Gem-associated protein 6: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Gem-associated protein 6''' is a [[protein]] that in humans is encoded by the ''GEMIN6'' [[gene]].<ref name="pmid11748230">{{cite journal | vauthors = Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G | title = Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7540–5 | date = Mar 2002 | pmid = 11748230 | pmc = | doi = 10.1074/jbc.M110141200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79833| accessdate = }}</ref>The gem-associated proteins are those found in the [[Cell nucleus#Cajal bodies and gems|gems of Cajal bodies]].
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GEMIN6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y96.
| PDB = {{PDB2|1y96}}
| Name = Gem (nuclear organelle) associated protein 6
| HGNCid = 20044
| Symbol = GEMIN6
| AltSymbols =; FLJ23459
| OMIM = 607006
| ECnumber = 
| Homologene = 11711
| MGIid = 1914492
| GeneAtlas_image1 = PBB_GE_GEMIN6_219539_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016604 |text = nuclear body}}
| Process = {{GNF_GO|id=GO:0000245 |text = spliceosome assembly}} {{GNF_GO|id=GO:0000387 |text = spliceosomal snRNP biogenesis}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 79833
    | Hs_Ensembl = ENSG00000152147
    | Hs_RefseqProtein = NP_079051
    | Hs_RefseqmRNA = NM_024775
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 38858831
    | Hs_GenLoc_end = 38863102
    | Hs_Uniprot = Q8WXD5
    | Mm_EntrezGene = 67242
    | Mm_Ensembl = ENSMUSG00000055760
    | Mm_RefseqmRNA = NM_026053
    | Mm_RefseqProtein = NP_080329
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 80132815
    | Mm_GenLoc_end = 80136823
    | Mm_Uniprot = Q9CX53
  }}
}}
'''Gem (nuclear organelle) associated protein 6''', also known as '''GEMIN6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79833| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GEMIN6 is part of a large macromolecular complex, the [[survival of motor neuron protein|SMN]] localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of [[small nuclear ribonucleoprotein]]s (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79833| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
Gem-associated protein 6 has been shown to [[Protein-protein interaction|interact]] with [[gem-associated protein 7]].<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | display-authors = 6 | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid12065586>{{cite journal | vauthors = Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G | title = Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 35 | pages = 31957–62 | date = Aug 2002 | pmid = 12065586 | doi = 10.1074/jbc.M203478200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G | title = Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 35 | pages = 31957–62 | date = Aug 2002 | pmid = 12065586 | doi = 10.1074/jbc.M203478200 }}
| citations =
* {{cite journal | vauthors = Ma Y, Dostie J, Dreyfuss G, Van Duyne GD | title = The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure | journal = Structure | volume = 13 | issue = 6 | pages = 883–92 | date = Jun 2005 | pmid = 15939020 | doi = 10.1016/j.str.2005.03.014 }}
*{{cite journal | author=Pellizzoni L, Baccon J, Rappsilber J, ''et al.'' |title=Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7540-5 |year= 2002 |pmid= 11748230 |doi= 10.1074/jbc.M110141200 }}
* {{cite journal | vauthors = Carissimi C, Saieva L, Gabanella F, Pellizzoni L | title = Gemin8 is required for the architecture and function of the survival motor neuron complex | journal = The Journal of Biological Chemistry | volume = 281 | issue = 48 | pages = 37009–16 | date = Dec 2006 | pmid = 17023415 | doi = 10.1074/jbc.M607505200 }}
*{{cite journal  | author=Baccon J, Pellizzoni L, Rappsilber J, ''et al.'' |title=Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31957-62 |year= 2002 |pmid= 12065586 |doi= 10.1074/jbc.M203478200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Ma Y, Dostie J, Dreyfuss G, Van Duyne GD |title=The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure. |journal=Structure |volume=13 |issue= 6 |pages= 883-92 |year= 2005 |pmid= 15939020 |doi= 10.1016/j.str.2005.03.014 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Carissimi C, Saieva L, Gabanella F, Pellizzoni L |title=Gemin8 is required for the architecture and function of the survival motor neuron complex. |journal=J. Biol. Chem. |volume=281 |issue= 48 |pages= 37009-16 |year= 2007 |pmid= 17023415 |doi= 10.1074/jbc.M607505200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=79833}}
{{WikiDoc Sources}}
{{Nucleus}}
 
{{gene-2-stub}}

Latest revision as of 02:15, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.[1][2]The gem-associated proteins are those found in the gems of Cajal bodies.

Function

GEMIN6 is part of a large macromolecular complex, the SMN localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM][2]

Interactions

Gem-associated protein 6 has been shown to interact with gem-associated protein 7.[3][4]

References

  1. ↑ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
  2. ↑ 2.0 2.1 "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6".
  3. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  4. ↑ Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.

Further reading

  • Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
  • Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (Jun 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
  • Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.
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