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{{Infobox_gene}}
{{PBB_Controls
'''Inter-alpha-trypsin inhibitor heavy chain H1''' is a [[protein]] that in humans is encoded by the ''ITIH1'' [[gene]].<ref name="pmid1385302">{{cite journal |vauthors=Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG | title = Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily | journal = Genomics | volume = 14 | issue = 1 | pages = 83–8 |date=Dec 1992 | pmid = 1385302 | pmc =  | doi =10.1016/S0888-7543(05)80287-3  }}</ref><ref name="pmid10100603">{{cite journal |vauthors=Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP | title = The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? | journal = FEBS Lett | volume = 446 | issue = 1 | pages = 6–8 |date=May 1999 | pmid = 10100603 | pmc = | doi =10.1016/S0014-5793(99)00173-8  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITIH1 inter-alpha (globulin) inhibitor H1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3697| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
* [[Inter-alpha-trypsin inhibitor]]
| image =
* [[ITIH2]]
| image_source =
* [[ITIH3]]
| PDB =
* [[ITIH4]]
| Name = Inter-alpha (globulin) inhibitor H1
| HGNCid = 6166
| Symbol = ITIH1
| AltSymbols =; H1P; IATIH; ITIH; MGC126415
| OMIM = 147270
| ECnumber = 
| Homologene = 1667
| MGIid = 96618
| GeneAtlas_image1 = PBB_GE_ITIH1_210888_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0030212 |text = hyaluronan metabolic process}} {{GNF_GO|id=GO:0045321 |text = leukocyte activation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3697
    | Hs_Ensembl = ENSG00000055957
    | Hs_RefseqProtein = NP_002206
    | Hs_RefseqmRNA = NM_002215
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 52786648
    | Hs_GenLoc_end = 52801117
    | Hs_Uniprot = P19827
    | Mm_EntrezGene = 16424
    | Mm_Ensembl = ENSMUSG00000006529
    | Mm_RefseqmRNA = NM_008406
    | Mm_RefseqProtein = NP_032432
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 29758373
    | Mm_GenLoc_end = 29772286
    | Mm_Uniprot = Q3UEI9
  }}
}}
'''Inter-alpha (globulin) inhibitor H1''', also known as '''ITIH1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITIH1 inter-alpha (globulin) inhibitor H1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3697| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Diarra-Mehrpour M, Bourguignon J, Bost F, etal |title=Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1 |journal=Biochim. Biophys. Acta |volume=1132 |issue= 1 |pages= 114–8 |year= 1992 |pmid= 1380832 |doi=  10.1016/0167-4781(92)90065-8}}
| citations =
*{{cite journal   |vauthors=Malki N, Balduyck M, Maes P, etal |title=The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 10 |pages= 1009–18 |year= 1992 |pmid= 1384548 |doi=10.1515/bchm3.1992.373.2.1009  }}
*{{cite journal | author=Jean L, Risler JL, Nagase T, ''et al.'' |title=The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 6-8 |year= 1999 |pmid= 10100603 |doi=  }}
*{{cite journal   |vauthors=Salier JP, Diarra-Mehrpour M, Sesboue R, etal |title=Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 23 |pages= 8272–6 |year= 1988 |pmid= 2446322 |doi=10.1073/pnas.84.23.8272 | pmc=299524  }}
*{{cite journal | author=Diarra-Mehrpour M, Bourguignon J, Bost F, ''et al.'' |title=Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1. |journal=Biochim. Biophys. Acta |volume=1132 |issue= 1 |pages= 114-8 |year= 1992 |pmid= 1380832 |doi= }}
*{{cite journal   |vauthors=Diarra-Mehrpour M, Bourguignon J, Sesboüé R, etal |title=Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes |journal=Eur. J. Biochem. |volume=179 |issue= 1 |pages= 147–54 |year= 1989 |pmid= 2465147 |doi=10.1111/j.1432-1033.1989.tb14532.x }}
*{{cite journal | author=Malki N, Balduyck M, Maes P, ''et al.'' |title=The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A. |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 10 |pages= 1009-18 |year= 1992 |pmid= 1384548 |doi=  }}
*{{cite journal  |vauthors=Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E |title=Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related |journal=Eur. J. Biochem. |volume=181 |issue= 3 |pages= 571–6 |year= 1989 |pmid= 2471637 |doi=10.1111/j.1432-1033.1989.tb14762.x  }}
*{{cite journal | author=Salier JP, Simon D, Rouet P, ''et al.'' |title=Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. |journal=Genomics |volume=14 |issue= 1 |pages= 83-8 |year= 1992 |pmid= 1385302 |doi=  }}
*{{cite journal  |vauthors=Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G |title=Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan |journal=J. Biol. Chem. |volume=264 |issue= 27 |pages= 15975–81 |year= 1989 |pmid= 2476436 |doi=  }}
*{{cite journal  | author=Salier JP, Diarra-Mehrpour M, Sesboue R, ''et al.'' |title=Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 23 |pages= 8272-6 |year= 1988 |pmid= 2446322 |doi= }}
*{{cite journal   |vauthors=Schreitmüller T, Hochstrasser K, Reisinger PW, etal |title=cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins |journal=Biol. Chem. Hoppe-Seyler |volume=368 |issue= 8 |pages= 963–70 |year= 1987 |pmid= 3663330 |doi=10.1515/bchm3.1987.368.2.963 }}
*{{cite journal  | author=Diarra-Mehrpour M, Bourguignon J, Sesboüé R, ''et al.'' |title=Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes. |journal=Eur. J. Biochem. |volume=179 |issue= 1 |pages= 147-54 |year= 1989 |pmid= 2465147 |doi=  }}
*{{cite journal  |vauthors=Huang L, Yoneda M, Kimata K |title=A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26725–30 |year= 1994 |pmid= 7504674 |doi=  }}
*{{cite journal | author=Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E |title=Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related. |journal=Eur. J. Biochem. |volume=181 |issue= 3 |pages= 571-6 |year= 1989 |pmid= 2471637 |doi=  }}
*{{cite journal   |vauthors=Bost F, Bourguignon J, Martin JP, etal |title=Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene |journal=Eur. J. Biochem. |volume=218 |issue= 2 |pages= 283–91 |year= 1994 |pmid= 7505744 |doi=10.1111/j.1432-1033.1993.tb18376.x }}
*{{cite journal  | author=Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G |title=Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. |journal=J. Biol. Chem. |volume=264 |issue= 27 |pages= 15975-81 |year= 1989 |pmid= 2476436 |doi=  }}
*{{cite journal   |vauthors=Morelle W, Capon C, Balduyck M, etal |title=Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor |journal=Eur. J. Biochem. |volume=221 |issue= 2 |pages= 881–8 |year= 1994 |pmid= 7513643 |doi=10.1111/j.1432-1033.1994.tb18803.x  }}
*{{cite journal | author=Schreitmüller T, Hochstrasser K, Reisinger PW, ''et al.'' |title=cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins. |journal=Biol. Chem. Hoppe-Seyler |volume=368 |issue= 8 |pages= 963-70 |year= 1987 |pmid= 3663330 |doi=  }}
*{{cite journal   |vauthors=Diarra-Mehrpour M, Bourguignon J, Sarafan N, etal |title=Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes |journal=Biochim. Biophys. Acta |volume=1219 |issue= 2 |pages= 551–4 |year= 1994 |pmid= 7522574 |doi=  10.1016/0167-4781(94)90087-6}}
*{{cite journal | author=Huang L, Yoneda M, Kimata K |title=A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26725-30 |year= 1994 |pmid= 7504674 |doi= }}
*{{cite journal   |vauthors=Ding M, Umetsu K, Yuasa I, etal |title=Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism |journal=Hum. Genet. |volume=95 |issue= 4 |pages= 435–6 |year= 1995 |pmid= 7535743 |doi=10.1007/BF00208970 }}
*{{cite journal | author=Bost F, Bourguignon J, Martin JP, ''et al.'' |title=Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene. |journal=Eur. J. Biochem. |volume=218 |issue= 2 |pages= 283-91 |year= 1994 |pmid= 7505744 |doi=  }}
*{{cite journal   |vauthors=Zhao M, Yoneda M, Ohashi Y, etal |title=Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26657–63 |year= 1995 |pmid= 7592891 |doi=10.1074/jbc.270.44.26657  }}
*{{cite journal | author=Morelle W, Capon C, Balduyck M, ''et al.'' |title=Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor. |journal=Eur. J. Biochem. |volume=221 |issue= 2 |pages= 881-8 |year= 1994 |pmid= 7513643 |doi=  }}
*{{cite journal   |vauthors=Bourguignon J, Diarra-Mehrpour M, Thiberville L, etal |title=Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence |journal=Eur. J. Biochem. |volume=212 |issue= 3 |pages= 771–6 |year= 1993 |pmid= 7681778 |doi=10.1111/j.1432-1033.1993.tb17717.x }}
*{{cite journal | author=Diarra-Mehrpour M, Bourguignon J, Sarafan N, ''et al.'' |title=Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 2 |pages= 551-4 |year= 1994 |pmid= 7522574 |doi= }}
*{{cite journal   |vauthors=Olsen EH, Rahbek-Nielsen H, Thogersen IB, etal |title=Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2 |journal=Biochemistry |volume=37 |issue= 1 |pages= 408–16 |year= 1998 |pmid= 9425062 |doi= 10.1021/bi971137d }}
*{{cite journal | author=Ding M, Umetsu K, Yuasa I, ''et al.'' |title=Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism. |journal=Hum. Genet. |volume=95 |issue= 4 |pages= 435-6 |year= 1995 |pmid= 7535743 |doi=  }}
*{{cite journal   |vauthors=Flahaut C, Capon C, Balduyck M, etal |title=Glycosylation pattern of human inter-alpha-inhibitor heavy chains |journal=Biochem. J. |volume=333 ( Pt 3) |issue= Pt 3|pages= 749–56 |year= 1998 |pmid= 9677337 |doi= | pmc=1219641 }}
*{{cite journal | author=Zhao M, Yoneda M, Ohashi Y, ''et al.'' |title=Evidence for the covalent binding of SHAP, heavy chains of inter-alpha-trypsin inhibitor, to hyaluronan. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26657-63 |year= 1995 |pmid= 7592891 |doi= }}
*{{cite journal   |vauthors=Flahaut C, Mizon C, Aumercier-Maes P, etal |title=Disulphide bonds assignment in the inter-alpha-inhibitor heavy chains--structural and functional implications |journal=Eur. J. Biochem. |volume=255 |issue= 1 |pages= 107–15 |year= 1998 |pmid= 9692908 |doi=10.1046/j.1432-1327.1998.2550107.x  }}
*{{cite journal | author=Bourguignon J, Diarra-Mehrpour M, Thiberville L, ''et al.'' |title=Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence. |journal=Eur. J. Biochem. |volume=212 |issue= 3 |pages= 771-6 |year= 1993 |pmid= 7681778 |doi=  }}
*{{cite journal   |vauthors=Diarra-Mehrpour M, Sarafan N, Bourguignon J, etal |title=Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26809–19 |year= 1998 |pmid= 9756925 |doi=10.1074/jbc.273.41.26809  }}
*{{cite journal | author=Olsen EH, Rahbek-Nielsen H, Thogersen IB, ''et al.'' |title=Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. |journal=Biochemistry |volume=37 |issue= 1 |pages= 408-16 |year= 1998 |pmid= 9425062 |doi= 10.1021/bi971137d }}
*{{cite journal | author=Flahaut C, Capon C, Balduyck M, ''et al.'' |title=Glycosylation pattern of human inter-alpha-inhibitor heavy chains. |journal=Biochem. J. |volume=333 ( Pt 3) |issue= |pages= 749-56 |year= 1998 |pmid= 9677337 |doi= }}
*{{cite journal  | author=Flahaut C, Mizon C, Aumercier-Maes P, ''et al.'' |title=Disulphide bonds assignment in the inter-alpha-inhibitor heavy chains--structural and functional implications. |journal=Eur. J. Biochem. |volume=255 |issue= 1 |pages= 107-15 |year= 1998 |pmid= 9692908 |doi=  }}
*{{cite journal  | author=Diarra-Mehrpour M, Sarafan N, Bourguignon J, ''et al.'' |title=Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26809-19 |year= 1998 |pmid= 9756925 |doi= }}
}}
{{refend}}
{{refend}}


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Latest revision as of 00:11, 1 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inter-alpha-trypsin inhibitor heavy chain H1 is a protein that in humans is encoded by the ITIH1 gene.[1][2][3]

See also

References

  1. ↑ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
  2. ↑ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603.
  3. ↑ "Entrez Gene: ITIH1 inter-alpha (globulin) inhibitor H1".

Further reading


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