DNASE1L3: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Deoxyribonuclease gamma''' is an [[enzyme]] that in humans is encoded by the ''DNASE1L3'' [[gene]].<ref name="pmid9205125">{{cite journal | vauthors = Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC | title = Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I | journal = Genomics | volume = 42 | issue = 3 | pages = 507–13 |date=Sep 1997 | pmid = 9205125 | pmc =  | doi = 10.1006/geno.1997.4748 }}</ref><ref name="pmid9714828">{{cite journal | vauthors = Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP | title = Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages | journal = Gene | volume = 215 | issue = 2 | pages = 291–301 |date=Oct 1998 | pmid = 9714828 | pmc = | doi =10.1016/S0378-1119(98)00281-9  }}</ref><ref name="pmid14646506">{{cite journal | vauthors = Shiokawa D, Hirai M, Tanuma S | title = cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein | journal = Apoptosis | volume = 3 | issue = 2 | pages = 89–95 |date=Dec 2003 | pmid = 14646506 | pmc =  | doi =10.1023/A:1009692807692 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1776| accessdate = }}</ref>
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| update_protein_box = yes
This gene encodes a member of the [[DNase]] family. The protein hydrolyzes DNA, is not inhibited by [[actin]], and mediates the breakdown of DNA during [[apoptosis]]. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez" />
| update_summary = yes
 
| update_citations = yes
Homozygosity for a null allele results in [[systemic lupus erythematosus]].<ref name="Al-MayoufSunker2011">{{cite journal|last1=Al-Mayouf|first1=Sulaiman M|last2=Sunker|first2=Asma|last3=Abdwani|first3=Reem|last4=Abrawi|first4=Safiya Al|last5=Almurshedi|first5=Fathiya|last6=Alhashmi|first6=Nadia|last7=Al Sonbul|first7=Abdullah|last8=Sewairi|first8=Wafaa|last9=Qari|first9=Aliya|last10=Abdallah|first10=Eiman|last11=Al-Owain|first11=Mohammed|last12=Al Motywee|first12=Saleh|last13=Al-Rayes|first13=Hanan|last14=Hashem|first14=Mais|last15=Khalak|first15=Hanif|last16=Al-Jebali|first16=Latifa|last17=Alkuraya|first17=Fowzan S|title=Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus|journal=Nature Genetics|volume=43|issue=12|year=2011|pages=1186–1188|issn=1061-4036|doi=10.1038/ng.975}}</ref>
}}{{GNF_Protein_box
 
| image =
| image_source =
| PDB =
| Name = Deoxyribonuclease I-like 3
| HGNCid = 2959
| Symbol = DNASE1L3
| AltSymbols =; DHP2; DNAS1L3; LSD
| OMIM = 602244
| ECnumber =
| Homologene = 3630
| MGIid = 1314633
  | GeneAtlas_image1 = PBB_GE_DNASE1L3_205554_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004536 |text = deoxyribonuclease activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1776
    | Hs_Ensembl = ENSG00000163687
    | Hs_RefseqProtein = NP_004935
    | Hs_RefseqmRNA = NM_004944
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 58153454
    | Hs_GenLoc_end = 58175893
    | Hs_Uniprot = Q13609
    | Mm_EntrezGene = 13421
    | Mm_Ensembl = ENSMUSG00000025279
    | Mm_RefseqmRNA = NM_007870
    | Mm_RefseqProtein = NP_031896
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 6757066
    | Mm_GenLoc_end = 6786061
    | Mm_Uniprot = Q3T9W0
  }}
}}
'''Deoxyribonuclease I-like 3''', also known as '''DNASE1L3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1776| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.<ref name="entrez">{{cite web | title = Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1776| accessdate = }}</ref>
}}
==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Tanuma S, Shiokawa D |title=Multiple forms of nuclear deoxyribonuclease in rat thymocytes. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 2 |pages= 789–97 |year= 1994 |pmid= 8093058 |doi= 10.1006/bbrc.1994.2252 }}
| citations =
*{{cite journal  | vauthors=Zeng Z, Parmelee D, Hyaw H |title=Cloning and characterization of a novel human DNase. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 2 |pages= 499–504 |year= 1997 |pmid= 9070308 |doi= 10.1006/bbrc.1996.5923 |display-authors=etal}}
*{{cite journal  | author=Tanuma S, Shiokawa D |title=Multiple forms of nuclear deoxyribonuclease in rat thymocytes. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 2 |pages= 789-97 |year= 1994 |pmid= 8093058 |doi= 10.1006/bbrc.1994.2252 }}
*{{cite journal  | vauthors=Shiokawa D, Tanuma S |title=Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. |journal=Biochemistry |volume=40 |issue= 1 |pages= 143–52 |year= 2001 |pmid= 11141064 |doi=10.1021/bi001041a }}
*{{cite journal  | author=Zeng Z, Parmelee D, Hyaw H, ''et al.'' |title=Cloning and characterization of a novel human DNase. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 2 |pages= 499-504 |year= 1997 |pmid= 9070308 |doi= 10.1006/bbrc.1996.5923 }}
*{{cite journal  | vauthors=Wilber A, Lu M, Schneider MC |title=Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection. |journal=Mol. Ther. |volume=6 |issue= 1 |pages= 35–42 |year= 2003 |pmid= 12095301 |doi=10.1006/mthe.2002.0625 }}
*{{cite journal  | author=Rodriguez AM, Rodin D, Nomura H, ''et al.'' |title=Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I. |journal=Genomics |volume=42 |issue= 3 |pages= 507-13 |year= 1997 |pmid= 9205125 |doi= 10.1006/geno.1997.4748 }}
*{{cite journal  | vauthors=Boulares AH, Zoltoski AJ, Sherif ZA |title=The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells. |journal=Cancer Res. |volume=62 |issue= 15 |pages= 4439–44 |year= 2002 |pmid= 12154052 |doi=  |display-authors=etal}}
*{{cite journal  | author=Baron WF, Pan CQ, Spencer SA, ''et al.'' |title=Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. |journal=Gene |volume=215 |issue= 2 |pages= 291-301 |year= 1998 |pmid= 9714828 |doi= }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Shiokawa D, Tanuma S |title=Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis. |journal=Biochemistry |volume=40 |issue= 1 |pages= 143-52 |year= 2001 |pmid= 11141064 |doi=  }}
*{{cite journal  | vauthors=Shiokawa D, Shika Y, Tanuma S |title=Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity. |journal=Biochem. J. |volume=376 |issue= Pt 2 |pages= 377–81 |year= 2003 |pmid= 12943533 |doi= 10.1042/BJ20030820  | pmc=1223774 }}
*{{cite journal  | author=Wilber A, Lu M, Schneider MC |title=Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection. |journal=Mol. Ther. |volume=6 |issue= 1 |pages= 35-42 |year= 2003 |pmid= 12095301 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Boulares AH, Zoltoski AJ, Sherif ZA, ''et al.'' |title=The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells. |journal=Cancer Res. |volume=62 |issue= 15 |pages= 4439-44 |year= 2002 |pmid= 12154052 |doi=  }}
*{{cite journal  | vauthors=Boulares AH, Ren T |title=Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3. |journal=Basic Clin. Pharmacol. Toxicol. |volume=94 |issue= 1 |pages= 19–29 |year= 2004 |pmid= 14725611 |doi=10.1111/j.1742-7843.2004.pto_940105.x }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Shiokawa D, Shika Y, Tanuma S |title=Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity. |journal=Biochem. J. |volume=376 |issue= Pt 2 |pages= 377-81 |year= 2003 |pmid= 12943533 |doi= 10.1042/BJ20030820 }}
*{{cite journal  | vauthors=Okamoto M, Okamoto N, Yashiro H |title=Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes. |journal=Biochem. Biophys. Res. Commun. |volume=327 |issue= 1 |pages= 76–83 |year= 2005 |pmid= 15629432 |doi= 10.1016/j.bbrc.2004.11.142 |display-authors=etal}}
*{{cite journal | author=Shiokawa D, Hirai M, Tanuma S |title=cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein. |journal=Apoptosis |volume=3 |issue= 2 |pages= 89-95 |year= 2003 |pmid= 14646506 |doi=  }}
*{{cite journal  | vauthors=Boulares H, Zoltoski A, Kandan S |title=Correlation between decreased sensitivity of the Daudi lymphoma cells to VP-16-induced apoptosis and deficiency in DNAS1L3 expression. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 2 |pages= 653–62 |year= 2006 |pmid= 16427601 |doi= 10.1016/j.bbrc.2006.01.014 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Boulares AH, Ren T |title=Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3. |journal=Basic Clin. Pharmacol. Toxicol. |volume=94 |issue= 1 |pages= 19-29 |year= 2004 |pmid= 14725611 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Okamoto M, Okamoto N, Yashiro H, ''et al.'' |title=Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes. |journal=Biochem. Biophys. Res. Commun. |volume=327 |issue= 1 |pages= 76-83 |year= 2005 |pmid= 15629432 |doi= 10.1016/j.bbrc.2004.11.142 }}
*{{cite journal  | author=Boulares H, Zoltoski A, Kandan S, ''et al.'' |title=Correlation between decreased sensitivity of the Daudi lymphoma cells to VP-16-induced apoptosis and deficiency in DNAS1L3 expression. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 2 |pages= 653-62 |year= 2006 |pmid= 16427601 |doi= 10.1016/j.bbrc.2006.01.014 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 18:39, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene.[1][2][3][4]

This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[4]

Homozygosity for a null allele results in systemic lupus erythematosus.[5]

References

  1. ↑ Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (Sep 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
  2. ↑ Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (Oct 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828.
  3. ↑ Shiokawa D, Hirai M, Tanuma S (Dec 2003). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506.
  4. ↑ 4.0 4.1 "Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3".
  5. ↑ Al-Mayouf, Sulaiman M; Sunker, Asma; Abdwani, Reem; Abrawi, Safiya Al; Almurshedi, Fathiya; Alhashmi, Nadia; Al Sonbul, Abdullah; Sewairi, Wafaa; Qari, Aliya; Abdallah, Eiman; Al-Owain, Mohammed; Al Motywee, Saleh; Al-Rayes, Hanan; Hashem, Mais; Khalak, Hanif; Al-Jebali, Latifa; Alkuraya, Fowzan S (2011). "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus". Nature Genetics. 43 (12): 1186–1188. doi:10.1038/ng.975. ISSN 1061-4036.

Further reading


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