Inosine monophosphate synthase: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Bifunctional purine biosynthesis protein PURH''' is a [[protein]] that in humans is encoded by the ''ATIC'' [[gene]].<ref name="pmid8567683">{{cite journal |vauthors=Rayl EA, Moroson BA, Beardsley GP | title = The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping | journal = J Biol Chem | volume = 271 | issue = 4 | pages = 2225–33 |date=Mar 1996 | pmid = 8567683 | pmc =  | doi = 10.1074/jbc.271.4.2225}}</ref><ref name="pmid9378707">{{cite journal |vauthors=Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K | title = Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase | journal = J Biochem | volume = 122 | issue = 2 | pages = 309–13 |date=Nov 1997 | pmid = 9378707 | pmc =  | doi =  10.1093/oxfordjournals.jbchem.a021754}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=471| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_ATIC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p4r.
| PDB = {{PDB2|1p4r}}, {{PDB2|1pkx}}, {{PDB2|1pl0}}
| Name = 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
| HGNCid = 794
| Symbol = ATIC
| AltSymbols =; AICAR; AICARFT; IMPCHASE; PURH
| OMIM = 601731
| ECnumber =
| Homologene = 2983
| MGIid = 1351352
  | GeneAtlas_image1 = PBB_GE_ATIC_208758_at_tn.png
| Function = {{GNF_GO|id=GO:0003937 |text = IMP cyclohydrolase activity}} {{GNF_GO|id=GO:0004643 |text = phosphoribosylaminoimidazolecarboxamide formyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0006164 |text = purine nucleotide biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 471
    | Hs_Ensembl = ENSG00000138363
    | Hs_RefseqProtein = NP_004035
    | Hs_RefseqmRNA = NM_004044
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 215885036
    | Hs_GenLoc_end = 215922724
    | Hs_Uniprot = P31939
    | Mm_EntrezGene = 108147
    | Mm_Ensembl = ENSMUSG00000026192
    | Mm_RefseqmRNA = XM_987290
    | Mm_RefseqProtein = XP_992384
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 71490367
    | Mm_GenLoc_end = 71512612
    | Mm_Uniprot = Q3UTQ3
  }}
}}
'''5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase''', also known as '''ATIC''' and '''Inosine monophosphate synthase''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=471| accessdate = }}</ref>
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi=  }}
*{{cite journal  | author=Rasmussen HH |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199 |name-list-format=vanc| author2=van Damme J | author3=Puype M  | display-authors=3  | last4=Gesser  | first4=Borbala  | last5=Celis  | first5=Julio E.  | last6=Vandekerckhove  | first6=Joël }}
*{{cite journal | author=Rayl EA, Moroson BA, Beardsley GP |title=The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping. |journal=J. Biol. Chem. |volume=271 |issue= 4 |pages= 2225-33 |year= 1996 |pmid= 8567683 |doi=  }}
*{{cite journal  | author=Yamauchi M |title=Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript |journal=DNA Res. |volume=2 |issue= 6 |pages= 269–75 |year= 1996 |pmid= 8867801 |doi=10.1093/dnares/2.6.269 |name-list-format=vanc| author2=Seki N  | author3=Mita K  | display-authors=3  | last4=Saito | first4=T | last5=Tsuji  | first5=S  | last6=Hongo  | first6=E  | last7=Morimyo  | first7=M  | last8=Shiomi  | first8=T  | last9=Koyama  | first9=H }}
*{{cite journal  | author=Yamauchi M, Seki N, Mita K, ''et al.'' |title=Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript. |journal=DNA Res. |volume=2 |issue= 6 |pages= 269-75 |year= 1996 |pmid= 8867801 |doi=  }}
*{{cite journal  | author=Beardsley GP |title=Structure and functional relationships in human pur H |journal=Adv. Exp. Med. Biol. |volume=431 |issue=  |pages= 221–6 |year= 1998 |pmid= 9598063 |doi=10.1007/978-1-4615-5381-6_43  |name-list-format=vanc| author2=Rayl EA  | author3=Gunn K  | display-authors=3  | last4=Moroson  | first4=BA  | last5=Seow  | first5=H  | last6=Anderson  | first6=KS  | last7=Vergis  | first7=J  | last8=Fleming  | first8=K  | last9=Worland  | first9=S  | series=Advances in Experimental Medicine and Biology  | isbn=978-0-306-45778-4 }}
*{{cite journal | author=Sugita T, Aya H, Ueno M, ''et al.'' |title=Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. |journal=J. Biochem. |volume=122 |issue= 2 |pages= 309-13 |year= 1997 |pmid= 9378707 |doi=  }}
*{{cite journal  |vauthors=Vergis JM, Bulock KG, Fleming KG, Beardsley GP |title=Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7727–33 |year= 2001 |pmid= 11096114 |doi= 10.1074/jbc.M009940200 }}
*{{cite journal  | author=Beardsley GP, Rayl EA, Gunn K, ''et al.'' |title=Structure and functional relationships in human pur H. |journal=Adv. Exp. Med. Biol. |volume=431 |issue=  |pages= 221-6 |year= 1998 |pmid= 9598063 |doi=  }}
*{{cite journal  |vauthors=Bulock KG, Beardsley GP, Anderson KS |title=The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22168–74 |year= 2002 |pmid= 11948179 |doi= 10.1074/jbc.M111964200 }}
*{{cite journal  | author=Vergis JM, Bulock KG, Fleming KG, Beardsley GP |title=Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7727-33 |year= 2001 |pmid= 11096114 |doi= 10.1074/jbc.M009940200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Bulock KG, Beardsley GP, Anderson KS |title=The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22168-74 |year= 2002 |pmid= 11948179 |doi= 10.1074/jbc.M111964200 }}
*{{cite journal  | author=Cheong CG |title=Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 18034–45 |year= 2004 |pmid= 14966129 |doi= 10.1074/jbc.M313691200 |name-list-format=vanc| author2=Wolan DW  | author3=Greasley SE  | display-authors=3  | last4=Horton  | first4=PA  | last5=Beardsley  | first5=GP  | last6=Wilson  | first6=IA }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Marie S |title=AICA-Ribosiduria: A Novel, Neurologically Devastating Inborn Error of Purine Biosynthesis Caused by Mutation of ATIC |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1276–81 |year= 2004 |pmid= 15114530 |doi= 10.1086/421475 | pmc=1182092  |name-list-format=vanc| author2=Heron B  | author3=Bitoun P  | display-authors=3  | last4=Timmerman  | first4=Thérèse  | last5=Van Den Berghe  | first5=Georges  | last6=Vincent  | first6=Marie-Françoise }}
*{{cite journal  | author=Cheong CG, Wolan DW, Greasley SE, ''et al.'' |title=Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 18034-45 |year= 2004 |pmid= 14966129 |doi= 10.1074/jbc.M313691200 }}
*{{cite journal  | author=Dervieux T |title=Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis |journal=Arthritis Rheum. |volume=50 |issue= 9 |pages= 2766–74 |year= 2004 |pmid= 15457444 |doi= 10.1002/art.20460 |name-list-format=vanc| author2=Furst D  | author3=Lein DO  | display-authors=3  | last4=Capps  | first4=Robert  | last5=Smith  | first5=Katie  | last6=Walsh  | first6=Michael  | last7=Kremer  | first7=Joel }}
*{{cite journal  | author=Marie S, Heron B, Bitoun P, ''et al.'' |title=AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1276-81 |year= 2004 |pmid= 15114530 |doi= 10.1086/421475 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Dervieux T, Furst D, Lein DO, ''et al.'' |title=Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. |journal=Arthritis Rheum. |volume=50 |issue= 9 |pages= 2766-74 |year= 2004 |pmid= 15457444 |doi= 10.1002/art.20460 }}
*{{cite journal  | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948  |name-list-format=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor  | first9=Liam }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=471}}


==External links==
==External links==
* {{MeshName|Inosine+monophosphate+synthase}}
* {{MeshName|Inosine+monophosphate+synthase}}


{{biochem-stub}}
{{Methyltransferases}}
{{Methyltransferases}}
{{Carbon-nitrogen non-peptide hydrolases}}
{{Carbon-nitrogen non-peptide hydrolases}}
{{Nucleotide metabolism}}
{{Nucleotide metabolism}}
{{WikiDoc Sources}}
 
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Latest revision as of 04:44, 1 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.[1][2][3]

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

  • EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • EC 3.5.4.10 - IMP cyclohydrolase

References

  1. ↑ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping". J Biol Chem. 271 (4): 2225–33. doi:10.1074/jbc.271.4.2225. PMID 8567683.
  2. ↑ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase". J Biochem. 122 (2): 309–13. doi:10.1093/oxfordjournals.jbchem.a021754. PMID 9378707.
  3. ↑ "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase".

Further reading

External links



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