DYNC1I2: Difference between revisions

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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Cytoplasmic dynein 1 intermediate chain 2''' is a [[protein]] that in humans is encoded by the ''DYNC1I2'' [[gene]].<ref name="pmid10049579">{{cite journal | vauthors = Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC | title = Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human | journal = Genomics | volume = 55 | issue = 3 | pages = 257–67 |date=May 1999 | pmid = 10049579 | pmc =  | doi = 10.1006/geno.1998.5665 }}</ref><ref name="pmid16260502">{{cite journal | vauthors = Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB | title = Cytoplasmic dynein nomenclature | journal = J Cell Biol | volume = 171 | issue = 3 | pages = 411–3 |date=Nov 2005 | pmid = 16260502 | pmc = 2171247 | doi = 10.1083/jcb.200508078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1781| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_DYNC1I2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2pg1.
| PDB = {{PDB2|2pg1}}
| Name = Dynein, cytoplasmic 1, intermediate chain 2
| HGNCid = 2964
| Symbol = DYNC1I2
| AltSymbols =; DNCI2; FLJ21089; FLJ90842; IC2; MGC104199; MGC111094; MGC9324
| OMIM = 603331
| ECnumber =
| Homologene = 37921
| MGIid = 107750
  | GeneAtlas_image1 = PBB_GE_DYNC1I2_211684_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}}  
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0030286 |text = dynein complex}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1781
    | Hs_Ensembl = ENSG00000077380
    | Hs_RefseqProtein = NP_001369
    | Hs_RefseqmRNA = NM_001378
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 172252226
    | Hs_GenLoc_end = 172313165
    | Hs_Uniprot = Q13409
    | Mm_EntrezGene = 13427
    | Mm_Ensembl = ENSMUSG00000027012
    | Mm_RefseqmRNA = NM_010064
    | Mm_RefseqProtein = NP_034194
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 71012815
    | Mm_GenLoc_end = 71064133
    | Mm_Uniprot = Q3UDA2
  }}
}}
'''Dynein, cytoplasmic 1, intermediate chain 2''', also known as '''DYNC1I2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1781| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Vaughan KT, Vallee RB |title=Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. |journal=J. Cell Biol. |volume=131 |issue= 6 Pt 1 |pages= 1507-16 |year= 1996 |pmid= 8522607 |doi= }}
*{{cite journal  | vauthors=Vaughan KT, Vallee RB |title=Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued |journal=J. Cell Biol. |volume=131 |issue= 6 Pt 1 |pages= 1507–16 |year= 1996 |pmid= 8522607 |doi=10.1083/jcb.131.6.1507  | pmc=2120689  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3 | last4=Suyama  | first4=A  | last5=Sugano  | first5=S  }}
*{{cite journal  | author=Crackower MA, Sinasac DS, Xia J, ''et al.'' |title=Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. |journal=Genomics |volume=55 |issue= 3 |pages= 257-67 |year= 1999 |pmid= 10049579 |doi= 10.1006/geno.1998.5665 }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Wiemann S |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 |name-list-format=vanc| author2=Weil B  | author3=Wellenreuther R  | display-authors=3  | last4=Gassenhuber  | first4=J  | last5=Glassl  | first5=S  | last6=Ansorge  | first6=W  | last7=Böcher  | first7=M  | last8=Blöcker  | first8=H  | last9=Bauersachs  | first9=S }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Davies TH, Ning YM, Sánchez ER |title=A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4597–600 |year= 2002 |pmid= 11751894 |doi= 10.1074/jbc.C100531200 }}
*{{cite journal | author=Davies TH, Ning YM, Sánchez ER |title=A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4597-600 |year= 2002 |pmid= 11751894 |doi= 10.1074/jbc.C100531200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Fortna A |title=Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution |journal=PLoS Biol. |volume=2 |issue= 7 |pages= E207 |year= 2006 |pmid= 15252450 |doi= 10.1371/journal.pbio.0020207  | pmc=449870  |name-list-format=vanc| author2=Kim Y  | author3=MacLaren E | display-authors=3  | last4=Marshall  | first4=Kriste  | last5=Hahn  | first5=Gretchen  | last6=Meltesen  | first6=Lynne  | last7=Brenton  | first7=Matthew  | last8=Hink  | first8=Raquel  | last9=Burgers  | first9=Sonya }}
*{{cite journal | author=Fortna A, Kim Y, MacLaren E, ''et al.'' |title=Lineage-specific gene duplication and loss in human and great ape evolution. |journal=PLoS Biol. |volume=2 |issue= 7 |pages= E207 |year= 2006 |pmid= 15252450 |doi= 10.1371/journal.pbio.0020207 }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J  | last9=Hofmann  | first9=O }}
*{{cite journal | author=Pfister KK, Fisher EM, Gibbons IR, ''et al.'' |title=Cytoplasmic dynein nomenclature. |journal=J. Cell Biol. |volume=171 |issue= 3 |pages= 411-3 |year= 2006 |pmid= 16260502 |doi= 10.1083/jcb.200508078 }}
*{{cite journal  | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948  |name-list-format=vanc| author2=Chu P  | author3=Elisma F  | display-authors=3  | last4=Li  | first4=Hongyan  | last5=Taylor  | first5=Paul  | last6=Climie  | first6=Shane  | last7=McBroom-Cerajewski  | first7=Linda  | last8=Robinson  | first8=Mark D  | last9=O'Connor | first9=Liam }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1781}}
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Latest revision as of 18:47, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cytoplasmic dynein 1 intermediate chain 2 is a protein that in humans is encoded by the DYNC1I2 gene.[1][2][3]


References

  1. ↑ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579.
  2. ↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  3. ↑ "Entrez Gene: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2".

Further reading



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