PPM1B: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein phosphatase 1B''' is an [[enzyme]] that in humans is encoded by the ''PPM1B'' [[gene]].<ref name="pmid9684878">{{cite journal | vauthors = Marley AE, Kline A, Crabtree G, Sullivan JE, Beri RK | title = The cloning expression and tissue distribution of human PP2Cbeta | journal = FEBS Lett | volume = 431 | issue = 1 | pages = 121–4 | date = August 1998 | pmid = 9684878 | pmc =  | doi = 10.1016/S0014-5793(98)00708-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPM1B protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5495| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PPM1B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2p8e.
| PDB = {{PDB2|2p8e}}
| Name = Protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform
| HGNCid = 9276
| Symbol = PPM1B
| AltSymbols =; MGC21657; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX
| OMIM = 603770
| ECnumber = 
| Homologene = 2027
| MGIid = 101841
| GeneAtlas_image1 = PBB_GE_PPM1B_213225_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003824 |text = catalytic activity}} {{GNF_GO|id=GO:0004722 |text = protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0015071 |text = protein phosphatase type 2C activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}}
| Component = {{GNF_GO|id=GO:0008287 |text = protein serine/threonine phosphatase complex}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5495
    | Hs_Ensembl = ENSG00000138032
    | Hs_RefseqProtein = NP_001028728
    | Hs_RefseqmRNA = NM_001033556
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 44249504
    | Hs_GenLoc_end = 44325029
    | Hs_Uniprot = O75688
    | Mm_EntrezGene = 19043
    | Mm_Ensembl = ENSMUSG00000061130
    | Mm_RefseqmRNA = XM_984927
    | Mm_RefseqProtein = XP_990021
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 84866325
    | Mm_GenLoc_end = 84922931
    | Mm_Uniprot = Q3V461
  }}
}}
'''Protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform''', also known as '''PPM1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPM1B protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5495| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein [[phosphatase]]s. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate [[cyclin-dependent kinase]]s (CDKs), and thus may be involved in [[cell cycle]] control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.<ref name="entrez">{{cite web | title = Entrez Gene: PPM1B protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5495| accessdate = }}</ref>
PPM1B has been shown to [[Protein-protein interaction|interact]] with:
}}
* [[Cyclin-dependent kinase 2|CDK2]],<ref name = pmid10934208>{{cite journal | vauthors = Cheng A, Kaldis P, Solomon MJ | title = Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms | journal = J. Biol. Chem. | volume = 275 | issue = 44 | pages = 34744–9 | date = November 2000 | pmid = 10934208 | doi = 10.1074/jbc.M006210200 }}</ref>
* [[Cyclin-dependent kinase 6|CDK6]],<ref name = pmid10934208/>
* [[CHUK]],<ref name = pmid14585847/>
* [[IKBKG]],<ref name = pmid14585847>{{cite journal | vauthors = Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB | title = Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity | journal = J. Biol. Chem. | volume = 279 | issue = 3 | pages = 1739–46 | date = January 2004 | pmid = 14585847 | doi = 10.1074/jbc.M306273200 }}</ref>
* [[IKK2]],<ref name = pmid14585847/>
* [[MAP3K7]],<ref name = pmid11104763>{{cite journal | vauthors = Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, Kanamaru R, Matsumoto K, Tamura S | title = Regulation of the TAK1 signaling pathway by protein phosphatase 2C | journal = J. Biol. Chem. | volume = 276 | issue = 8 | pages = 5753–9 | date = February 2001 | pmid = 11104763 | doi = 10.1074/jbc.M007773200 }}</ref> and
* [[PPARγ]].<ref name = pmid23320500>{{cite journal | vauthors = Tasdelen I, van Beekum O, Gorbenko O, Fleskens V, van den Broek NJ, Koppen A, Hamers N, Berger R, Coffer PJ, Brenkman AB, Kalkhoven E | title = The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity | journal = Biochem. J. | volume = 451 | issue = 1 | pages = 45–53 | pmid = 23320500 | doi = 10.1042/BJ20121113 }}</ref>
 
== References==
{{reflist}}
{{Clear}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Hishiya A, Ohnishi M, Tamura S, Nakamura F | title = Protein phosphatase 2C inactivates F-actin binding of human platelet moesin. | journal = J. Biol. Chem. | volume = 274 | issue = 38 | pages = 26705–12 | year = 1999 | pmid = 10480873 | doi = 10.1074/jbc.274.38.26705 }}
| citations =
*{{cite journal | vauthors = Cheng A, Ross KE, Kaldis P, Solomon MJ | title = Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. | journal = Genes Dev. | volume = 13 | issue = 22 | pages = 2946–57 | year = 2000 | pmid = 10580002 | pmc = 317162 | doi = 10.1101/gad.13.22.2946 }}
*{{cite journal | author=Marley AE, Kline A, Crabtree G, ''et al.'' |title=The cloning expression and tissue distribution of human PP2Cbeta. |journal=FEBS Lett. |volume=431 |issue= 1 |pages= 121-4 |year= 1998 |pmid= 9684878 |doi=  }}
*{{cite journal | vauthors = Cheng A, Kaldis P, Solomon MJ | title = Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms. | journal = J. Biol. Chem. | volume = 275 | issue = 44 | pages = 34744–9 | year = 2000 | pmid = 10934208 | doi = 10.1074/jbc.M006210200 }}
*{{cite journal  | author=Hishiya A, Ohnishi M, Tamura S, Nakamura F |title=Protein phosphatase 2C inactivates F-actin binding of human platelet moesin. |journal=J. Biol. Chem. |volume=274 |issue= 38 |pages= 26705-12 |year= 1999 |pmid= 10480873 |doi= }}
*{{cite journal | vauthors = Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, Kanamaru R, Matsumoto K, Tamura S | title = Regulation of the TAK1 signaling pathway by protein phosphatase 2C. | journal = J. Biol. Chem. | volume = 276 | issue = 8 | pages = 5753–9 | year = 2001 | pmid = 11104763 | doi = 10.1074/jbc.M007773200 }}
*{{cite journal | author=Cheng A, Ross KE, Kaldis P, Solomon MJ |title=Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. |journal=Genes Dev. |volume=13 |issue= 22 |pages= 2946-57 |year= 2000 |pmid= 10580002 |doi= }}
*{{cite journal | vauthors = Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E | title = A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease. | journal = Am. J. Hum. Genet. | volume = 69 | issue = 4 | pages = 869–75 | year = 2001 | pmid = 11524703 | pmc = 1226072 | doi = 10.1086/323624 }}
*{{cite journal | author=Cheng A, Kaldis P, Solomon MJ |title=Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34744-9 |year= 2000 |pmid= 10934208 |doi= 10.1074/jbc.M006210200 }}
*{{cite journal | vauthors = Seroussi E, Shani N, Ben-Meir D, Chajut A, Divinski I, Faier S, Gery S, Karby S, Kariv-Inbal Z, Sella O, Smorodinsky NI, Lavi S | title = Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta. | journal = J. Mol. Biol. | volume = 312 | issue = 3 | pages = 439–51 | year = 2001 | pmid = 11563908 | doi = 10.1006/jmbi.2001.4967 }}
*{{cite journal | author=Hanada M, Ninomiya-Tsuji J, Komaki K, ''et al.'' |title=Regulation of the TAK1 signaling pathway by protein phosphatase 2C. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5753-9 |year= 2001 |pmid= 11104763 |doi= 10.1074/jbc.M007773200 }}
*{{cite journal | vauthors = Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB | title = Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity. | journal = J. Biol. Chem. | volume = 279 | issue = 3 | pages = 1739–46 | year = 2004 | pmid = 14585847 | doi = 10.1074/jbc.M306273200 }}
*{{cite journal | author=Parvari R, Brodyansky I, Elpeleg O, ''et al.'' |title=A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease. |journal=Am. J. Hum. Genet. |volume=69 |issue= 4 |pages= 869-75 |year= 2001 |pmid= 11524703 |doi= }}
*{{cite journal | vauthors = Parvari R, Gonen Y, Alshafee I, Buriakovsky S, Regev K, Hershkovitz E | title = The 2p21 deletion syndrome: characterization of the transcription content. | journal = Genomics | volume = 86 | issue = 2 | pages = 195–211 | year = 2005 | pmid = 15913950 | doi = 10.1016/j.ygeno.2005.04.001 }}
*{{cite journal | author=Seroussi E, Shani N, Ben-Meir D, ''et al.'' |title=Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta. |journal=J. Mol. Biol. |volume=312 |issue= 3 |pages= 439-51 |year= 2001 |pmid= 11563908 |doi= 10.1006/jmbi.2001.4967 }}
*{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Prajapati S, Verma U, Yamamoto Y, ''et al.'' |title=Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity. |journal=J. Biol. Chem. |volume=279 |issue= 3 |pages= 1739-46 |year= 2004 |pmid= 14585847 |doi= 10.1074/jbc.M306273200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Parvari R, Gonen Y, Alshafee I, ''et al.'' |title=The 2p21 deletion syndrome: characterization of the transcription content. |journal=Genomics |volume=86 |issue= 2 |pages= 195-211 |year= 2005 |pmid= 15913950 |doi= 10.1016/j.ygeno.2005.04.001 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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{{PDB Gallery|geneid=5495}}
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{{gene-2-stub}}

Latest revision as of 18:32, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.[1][2]

Function

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.[2]

Interactions

PPM1B has been shown to interact with:

References

  1. ↑ Marley AE, Kline A, Crabtree G, Sullivan JE, Beri RK (August 1998). "The cloning expression and tissue distribution of human PP2Cbeta". FEBS Lett. 431 (1): 121–4. doi:10.1016/S0014-5793(98)00708-X. PMID 9684878.
  2. ↑ 2.0 2.1 "Entrez Gene: PPM1B protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform".
  3. ↑ 3.0 3.1 Cheng A, Kaldis P, Solomon MJ (November 2000). "Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms". J. Biol. Chem. 275 (44): 34744–9. doi:10.1074/jbc.M006210200. PMID 10934208.
  4. ↑ 4.0 4.1 4.2 Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB (January 2004). "Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity". J. Biol. Chem. 279 (3): 1739–46. doi:10.1074/jbc.M306273200. PMID 14585847.
  5. ↑ Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, Kanamaru R, Matsumoto K, Tamura S (February 2001). "Regulation of the TAK1 signaling pathway by protein phosphatase 2C". J. Biol. Chem. 276 (8): 5753–9. doi:10.1074/jbc.M007773200. PMID 11104763.
  6. ↑ Tasdelen I, van Beekum O, Gorbenko O, Fleskens V, van den Broek NJ, Koppen A, Hamers N, Berger R, Coffer PJ, Brenkman AB, Kalkhoven E. "The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity". Biochem. J. 451 (1): 45–53. doi:10.1042/BJ20121113. PMID 23320500.

Further reading


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