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{{Use dmy dates|date=April 2013}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Arf-GAP domain and FG repeats-containing protein 1''' is a [[protein]] that in humans is encoded by the ''AGFG1'' [[gene]].<ref name="pmid7637788">{{cite journal | vauthors = Fritz CC, Zapp ML, Green MR | title = A human nucleoporin-like protein that specifically interacts with HIV Rev | journal = Nature | volume = 376 | issue = 6540 | pages = 530–3 | date = Sep 1995 | pmid = 7637788 | pmc = | doi = 10.1038/376530a0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HRB HIV-1 Rev binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3267| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_HRB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2d9l.
| PDB = {{PDB2|2d9l}}, {{PDB2|2olm}}
| Name = HIV-1 Rev binding protein
| HGNCid = 5175
| Symbol = HRB
| AltSymbols =; MGC116938; MGC116940; RAB; RIP
| OMIM = 600862
| ECnumber = 
| Homologene = 37929
| MGIid = 1333754
| GeneAtlas_image1 = PBB_GE_HRB_218092_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HRB_213926_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_HRB_218091_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}}
| Process = {{GNF_GO|id=GO:0001675 |text = acrosome formation}} {{GNF_GO|id=GO:0006406 |text = mRNA export from nucleus}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0043087 |text = regulation of GTPase activity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3267
    | Hs_Ensembl = ENSG00000173744
    | Hs_RefseqProtein = XP_946431
    | Hs_RefseqmRNA = XM_941338
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 228045286
    | Hs_GenLoc_end = 228130548
    | Hs_Uniprot = P52594
    | Mm_EntrezGene = 15463
    | Mm_Ensembl = ENSMUSG00000026159
    | Mm_RefseqmRNA = NM_010472
    | Mm_RefseqProtein = NP_034602
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 82718507
    | Mm_GenLoc_end = 82775299
    | Mm_Uniprot = Q8K2K6
  }}
}}
'''HIV-1 Rev binding protein''', also known as '''HRB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HRB HIV-1 Rev binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3267| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: HRB HIV-1 Rev binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3267| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
HRB (gene) has been shown to [[Protein-protein interaction|interact]] with [[EPS15L1]]<ref name=pmid10613896>{{cite journal | vauthors = Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP | title = The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport | journal = J. Cell Biol. | volume = 147 | issue = 7 | pages = 1379–84 | date = Dec 1999 | pmid = 10613896 | pmc = 2174238 | doi = 10.1083/jcb.147.7.1379 }}</ref> and [[EPS15]].<ref name=pmid10613896/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY | title = Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions | journal = Cell Res. | volume = 15 | issue = 11–12 | pages = 923–34 | year = 2006 | pmid = 16354571 | doi = 10.1038/sj.cr.7290370 }}
| citations =
* {{cite journal | vauthors = Bogerd HP, Fridell RA, Madore S, Cullen BR | title = Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins | journal = Cell | volume = 82 | issue = 3 | pages = 485–94 | year = 1995 | pmid = 7634337 | doi = 10.1016/0092-8674(95)90437-9 }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923-34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
* {{cite journal | vauthors = Fridell RA, Bogerd HP, Cullen BR | title = Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 9 | pages = 4421–4 | year = 1996 | pmid = 8633082 | pmc = 39553 | doi = 10.1073/pnas.93.9.4421 }}
*{{cite journal | author=Bogerd HP, Fridell RA, Madore S, Cullen BR |title=Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. |journal=Cell |volume=82 |issue= 3 |pages= 485-94 |year= 1995 |pmid= 7634337 |doi= }}
* {{cite journal | vauthors = Fritz CC, Green MR | title = HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs | journal = Curr. Biol. | volume = 6 | issue = 7 | pages = 848–54 | year = 1997 | pmid = 8805303 | doi = 10.1016/S0960-9822(02)00608-5 }}
*{{cite journal | author=Fritz CC, Zapp ML, Green MR |title=A human nucleoporin-like protein that specifically interacts with HIV Rev. |journal=Nature |volume=376 |issue= 6540 |pages= 530-3 |year= 1995 |pmid= 7637788 |doi= 10.1038/376530a0 }}
* {{cite journal | vauthors = Stutz F, Izaurralde E, Mattaj IW, Rosbash M | title = A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus | journal = Mol. Cell. Biol. | volume = 16 | issue = 12 | pages = 7144–50 | year = 1997 | pmid = 8943370 | pmc = 231718 | doi =  10.1128/mcb.16.12.7144}}
*{{cite journal | author=Fridell RA, Bogerd HP, Cullen BR |title=Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 9 |pages= 4421-4 |year= 1996 |pmid= 8633082 |doi= }}
* {{cite journal | vauthors = Jones T, Sheer D, Bevec D, Kappel B, Hauber J, Steinkasserer A | title = The human HIV-1 Rev binding-protein hRIP/Rab (HRB) maps to chromosome 2q36 | journal = Genomics | volume = 40 | issue = 1 | pages = 198–9 | year = 1997 | pmid = 9070945 | doi = 10.1006/geno.1996.4457 }}
*{{cite journal | author=Fritz CC, Green MR |title=HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 848-54 |year= 1997 |pmid= 8805303 |doi=  }}
* {{cite journal | vauthors = Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP | title = Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module | journal = Genes Dev. | volume = 11 | issue = 17 | pages = 2239–49 | year = 1997 | pmid = 9303539 | pmc = 275390 | doi = 10.1101/gad.11.17.2239 }}
*{{cite journal | author=Stutz F, Izaurralde E, Mattaj IW, Rosbash M |title=A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. |journal=Mol. Cell. Biol. |volume=16 |issue= 12 |pages= 7144-50 |year= 1997 |pmid= 8943370 |doi= }}
* {{cite journal | vauthors = Neville M, Stutz F, Lee L, Davis LI, Rosbash M | title = The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export | journal = Curr. Biol. | volume = 7 | issue = 10 | pages = 767–75 | year = 1998 | pmid = 9368759 | doi = 10.1016/S0960-9822(06)00335-6 }}
*{{cite journal | author=Jones T, Sheer D, Bevec D, ''et al.'' |title=The human HIV-1 Rev binding-protein hRIP/Rab (HRB) maps to chromosome 2q36. |journal=Genomics |volume=40 |issue= 1 |pages= 198-9 |year= 1997 |pmid= 9070945 |doi= 10.1006/geno.1996.4457 }}
* {{cite journal | vauthors = Güre AO, Altorki NK, Stockert E, Scanlan MJ, Old LJ, Chen YT | title = Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3 | journal = Cancer Res. | volume = 58 | issue = 5 | pages = 1034–41 | year = 1998 | pmid = 9500467 | doi =  }}
*{{cite journal | author=Salcini AE, Confalonieri S, Doria M, ''et al.'' |title=Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239-49 |year= 1997 |pmid= 9303539 |doi= }}
* {{cite journal | vauthors = Farjot G, Sergeant A, Mikaélian I | title = A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1 | journal = J. Biol. Chem. | volume = 274 | issue = 24 | pages = 17309–17 | year = 1999 | pmid = 10358091 | doi = 10.1074/jbc.274.24.17309 }}
*{{cite journal | author=Neville M, Stutz F, Lee L, ''et al.'' |title=The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. |journal=Curr. Biol. |volume=7 |issue= 10 |pages= 767-75 |year= 1998 |pmid= 9368759 |doi=  }}
* {{cite journal | vauthors = Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP | title = The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport | journal = J. Cell Biol. | volume = 147 | issue = 7 | pages = 1379–84 | year = 2000 | pmid = 10613896 | pmc = 2174238 | doi = 10.1083/jcb.147.7.1379 }}
*{{cite journal | author=Güre AO, Altorki NK, Stockert E, ''et al.'' |title=Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. |journal=Cancer Res. |volume=58 |issue= 5 |pages= 1034-41 |year= 1998 |pmid= 9500467 |doi= }}
* {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 7 | pages = 3491–6 | year = 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 }}
*{{cite journal | author=Farjot G, Sergeant A, Mikaélian I |title=A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 17309-17 |year= 1999 |pmid= 10358091 |doi= }}
* {{cite journal | vauthors = Yang J, Bogerd HP, Wang PJ, Page DC, Cullen BR | title = Two closely related human nuclear export factors utilize entirely distinct export pathways | journal = Mol. Cell | volume = 8 | issue = 2 | pages = 397–406 | year = 2001 | pmid = 11545741 | doi = 10.1016/S1097-2765(01)00303-3 }}
*{{cite journal | author=Doria M, Salcini AE, Colombo E, ''et al.'' |title=The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. |journal=J. Cell Biol. |volume=147 |issue= 7 |pages= 1379-84 |year= 2000 |pmid= 10613896 |doi= }}
* {{cite journal | vauthors = Chen D, Li X, Zhai Z, Shu HB | title = A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation | journal = J. Biol. Chem. | volume = 277 | issue = 18 | pages = 15985–91 | year = 2002 | pmid = 11854271 | doi = 10.1074/jbc.M108675200 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
* {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Mol. Biol. Cell | volume = 13 | issue = 11 | pages = 4100–9 | year = 2003 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
*{{cite journal | author=Yang J, Bogerd HP, Wang PJ, ''et al.'' |title=Two closely related human nuclear export factors utilize entirely distinct export pathways. |journal=Mol. Cell |volume=8 |issue= 2 |pages= 397-406 |year= 2001 |pmid= 11545741 |doi= }}
* {{cite journal | vauthors = Kiss A, Li L, Gettemeier T, Venkatesh LK | title = Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors | journal = Virology | volume = 314 | issue = 2 | pages = 591–600 | year = 2003 | pmid = 14554087 | doi = 10.1016/S0042-6822(03)00531-2 }}
*{{cite journal | author=Chen D, Li X, Zhai Z, Shu HB |title=A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15985-91 |year= 2002 |pmid= 11854271 |doi= 10.1074/jbc.M108675200 }}
* {{cite journal | vauthors = Sánchez-Velar N, Udofia EB, Yu Z, Zapp ML | title = hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region | journal = Genes Dev. | volume = 18 | issue = 1 | pages = 23–34 | year = 2004 | pmid = 14701878 | pmc = 314270 | doi = 10.1101/gad.1149704 }}
*{{cite journal | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Kiss A, Li L, Gettemeier T, Venkatesh LK |title=Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors. |journal=Virology |volume=314 |issue= 2 |pages= 591-600 |year= 2003 |pmid= 14554087 |doi=  }}
*{{cite journal  | author=Sánchez-Velar N, Udofia EB, Yu Z, Zapp ML |title=hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region. |journal=Genes Dev. |volume=18 |issue= 1 |pages= 23-34 |year= 2004 |pmid= 14701878 |doi= 10.1101/gad.1149704 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 14:04, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Arf-GAP domain and FG repeats-containing protein 1 is a protein that in humans is encoded by the AGFG1 gene.[1][2]

Function

The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[2]

Interactions

HRB (gene) has been shown to interact with EPS15L1[3] and EPS15.[3]

References

  1. ↑ Fritz CC, Zapp ML, Green MR (Sep 1995). "A human nucleoporin-like protein that specifically interacts with HIV Rev". Nature. 376 (6540): 530–3. doi:10.1038/376530a0. PMID 7637788.
  2. ↑ 2.0 2.1 "Entrez Gene: HRB HIV-1 Rev binding protein".
  3. ↑ 3.0 3.1 Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP (Dec 1999). "The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport". J. Cell Biol. 147 (7): 1379–84. doi:10.1083/jcb.147.7.1379. PMC 2174238. PMID 10613896.

Further reading


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