Exosome component 9: Difference between revisions

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{{Infobox_gene}}
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'''Exosome component 9''', also known as '''EXOSC9''', is a human [[gene]], the protein product of which is part of the [[exosome complex]] and is an autoantigen is patients with certain auto immune diseases, most notably [[scleromyositis]].<ref name="entrez">{{cite web | title = Entrez Gene: EXOSC9 exosome component 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5393| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_EXOSC9_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2nn6.
| PDB = {{PDB2|2nn6}}
| Name = Exosome component 9
| HGNCid = 9137
| Symbol = EXOSC9
| AltSymbols =; PM/Scl-75; PMSCL1; RRP45; Rrp45p; p5; p6
| OMIM = 606180
| ECnumber = 
| Homologene = 3693
| MGIid = 1355319
| GeneAtlas_image1 = PBB_GE_EXOSC9_205061_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000175 |text = 3'-5'-exoribonuclease activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004527 |text = exonuclease activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0000176 |text = nuclear exosome (RNase complex)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}} {{GNF_GO|id=GO:0006396 |text = RNA processing}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5393
    | Hs_Ensembl = ENSG00000123737
    | Hs_RefseqProtein = NP_001029366
    | Hs_RefseqmRNA = NM_001034194
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 122941922
    | Hs_GenLoc_end = 122957626
    | Hs_Uniprot = Q06265
    | Mm_EntrezGene = 50911
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_019393
    | Mm_RefseqProtein = NP_062266
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Exosome component 9''', also known as '''EXOSC9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EXOSC9 exosome component 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5393| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Alderuccio F, Chan EK, Tan EM |title=Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex. |journal=J. Exp. Med. |volume=173 |issue= 4 |pages= 941-52 |year= 1991 |pmid= 2007859 |doi=  }}
*{{cite journal  | vauthors=Alderuccio F, Chan EK, Tan EM |title=Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex |journal=J. Exp. Med. |volume=173 |issue= 4 |pages= 941–52 |year= 1991 |pmid= 2007859 |doi=10.1084/jem.173.4.941  | pmc=2190817 }}
*{{cite journal  | author=Allmang C, Petfalski E, Podtelejnikov A, ''et al.'' |title=The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. |journal=Genes Dev. |volume=13 |issue= 16 |pages= 2148-58 |year= 1999 |pmid= 10465791 |doi= }}
*{{cite journal  | author=Allmang C |title=The yeast exosome and human PM–Scl are related complexes of 3′ → 5′ exonucleases |journal=Genes Dev. |volume=13 |issue= 16 |pages= 2148–58 |year= 1999 |pmid= 10465791 |doi=10.1101/gad.13.16.2148  | pmc=316947 |name-list-format=vanc| author2=Petfalski E  | author3=Podtelejnikov A  | display-authors=| last4=Mann  | first4=M.  | last5=Tollervey  | first5=D.  | last6=Mitchell  | first6=P. }}
*{{cite journal | author=Brouwer R, Allmang C, Raijmakers R, ''et al.'' |title=Three novel components of the human exosome. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6177-84 |year= 2001 |pmid= 11110791 |doi= 10.1074/jbc.M007603200 }}
*{{cite journal  | author=Brouwer R |title=Three novel components of the human exosome |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6177–84 |year= 2001 |pmid= 11110791 |doi= 10.1074/jbc.M007603200 |name-list-format=vanc| author2=Allmang C | author3=Raijmakers R  | display-authors=3  | last4=Van Aarssen  | first4=| last5=Egberts  | first5=WV  | last6=Petfalski  | first6=| last7=Van Venrooij  | first7=WJ  | last8=Tollervey  | first8=D  | last9=Pruijn  | first9=GJ }}
*{{cite journal  | author=Chen CY, Gherzi R, Ong SE, ''et al.'' |title=AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. |journal=Cell |volume=107 |issue= 4 |pages= 451-64 |year= 2002 |pmid= 11719186 |doi=  }}
*{{cite journal  | author=Chen CY |title=AU binding proteins recruit the exosome to degrade ARE-containing mRNAs |journal=Cell |volume=107 |issue= 4 |pages= 451–64 |year= 2002 |pmid= 11719186 |doi=10.1016/S0092-8674(01)00578-5 |name-list-format=vanc| author2=Gherzi R | author3=Ong SE  | display-authors=3  | last4=Chan  | first4=Edward L. | last5=Raijmakers  | first5=Reinout  | last6=Pruijn  | first6=Ger J.M.  | last7=Stoecklin  | first7=Georg  | last8=Moroni  | first8=Christoph  | last9=Mann  | first9=Matthias }}
*{{cite journal | author=Mukherjee D, Gao M, O'Connor JP, ''et al.'' |title=The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. |journal=EMBO J. |volume=21 |issue= 1-2 |pages= 165-74 |year= 2002 |pmid= 11782436 |doi= 10.1093/emboj/21.1.165 }}
*{{cite journal  | author=Mukherjee D |title=The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements |journal=EMBO J. |volume=21 |issue= 1–2 |pages= 165–74 |year= 2002 |pmid= 11782436 |doi= 10.1093/emboj/21.1.165 | pmc=125812 |name-list-format=vanc| author2=Gao M  | author3=O'Connor JP  | display-authors=3  | last4=Raijmakers  | first4=| last5=Pruijn  | first5=| last6=Lutz  | first6=CS  | last7=Wilusz  | first7=J }}
*{{cite journal  | author=Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions of hCsl4p with other human exosome subunits. |journal=J. Mol. Biol. |volume=315 |issue= 4 |pages= 809-18 |year= 2002 |pmid= 11812149 |doi= 10.1006/jmbi.2001.5265 }}
*{{cite journal  | vauthors=Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions of hCsl4p with other human exosome subunits |journal=J. Mol. Biol. |volume=315 |issue= 4 |pages= 809–18 |year= 2002 |pmid= 11812149 |doi= 10.1006/jmbi.2001.5265 }}
*{{cite journal | author=Brouwer R, Vree Egberts WT, Hengstman GJ, ''et al.'' |title=Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. |journal=Arthritis Res. |volume=4 |issue= 2 |pages= 134-8 |year= 2002 |pmid= 11879549 |doi=  }}
*{{cite journal  | author=Brouwer R |title=Autoantibodies directed to novel components of the PM/Scl complex, the human exosome |journal=Arthritis Res. |volume=4 |issue= 2 |pages= 134–8 |year= 2002 |pmid= 11879549 |doi=10.1186/ar389  | pmc=83843  |name-list-format=vanc| author2=Vree Egberts WT  | author3=Hengstman GJ  | display-authors=| last4=Raijmakers  | first4=Reinout  | last5=Van Engelen  | first5=Baziel GM | last6=Peter Seelig  | first6=Hans  | last7=Renz  | first7=Manfred  | last8=Mierau  | first8=Rudolf  | last9=Genth  | first9=Ekkehard  }}
*{{cite journal  | author=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. |journal=J. Mol. Biol. |volume=323 |issue= 4 |pages= 653-63 |year= 2002 |pmid= 12419256 |doi=  }}
*{{cite journal  | vauthors=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring |journal=J. Mol. Biol. |volume=323 |issue= 4 |pages= 653–63 |year= 2002 |pmid= 12419256 |doi=10.1016/S0022-2836(02)00947-6  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |title=The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30698-704 |year= 2003 |pmid= 12788944 |doi= 10.1074/jbc.M302488200 }}
*{{cite journal  | vauthors=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |title=The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30698–704 |year= 2003 |pmid= 12788944 |doi= 10.1074/jbc.M302488200 }}
*{{cite journal  | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi}}
*{{cite journal  | author=Lehner B |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 |name-list-format=vanc| author2=Semple JI  | author3=Brown SE  | display-authors=3  | last4=Counsell  | first4=Damian  | last5=Campbell  | first5=R.Duncan  | last6=Sanderson  | first6=Christopher M  }}
*{{cite journal  | author=Raijmakers R, Renz M, Wiemann C, ''et al.'' |title=PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. |journal=Arthritis Rheum. |volume=50 |issue= 2 |pages= 565-9 |year= 2004 |pmid= 14872500 |doi= 10.1002/art.20056 }}
*{{cite journal  | author=Raijmakers R |title=PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome |journal=Arthritis Rheum. |volume=50 |issue= 2 |pages= 565–9 |year= 2004 |pmid= 14872500 |doi= 10.1002/art.20056  |name-list-format=vanc| author2=Renz M  | author3=Wiemann C  | display-authors=3  | last4=Egberts  | first4=Wilma Vree  | last5=Seelig  | first5=Hans Peter  | last6=Van Venrooij  | first6=Walther J.  | last7=Pruijn  | first7=Ger J. M. }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004  | pmc=442147 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207  |name-list-format=vanc| author2=Lam YW  | author3=Leung AK  | display-authors=3  | last4=Ong  | first4=Shao-En  | last5=Lyon  | first5=Carol E.  | last6=Lamond  | first6=Angus I.  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Tsang HT, Connell JW, Brown SE, ''et al.'' |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. |journal=Genomics |volume=88 |issue= 3 |pages= 333-46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003 }}
*{{cite journal  | author=Tsang HT |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex |journal=Genomics |volume=88 |issue= 3 |pages= 333–46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003  |name-list-format=vanc| author2=Connell JW  | author3=Brown SE  | display-authors=3  | last4=Thompson  | first4=Amanda  | last5=Reid  | first5=Evan  | last6=Sanderson  | first6=Christopher M. }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026  |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal | author=van Dijk EL, Schilders G, Pruijn GJ |title=Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. |journal=RNA |volume=13 |issue= 7 |pages= 1027-35 |year= 2007 |pmid= 17545563 |doi= 10.1261/rna.575107 }}
*{{cite journal  | vauthors=van Dijk EL, Schilders G, Pruijn GJ |title=Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways |journal=RNA |volume=13 |issue= 7 |pages= 1027–35 |year= 2007 |pmid= 17545563 |doi= 10.1261/rna.575107  | pmc=1894934 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5393}}
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Latest revision as of 04:17, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.[1]


References

  1. "Entrez Gene: EXOSC9 exosome component 9".

Further reading