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{{Infobox_gene}}
{{PBB_Controls
'''LIM and senescent cell antigen-like-containing domain protein 1''' is a [[protein]] that in humans is encoded by the ''LIMS1'' [[gene]].<ref name="pmid7517666">{{cite journal | vauthors = Rearden A | title = A new LIM protein containing an autoepitope homologous to "senescent cell antigen" | journal = Biochem. Biophys. Res. Commun. | volume = 201 | issue = 3 | pages = 1124–31  | date = Aug 1994 | pmid = 7517666 | pmc =  | doi = 10.1006/bbrc.1994.1822 }}</ref><ref name="pmid10022929">{{cite journal | vauthors = Tu Y, Li F, Goicoechea S, Wu C | title = The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2425–34  | date = Mar 1999 | pmid = 10022929 | pmc = 84035 | doi = 10.1128/mcb.19.3.2425}}</ref><ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_LIMS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1g47.
| PDB = {{PDB2|1g47}}, {{PDB2|1nyp}}, {{PDB2|1u5s}}, {{PDB2|2cor}}, {{PDB2|2d8x}}
| Name = LIM and senescent cell antigen-like domains 1
| HGNCid = 6616
| Symbol = LIMS1
| AltSymbols =; PINCH; PINCH1
| OMIM = 602567
| ECnumber = 
| Homologene = 
| MGIid = 
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007569 |text = cell aging}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3987
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001129158
    | Hs_RefseqmRNA = XM_001129158
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''LIM and senescent cell antigen-like domains 1''', also known as '''LIMS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LIMS1 LIM and senescent cell antigen-like domains 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3987| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.<ref name="entrez">{{cite web | title = Entrez Gene: LIMS1 LIM and senescent cell antigen-like domains 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3987| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.<ref name="entrez">{{cite web | title = Entrez Gene: LIMS1 LIM and senescent cell antigen-like domains 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3987| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
LIMS1 has been shown to [[Protein-protein interaction|interact]] with [[Integrin-linked kinase]]<ref name=pmid10022929 /><ref name=pmid12167643>{{cite journal | vauthors = Zhang Y, Chen K, Guo L, Wu C | title = Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration | journal = J. Biol. Chem. | volume = 277 | issue = 41 | pages = 38328–38  | date = Oct 2002 | pmid = 12167643 | doi = 10.1074/jbc.M205576200 }}</ref> and [[NCK2]].<ref name=pmid10022929/><ref name=pmid9843575>{{cite journal | vauthors = Tu Y, Li F, Wu C | title = Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways | journal = Mol. Biol. Cell | volume = 9 | issue = 12 | pages = 3367–82  | date = Dec 1998 | pmid = 9843575 | pmc = 25640 | doi = 10.1091/mbc.9.12.3367 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Tu Y, Li F, Wu C | title = Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways | journal = Mol. Biol. Cell | volume = 9 | issue = 12 | pages = 3367–82 | year = 1998 | pmid = 9843575 | pmc = 25640 | doi = 10.1091/mbc.9.12.3367 }}
| citations =
* {{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = Int. J. Cancer | volume = 83 | issue = 4 | pages = 456–64 | year = 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
*{{cite journal | author=Rearden A |title=A new LIM protein containing an autoepitope homologous to "senescent cell antigen". |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 3 |pages= 1124-31 |year= 1994 |pmid= 7517666 |doi= 10.1006/bbrc.1994.1822 }}
* {{cite journal | vauthors = Velyvis A, Yang Y, Wu C, Qin J | title = Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain | journal = J. Biol. Chem. | volume = 276 | issue = 7 | pages = 4932–9 | year = 2001 | pmid = 11078733 | doi = 10.1074/jbc.M007632200 }}
*{{cite journal  | author=Tu Y, Li F, Wu C |title=Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. |journal=Mol. Biol. Cell |volume=9 |issue= 12 |pages= 3367-82 |year= 1999 |pmid= 9843575 |doi= }}
* {{cite journal | vauthors = Tu Y, Huang Y, Zhang Y, Hua Y, Wu C | title = A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading | journal = J. Cell Biol. | volume = 153 | issue = 3 | pages = 585–98 | year = 2001 | pmid = 11331308 | pmc = 2190577 | doi = 10.1083/jcb.153.3.585 }}
*{{cite journal  | author=Tu Y, Li F, Goicoechea S, Wu C |title=The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2425-34 |year= 1999 |pmid= 10022929 |doi=  }}
* {{cite journal | vauthors = Zhang Y, Chen K, Tu Y, Velyvis A, Yang Y, Qin J, Wu C | title = Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites | journal = J. Cell Sci. | volume = 115 | issue = Pt 24 | pages = 4777–86 | year = 2002 | pmid = 12432066 | doi = 10.1242/jcs.00166 }}
*{{cite journal | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi= }}
* {{cite journal | vauthors = Campana WM, Myers RR, Rearden A | title = Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury | journal = Glia | volume = 41 | issue = 3 | pages = 213–23 | year = 2003 | pmid = 12528177 | doi = 10.1002/glia.10138 }}
*{{cite journal | author=Velyvis A, Yang Y, Wu C, Qin J |title=Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4932-9 |year= 2001 |pmid= 11078733 |doi= 10.1074/jbc.M007632200 }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal | author=Tu Y, Huang Y, Zhang Y, ''et al.'' |title=A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading. |journal=J. Cell Biol. |volume=153 |issue= 3 |pages= 585-98 |year= 2001 |pmid= 11331308 |doi= }}
* {{cite journal | vauthors = Velyvis A, Vaynberg J, Yang Y, Vinogradova O, Zhang Y, Wu C, Qin J | title = Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling | journal = Nat. Struct. Biol. | volume = 10 | issue = 7 | pages = 558–64 | year = 2003 | pmid = 12794636 | doi = 10.1038/nsb938 }}
*{{cite journal | author=Zhang Y, Chen K, Tu Y, ''et al.'' |title=Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. |journal=J. Cell. Sci. |volume=115 |issue= Pt 24 |pages= 4777-86 |year= 2003 |pmid= 12432066 |doi=  }}
* {{cite journal | vauthors = Fukuda T, Chen K, Shi X, Wu C | title = PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51324–33 | year = 2003 | pmid = 14551191 | doi = 10.1074/jbc.M309122200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D | title = Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair | journal = Nature | volume = 432 | issue = 7016 | pages = 466–72 | year = 2004 | pmid = 15565145 | doi = 10.1038/nature03000 }}
*{{cite journal | author=Campana WM, Myers RR, Rearden A |title=Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury. |journal=Glia |volume=41 |issue= 3 |pages= 213-23 |year= 2003 |pmid= 12528177 |doi= 10.1002/glia.10138 }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | year = 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
* {{cite journal | vauthors = Dougherty GW, Chopp T, Qi SM, Cutler ML | title = The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions | journal = Exp. Cell Res. | volume = 306 | issue = 1 | pages = 168–79 | year = 2005 | pmid = 15878342 | doi = 10.1016/j.yexcr.2005.01.025 }}
*{{cite journal | author=Velyvis A, Vaynberg J, Yang Y, ''et al.'' |title=Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. |journal=Nat. Struct. Biol. |volume=10 |issue= 7 |pages= 558-64 |year= 2003 |pmid= 12794636 |doi= 10.1038/nsb938 }}
* {{cite journal | vauthors = Xu Z, Fukuda T, Li Y, Zha X, Qin J, Wu C | title = Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival | journal = J. Biol. Chem. | volume = 280 | issue = 30 | pages = 27631–7 | year = 2005 | pmid = 15941716 | doi = 10.1074/jbc.M504189200 }}
*{{cite journal | author=Fukuda T, Chen K, Shi X, Wu C |title=PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51324-33 |year= 2004 |pmid= 14551191 |doi= 10.1074/jbc.M309122200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Bock-Marquette I, Saxena A, White MD, ''et al.'' |title=Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. |journal=Nature |volume=432 |issue= 7016 |pages= 466-72 |year= 2004 |pmid= 15565145 |doi= 10.1038/nature03000 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Dougherty GW, Chopp T, Qi SM, Cutler ML |title=The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions. |journal=Exp. Cell Res. |volume=306 |issue= 1 |pages= 168-79 |year= 2005 |pmid= 15878342 |doi= 10.1016/j.yexcr.2005.01.025 }}
*{{cite journal | author=Xu Z, Fukuda T, Li Y, ''et al.'' |title=Molecular dissection of PINCH-1 reveals a mechanism of coupling and uncoupling of cell shape modulation and survival. |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 27631-7 |year= 2005 |pmid= 15941716 |doi= 10.1074/jbc.M504189200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3987}}


{{protein-stub}}
{{protein-stub}}
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Latest revision as of 20:12, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

LIM and senescent cell antigen-like-containing domain protein 1 is a protein that in humans is encoded by the LIMS1 gene.[1][2][3]

Function

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.[3]

Interactions

LIMS1 has been shown to interact with Integrin-linked kinase[2][4] and NCK2.[2][5]

References

  1. ↑ Rearden A (Aug 1994). "A new LIM protein containing an autoepitope homologous to "senescent cell antigen"". Biochem. Biophys. Res. Commun. 201 (3): 1124–31. doi:10.1006/bbrc.1994.1822. PMID 7517666.
  2. ↑ 2.0 2.1 2.2 Tu Y, Li F, Goicoechea S, Wu C (Mar 1999). "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells". Mol. Cell. Biol. 19 (3): 2425–34. doi:10.1128/mcb.19.3.2425. PMC 84035. PMID 10022929.
  3. ↑ 3.0 3.1 "Entrez Gene: LIMS1 LIM and senescent cell antigen-like domains 1".
  4. ↑ Zhang Y, Chen K, Guo L, Wu C (Oct 2002). "Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration". J. Biol. Chem. 277 (41): 38328–38. doi:10.1074/jbc.M205576200. PMID 12167643.
  5. ↑ Tu Y, Li F, Wu C (Dec 1998). "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways". Mol. Biol. Cell. 9 (12): 3367–82. doi:10.1091/mbc.9.12.3367. PMC 25640. PMID 9843575.

Further reading


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