RBP2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Retinol-binding protein 2''' ('''RBP2''') is a [[protein]] that in humans is encoded by the ''RBP2'' [[gene]].<ref name="pmid7657783">{{cite journal | vauthors = Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP | title = Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle | journal = Hum Reprod | volume = 10 | issue = 5 | pages = 1297–304 | date = Oct 1995 | pmid = 7657783 | pmc =  | doi = }}</ref><ref name="pmid10072590">{{cite journal | vauthors = De Baere E, Speleman F, Van Roy N, Mortier K, De Paepe A, Messiaen L | title = Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 83 | issue = 3–4 | pages = 240–1 | date = Mar 1999 | pmid = 10072590 | pmc = | doi = 10.1159/000015191 }}</ref><ref name="entrez"/>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RBP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b4m.
| PDB = {{PDB2|1b4m}}, {{PDB2|1eii}}, {{PDB2|1opa}}, {{PDB2|1opb}}
| Name = Retinol binding protein 2, cellular
| HGNCid = 9920
| Symbol = RBP2
| AltSymbols =; CRABP-II; CRBP2; CRBPII; RBPC2
| OMIM = 180280
| ECnumber = 
| Homologene = 3070
| MGIid = 97877
| Function = {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0016918 |text = retinal binding}} {{GNF_GO|id=GO:0019841 |text = retinol binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006776 |text = vitamin A metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0008544 |text = epidermis development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5948
    | Hs_Ensembl = ENSG00000114113
    | Hs_RefseqProtein = NP_004155
    | Hs_RefseqmRNA = NM_004164
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 140654417
    | Hs_GenLoc_end = 140678042
    | Hs_Uniprot = P50120
    | Mm_EntrezGene = 19660
    | Mm_Ensembl = ENSMUSG00000032454
    | Mm_RefseqmRNA = NM_009034
    | Mm_RefseqProtein = NP_033060
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 98299905
    | Mm_GenLoc_end = 98319089
    | Mm_Uniprot = Q059R7
  }}
}}
'''Retinol binding protein 2, cellular''', also known as '''RBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RBP2 retinol binding protein 2, cellular| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5948| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of [[vitamin A]]. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.<ref name="entrez">{{cite web | title = Entrez Gene: RBP2 retinol binding protein 2, cellular| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5948| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.<ref name="entrez">{{cite web | title = Entrez Gene: RBP2 retinol binding protein 2, cellular| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5948| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = van Eijk HG, Tio TH, Bos G | title = Iron in skin biopsies | journal = Archiv für dermatologische Forschung | volume = 251 | issue = 3 | pages = 245–8 | year = 1975 | pmid = 1115525 | doi =  }}
| citations =
* {{cite journal | vauthors = Herr FM, Ong DE | title = Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins | journal = Biochemistry | volume = 31 | issue = 29 | pages = 6748–55 | year = 1992 | pmid = 1322170 | doi = 10.1021/bi00144a014 }}
*{{cite journal | author=van Eijk HG, Tio TH, Bos G |title=Iron in skin biopsies. |journal=Archiv für dermatologische Forschung |volume=251 |issue= 3 |pages= 245-8 |year= 1975 |pmid= 1115525 |doi=  }}
* {{cite journal | vauthors = Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ | title = Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro | journal = J. Biol. Chem. | volume = 266 | issue = 26 | pages = 17662–6 | year = 1991 | pmid = 1654334 | doi =  }}
*{{cite journal | author=Herr FM, Ong DE |title=Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins. |journal=Biochemistry |volume=31 |issue= 29 |pages= 6748-55 |year= 1992 |pmid= 1322170 |doi= }}
* {{cite journal | vauthors = Colantuoni V, Cortese R, Nilsson M, Lundvall J, Båvik CO, Eriksson U, Peterson PA, Sundelin J | title = Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein | journal = Biochem. Biophys. Res. Commun. | volume = 130 | issue = 1 | pages = 431–9 | year = 1985 | pmid = 2992469 | doi = 10.1016/0006-291X(85)90435-8 }}
*{{cite journal | author=Aström A, Tavakkol A, Pettersson U, ''et al.'' |title=Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. |journal=J. Biol. Chem. |volume=266 |issue= 26 |pages= 17662-6 |year= 1991 |pmid= 1654334 |doi=  }}
* {{cite journal | vauthors = Demmer LA, Birkenmeier EH, Sweetser DA, Levin MS, Zollman S, Sparkes RS, Mohandas T, Lusis AJ, Gordon JI | title = The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene | journal = J. Biol. Chem. | volume = 262 | issue = 6 | pages = 2458–67 | year = 1987 | pmid = 3029082 | doi =  }}
*{{cite journal | author=Colantuoni V, Cortese R, Nilsson M, ''et al.'' |title=Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=130 |issue= 1 |pages= 431-9 |year= 1985 |pmid= 2992469 |doi= }}
* {{cite journal | vauthors = Folli C, Calderone V, Ottonello S, Bolchi A, Zanotti G, Stoppini M, Berni R | title = Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 7 | pages = 3710–5 | year = 2001 | pmid = 11274389 | pmc = 31117 | doi = 10.1073/pnas.061455898 | bibcode = 2001PNAS...98.3710F }}
*{{cite journal | author=Demmer LA, Birkenmeier EH, Sweetser DA, ''et al.'' |title=The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene. |journal=J. Biol. Chem. |volume=262 |issue= 6 |pages= 2458-67 |year= 1987 |pmid= 3029082 |doi=  }}
* {{cite journal | vauthors = Chan SW, Hong W | title = Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28402–12 | year = 2001 | pmid = 11358960 | doi = 10.1074/jbc.M100313200 }}
*{{cite journal | author=Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP |title=Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle. |journal=Hum. Reprod. |volume=10 |issue= 5 |pages= 1297-304 |year= 1995 |pmid= 7657783 |doi=  }}
* {{cite journal | vauthors = Zhang L, E X, Luker KE, Shao JS, Levin MS, Suh E, Li E | title = Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation | journal = Am. J. Physiol. Gastrointest. Liver Physiol. | volume = 282 | issue = 6 | pages = G1079–87 | year = 2002 | pmid = 12016134 | doi = 10.1152/ajpgi.00041.2001 }}
*{{cite journal  | author=De Baere E, Speleman F, Van Roy N, ''et al.'' |title=Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 3-4 |pages= 240-1 |year= 1999 |pmid= 10072590 |doi=  }}
*{{cite journal  | author=Folli C, Calderone V, Ottonello S, ''et al.'' |title=Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 7 |pages= 3710-5 |year= 2001 |pmid= 11274389 |doi= 10.1073/pnas.061455898 }}
*{{cite journal | author=Chan SW, Hong W |title=Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28402-12 |year= 2001 |pmid= 11358960 |doi= 10.1074/jbc.M100313200 }}
*{{cite journal | author=Zhang L, E X, Luker KE, ''et al.'' |title=Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 6 |pages= G1079-87 |year= 2002 |pmid= 12016134 |doi= 10.1152/ajpgi.00041.2001 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=5948}}
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{{gene-3-stub}}
 
[[Category:Lipocalins]]

Latest revision as of 03:18, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Retinol-binding protein 2 (RBP2) is a protein that in humans is encoded by the RBP2 gene.[1][2][3]

Function

RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.[3]

References

  1. ↑ Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP (Oct 1995). "Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle". Hum Reprod. 10 (5): 1297–304. PMID 7657783.
  2. ↑ De Baere E, Speleman F, Van Roy N, Mortier K, De Paepe A, Messiaen L (Mar 1999). "Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization". Cytogenet Cell Genet. 83 (3–4): 240–1. doi:10.1159/000015191. PMID 10072590.
  3. ↑ 3.0 3.1 "Entrez Gene: RBP2 retinol binding protein 2, cellular".

Further reading

  • van Eijk HG, Tio TH, Bos G (1975). "Iron in skin biopsies". Archiv für dermatologische Forschung. 251 (3): 245–8. PMID 1115525.
  • Herr FM, Ong DE (1992). "Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins". Biochemistry. 31 (29): 6748–55. doi:10.1021/bi00144a014. PMID 1322170.
  • Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ (1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. PMID 1654334.
  • Colantuoni V, Cortese R, Nilsson M, Lundvall J, Båvik CO, Eriksson U, Peterson PA, Sundelin J (1985). "Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein". Biochem. Biophys. Res. Commun. 130 (1): 431–9. doi:10.1016/0006-291X(85)90435-8. PMID 2992469.
  • Demmer LA, Birkenmeier EH, Sweetser DA, Levin MS, Zollman S, Sparkes RS, Mohandas T, Lusis AJ, Gordon JI (1987). "The cellular retinol binding protein II gene. Sequence analysis of the rat gene, chromosomal localization in mice and humans, and documentation of its close linkage to the cellular retinol binding protein gene". J. Biol. Chem. 262 (6): 2458–67. PMID 3029082.
  • Folli C, Calderone V, Ottonello S, Bolchi A, Zanotti G, Stoppini M, Berni R (2001). "Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3710–5. Bibcode:2001PNAS...98.3710F. doi:10.1073/pnas.061455898. PMC 31117. PMID 11274389.
  • Chan SW, Hong W (2001). "Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription". J. Biol. Chem. 276 (30): 28402–12. doi:10.1074/jbc.M100313200. PMID 11358960.
  • Zhang L, E X, Luker KE, Shao JS, Levin MS, Suh E, Li E (2002). "Analysis of human cellular retinol-binding protein II promoter during enterocyte differentiation". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (6): G1079–87. doi:10.1152/ajpgi.00041.2001. PMID 12016134.


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