MAGI1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1''' is an [[enzyme]] that in humans is encoded by the ''MAGI1'' [[gene]].<ref name="pmid9647739">{{cite journal | vauthors = Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 597–604 | date = Jun 1998 | pmid = 9647739 | pmc =  | doi = 10.1006/bbrc.1998.8603 }}</ref><ref name="pmid9225980">{{cite journal | vauthors = Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA | title = cDNAs with long CAG trinucleotide repeats from human brain | journal = Human Genetics | volume = 100 | issue = 1 | pages = 114–22 | date = Jul 1997 | pmid = 9225980 | pmc = | doi = 10.1007/s004390050476 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9223| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MAGI1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2i04.
| PDB = {{PDB2|2i04}}
| Name = Membrane associated guanylate kinase, WW and PDZ domain containing 1
| HGNCid = 946
| Symbol = MAGI1
| AltSymbols =; BAP1; AIP3; BAIAP1; MAGI-1; TNRC19; WWP3
| OMIM = 602625
| ECnumber = 
| Homologene = 31257
| MGIid = 1203522
| GeneAtlas_image1 = PBB_GE_MAGI1_206144_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005923 |text = tight junction}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9223
    | Hs_Ensembl = ENSG00000151276
    | Hs_RefseqProtein = NP_001028229
    | Hs_RefseqmRNA = NM_001033057
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 65317093
    | Hs_GenLoc_end = 65999023
    | Hs_Uniprot = Q96QZ7
    | Mm_EntrezGene = 14924
    | Mm_Ensembl = ENSMUSG00000045095
    | Mm_RefseqmRNA = NM_001029850
    | Mm_RefseqProtein = NP_001025021
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 93643711
    | Mm_GenLoc_end = 94248785
    | Mm_Uniprot = A0JLR6
  }}
}}
'''Membrane associated guanylate kinase, WW and PDZ domain containing 1''', also known as '''MAGI1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9223| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the [[membrane-associated guanylate kinase]] homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell–cell contact. The product of this gene may play a role as scaffolding protein at cell–cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9223| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAGI1 has been shown to [[Protein-protein interaction|interact]] with:
* [[ACCN3]],<ref name = pmid15317815>{{cite journal | vauthors = Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ | title = PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current | journal = The Journal of Biological Chemistry | volume = 279 | issue = 45 | pages = 46962–8 | date = Nov 2004 | pmid = 15317815 | doi = 10.1074/jbc.M405874200 }}</ref>
* [[ATN1]],<ref name = pmid9647693>{{cite journal | vauthors = Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA | title = Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins | journal = Molecular and Cellular Neurosciences | volume = 11 | issue = 3 | pages = 149–60 | date = Jun 1998 | pmid = 9647693 | doi = 10.1006/mcne.1998.0677 }}</ref>
* [[Actinin alpha 4]],<ref name = pmid12042308>{{cite journal | vauthors = Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B | title = Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30183–90 | date = Aug 2002 | pmid = 12042308 | doi = 10.1074/jbc.M203072200 }}</ref>
* [[Beta-catenin]],<ref name = pmid10772923>{{cite journal | vauthors = Dobrosotskaya IY, James GL | title = MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures | journal = Biochemical and Biophysical Research Communications | volume = 270 | issue = 3 | pages = 903–9 | date = Apr 2000 | pmid = 10772923 | doi = 10.1006/bbrc.2000.2471 }}</ref>
* [[Brain-specific angiogenesis inhibitor 1]],<ref name = pmid9647739 />
* [[Calcium-activated potassium channel subunit alpha-1]],<ref name = pmid19403801>{{cite journal | vauthors = Ridgway LD, Kim EY, Dryer SE | title = MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface | journal = American Journal of Physiology. Cell Physiology | volume = 297 | issue = 1 | pages = C55-65 | date = Jul 2009 | pmid = 19403801 | pmc = 3774261 | doi = 10.1152/ajpcell.00073.2009 }}</ref>
* [[FCHSD2]],<ref name = pmid14627983>{{cite journal | vauthors = Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y | title = Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains | journal = Oncogene | volume = 22 | issue = 52 | pages = 8422–31 | date = Nov 2003 | pmid = 14627983 | doi = 10.1038/sj.onc.1206996 }}</ref>
* [[LRP2]],<ref name = pmid11274227>{{cite journal | vauthors = Patrie KM, Drescher AJ, Goyal M, Wiggins RC, Margolis B | title = The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes | journal = Journal of the American Society of Nephrology | volume = 12 | issue = 4 | pages = 667–77 | date = Apr 2001 | pmid = 11274227 | doi =  }}</ref>  and
* [[SYNPO]].<ref name = pmid12042308/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM | title = Identification of novel human WW domain-containing proteins by cloning of ligand targets | journal = The Journal of Biological Chemistry | volume = 272 | issue = 23 | pages = 14611–6 | date = Jun 1997 | pmid = 9169421 | doi = 10.1074/jbc.272.23.14611 }}
| citations =
* {{cite journal | vauthors = Dobrosotskaya I, Guy RK, James GL | title = MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains | journal = The Journal of Biological Chemistry | volume = 272 | issue = 50 | pages = 31589–97 | date = Dec 1997 | pmid = 9395497 | doi = 10.1074/jbc.272.50.31589 }}
*{{cite journal | author=Pirozzi G, McConnell SJ, Uveges AJ, ''et al.'' |title=Identification of novel human WW domain-containing proteins by cloning of ligand targets. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14611-6 |year= 1997 |pmid= 9169421 |doi= }}
* {{cite journal | vauthors = Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA | title = Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins | journal = Molecular and Cellular Neurosciences | volume = 11 | issue = 3 | pages = 149–60 | date = Jun 1998 | pmid = 9647693 | doi = 10.1006/mcne.1998.0677 }}
*{{cite journal  | author=Margolis RL, Abraham MR, Gatchell SB, ''et al.'' |title=cDNAs with long CAG trinucleotide repeats from human brain. |journal=Hum. Genet. |volume=100 |issue= 1 |pages= 114-22 |year= 1997 |pmid= 9225980 |doi=  }}
* {{cite journal | vauthors = Dobrosotskaya IY, James GL | title = MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures | journal = Biochemical and Biophysical Research Communications | volume = 270 | issue = 3 | pages = 903–9 | date = Apr 2000 | pmid = 10772923 | doi = 10.1006/bbrc.2000.2471 }}
*{{cite journal | author=Dobrosotskaya I, Guy RK, James GL |title=MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains. |journal=J. Biol. Chem. |volume=272 |issue= 50 |pages= 31589-97 |year= 1998 |pmid= 9395497 |doi= }}
* {{cite journal | vauthors = Patrie KM, Drescher AJ, Goyal M, Wiggins RC, Margolis B | title = The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes | journal = Journal of the American Society of Nephrology | volume = 12 | issue = 4 | pages = 667–77 | date = Apr 2001 | pmid = 11274227 | doi =  }}
*{{cite journal | author=Wood JD, Yuan J, Margolis RL, ''et al.'' |title=Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 149-60 |year= 1998 |pmid= 9647693 |doi= 10.1006/mcne.1998.0677 }}
* {{cite journal | vauthors = Dobrosotskaya IY | title = Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1 | journal = Biochemical and Biophysical Research Communications | volume = 283 | issue = 4 | pages = 969–75 | date = May 2001 | pmid = 11350080 | doi = 10.1006/bbrc.2001.4880 }}
*{{cite journal | author=Shiratsuchi T, Futamura M, Oda K, ''et al.'' |title=Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 3 |pages= 597-604 |year= 1998 |pmid= 9647739 |doi= 10.1006/bbrc.1998.8603 }}
* {{cite journal | vauthors = Laura RP, Ross S, Koeppen H, Lasky LA | title = MAGI-1: a widely expressed, alternatively spliced tight junction protein | journal = Experimental Cell Research | volume = 275 | issue = 2 | pages = 155–70 | date = May 2002 | pmid = 11969287 | doi = 10.1006/excr.2002.5475 }}
*{{cite journal  | author=Dobrosotskaya IY, James GL |title=MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures. |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 3 |pages= 903-9 |year= 2000 |pmid= 10772923 |doi= 10.1006/bbrc.2000.2471 }}
* {{cite journal | vauthors = Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B | title = Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30183–90 | date = Aug 2002 | pmid = 12042308 | doi = 10.1074/jbc.M203072200 }}
*{{cite journal | author=Patrie KM, Drescher AJ, Goyal M, ''et al.'' |title=The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes. |journal=J. Am. Soc. Nephrol. |volume=12 |issue= 4 |pages= 667-77 |year= 2001 |pmid= 11274227 |doi=  }}
* {{cite journal | vauthors = Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y | title = Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains | journal = Oncogene | volume = 22 | issue = 52 | pages = 8422–31 | date = Nov 2003 | pmid = 14627983 | doi = 10.1038/sj.onc.1206996 }}
*{{cite journal | author=Dobrosotskaya IY |title=Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 4 |pages= 969-75 |year= 2001 |pmid= 11350080 |doi= 10.1006/bbrc.2001.4880 }}
* {{cite journal | vauthors = Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ | title = PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current | journal = The Journal of Biological Chemistry | volume = 279 | issue = 45 | pages = 46962–8 | date = Nov 2004 | pmid = 15317815 | doi = 10.1074/jbc.M405874200 }}
*{{cite journal | author=Laura RP, Ross S, Koeppen H, Lasky LA |title=MAGI-1: a widely expressed, alternatively spliced tight junction protein. |journal=Exp. Cell Res. |volume=275 |issue= 2 |pages= 155-70 |year= 2002 |pmid= 11969287 |doi= 10.1006/excr.2002.5475 }}
* {{cite journal | vauthors = Wright GJ, Leslie JD, Ariza-McNaughton L, Lewis J | title = Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development | journal = Development | volume = 131 | issue = 22 | pages = 5659–69 | date = Nov 2004 | pmid = 15509766 | doi = 10.1242/dev.01417 }}
*{{cite journal | author=Patrie KM, Drescher AJ, Welihinda A, ''et al.'' |title=Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30183-90 |year= 2002 |pmid= 12042308 |doi= 10.1074/jbc.M203072200 }}
* {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 6 | pages = 785–95 | date = Jun 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Mizuhara E, Nakatani T, Minaki Y, Sakamoto Y, Ono Y, Takai Y | title = MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface | journal = The Journal of Biological Chemistry | volume = 280 | issue = 28 | pages = 26499–507 | date = Jul 2005 | pmid = 15908431 | doi = 10.1074/jbc.M500375200 }}
*{{cite journal  | author=Ohno H, Hirabayashi S, Kansaku A, ''et al.'' |title=Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. |journal=Oncogene |volume=22 |issue= 52 |pages= 8422-31 |year= 2003 |pmid= 14627983 |doi= 10.1038/sj.onc.1206996 }}
* {{cite journal | vauthors = Patrie KM | title = Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1 | journal = Biochimica et Biophysica Acta | volume = 1745 | issue = 1 | pages = 131–44 | date = Aug 2005 | pmid = 16019084 | doi = 10.1016/j.bbamcr.2005.05.011 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Bratt A, Birot O, Sinha I, Veitonmäki N, Aase K, Ernkvist M, Holmgren L | title = Angiomotin regulates endothelial cell-cell junctions and cell motility | journal = The Journal of Biological Chemistry | volume = 280 | issue = 41 | pages = 34859–69 | date = Oct 2005 | pmid = 16043488 | doi = 10.1074/jbc.M503915200 }}
*{{cite journal  | author=Hruska-Hageman AM, Benson CJ, Leonard AS, ''et al.'' |title=PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46962-8 |year= 2004 |pmid= 15317815 |doi= 10.1074/jbc.M405874200 }}
* {{cite journal | vauthors = Sakurai A, Fukuhara S, Yamagishi A, Sako K, Kamioka Y, Masuda M, Nakaoka Y, Mochizuki N | title = MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion | journal = Molecular Biology of the Cell | volume = 17 | issue = 2 | pages = 966–76 | date = Feb 2006 | pmid = 16339077 | pmc = 1356604 | doi = 10.1091/mbc.E05-07-0647 }}
*{{cite journal | author=Wright GJ, Leslie JD, Ariza-McNaughton L, Lewis J |title=Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. |journal=Development |volume=131 |issue= 22 |pages= 5659-69 |year= 2005 |pmid= 15509766 |doi= 10.1242/dev.01417 }}
*{{cite journal | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Mizuhara E, Nakatani T, Minaki Y, ''et al.'' |title=MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. |journal=J. Biol. Chem. |volume=280 |issue= 28 |pages= 26499-507 |year= 2005 |pmid= 15908431 |doi= 10.1074/jbc.M500375200 }}
*{{cite journal | author=Patrie KM |title=Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. |journal=Biochim. Biophys. Acta |volume=1745 |issue= 1 |pages= 131-44 |year= 2005 |pmid= 16019084 |doi= 10.1016/j.bbamcr.2005.05.011 }}
*{{cite journal | author=Bratt A, Birot O, Sinha I, ''et al.'' |title=Angiomotin regulates endothelial cell-cell junctions and cell motility. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 34859-69 |year= 2005 |pmid= 16043488 |doi= 10.1074/jbc.M503915200 }}
*{{cite journal | author=Sakurai A, Fukuhara S, Yamagishi A, ''et al.'' |title=MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. |journal=Mol. Biol. Cell |volume=17 |issue= 2 |pages= 966-76 |year= 2006 |pmid= 16339077 |doi= 10.1091/mbc.E05-07-0647 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=9223}}
{{WikiDoc Sources}}

Latest revision as of 06:02, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 is an enzyme that in humans is encoded by the MAGI1 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell–cell contact. The product of this gene may play a role as scaffolding protein at cell–cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

Interactions

MAGI1 has been shown to interact with:

References

  1. ↑ 1.0 1.1 Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739.
  2. ↑ Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980.
  3. ↑ 3.0 3.1 "Entrez Gene: MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1".
  4. ↑ Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (Nov 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". The Journal of Biological Chemistry. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815.
  5. ↑ Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (Jun 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Molecular and Cellular Neurosciences. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
  6. ↑ 6.0 6.1 Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B (Aug 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". The Journal of Biological Chemistry. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.
  7. ↑ Dobrosotskaya IY, James GL (Apr 2000). "MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures". Biochemical and Biophysical Research Communications. 270 (3): 903–9. doi:10.1006/bbrc.2000.2471. PMID 10772923.
  8. ↑ Ridgway LD, Kim EY, Dryer SE (Jul 2009). "MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface". American Journal of Physiology. Cell Physiology. 297 (1): C55–65. doi:10.1152/ajpcell.00073.2009. PMC 3774261. PMID 19403801.
  9. ↑ Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (Nov 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983.
  10. ↑ Patrie KM, Drescher AJ, Goyal M, Wiggins RC, Margolis B (Apr 2001). "The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes". Journal of the American Society of Nephrology. 12 (4): 667–77. PMID 11274227.

Further reading

  • Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (Jun 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". The Journal of Biological Chemistry. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
  • Dobrosotskaya I, Guy RK, James GL (Dec 1997). "MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domains". The Journal of Biological Chemistry. 272 (50): 31589–97. doi:10.1074/jbc.272.50.31589. PMID 9395497.
  • Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (Jun 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Molecular and Cellular Neurosciences. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
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  • Dobrosotskaya IY (May 2001). "Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1". Biochemical and Biophysical Research Communications. 283 (4): 969–75. doi:10.1006/bbrc.2001.4880. PMID 11350080.
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  • Bratt A, Birot O, Sinha I, Veitonmäki N, Aase K, Ernkvist M, Holmgren L (Oct 2005). "Angiomotin regulates endothelial cell-cell junctions and cell motility". The Journal of Biological Chemistry. 280 (41): 34859–69. doi:10.1074/jbc.M503915200. PMID 16043488.
  • Sakurai A, Fukuhara S, Yamagishi A, Sako K, Kamioka Y, Masuda M, Nakaoka Y, Mochizuki N (Feb 2006). "MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion". Molecular Biology of the Cell. 17 (2): 966–76. doi:10.1091/mbc.E05-07-0647. PMC 1356604. PMID 16339077.
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