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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Estrogen sulfotransferase''' is an [[enzyme]] that in humans is encoded by the ''SULT1E1'' [[gene]].<ref name="pmid7961757">{{cite journal | vauthors = Bernier F, Leblanc G, Labrie F, Luu-The V | title = Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene | journal = J Biol Chem | volume = 269 | issue = 45 | pages = 28200–5 |date=Dec 1994 | pmid = 7961757 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6783| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SULT1E1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1g3m.
| PDB = {{PDB2|1g3m}}, {{PDB2|1hy3}}
| Name = Sulfotransferase family 1E, estrogen-preferring, member 1
| HGNCid = 11377
| Symbol = SULT1E1
| AltSymbols =; EST; EST-1; MGC34459; STE
| OMIM = 600043
| ECnumber = 
| Homologene = 68469
| MGIid = 98431
| GeneAtlas_image1 = PBB_GE_SULT1E1_219934_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004304 |text = estrone sulfotransferase activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
  | Component =  
  | Process = {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0008210 |text = estrogen metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6783
    | Hs_Ensembl = ENSG00000109193
    | Hs_RefseqProtein = NP_005411
    | Hs_RefseqmRNA = NM_005420
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 70741520
    | Hs_GenLoc_end = 70760459
    | Hs_Uniprot = P49888
    | Mm_EntrezGene = 20860
    | Mm_Ensembl = ENSMUSG00000029272
    | Mm_RefseqmRNA = XM_976056
    | Mm_RefseqProtein = XP_981150
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 88650522
    | Mm_GenLoc_end = 88666155
    | Mm_Uniprot = Q8JZX7
  }}
}}
'''Sulfotransferase family 1E, estrogen-preferring, member 1''', also known as '''SULT1E1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6783| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.<ref name="entrez">{{cite web | title = Entrez Gene: SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6783| accessdate = }}</ref>
| summary_text = Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.<ref name="entrez"/>
}}
}}
==See also==
* [[Steroidogenic enzyme]]
* [[Steroid sulfotransferase]]
* [[Estrone sulfotransferase]]
* [[Steroid sulfatase]]


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Weinshilboum RM, Otterness DM, Aksoy IA, ''et al.'' |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3-14 |year= 1997 |pmid= 9034160 |doi=  }}
*{{cite journal   |vauthors=Weinshilboum RM, Otterness DM, Aksoy IA, etal |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3–14 |year= 1997 |pmid= 9034160 |doi=  }}
*{{cite journal | author=Glatt H, Engelke CE, Pabel U, ''et al.'' |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue=  |pages= 341-8 |year= 2000 |pmid= 10720750 |doi=  }}
*{{cite journal   |vauthors=Glatt H, Engelke CE, Pabel U, etal |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue=  |pages= 341–8 |year= 2000 |pmid= 10720750 |doi=10.1016/S0378-4274(99)00214-3 }}
*{{cite journal  | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1-2 |pages= 141-70 |year= 2001 |pmid= 11154739 |doi=  }}
*{{cite journal  | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1–2 |pages= 141–70 |year= 2001 |pmid= 11154739 |doi=10.1016/S0009-2797(00)00202-7 }}
*{{cite journal | author=Glatt H, Boeing H, Engelke CE, ''et al.'' |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27-40 |year= 2001 |pmid= 11535246 |doi=  }}
*{{cite journal   |vauthors=Glatt H, Boeing H, Engelke CE, etal |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects |journal=Mutat. Res. |volume=482 |issue= 1–2 |pages= 27–40 |year= 2001 |pmid= 11535246 |doi=  10.1016/S0027-5107(01)00207-X}}
*{{cite journal  | author=Falany CN, Krasnykh V, Falany JL |title=Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase. |journal=J. Steroid Biochem. Mol. Biol. |volume=52 |issue= 6 |pages= 529-39 |year= 1995 |pmid= 7779757 |doi= }}
*{{cite journal  | vauthors=Falany CN, Krasnykh V, Falany JL |title=Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase |journal=J. Steroid Biochem. Mol. Biol. |volume=52 |issue= 6 |pages= 529–39 |year= 1995 |pmid= 7779757 |doi=10.1016/0960-0760(95)00015-R }}
*{{cite journal  | author=Bernier F, Leblanc G, Labrie F, Luu-The V |title=Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene. |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 28200-5 |year= 1994 |pmid= 7961757 |doi= }}
*{{cite journal  | vauthors=Aksoy IA, Wood TC, Weinshilboum R |title=Human liver estrogen sulfotransferase: identification by cDNA cloning and expression |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 3 |pages= 1621–9 |year= 1994 |pmid= 8185618 |doi= 10.1006/bbrc.1994.1637 }}
*{{cite journal  | author=Aksoy IA, Wood TC, Weinshilboum R |title=Human liver estrogen sulfotransferase: identification by cDNA cloning and expression. |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 3 |pages= 1621-9 |year= 1994 |pmid= 8185618 |doi= 10.1006/bbrc.1994.1637 }}
*{{cite journal   |vauthors=Her C, Aksoy IA, Kimura S, etal |title=Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization |journal=Genomics |volume=29 |issue= 1 |pages= 16–23 |year= 1996 |pmid= 8530066 |doi= 10.1006/geno.1995.1210 }}
*{{cite journal | author=Her C, Aksoy IA, Kimura S, ''et al.'' |title=Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization. |journal=Genomics |volume=29 |issue= 1 |pages= 16-23 |year= 1996 |pmid= 8530066 |doi= 10.1006/geno.1995.1210 }}
*{{cite journal  | vauthors=Falany JL, Falany CN |title=Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines |journal=Cancer Res. |volume=56 |issue= 7 |pages= 1551–5 |year= 1996 |pmid= 8603401 |doi=  }}
*{{cite journal  | author=Falany JL, Falany CN |title=Expression of cytosolic sulfotransferases in normal mammary epithelial cells and breast cancer cell lines. |journal=Cancer Res. |volume=56 |issue= 7 |pages= 1551-5 |year= 1996 |pmid= 8603401 |doi=  }}
*{{cite journal  | vauthors=Her C, Szumlanski C, Aksoy IA, Weinshilboum RM |title=Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation |journal=Drug Metab. Dispos. |volume=24 |issue= 12 |pages= 1328–35 |year= 1997 |pmid= 8971138 |doi=  }}
*{{cite journal  | author=Her C, Szumlanski C, Aksoy IA, Weinshilboum RM |title=Human jejunal estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase: immunochemical characterization of individual variation. |journal=Drug Metab. Dispos. |volume=24 |issue= 12 |pages= 1328-35 |year= 1997 |pmid= 8971138 |doi=  }}
*{{cite journal  | vauthors=Song WC, Qian Y, Sun X, Negishi M |title=Cellular localization and regulation of expression of testicular estrogen sulfotransferase |journal=Endocrinology |volume=138 |issue= 11 |pages= 5006–12 |year= 1997 |pmid= 9348232 |doi=10.1210/en.138.11.5006 }}
*{{cite journal  | author=Song WC, Qian Y, Sun X, Negishi M |title=Cellular localization and regulation of expression of testicular estrogen sulfotransferase. |journal=Endocrinology |volume=138 |issue= 11 |pages= 5006-12 |year= 1997 |pmid= 9348232 |doi=  }}
*{{cite journal   |vauthors=Rubin GL, Harrold AJ, Mills JA, etal |title=Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy |journal=Mol. Hum. Reprod. |volume=5 |issue= 11 |pages= 995–1002 |year= 1999 |pmid= 10541560 |doi=10.1093/molehr/5.11.995 }}
*{{cite journal | author=Rubin GL, Harrold AJ, Mills JA, ''et al.'' |title=Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy. |journal=Mol. Hum. Reprod. |volume=5 |issue= 11 |pages= 995-1002 |year= 1999 |pmid= 10541560 |doi=  }}
*{{cite journal  | vauthors=Meinl W, Glatt H |title=Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 855–62 |year= 2001 |pmid= 11688987 |doi= 10.1006/bbrc.2001.5829 }}
*{{cite journal  | author=Meinl W, Glatt H |title=Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 855-62 |year= 2001 |pmid= 11688987 |doi= 10.1006/bbrc.2001.5829 }}
*{{cite journal  | vauthors=Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M |title=Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17928–32 |year= 2002 |pmid= 11884392 |doi= 10.1074/jbc.M111651200 }}
*{{cite journal  | author=Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M |title=Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17928-32 |year= 2002 |pmid= 11884392 |doi= 10.1074/jbc.M111651200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Shevtsov S, Petrotchenko EV, Pedersen LC, Negishi M |title=Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase |journal=Environ. Health Perspect. |volume=111 |issue= 7 |pages= 884–8 |year= 2003 |pmid= 12782487 |doi= 10.1289/ehp.6056| pmc=1241520 }}
*{{cite journal  | author=Shevtsov S, Petrotchenko EV, Pedersen LC, Negishi M |title=Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. |journal=Environ. Health Perspect. |volume=111 |issue= 7 |pages= 884-8 |year= 2003 |pmid= 12782487 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6783}}
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Latest revision as of 07:17, 11 September 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.[1][2]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.[2]

See also

References

  1. ↑ Bernier F, Leblanc G, Labrie F, Luu-The V (Dec 1994). "Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene". J Biol Chem. 269 (45): 28200–5. PMID 7961757.
  2. ↑ 2.0 2.1 "Entrez Gene: SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1".

Further reading



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