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{{Infobox_gene}}
{{PBB_Controls
'''Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta''' is an [[enzyme]] that in humans is encoded by the ''PDE6D'' [[gene]].<ref name="pmid9533031">{{cite journal | vauthors = Ershova G, Derré J, Chételin S, Nancy V, Berger R, Kaplan J, Munnich A, de Gunzburg J | title = cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36 | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1-2 | pages = 139–41 | date = Apr 1998 | pmid = 9533031 | pmc =  | doi = 10.1159/000134701 }}</ref><ref name="pmid9570951">{{cite journal | vauthors = Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA, Baehr W | title = Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene | journal = Genomics | volume = 49 | issue = 1 | pages = 76–82 | date = Apr 1998 | pmid = 9570951 | pmc =  | doi = 10.1006/geno.1998.5210 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5147| accessdate = }}</ref> PDE6D was originally identified as a fourth subunit of [[rod cell]]-specific [[cyclic guanosine monophosphate|cGMP]] [[phosphodiesterase]] (PDE) ({{EC number|3.1.4.35}}). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.<ref name="PUB00010494">{{cite journal |vauthors=Wittinghofer A, Renault L, Hanzal-bayer M, Roversi P, Hillig RC |title=The complex of Arl2-GTP and PDE delta: from structure to function |journal=EMBO J. |volume=21 |issue=9 |pages=2095–2106 |year=2002 |pmid=11980706 |doi=10.1093/emboj/21.9.2095 |pmc=125981}}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PDE6D_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ksg.
| PDB = {{PDB2|1ksg}}, {{PDB2|1ksh}}, {{PDB2|1ksj}}
| Name = Phosphodiesterase 6D, cGMP-specific, rod, delta
| HGNCid = 8788
| Symbol = PDE6D
| AltSymbols =; PDED
| OMIM = 602676
| ECnumber = 
| Homologene = 1954
| MGIid = 1270843
| GeneAtlas_image1 = PBB_GE_PDE6D_204091_at_tn.png
| Function = {{GNF_GO|id=GO:0004114 |text = 3',5'-cyclic-nucleotide phosphodiesterase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5147
    | Hs_Ensembl = ENSG00000156973
    | Hs_RefseqProtein = NP_002592
    | Hs_RefseqmRNA = NM_002601
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 232305380
    | Hs_GenLoc_end = 232354217
    | Hs_Uniprot = O43924
    | Mm_EntrezGene = 18582
    | Mm_Ensembl = ENSMUSG00000026239
    | Mm_RefseqmRNA = XM_974388
    | Mm_RefseqProtein = XP_979482
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 88374186
    | Mm_GenLoc_end = 88413672
    | Mm_Uniprot = Q3TDQ8
  }}
}}
'''Phosphodiesterase 6D, cGMP-specific, rod, delta''', also known as '''PDE6D''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5147| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
PDE6D has been shown to [[Protein-protein interaction|interact]] with:
{{reflist|2}}
{{div col|colwidth=20em}}
==Further reading==
* [[ARL2]],<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name = pmid11980706>{{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = The EMBO Journal | volume = 21 | issue = 9 | pages = 2095–106 | date = May 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}</ref>
* [[HRAS]],<ref name = pmid11980706/><ref name = pmid11786539/>
* [[RAP1A]],<ref name = pmid11980706/><ref name = pmid11786539>{{cite journal | vauthors = Nancy V, Callebaut I, El Marjou A, de Gunzburg J | title = The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 15076–84 | date = Apr 2002 | pmid = 11786539 | doi = 10.1074/jbc.M109983200 }}</ref>
* [[Retinitis pigmentosa GTPase regulator]]<ref name = pmid9990021>{{cite journal | vauthors = Linari M, Ueffing M, Manson F, Wright A, Meitinger T, Becker J | title = The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 4 | pages = 1315–20 | date = Feb 1999 | pmid = 9990021 | pmc = 15460 | doi =  10.1073/pnas.96.4.1315}}</ref>  and
* [[Rnd1]].<ref name = pmid11980706/><ref name = pmid11786539/>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Marzesco AM, Galli T, Louvard D, Zahraoui A | title = The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes | journal = The Journal of Biological Chemistry | volume = 273 | issue = 35 | pages = 22340–5 | date = Aug 1998 | pmid = 9712853 | doi = 10.1074/jbc.273.35.22340 }}
| citations =
* {{cite journal | vauthors = Lorenz B, Migliaccio C, Lichtner P, Meyer C, Strom TM, D'Urso M, Becker J, Ciccodicola A, Meitinger T | title = Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse | journal = European Journal of Human Genetics | volume = 6 | issue = 3 | pages = 283–90 | year = 1998 | pmid = 9781033 | doi = 10.1038/sj.ejhg.5200215 }}
*{{cite journal  | author=Ershova G, Derré J, Chételin S, ''et al.'' |title=cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 139-41 |year= 1998 |pmid= 9533031 |doi=  }}
* {{cite journal | vauthors = Linari M, Ueffing M, Manson F, Wright A, Meitinger T, Becker J | title = The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 4 | pages = 1315–20 | date = Feb 1999 | pmid = 9990021 | pmc = 15460 | doi = 10.1073/pnas.96.4.1315 }}
*{{cite journal | author=Li N, Florio SK, Pettenati MJ, ''et al.'' |title=Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene. |journal=Genomics |volume=49 |issue= 1 |pages= 76-82 |year= 1998 |pmid= 9570951 |doi= 10.1006/geno.1998.5210 }}
* {{cite journal | vauthors = Mou H, Grazio HJ, Cook TA, Beavo JA, Cote RH | title = cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits | journal = The Journal of Biological Chemistry | volume = 274 | issue = 26 | pages = 18813–20 | date = Jun 1999 | pmid = 10373499 | doi = 10.1074/jbc.274.26.18813 }}
*{{cite journal  | author=Marzesco AM, Galli T, Louvard D, Zahraoui A |title=The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22340-5 |year= 1998 |pmid= 9712853 |doi= }}
* {{cite journal | vauthors = Linari M, Hanzal-Bayer M, Becker J | title = The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner | journal = FEBS Letters | volume = 458 | issue = 1 | pages = 55–9 | date = Sep 1999 | pmid = 10518933 | doi = 10.1016/S0014-5793(99)01117-5 }}
*{{cite journal | author=Lorenz B, Migliaccio C, Lichtner P, ''et al.'' |title=Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 3 |pages= 283-90 |year= 1998 |pmid= 9781033 |doi= 10.1038/sj.ejhg.5200215 }}
* {{cite journal | vauthors = Nancy V, Callebaut I, El Marjou A, de Gunzburg J | title = The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 15076–84 | date = Apr 2002 | pmid = 11786539 | doi = 10.1074/jbc.M109983200 }}
*{{cite journal | author=Linari M, Ueffing M, Manson F, ''et al.'' |title=The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 4 |pages= 1315-20 |year= 1999 |pmid= 9990021 |doi= }}
* {{cite journal | vauthors = Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC | title = The complex of Arl2-GTP and PDE delta: from structure to function | journal = The EMBO Journal | volume = 21 | issue = 9 | pages = 2095–106 | date = May 2002 | pmid = 11980706 | pmc = 125981 | doi = 10.1093/emboj/21.9.2095 }}
*{{cite journal | author=Mou H, Grazio HJ, Cook TA, ''et al.'' |title=cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18813-20 |year= 1999 |pmid= 10373499 |doi= }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Linari M, Hanzal-Bayer M, Becker J |title=The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. |journal=FEBS Lett. |volume=458 |issue= 1 |pages= 55-9 |year= 1999 |pmid= 10518933 |doi= }}
* {{cite journal | vauthors = Wilson SJ, Smyth EM | title = Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 17 | pages = 11780–6 | date = Apr 2006 | pmid = 16527812 | doi = 10.1074/jbc.M513110200 }}
*{{cite journal | author=Nancy V, Callebaut I, El Marjou A, de Gunzburg J |title=The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15076-84 |year= 2002 |pmid= 11786539 |doi= 10.1074/jbc.M109983200 }}
*{{cite journal | author=Hanzal-Bayer M, Renault L, Roversi P, ''et al.'' |title=The complex of Arl2-GTP and PDE delta: from structure to function. |journal=EMBO J. |volume=21 |issue= 9 |pages= 2095-106 |year= 2002 |pmid= 11980706 |doi= 10.1093/emboj/21.9.2095 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Wilson SJ, Smyth EM |title=Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6. |journal=J. Biol. Chem. |volume=281 |issue= 17 |pages= 11780-6 |year= 2006 |pmid= 16527812 |doi= 10.1074/jbc.M513110200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=5147}}
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{{gene-2-stub}}

Latest revision as of 03:08, 27 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

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n/a

UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene.[1][2][3] PDE6D was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE) (EC 3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport.[4]


Interactions

PDE6D has been shown to interact with:

References

  1. ↑ Ershova G, Derré J, Chételin S, Nancy V, Berger R, Kaplan J, Munnich A, de Gunzburg J (Apr 1998). "cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36". Cytogenetics and Cell Genetics. 79 (1–2): 139–41. doi:10.1159/000134701. PMID 9533031.
  2. ↑ Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA, Baehr W (Apr 1998). "Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene". Genomics. 49 (1): 76–82. doi:10.1006/geno.1998.5210. PMID 9570951.
  3. ↑ "Entrez Gene: PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta".
  4. ↑ Wittinghofer A, Renault L, Hanzal-bayer M, Roversi P, Hillig RC (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–2106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
  5. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  6. ↑ 6.0 6.1 6.2 6.3 Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
  7. ↑ 7.0 7.1 7.2 Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
  8. ↑ Linari M, Ueffing M, Manson F, Wright A, Meitinger T, Becker J (Feb 1999). "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1315–20. doi:10.1073/pnas.96.4.1315. PMC 15460. PMID 9990021.

Further reading

  • Marzesco AM, Galli T, Louvard D, Zahraoui A (Aug 1998). "The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes". The Journal of Biological Chemistry. 273 (35): 22340–5. doi:10.1074/jbc.273.35.22340. PMID 9712853.
  • Lorenz B, Migliaccio C, Lichtner P, Meyer C, Strom TM, D'Urso M, Becker J, Ciccodicola A, Meitinger T (1998). "Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse". European Journal of Human Genetics. 6 (3): 283–90. doi:10.1038/sj.ejhg.5200215. PMID 9781033.
  • Linari M, Ueffing M, Manson F, Wright A, Meitinger T, Becker J (Feb 1999). "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1315–20. doi:10.1073/pnas.96.4.1315. PMC 15460. PMID 9990021.
  • Mou H, Grazio HJ, Cook TA, Beavo JA, Cote RH (Jun 1999). "cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits". The Journal of Biological Chemistry. 274 (26): 18813–20. doi:10.1074/jbc.274.26.18813. PMID 10373499.
  • Linari M, Hanzal-Bayer M, Becker J (Sep 1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner". FEBS Letters. 458 (1): 55–9. doi:10.1016/S0014-5793(99)01117-5. PMID 10518933.
  • Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry. 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
  • Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Wilson SJ, Smyth EM (Apr 2006). "Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6". The Journal of Biological Chemistry. 281 (17): 11780–6. doi:10.1074/jbc.M513110200. PMID 16527812.
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