TMEFF2: Difference between revisions

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{{Infobox_gene}}
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'''Tomoregulin-2''' is a [[protein]] that in humans is encoded by the ''TMEFF2'' [[gene]].<ref name="pmid10903839">{{cite journal | vauthors = Horie M, Mitsumoto Y, Kyushiki H, Kanemoto N, Watanabe A, Taniguchi Y, Nishino N, Okamoto T, Kondo M, Mori T, Noguchi K, Nakamura Y, Takahashi EI, Tanigami A | title = Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons | journal = Genomics | volume = 67 | issue = 2 | pages = 146–52 | date = July 2000 | pmid = 10903839 | pmc =  | doi = 10.1006/geno.2000.6228 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23671| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Transmembrane protein with EGF-like and two follistatin-like domains 2
| HGNCid = 11867
| Symbol = TMEFF2
| AltSymbols =; TR; HPP1; TENB2; TPEF
| OMIM = 605734
| ECnumber = 
| Homologene = 9417
| MGIid = 1861735
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23671
    | Hs_Ensembl = ENSG00000144339
    | Hs_RefseqProtein = NP_057276
    | Hs_RefseqmRNA = NM_016192
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 192523282
    | Hs_GenLoc_end = 192767887
    | Hs_Uniprot = Q9UIK5
    | Mm_EntrezGene = 56363
    | Mm_Ensembl = ENSMUSG00000026109
    | Mm_RefseqmRNA = NM_019790
    | Mm_RefseqProtein = NP_062764
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 50872068
    | Mm_GenLoc_end = 51131815
    | Mm_Uniprot = Q9QYM9
  }}
}}
'''Transmembrane protein with EGF-like and two follistatin-like domains 2''', also known as '''TMEFF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23671| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Uchida T, Wada K, Akamatsu T, Yonezawa M, Noguchi H, Mizoguchi A, Kasuga M, Sakamoto C | title = A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells | journal = Biochemical and Biophysical Research Communications | volume = 266 | issue = 2 | pages = 593–602 | date = December 1999 | pmid = 10600548 | doi = 10.1006/bbrc.1999.1873 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Liang G, Robertson KD, Talmadge C, Sumegi J, Jones PA | title = The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells | journal = Cancer Research | volume = 60 | issue = 17 | pages = 4907–12 | date = September 2000 | pmid = 10987305 | doi =  }}
*{{cite journal | author=Uchida T, Wada K, Akamatsu T, ''et al.'' |title=A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 2 |pages= 593-602 |year= 2000 |pmid= 10600548 |doi= 10.1006/bbrc.1999.1873 }}
* {{cite journal | vauthors = Young J, Biden KG, Simms LA, Huggard P, Karamatic R, Eyre HJ, Sutherland GR, Herath N, Barker M, Anderson GJ, Fitzpatrick DR, Ramm GA, Jass JR, Leggett BA | title = HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 1 | pages = 265–70 | date = January 2001 | pmid = 11120884 | pmc = 14579 | doi = 10.1073/pnas.011415298 }}
*{{cite journal | author=Horie M, Mitsumoto Y, Kyushiki H, ''et al.'' |title=Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons. |journal=Genomics |volume=67 |issue= 2 |pages= 146-52 |year= 2000 |pmid= 10903839 |doi= 10.1006/geno.2000.6228 }}
* {{cite journal | vauthors = Glynne-Jones E, Harper ME, Seery LT, James R, Anglin I, Morgan HE, Taylor KM, Gee JM, Nicholson RI | title = TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence | journal = International Journal of Cancer | volume = 94 | issue = 2 | pages = 178–84 | date = October 2001 | pmid = 11668495 | doi = 10.1002/ijc.1450 }}
*{{cite journal  | author=Liang G, Robertson KD, Talmadge C, ''et al.'' |title=The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells. |journal=Cancer Res. |volume=60 |issue= 17 |pages= 4907-12 |year= 2000 |pmid= 10987305 |doi=  }}
* {{cite journal | vauthors = Shibata DM, Sato F, Mori Y, Perry K, Yin J, Wang S, Xu Y, Olaru A, Selaru F, Spring K, Young J, Abraham JM, Meltzer SJ | title = Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas | journal = Cancer Research | volume = 62 | issue = 20 | pages = 5637–40 | date = October 2002 | pmid = 12384516 | doi =  }}
*{{cite journal | author=Young J, Biden KG, Simms LA, ''et al.'' |title=HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 1 |pages= 265-70 |year= 2001 |pmid= 11120884 |doi= 10.1073/pnas.011415298 }}
* {{cite journal | vauthors = Sato F, Shibata D, Harpaz N, Xu Y, Yin J, Mori Y, Wang S, Olaru A, Deacu E, Selaru FM, Kimos MC, Hytiroglou P, Young J, Leggett B, Gazdar AF, Toyooka S, Abraham JM, Meltzer SJ | title = Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma | journal = Cancer Research | volume = 62 | issue = 23 | pages = 6820–2 | date = December 2002 | pmid = 12460892 | doi =  }}
*{{cite journal | author=Glynne-Jones E, Harper ME, Seery LT, ''et al.'' |title=TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence. |journal=Int. J. Cancer |volume=94 |issue= 2 |pages= 178-84 |year= 2001 |pmid= 11668495 |doi= }}
* {{cite journal | vauthors = Gery S, Koeffler HP | title = Repression of the TMEFF2 promoter by c-Myc | journal = Journal of Molecular Biology | volume = 328 | issue = 5 | pages = 977–83 | date = May 2003 | pmid = 12729735 | doi = 10.1016/S0022-2836(03)00404-2 }}
*{{cite journal | author=Shibata DM, Sato F, Mori Y, ''et al.'' |title=Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas. |journal=Cancer Res. |volume=62 |issue= 20 |pages= 5637-40 |year= 2002 |pmid= 12384516 |doi=  }}
* {{cite journal | vauthors = Sabbioni S, Miotto E, Veronese A, Sattin E, Gramantieri L, Bolondi L, Calin GA, Gafà R, Lanza G, Carli G, Ferrazzi E, Feo C, Liboni A, Gullini S, Negrini M | title = Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood | journal = Molecular Diagnosis | volume = 7 | issue = 3-4 | pages = 201–7 | year = 2004 | pmid = 15068392 | doi = 10.2165/00066982-200307030-00010 }}
*{{cite journal | author=Sato F, Shibata D, Harpaz N, ''et al.'' |title=Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma. |journal=Cancer Res. |volume=62 |issue= 23 |pages= 6820-2 |year= 2003 |pmid= 12460892 |doi=  }}
* {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | date = October 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Schulmann K, Sterian A, Berki A, Yin J, Sato F, Xu Y, Olaru A, Wang S, Mori Y, Deacu E, Hamilton J, Kan T, Krasna MJ, Beer DG, Pepe MS, Abraham JM, Feng Z, Schmiegel W, Greenwald BD, Meltzer SJ | title = Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk | journal = Oncogene | volume = 24 | issue = 25 | pages = 4138–48 | date = June 2005 | pmid = 15824739 | doi = 10.1038/sj.onc.1208598 }}
*{{cite journal  | author=Gery S, Koeffler HP |title=Repression of the TMEFF2 promoter by c-Myc. |journal=J. Mol. Biol. |volume=328 |issue= 5 |pages= 977-83 |year= 2003 |pmid= 12729735 |doi= }}
* {{cite journal | vauthors = Suzuki M, Shigematsu H, Shames DS, Sunaga N, Takahashi T, Shivapurkar N, Iizasa T, Frenkel EP, Minna JD, Fujisawa T, Gazdar AF | title = DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers | journal = British Journal of Cancer | volume = 93 | issue = 9 | pages = 1029–37 | date = October 2005 | pmid = 16234815 | pmc = 2361683 | doi = 10.1038/sj.bjc.6602837 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Sabbioni S, Miotto E, Veronese A, ''et al.'' |title=Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood. |journal=Mol. Diagn. |volume=7 |issue= 3-4 |pages= 201-7 |year= 2004 |pmid= 15068392 |doi= }}
*{{cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Schulmann K, Sterian A, Berki A, ''et al.'' |title=Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk. |journal=Oncogene |volume=24 |issue= 25 |pages= 4138-48 |year= 2005 |pmid= 15824739 |doi= 10.1038/sj.onc.1208598 }}
*{{cite journal | author=Suzuki M, Shigematsu H, Shames DS, ''et al.'' |title=DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers. |journal=Br. J. Cancer |volume=93 |issue= 9 |pages= 1029-37 |year= 2005 |pmid= 16234815 |doi= 10.1038/sj.bjc.6602837 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-2-stub}}

Latest revision as of 11:58, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tomoregulin-2 is a protein that in humans is encoded by the TMEFF2 gene.[1][2]

References

  1. ↑ Horie M, Mitsumoto Y, Kyushiki H, Kanemoto N, Watanabe A, Taniguchi Y, Nishino N, Okamoto T, Kondo M, Mori T, Noguchi K, Nakamura Y, Takahashi EI, Tanigami A (July 2000). "Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons". Genomics. 67 (2): 146–52. doi:10.1006/geno.2000.6228. PMID 10903839.
  2. ↑ "Entrez Gene: TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2".

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Uchida T, Wada K, Akamatsu T, Yonezawa M, Noguchi H, Mizoguchi A, Kasuga M, Sakamoto C (December 1999). "A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells". Biochemical and Biophysical Research Communications. 266 (2): 593–602. doi:10.1006/bbrc.1999.1873. PMID 10600548.
  • Liang G, Robertson KD, Talmadge C, Sumegi J, Jones PA (September 2000). "The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells". Cancer Research. 60 (17): 4907–12. PMID 10987305.
  • Young J, Biden KG, Simms LA, Huggard P, Karamatic R, Eyre HJ, Sutherland GR, Herath N, Barker M, Anderson GJ, Fitzpatrick DR, Ramm GA, Jass JR, Leggett BA (January 2001). "HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers". Proceedings of the National Academy of Sciences of the United States of America. 98 (1): 265–70. doi:10.1073/pnas.011415298. PMC 14579. PMID 11120884.
  • Glynne-Jones E, Harper ME, Seery LT, James R, Anglin I, Morgan HE, Taylor KM, Gee JM, Nicholson RI (October 2001). "TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence". International Journal of Cancer. 94 (2): 178–84. doi:10.1002/ijc.1450. PMID 11668495.
  • Shibata DM, Sato F, Mori Y, Perry K, Yin J, Wang S, Xu Y, Olaru A, Selaru F, Spring K, Young J, Abraham JM, Meltzer SJ (October 2002). "Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas". Cancer Research. 62 (20): 5637–40. PMID 12384516.
  • Sato F, Shibata D, Harpaz N, Xu Y, Yin J, Mori Y, Wang S, Olaru A, Deacu E, Selaru FM, Kimos MC, Hytiroglou P, Young J, Leggett B, Gazdar AF, Toyooka S, Abraham JM, Meltzer SJ (December 2002). "Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma". Cancer Research. 62 (23): 6820–2. PMID 12460892.
  • Gery S, Koeffler HP (May 2003). "Repression of the TMEFF2 promoter by c-Myc". Journal of Molecular Biology. 328 (5): 977–83. doi:10.1016/S0022-2836(03)00404-2. PMID 12729735.
  • Sabbioni S, Miotto E, Veronese A, Sattin E, Gramantieri L, Bolondi L, Calin GA, Gafà R, Lanza G, Carli G, Ferrazzi E, Feo C, Liboni A, Gullini S, Negrini M (2004). "Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood". Molecular Diagnosis. 7 (3–4): 201–7. doi:10.2165/00066982-200307030-00010. PMID 15068392.
  • Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Schulmann K, Sterian A, Berki A, Yin J, Sato F, Xu Y, Olaru A, Wang S, Mori Y, Deacu E, Hamilton J, Kan T, Krasna MJ, Beer DG, Pepe MS, Abraham JM, Feng Z, Schmiegel W, Greenwald BD, Meltzer SJ (June 2005). "Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk". Oncogene. 24 (25): 4138–48. doi:10.1038/sj.onc.1208598. PMID 15824739.
  • Suzuki M, Shigematsu H, Shames DS, Sunaga N, Takahashi T, Shivapurkar N, Iizasa T, Frenkel EP, Minna JD, Fujisawa T, Gazdar AF (October 2005). "DNA methylation-associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers". British Journal of Cancer. 93 (9): 1029–37. doi:10.1038/sj.bjc.6602837. PMC 2361683. PMID 16234815.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.


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