="entrez">{{cite web | title = Entrez Gene: UBE4B ubiquitination factor E4B (UFD2 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10277| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 1}}
{{refbegin | 1}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Onyango P, Lubyova B, Gardellin P, ''et al.'' |title=Molecular cloning and expression analysis of five novel genes in chromosome 1p36 |journal=Genomics |volume=50 |issue= 2 |pages= 187-98 |year= 1998 |pmid= 9653645 |doi= 10.1006/geno.1997.5186 }}
*{{cite journal   |vauthors=Onyango P, Lubyova B, Gardellin P, etal |title=Molecular cloning and expression analysis of five novel genes in chromosome 1p36 |journal=Genomics |volume=50 |issue= 2 |pages= 187–98 |year= 1998 |pmid= 9653645 |doi= 10.1006/geno.1997.5186 }}
*{{cite journal | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
*{{cite journal   |vauthors=Ohira M, Kageyama H, Mihara M, etal |title=Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line |journal=Oncogene |volume=19 |issue= 37 |pages= 4302–7 |year= 2000 |pmid= 10980605 |doi= 10.1038/sj.onc.1203786 }}
*{{cite journal  | author=Koegl M, Hoppe T, Schlenker S, ''et al.'' |title=A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly |journal=Cell |volume=96 |issue= 5 |pages= 635-44 |year= 1999 |pmid= 10089879 |doi=  }}
*{{cite journal   |vauthors=Mahoney JA, Odin JA, White SM, etal |title=The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 587–95 |year= 2002 |pmid= 11802788 |doi=10.1042/0264-6021:3610587  | pmc=1222341 }}
*{{cite journal  | author=Ohira M, Kageyama H, Mihara M, ''et al.'' |title=Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line |journal=Oncogene |volume=19 |issue= 37 |pages= 4302-7 |year= 2000 |pmid= 10980605 |doi= 10.1038/sj.onc.1203786 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Mahoney JA, Odin JA, White SM, ''et al.'' |title=The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 587-95 |year= 2002 |pmid= 11802788 |doi=  }}
*{{cite journal   |vauthors=Kaneko C, Hatakeyama S, Matsumoto M, etal |title=Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a |journal=Biochem. Biophys. Res. Commun. |volume=300 |issue= 2 |pages= 297–304 |year= 2003 |pmid= 12504083 |doi=10.1016/S0006-291X(02)02834-6 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Krona C, Ejeskär K, Abel F, etal |title=Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2 |journal=Oncogene |volume=22 |issue= 15 |pages= 2343–51 |year= 2003 |pmid= 12700669 |doi= 10.1038/sj.onc.1206324 }}
*{{cite journal | author=Kaneko C, Hatakeyama S, Matsumoto M, ''et al.'' |title=Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a |journal=Biochem. Biophys. Res. Commun. |volume=300 |issue= 2 |pages= 297-304 |year= 2003 |pmid= 12504083 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Krona C, Ejeskär K, Abel F, ''et al.'' |title=Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2 |journal=Oncogene |volume=22 |issue= 15 |pages= 2343-51 |year= 2003 |pmid= 12700669 |doi= 10.1038/sj.onc.1206324 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Okumura F, Hatakeyama S, Matsumoto M, etal |title=Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53533–43 |year= 2005 |pmid= 15466860 |doi= 10.1074/jbc.M402916200 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Okumura F, Hatakeyama S, Matsumoto M, ''et al.'' |title=Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53533-43 |year= 2005 |pmid= 15466860 |doi= 10.1074/jbc.M402916200 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Spinette S, Mahoney JA, Rosen A |title=The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death |journal=Biochem. Biophys. Res. Commun. |volume=347 |issue= 4 |pages= 1103–12 |year= 2006 |pmid= 16870146 |doi= 10.1016/j.bbrc.2006.06.194 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Spinette S, Mahoney JA, Rosen A |title=The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death |journal=Biochem. Biophys. Res. Commun. |volume=347 |issue= 4 |pages= 1103-12 |year= 2006 |pmid= 16870146 |doi= 10.1016/j.bbrc.2006.06.194 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|UBE4B}}
* {{UCSC gene details|UBE4B}}
 
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Latest revision as of 09:32, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.[1][2][3] The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.[3]

References

  1. ↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  2. ↑ Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell. 96 (5): 635–44. doi:10.1016/S0092-8674(00)80574-7. PMID 10089879.
  3. ↑ 3.0 3.1 "Entrez Gene: UBE4B ubiquitination factor E4B (UFD2 homolog, yeast)".

Further reading

External links



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