TM4SF1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transmembrane 4 L6 family member 1''' is a [[protein]] that in humans is encoded by the ''TM4SF1'' [[gene]].<ref name="pmid1565644">{{cite journal | vauthors = Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A | title = Cloning and expression of the tumor-associated antigen L6 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 8 | pages = 3503–7 | date = Apr 1992 | pmid = 1565644 | pmc = 48896 | doi = 10.1073/pnas.89.8.3503 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TM4SF1 transmembrane 4 L six family member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4071| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transmembrane 4 L six family member 1
| HGNCid = 11853
| Symbol = TM4SF1
| AltSymbols =; H-L6; L6; M3S1; TAAL6
| OMIM = 191155
| ECnumber = 
| Homologene = 7409
| MGIid = 104678
| GeneAtlas_image1 = PBB_GE_TM4SF1_209386_at_tn.png
| GeneAtlas_image2 = PBB_GE_TM4SF1_209387_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TM4SF1_215034_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4071
    | Hs_Ensembl = ENSG00000169908
    | Hs_RefseqProtein = NP_055035
    | Hs_RefseqmRNA = NM_014220
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 150569495
    | Hs_GenLoc_end = 150578258
    | Hs_Uniprot = P30408
    | Mm_EntrezGene = 17112
    | Mm_Ensembl = ENSMUSG00000027800
    | Mm_RefseqmRNA = NM_008536
    | Mm_RefseqProtein = NP_032562
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 57377606
    | Mm_GenLoc_end = 57382717
    | Mm_Uniprot = Q3UZY2
  }}
}}
'''Transmembrane 4 L six family member 1''', also known as '''TM4SF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TM4SF1 transmembrane 4 L six family member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4071| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the [[tetraspanin]] family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface [[antigen]] and is highly expressed in different [[carcinoma]]s.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.<ref name="entrez">{{cite web | title = Entrez Gene: TM4SF1 transmembrane 4 L six family member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4071| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Berditchevski F | title = Complexes of tetraspanins with integrins: more than meets the eye | journal = Journal of Cell Science | volume = 114 | issue = Pt 23 | pages = 4143–51 | date = Dec 2001 | pmid = 11739647 | doi =  }}
| citations =
* {{cite journal | vauthors = Marken JS, Bajorath J, Edwards CP, Farr AG, Schieven GL, Hellström I, Hellström KE, Aruffo A | title = Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody | journal = The Journal of Biological Chemistry | volume = 269 | issue = 10 | pages = 7397–401 | date = Mar 1994 | pmid = 7510285 | doi =  }}
*{{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi=  }}
* {{cite journal | vauthors = Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC | title = Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening | journal = Genomics | volume = 23 | issue = 1 | pages = 42–50 | date = Sep 1994 | pmid = 7829101 | doi = 10.1006/geno.1994.1457 }}
*{{cite journal | author=Marken JS, Schieven GL, Hellström I, ''et al.'' |title=Cloning and expression of the tumor-associated antigen L6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3503-7 |year= 1992 |pmid= 1565644 |doi=  }}
* {{cite journal | vauthors = Virtaneva KI, Emi N, Marken JS, Aruffo A, Jones C, Spurr NK, Schröder JP | title = Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins | journal = Immunogenetics | volume = 39 | issue = 5 | pages = 329–34 | year = 1994 | pmid = 8168850 | doi = 10.1007/BF00189229 }}
*{{cite journal  | author=Marken JS, Bajorath J, Edwards CP, ''et al.'' |title=Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody. |journal=J. Biol. Chem. |volume=269 |issue= 10 |pages= 7397-401 |year= 1994 |pmid= 7510285 |doi=  }}
* {{cite journal | vauthors = Borrell-Pagès M, Fernández-Larrea J, Borroto A, Rojo F, Baselga J, Arribas J | title = The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein | journal = Molecular Biology of the Cell | volume = 11 | issue = 12 | pages = 4217–25 | date = Dec 2000 | pmid = 11102519 | pmc = 15068 | doi = 10.1091/mbc.11.12.4217 }}
*{{cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, ''et al.'' |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42-50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
* {{cite journal | vauthors = Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, Kramer MD, Reinartz J | title = Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes | journal = Experimental Cell Research | volume = 267 | issue = 2 | pages = 233–42 | date = Jul 2001 | pmid = 11426942 | doi = 10.1006/excr.2001.5250 }}
*{{cite journal | author=Virtaneva KI, Emi N, Marken JS, ''et al.'' |title=Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins. |journal=Immunogenetics |volume=39 |issue= 5 |pages= 329-34 |year= 1994 |pmid= 8168850 |doi= }}
* {{cite journal | vauthors = Kaneko R, Tsuji N, Kamagata C, Endoh T, Nakamura M, Kobayashi D, Yagihashi A, Watanabe N | title = Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa | journal = The American Journal of Gastroenterology | volume = 96 | issue = 12 | pages = 3457–8 | date = Dec 2001 | pmid = 11774983 | doi = 10.1111/j.1572-0241.2001.05355.x }}
*{{cite journal | author=Borrell-Pagès M, Fernández-Larrea J, Borroto A, ''et al.'' |title=The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein. |journal=Mol. Biol. Cell |volume=11 |issue= 12 |pages= 4217-25 |year= 2001 |pmid= 11102519 |doi= }}
* {{cite journal | vauthors = Kao YR, Shih JY, Wen WC, Ko YP, Chen BM, Chan YL, Chu YW, Yang PC, Wu CW, Roffler SR | title = Tumor-associated antigen L6 and the invasion of human lung cancer cells | journal = Clinical Cancer Research | volume = 9 | issue = 7 | pages = 2807–16 | date = Jul 2003 | pmid = 12855661 | doi =  }}
*{{cite journal | author=Storim J, Friedl P, Schaefer BM, ''et al.'' |title=Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes. |journal=Exp. Cell Res. |volume=267 |issue= 2 |pages= 233-42 |year= 2001 |pmid= 11426942 |doi= 10.1006/excr.2001.5250 }}
* {{cite journal | vauthors = Chang YW, Chen SC, Cheng EC, Ko YP, Lin YC, Kao YR, Tsay YG, Yang PC, Wu CW, Roffler SR | title = CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells | journal = International Journal of Cancer | volume = 116 | issue = 2 | pages = 243–52 | date = Aug 2005 | pmid = 15812828 | doi = 10.1002/ijc.21089 }}
*{{cite journal | author=Kaneko R, Tsuji N, Kamagata C, ''et al.'' |title=Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa. |journal=Am. J. Gastroenterol. |volume=96 |issue= 12 |pages= 3457-8 |year= 2002 |pmid= 11774983 |doi= }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder W, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC | title = Novel Anti-TM4SF1 Antibody Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature | journal = Molecular Cancer Therapeutics | volume =  14| date = Jun 2015 | pmid = 26089370 | doi = 10.1158/1535-7163.MCT-15-0188 | url = http://mct.aacrjournals.org/content/early/2015/06/18/1535-7163.MCT-15-0188.abstract | pages=1868–76}}
*{{cite journal | author=Kao YR, Shih JY, Wen WC, ''et al.'' |title=Tumor-associated antigen L6 and the invasion of human lung cancer cells. |journal=Clin. Cancer Res. |volume=9 |issue= 7 |pages= 2807-16 |year= 2004 |pmid= 12855661 |doi=  }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Chang YW, Chen SC, Cheng EC, ''et al.'' |title=CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells. |journal=Int. J. Cancer |volume=116 |issue= 2 |pages= 243-52 |year= 2005 |pmid= 15812828 |doi= 10.1002/ijc.21089 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
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Latest revision as of 22:07, 25 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transmembrane 4 L6 family member 1 is a protein that in humans is encoded by the TM4SF1 gene.[1][2]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.[2]

References

  1. ↑ Marken JS, Schieven GL, Hellström I, Hellström KE, Aruffo A (Apr 1992). "Cloning and expression of the tumor-associated antigen L6". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3503–7. doi:10.1073/pnas.89.8.3503. PMC 48896. PMID 1565644.
  2. ↑ 2.0 2.1 "Entrez Gene: TM4SF1 transmembrane 4 L six family member 1".

Further reading

  • Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. PMID 11739647.
  • Marken JS, Bajorath J, Edwards CP, Farr AG, Schieven GL, Hellström I, Hellström KE, Aruffo A (Mar 1994). "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody". The Journal of Biological Chemistry. 269 (10): 7397–401. PMID 7510285.
  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (Sep 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
  • Virtaneva KI, Emi N, Marken JS, Aruffo A, Jones C, Spurr NK, Schröder JP (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins". Immunogenetics. 39 (5): 329–34. doi:10.1007/BF00189229. PMID 8168850.
  • Borrell-Pagès M, Fernández-Larrea J, Borroto A, Rojo F, Baselga J, Arribas J (Dec 2000). "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein". Molecular Biology of the Cell. 11 (12): 4217–25. doi:10.1091/mbc.11.12.4217. PMC 15068. PMID 11102519.
  • Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, Kramer MD, Reinartz J (Jul 2001). "Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes". Experimental Cell Research. 267 (2): 233–42. doi:10.1006/excr.2001.5250. PMID 11426942.
  • Kaneko R, Tsuji N, Kamagata C, Endoh T, Nakamura M, Kobayashi D, Yagihashi A, Watanabe N (Dec 2001). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa". The American Journal of Gastroenterology. 96 (12): 3457–8. doi:10.1111/j.1572-0241.2001.05355.x. PMID 11774983.
  • Kao YR, Shih JY, Wen WC, Ko YP, Chen BM, Chan YL, Chu YW, Yang PC, Wu CW, Roffler SR (Jul 2003). "Tumor-associated antigen L6 and the invasion of human lung cancer cells". Clinical Cancer Research. 9 (7): 2807–16. PMID 12855661.
  • Chang YW, Chen SC, Cheng EC, Ko YP, Lin YC, Kao YR, Tsay YG, Yang PC, Wu CW, Roffler SR (Aug 2005). "CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells". International Journal of Cancer. 116 (2): 243–52. doi:10.1002/ijc.21089. PMID 15812828.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder W, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC (Jun 2015). "Novel Anti-TM4SF1 Antibody Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature". Molecular Cancer Therapeutics. 14: 1868–76. doi:10.1158/1535-7163.MCT-15-0188. PMID 26089370.


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