B3GNT2: Difference between revisions

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Latest revision as of 02:23, 30 August 2017

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene.^[1]^[2]^[3]

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains.^[3]

References

↑ Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T (Mar 1999). "A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases". Proc Natl Acad Sci U S A. 96 (2): 406–11. doi:10.1073/pnas.96.2.406. PMC 15149. PMID 9892646.
↑ Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K (May 2001). "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family". J Biol Chem. 276 (5): 3498–507. doi:10.1074/jbc.M004800200. PMID 11042166.
↑ ^3.0 ^3.1 "Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2".

External links

Human B3GNT2 genome location and B3GNT2 gene details page in the UCSC Genome Browser.

Amado M, Almeida R, Schwientek T, Clausen H (2000). "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions". Biochim. Biophys. Acta. 1473 (1): 35–53. doi:10.1016/S0304-4165(99)00168-3. PMID 10580128.
Ju T, Cummings RD (2003). "A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16613–8. doi:10.1073/pnas.262438199. PMC 139192. PMID 12464682.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Isshiki S, Kudo T, Nishihara S, et al. (2003). "Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins". J. Biol. Chem. 278 (38): 36611–20. doi:10.1074/jbc.M302681200. PMID 12855703.
Hayashi N, Nakamori S, Okami J, et al. (2004). "Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue". Pathobiology. 71 (1): 26–34. doi:10.1159/000072959. PMID 14555842.
Mare L, Trinchera M (2004). "Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans". Eur. J. Biochem. 271 (1): 186–94. doi:10.1046/j.1432-1033.2003.03919.x. PMID 14686931.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zheng H, Li Y, Ji C, et al. (2005). "Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase". Mol. Biol. Rep. 31 (3): 171–5. doi:10.1023/B:MOLE.0000043552.32411.67. PMID 15560372.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[pmid9892646-1] Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T (Mar 1999). "A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases". Proc Natl Acad Sci U S A. 96 (2): 406–11. doi:10.1073/pnas.96.2.406. PMC 15149. PMID 9892646.

[pmid11042166-2] Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K (May 2001). "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family". J Biol Chem. 276 (5): 3498–507. doi:10.1074/jbc.M004800200. PMID 11042166.

[entrez-3] 3.0 ^3.1 "Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2''' is an [[enzyme]] that in humans is encoded by the ''B3GNT2'' [[gene]].<ref name="pmid9892646">{{cite journal | vauthors = Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T | title = A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 2 | pages = 406–11 |date=Mar 1999 | pmid = 9892646 | pmc = 15149 | doi =10.1073/pnas.96.2.406  }}</ref><ref name="pmid11042166">{{cite journal | vauthors = Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K | title = Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family | journal = J Biol Chem | volume = 276 | issue = 5 | pages = 3498–507 |date=May 2001 | pmid = 11042166 | pmc =  | doi = 10.1074/jbc.M004800200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10678| accessdate = }}</ref>
-| update_page = yes
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
- | HGNCid = 15629
- | Symbol = B3GNT2
- | AltSymbols =; B3GN-T1; B3GN-T2; B3GNT; B3GNT-2; B3GNT1; BETA3GNT
- | OMIM = 605581
- | ECnumber =
- | Homologene = 4797
- | MGIid = 1889505
- | GeneAtlas_image1 = PBB_GE_B3GNT2_219326_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0008378 |text = galactosyltransferase activity}} {{GNF_GO|id=GO:0008499 |text = UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
-  | Process = {{GNF_GO|id=GO:0006486 |text = protein amino acid glycosylation}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10678
-    | Hs_Ensembl = ENSG00000170340
-    | Hs_RefseqProtein = NP_006568
-    | Hs_RefseqmRNA = NM_006577
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 62276766
-    | Hs_GenLoc_end = 62305368
-    | Hs_Uniprot = Q9NY97
-    | Mm_EntrezGene = 53625
-    | Mm_Ensembl = ENSMUSG00000051650
-    | Mm_RefseqmRNA = NM_016888
-    | Mm_RefseqProtein = NP_058584
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 22734734
-    | Mm_GenLoc_end = 22760336
-    | Mm_Uniprot = Q5SQC0
-  }}
-}}
-'''UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2''', also known as '''B3GNT2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10678| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains.<ref name="entrez">{{cite web | title = Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10678| accessdate = }}</ref>
+| summary_text = This gene encodes a member of the [[Beta-1,3-N-acetylglucosaminyltransferase 3|beta-1,3-N-acetylglucosaminyltransferase]] family. This enzyme is a type II [[transmembrane protein]]. It prefers the [[Enzyme substrate (biology)|substrate]] of lacto-N-neotetraose, and is involved in the [[biosynthesis]] of poly-N-acetyllactosamine chains.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|B3GNT2}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Amado M, Almeida R, Schwientek T, Clausen H |title=Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. |journal=Biochim. Biophys. Acta |volume=1473 |issue= 1 |pages= 35-53 |year= 2000 |pmid= 10580128 |doi=  }}
+*{{cite journal  | vauthors=Amado M, Almeida R, Schwientek T, Clausen H |title=Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions |journal=Biochim. Biophys. Acta |volume=1473 |issue= 1 |pages= 35–53 |year= 2000 |pmid= 10580128 |doi=  10.1016/S0304-4165(99)00168-3}}
-*{{cite journal  | author=Zhou D, Dinter A, Gutiérrez Gallego R, ''et al.'' |title=A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 406-11 |year= 1999 |pmid= 9892646 |doi=  }}
+*{{cite journal  | vauthors=Ju T, Cummings RD |title=A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16613–8 |year= 2003 |pmid= 12464682 |doi= 10.1073/pnas.262438199  | pmc=139192 }}
-*{{cite journal  | author=Shiraishi N, Natsume A, Togayachi A, ''et al.'' |title=Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 3498-507 |year= 2001 |pmid= 11042166 |doi= 10.1074/jbc.M004800200 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Ju T, Cummings RD |title=A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16613-8 |year= 2003 |pmid= 12464682 |doi= 10.1073/pnas.262438199 }}
+*{{cite journal  | vauthors=Isshiki S, Kudo T, Nishihara S |title=Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36611–20 |year= 2003 |pmid= 12855703 |doi= 10.1074/jbc.M302681200 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Hayashi N, Nakamori S, Okami J |title=Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue |journal=Pathobiology |volume=71 |issue= 1 |pages= 26–34 |year= 2004 |pmid= 14555842 |doi= 10.1159/000072959 |display-authors=etal}}
-*{{cite journal  | author=Isshiki S, Kudo T, Nishihara S, ''et al.'' |title=Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36611-20 |year= 2003 |pmid= 12855703 |doi= 10.1074/jbc.M302681200 }}
+*{{cite journal  | vauthors=Mare L, Trinchera M |title=Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans |journal=Eur. J. Biochem. |volume=271 |issue= 1 |pages= 186–94 |year= 2004 |pmid= 14686931 |doi=10.1046/j.1432-1033.2003.03919.x  }}
-*{{cite journal  | author=Hayashi N, Nakamori S, Okami J, ''et al.'' |title=Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue. |journal=Pathobiology |volume=71 |issue= 1 |pages= 26-34 |year= 2004 |pmid= 14555842 |doi= 10.1159/000072959 }}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Mare L, Trinchera M |title=Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans. |journal=Eur. J. Biochem. |volume=271 |issue= 1 |pages= 186-94 |year= 2004 |pmid= 14686931 |doi=  }}
+*{{cite journal  | vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8  | pmc=395752 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 }}
+*{{cite journal  | vauthors=Zheng H, Li Y, Ji C |title=Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase |journal=Mol. Biol. Rep. |volume=31 |issue= 3 |pages= 171–5 |year= 2005 |pmid= 15560372 |doi=10.1023/B:MOLE.0000043552.32411.67  |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065  | pmc=1850943 |display-authors=etal}}
-*{{cite journal  | author=Zheng H, Li Y, Ji C, ''et al.'' |title=Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase. |journal=Mol. Biol. Rep. |volume=31 |issue= 3 |pages= 171-5 |year= 2005 |pmid= 15560372 |doi=  }}
-*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
 }}
 {{refend}}
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+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
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+| update_citations = yes
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+{{gene-2-stub}}

B3GNT2: Difference between revisions

Latest revision as of 02:23, 30 August 2017

References

External links

Further reading

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